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1. 发明申请

WO2004036212A3 METHOD FOR THE DETERMINATION OF THE ENDOTOXIN CONTENT IN LIQUIDS 审中-公开
标题翻译：测定液体中内毒素含量的方法
公开(公告)号：WO2004036212A3
公开(公告)日：2004-06-24
申请号：PCT/EP0311028
申请日：2003-10-06
申请人： FRESENIUS HEMOCARE GMBH , OTTO VEIT , ZIMMERMANN MICHAEL , SCHOEN ANDREA , HACKET FRANK , HARTUNG THOMAS
发明人： OTTO VEIT , ZIMMERMANN MICHAEL , SCHOEN ANDREA , HACKET FRANK , HARTUNG THOMAS
IPC分类号： G01N33/543 , G01N33/569 , G01N33/92
CPC分类号： G01N33/569 , G01N33/543 , G01N33/54366
摘要： The invention relates to a method for the determination of the endotoxin content in liquids, a through flow container for use in said method and the use of particular separating elements in a method for the determination of the endotoxin content in liquids.
摘要翻译：本发明涉及一种用于确定内毒素的液体中的内容，用于本发明方法中使用的Durchströmbehälter和在过程中使用某些分离元件，用于确定内毒素的液体中的内容。

2. 发明申请

WO0222253A2 ADSORBENT HAVING DIFFERENTLY MODIFIED SURFACE AREAS, METHOD FOR THE PRODUCTION THEREOF AND USE OF THE SAME 审中-公开
标题翻译：与其他的变形表面积吸附剂，方法其使用和
公开(公告)号：WO0222253A2
公开(公告)日：2002-03-21
申请号：PCT/EP0110678
申请日：2001-09-14
申请人： FRESENIUS HEMOCARE GMBH , BAUMANN HANNO , GERNER FRANZ JOSEF , HOFFMANN MICHAEL , HORRES ROLAND , KOKOTT ANDREAS , LEINENBACH HANS PETER , MATHAR GUENTER , METZGER WOLFGANG , OTTO VEIT , RUEGER WALTER , SCHIMMEL MARTIN
发明人： BAUMANN HANNO , GERNER FRANZ-JOSEF , HOFFMANN MICHAEL , HORRES ROLAND , KOKOTT ANDREAS , LEINENBACH HANS-PETER , MATHAR GUENTER , METZGER WOLFGANG , OTTO VEIT , RUEGER WALTER , SCHIMMEL MARTIN
IPC分类号： A61M1/36 , B01D15/00 , B01J20/26 , B01J20/28 , B01J20/30 , B01J20/32 , C08F2/18 , C08J9/36 , B01J20/00
CPC分类号： B01J20/3285 , A61M1/3679 , B01J20/30 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , B01J20/3272 , B01J20/3282
摘要： The invention relates to a method for producing an absorbent, comprising the following steps: (a) a particulate, porous carrier material comprising modifiable binding sites on the outer and inner surfaces thereof is provided, (b) the pores of said carrier material are filled with at least one liquid medium under the filling conditions, said medium being essentially immiscible with a solution under the modifying conditions, said solution enabling binding sites on the surfaces of the carrier material to be essentially fully modified, (c) the binding sites are essentially fully modified on the outer surfaces of the carrier material to form at least one surface modification M1, and (d) the medium which is essentially immiscible, under the modifying conditions, with a solution which enables binding sites on the surfaces of the carrier material to be essentially fully modified, is optionally removed from the pores. The invention also relates to an adsorbent for whole blood, in the form of essentially spherical, non-aggregated particles, comprising a porous carrier material having an average pore size of 1,5 mu m. The outer surfaces of the porous carrier material comprise at least one surface modification M1, and thus do not essentially interact with blood cells, and the inner surfaces of the porous carrier material, i.e. the surfaces of the pores of said porous carrier material, comprise at least one surface modification M2 which interacts with substances contained in blood.
摘要翻译：本发明涉及一种用于生产吸附剂的方法，包括以下步骤：（a）提供颗粒状的，具有外表面和内表面上的多孔载体材料可修改的结合位点，（B）填充所述载体材料的孔与当中的至少一个液体填充介质的条件，这是Mofifizierens的条件下与基本上不混溶的溶液与结合位点可以被基本上完全载体材料的表面上改性，（c）中基本上完全修饰的外表面上的结合位点所述支撑材料的至少一个表面改性M1和（d）任选地与溶液改性的条件下除去培养基中的与该支撑材料的表面上的结合位点基本上完全可以修改ändig是基本上不混溶，从毛孔。此外，本发明涉及在包含具有的平均孔径的多孔载体材料基本上为球形的，非聚集颗粒的形式用于全血的吸附剂 1.5微米的孔径，多孔载体材料的外表面包括至少一个表面改性M1，其中，外表面基本上是不与血细胞相互作用，并且所述多孔载体材料的内表面，即具有多孔载体材料的孔的表面，至少一个表面改性，其M2与存在于血液中的物质相互作用。

3. 发明专利

JP2001299904A ADSORBENT FOR REDUCING CONCENTRATION OF FIBRINOGEN AND/ OR FIBRIN, USE OF ADSORBENT FOR MANUFACTURE OF ADSORPTION DEVICE, AND ADSORPTION DEVICE PROVIDED WITH ADSORBENT 失效
公开(公告)号：JP2001299904A
公开(公告)日：2001-10-30
申请号：JP2001066649
申请日：2001-03-09
申请人： FRESENIUS HEMOCARE GMBH
发明人： LEINENBACH HANS-PETER , OTTO VEIT , HEPPER MARTIN
IPC分类号： A61M1/02 , B01J20/26 , B01J20/32 , C12N5/08
摘要： PROBLEM TO BE SOLVED: To provide an adsorbent showing a satisfactory removing ratio, manufacturable at a low cost, biodegradable, selective to fibrinogen and/or fibrin, and causing no immune prevention in an adsorption device for reducing the fibrinogen and/or fibrin in blood or blood plasma, and a device using it. SOLUTION: This absorbent for reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma contains a matrix and a synthetic side chain convalent-bonded to the matrix. The side chain has at least two amino groups in which nitrogen atoms in the chain are separated to each other by at least 2.6 Å, and these amino groups contain no peptide or have no aromatic group.

4. 发明专利

JP2001316420A PRODUCTION METHOD OF ABSORBENT FOR REDUCING FIBRINOGEN AND/OR FIBRIN LEVEL, ABSORBENT, AND USE THEREOF FOR MANUFACTURING ABSORPTION DEVICE 失效
公开(公告)号：JP2001316420A
公开(公告)日：2001-11-13
申请号：JP2001066671
申请日：2001-03-09
申请人： FRESENIUS HEMOCARE GMBH
发明人： LEINENBACH HANS-PETER , MITSCHULAT HEIKE , METZGER WOLFGANG , OTTO VEIT , HEPPER MARTIN
IPC分类号： A61L2/04 , A61M1/16 , A61M1/36 , B01D39/02 , B01J20/26 , B01J20/30 , B01J20/32 , C08F8/32 , C08F220/12 , C08F220/32 , C08F220/56
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an absorbent which is used to reduce a fibrinogen and/or fibrin level in blood or serum. SOLUTION: The method is characterized in that a copolymer derived from a carrier material is aminated to activate and then treated with heat at a high temperature above 100 deg.C.

5. 发明专利

JP2003012694A Exotoxin-ligand 审中-公开
标题翻译： EXOTOXIN-LIGAND
公开(公告)号：JP2003012694A
公开(公告)日：2003-01-15
申请号：JP2002087634
申请日：2002-03-27
申请人： Fresenius Hemocare Gmbh , フレセニウスヘモケアゲーエムベーハー
发明人： MASCHKE HANS E , OTTO VEIT
IPC分类号： A61K39/02 , A61K39/395 , A61K47/48 , C07K7/08
CPC分类号： B01J20/3274 , A61K47/58 , B01J20/321 , B01J20/3248
摘要： PROBLEM TO BE SOLVED: To provide a ligand for bonding bacteriotoxin and a new system that acts on or prevents the septic shock having the fear caused by bacteriotoxin. SOLUTION: This is a ligand relating to the bacteriotoxin, particularly enterotoxin or exotoxin of the gram-positive bacteria and can selectively interact to the structure bearing the amino acid sequence preserved in the bacteriotoxin. This invention additionally provides an adsorbent showing the ligand bonded to the matrix, an adsorption apparatus for reducing the concentration of bacteriotoxin in blood or plasma and a pharmaceutical composition that includes the ligand and is particularly suitable for treatment and/or prophylaxis of gram- positive septic shock.
摘要翻译：要解决的问题：提供用于结合细菌毒素的配体和作用于或防止由细菌毒素引起的恐惧的败血性休克的新系统。解决方案：这是一种与细菌毒素有关的配体，特别是革兰氏阳性菌的肠毒素或外毒素，并且可以选择性地与具有保留在细菌毒素中的氨基酸序列结构相互作用。本发明另外提供了一种吸附剂，其显示了与基质结合的配体，用于降低血液或血浆中细菌毒素浓度的吸附装置和包含该配体的药物组合物，特别适用于治疗和/或预防革兰氏阳性败血症休克。

6. 发明专利

AU2003293601A8 Method for the determination of the endotoxin content in liquids 未知
公开(公告)号：AU2003293601A8
公开(公告)日：2004-05-04
申请号：AU2003293601
申请日：2003-10-06
申请人： FRESENIUS HEMOCARE GMBH
发明人： HARTUNG THOMAS , SCHON ANDREA , OTTO VEIT , ZIMMERMANN MICHAEL , HACKET FRANK
IPC分类号： G01N33/543 , G01N33/569 , G01N33/92

7. 发明专利

DE10045434B4 未知
公开(公告)号：DE10045434B4
公开(公告)日：2005-07-14
申请号：DE10045434
申请日：2000-09-14
申请人： FRESENIUS HEMOCARE GMBH
发明人： LEINENBACH HANS-PETER , OTTO VEIT , BAUMANN HANNO , HOFFMANN MICHAEL , HORRES ROLAND , KOKOTT ANDREAS , MATHAR GUENTER
IPC分类号： A61M1/36 , B01D15/00 , B01J20/26 , B01J20/28 , B01J20/30 , B01J20/32 , C08F2/18 , C08J9/36
摘要： An adsorbent for whole blood in the form of essentially spherical non-aggregated particles. The adsorbent comprises a porous carrier material having an average pore size of ≦̸1.5 μm, whereby a maximum of 50% of the pore volume may be in pores having a pore size of >1.5 μm, whereby the outer surfaces of the porous carrier material have at least one surface modification M1 so that the outer surface essentially does not interact with blood cells, and the inner surfaces of the porous carrier material, e.g., the surfaces of the pores of the porous carrier material, have at least one surface modification M2 which interacts with substances present in blood.

8. 发明专利

DE10011482B4 未知
公开(公告)号：DE10011482B4
公开(公告)日：2004-06-09
申请号：DE10011482
申请日：2000-03-09
申请人： FRESENIUS HEMOCARE GMBH
发明人： LEINENBACH HANS PETER , MITSCHULAT HEIKE , METZGER WOLFGANG , OTTO VEIT , HEPPER MARTIN
IPC分类号： A61L2/04 , A61M1/16 , A61M1/36 , B01D39/02 , B01J20/26 , B01J20/30 , B01J20/32 , C08F8/32 , C08F220/12 , C08F220/32 , C08F220/56 , C07K17/08 , C07K1/16
摘要： Production of an adsorbent (I) for reducing the fibrinogen and/or fibrin concentration in blood or blood plasma involves: (1) preparing a carrier material; (2) activating by incorporating covalently bonded basic groups; and (3) heat treating at more than 100 degrees C. Independent claims are also included for: (1) (I) prepared by the above method; and (2) an adsorber for use as above, comprising a housing (preferably with a volume of 250-1250 ml, having an inlet at the top and an outlet at the bottom and including a filter (specifically a particle filter) in the outlet) which contains (I).

9. 发明专利

DE10247430A1 未知
公开(公告)号：DE10247430A1
公开(公告)日：2004-04-29
申请号：DE10247430
申请日：2002-10-11
申请人： FRESENIUS HEMOCARE GMBH
发明人： OTTO VEIT , ZIMMERMANN MICHAEL , SCHOEN ANDREA , HACKET FRANK , HARTUNG THOMAS
IPC分类号： G01N33/543 , G01N33/569

10. 发明专利

AU2159602A Adsorbent having differently modified surface areas, method for the production thereof and use of the same 未知
公开(公告)号：AU2159602A
公开(公告)日：2002-03-26
申请号：AU2159602
申请日：2001-09-14
申请人： FRESENIUS HEMOCARE GMBH
发明人： BAUMANN HANNO , GERNER FRANZ-JOSEF , HOFFMANN MICHAEL , HORRES ROLAND , KOKOTT ANDREAS , LEINENBACH HANS-PETER , MATHAR GUNTER , METZGER WOLFGANG , OTTO VEIT , RUGER WALTER , SCHIMMEL MARTIN
IPC分类号： A61M1/36 , B01D15/00 , B01J20/26 , B01J20/28 , B01J20/30 , B01J20/32 , C08F2/18 , C08J9/36 , B01J20/00
摘要： An adsorbent for whole blood in the form of essentially spherical non-aggregated particles. The adsorbent comprises a porous carrier material having an average pore size of ≦̸1.5 μm, whereby a maximum of 50% of the pore volume may be in pores having a pore size of >1.5 μm, whereby the outer surfaces of the porous carrier material have at least one surface modification M1 so that the outer surface essentially does not interact with blood cells, and the inner surfaces of the porous carrier material, e.g., the surfaces of the pores of the porous carrier material, have at least one surface modification M2 which interacts with substances present in blood.

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