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1. 发明申请

WO0222253A2 ADSORBENT HAVING DIFFERENTLY MODIFIED SURFACE AREAS, METHOD FOR THE PRODUCTION THEREOF AND USE OF THE SAME 审中-公开
标题翻译：与其他的变形表面积吸附剂，方法其使用和
公开(公告)号：WO0222253A2
公开(公告)日：2002-03-21
申请号：PCT/EP0110678
申请日：2001-09-14
申请人： FRESENIUS HEMOCARE GMBH , BAUMANN HANNO , GERNER FRANZ JOSEF , HOFFMANN MICHAEL , HORRES ROLAND , KOKOTT ANDREAS , LEINENBACH HANS PETER , MATHAR GUENTER , METZGER WOLFGANG , OTTO VEIT , RUEGER WALTER , SCHIMMEL MARTIN
发明人： BAUMANN HANNO , GERNER FRANZ-JOSEF , HOFFMANN MICHAEL , HORRES ROLAND , KOKOTT ANDREAS , LEINENBACH HANS-PETER , MATHAR GUENTER , METZGER WOLFGANG , OTTO VEIT , RUEGER WALTER , SCHIMMEL MARTIN
IPC分类号： A61M1/36 , B01D15/00 , B01J20/26 , B01J20/28 , B01J20/30 , B01J20/32 , C08F2/18 , C08J9/36 , B01J20/00
CPC分类号： B01J20/3285 , A61M1/3679 , B01J20/30 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , B01J20/3272 , B01J20/3282
摘要： The invention relates to a method for producing an absorbent, comprising the following steps: (a) a particulate, porous carrier material comprising modifiable binding sites on the outer and inner surfaces thereof is provided, (b) the pores of said carrier material are filled with at least one liquid medium under the filling conditions, said medium being essentially immiscible with a solution under the modifying conditions, said solution enabling binding sites on the surfaces of the carrier material to be essentially fully modified, (c) the binding sites are essentially fully modified on the outer surfaces of the carrier material to form at least one surface modification M1, and (d) the medium which is essentially immiscible, under the modifying conditions, with a solution which enables binding sites on the surfaces of the carrier material to be essentially fully modified, is optionally removed from the pores. The invention also relates to an adsorbent for whole blood, in the form of essentially spherical, non-aggregated particles, comprising a porous carrier material having an average pore size of 1,5 mu m. The outer surfaces of the porous carrier material comprise at least one surface modification M1, and thus do not essentially interact with blood cells, and the inner surfaces of the porous carrier material, i.e. the surfaces of the pores of said porous carrier material, comprise at least one surface modification M2 which interacts with substances contained in blood.
摘要翻译：本发明涉及一种用于生产吸附剂的方法，包括以下步骤：（a）提供颗粒状的，具有外表面和内表面上的多孔载体材料可修改的结合位点，（B）填充所述载体材料的孔与当中的至少一个液体填充介质的条件，这是Mofifizierens的条件下与基本上不混溶的溶液与结合位点可以被基本上完全载体材料的表面上改性，（c）中基本上完全修饰的外表面上的结合位点所述支撑材料的至少一个表面改性M1和（d）任选地与溶液改性的条件下除去培养基中的与该支撑材料的表面上的结合位点基本上完全可以修改ändig是基本上不混溶，从毛孔。此外，本发明涉及在包含具有的平均孔径的多孔载体材料基本上为球形的，非聚集颗粒的形式用于全血的吸附剂 1.5微米的孔径，多孔载体材料的外表面包括至少一个表面改性M1，其中，外表面基本上是不与血细胞相互作用，并且所述多孔载体材料的内表面，即具有多孔载体材料的孔的表面，至少一个表面改性，其M2与存在于血液中的物质相互作用。

2. 发明专利

DE10045434B4 未知
公开(公告)号：DE10045434B4
公开(公告)日：2005-07-14
申请号：DE10045434
申请日：2000-09-14
申请人： FRESENIUS HEMOCARE GMBH
发明人： LEINENBACH HANS-PETER , OTTO VEIT , BAUMANN HANNO , HOFFMANN MICHAEL , HORRES ROLAND , KOKOTT ANDREAS , MATHAR GUENTER
IPC分类号： A61M1/36 , B01D15/00 , B01J20/26 , B01J20/28 , B01J20/30 , B01J20/32 , C08F2/18 , C08J9/36
摘要： An adsorbent for whole blood in the form of essentially spherical non-aggregated particles. The adsorbent comprises a porous carrier material having an average pore size of ≦̸1.5 μm, whereby a maximum of 50% of the pore volume may be in pores having a pore size of >1.5 μm, whereby the outer surfaces of the porous carrier material have at least one surface modification M1 so that the outer surface essentially does not interact with blood cells, and the inner surfaces of the porous carrier material, e.g., the surfaces of the pores of the porous carrier material, have at least one surface modification M2 which interacts with substances present in blood.

3. 发明专利

DE10045434A1 未知
公开(公告)号：DE10045434A1
公开(公告)日：2002-04-04
申请号：DE10045434
申请日：2000-09-14
申请人： FRESENIUS HEMOCARE GMBH
发明人： LEINENBACH HANS-PETER , OTTO VEIT , BAUMANN HANNO , HOFFMANN MICHAEL , HORRES ROLAND , KOKOTT ANDREAS , MATHAR GUENTER
IPC分类号： A61M1/36 , B01D15/00 , B01J20/26 , B01J20/28 , B01J20/30 , B01J20/32 , C08F2/18 , C08J9/36
摘要： The invention relates to a method for producing an absorbent, comprising the following steps: (a) a particulate, porous carrier material comprising modifiable binding sites on the outer and inner surfaces thereof is provided, (b) the pores of said carrier material are filled with at least one liquid medium under the filling conditions, said medium being essentially immiscible with a solution under the modifying conditions, said solution enabling binding sites on the surfaces of the carrier material to be essentially fully modified, (c) the binding sites are essentially fully modified on the outer surfaces of the carrier material to form at least one surface modification M1, and (d) the medium which is essentially immiscible, under the modifying conditions, with a solution which enables binding sites on the surfaces of the carrier material to be essentially fully modified, is optionally removed from the pores. The invention also relates to an adsorbent for whole blood, in the form of essentially spherical, non-aggregated particles, comprising a porous carrier material having an average pore size of 1,5 mu m. The outer surfaces of the porous carrier material comprise at least one surface modification M1, and thus do not essentially interact with blood cells, and the inner surfaces of the porous carrier material, i.e. the surfaces of the pores of said porous carrier material, comprise at least one surface modification M2 which interacts with substances contained in blood.

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