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1. 发明专利

JP2001299904A ADSORBENT FOR REDUCING CONCENTRATION OF FIBRINOGEN AND/ OR FIBRIN, USE OF ADSORBENT FOR MANUFACTURE OF ADSORPTION DEVICE, AND ADSORPTION DEVICE PROVIDED WITH ADSORBENT 失效
公开(公告)号：JP2001299904A
公开(公告)日：2001-10-30
申请号：JP2001066649
申请日：2001-03-09
申请人： FRESENIUS HEMOCARE GMBH
发明人： LEINENBACH HANS-PETER , OTTO VEIT , HEPPER MARTIN
IPC分类号： A61M1/02 , B01J20/26 , B01J20/32 , C12N5/08
摘要： PROBLEM TO BE SOLVED: To provide an adsorbent showing a satisfactory removing ratio, manufacturable at a low cost, biodegradable, selective to fibrinogen and/or fibrin, and causing no immune prevention in an adsorption device for reducing the fibrinogen and/or fibrin in blood or blood plasma, and a device using it. SOLUTION: This absorbent for reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma contains a matrix and a synthetic side chain convalent-bonded to the matrix. The side chain has at least two amino groups in which nitrogen atoms in the chain are separated to each other by at least 2.6 Å, and these amino groups contain no peptide or have no aromatic group.

2. 发明专利

JP2004508188A Adsorbent having separate modified surface portion, its production method and use thereof 审中-公开
公开(公告)号：JP2004508188A
公开(公告)日：2004-03-18
申请号：JP2002526497
申请日：2001-09-14
申请人：フレセニウス、ヘモケア、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツングFresenius Hemocare Gmbh
发明人：アンドレアス、ココット , ウォルフガング、メッガー , ギュンター、マタール , ハンス‐ペーター、ライネンバッハ , ハンノ、バウマン , ファイト、オットー , フランツ‐ヨーゼフ、ゲルナー , マルチン、シンメル , ミヒャエル、ホフマン , ローランド、ホレス , ワルター、リューガー
IPC分类号： A61M1/36 , B01D15/00 , B01J20/26 , B01J20/28 , B01J20/30 , B01J20/32 , C08F2/18 , C08J9/36
CPC分类号： B01J20/3285 , A61M1/3679 , B01J20/30 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , B01J20/3272 , B01J20/3282
摘要：本発明は、次のステップを含んでなる吸着剤の製造方法に関する：（ａ）外および内表面上に修飾可能な結合部位を有する多多孔質粒状キャリア物質を用意し、（ｂ）充填条件下で液体であって、キャリア物質の表面上にある結合部位が本質的に完全に修飾されうる溶液と修飾条件下で本質的に混和性でない、少くとも１種の媒体によりキャリア物質の孔を満たし、（ｃ）キャリア物質の外表面上にある結合部位を本質的に完全に修飾して、少くとも１種の表面修飾基Ｍ
１を形成させ、および（ｄ）場合により、キャリア物質の外表面上にある結合部位が本質的に完全に修飾されうる溶液と、修飾条件下で本質的に混和性でない媒体を孔から除去する。また、本発明は、１．５μｍ以下の平均孔度を有する多多孔質キャリア物質を含んでなり、本質的に球形の非凝集粒子の形をとる全血用の吸着剤に関する。孔容量の最大５０％が＞１．５μｍの孔度を有する孔の形で構成される。外表面が本質的に血液細胞と相互作用しないように、多多孔質キャリア物質の外表面が少くとも１種の表面修飾基Ｍ
１を有し、多孔質キャリア物質の内表面、即ち、多孔質キャリア物質の孔の表面が、血中に含有される物質と相互作用する少くとも１種の表面修飾基Ｍ
２を有している。

3. 发明专利

JP2003116984A BLOOD DONATION APPARATUS 审中-公开
公开(公告)号：JP2003116984A
公开(公告)日：2003-04-22
申请号：JP2002274606
申请日：2002-09-20
申请人： FRESENIUS HEMOCARE GMBH
发明人： KOLB STEFAN , MEISBERGER ARTUR
IPC分类号： A61M1/02
摘要： PROBLEM TO BE SOLVED: To provide a blood donation apparatus easy to operate, in a blood donation apparatus 10, which is equipped with a receiving part for a blood donation container and a control part 20 and can store instruments required for an operator and can change, detect and/or read the parameters of blood donation work. SOLUTION: By locating the control part 20 higher than the receiving part of the blood donation apparatus 10, it is not necessary for the operator to frequently bend for measuring or changing the work parameters on the blood donation apparatus ordinarily located on the floor.

4. 发明专利

JP2003071325A Tube-bundled body and its manufacturing method 有权
标题翻译：管束体及其制造方法
公开(公告)号：JP2003071325A
公开(公告)日：2003-03-11
申请号：JP2002170967
申请日：2002-06-12
申请人： Fresenius Hemocare Gmbh , フレゼニウスヘモケアーゲーエムベーハー
发明人： FRIEDRICH VITTOHAOSU , WEBER WOLFRAM
IPC分类号： F16L11/12 , A61M1/36 , B04B5/00 , B04B5/04 , B04B11/02
CPC分类号： B04B5/0442 , A61M1/3696 , B04B2005/0492
摘要： PROBLEM TO BE SOLVED: To provide a tube-bundled body the service life of which is remarkably prolonged without increasing the manufacturing cost.
SOLUTION: This multi-lumen tube-bundled body is used in a centrifugal separator in which a sliding seal is not used and consists of at least two independent tubes. Each of the tubes is spiraled on the vertical axis and/or the parallel axis as a center. Both of the constituent parts of the tub-bundled body extending to the directions opposite to each other from the support position almost at the center of the tube-bundled body are twisted in the directions reverse to each other.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种管束，其使用寿命显着延长，而不增加制造成本。解决方案：该多腔管束体用于不使用滑动密封的离心分离器中，并由至少两个独立的管组成。每个管以垂直轴和/或平行轴为中心螺旋形。从捆扎体的中心的支撑位置向彼此相反的方向延伸的桶状捆扎体的两个构成部分在相反的方向上被扭曲。

5. 发明专利

JP2001316420A PRODUCTION METHOD OF ABSORBENT FOR REDUCING FIBRINOGEN AND/OR FIBRIN LEVEL, ABSORBENT, AND USE THEREOF FOR MANUFACTURING ABSORPTION DEVICE 失效
公开(公告)号：JP2001316420A
公开(公告)日：2001-11-13
申请号：JP2001066671
申请日：2001-03-09
申请人： FRESENIUS HEMOCARE GMBH
发明人： LEINENBACH HANS-PETER , MITSCHULAT HEIKE , METZGER WOLFGANG , OTTO VEIT , HEPPER MARTIN
IPC分类号： A61L2/04 , A61M1/16 , A61M1/36 , B01D39/02 , B01J20/26 , B01J20/30 , B01J20/32 , C08F8/32 , C08F220/12 , C08F220/32 , C08F220/56
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an absorbent which is used to reduce a fibrinogen and/or fibrin level in blood or serum. SOLUTION: The method is characterized in that a copolymer derived from a carrier material is aminated to activate and then treated with heat at a high temperature above 100 deg.C.

6. 发明专利

JP2003012694A Exotoxin-ligand 审中-公开
标题翻译： EXOTOXIN-LIGAND
公开(公告)号：JP2003012694A
公开(公告)日：2003-01-15
申请号：JP2002087634
申请日：2002-03-27
申请人： Fresenius Hemocare Gmbh , フレセニウスヘモケアゲーエムベーハー
发明人： MASCHKE HANS E , OTTO VEIT
IPC分类号： A61K39/02 , A61K39/395 , A61K47/48 , C07K7/08
CPC分类号： B01J20/3274 , A61K47/58 , B01J20/321 , B01J20/3248
摘要： PROBLEM TO BE SOLVED: To provide a ligand for bonding bacteriotoxin and a new system that acts on or prevents the septic shock having the fear caused by bacteriotoxin. SOLUTION: This is a ligand relating to the bacteriotoxin, particularly enterotoxin or exotoxin of the gram-positive bacteria and can selectively interact to the structure bearing the amino acid sequence preserved in the bacteriotoxin. This invention additionally provides an adsorbent showing the ligand bonded to the matrix, an adsorption apparatus for reducing the concentration of bacteriotoxin in blood or plasma and a pharmaceutical composition that includes the ligand and is particularly suitable for treatment and/or prophylaxis of gram- positive septic shock.
摘要翻译：要解决的问题：提供用于结合细菌毒素的配体和作用于或防止由细菌毒素引起的恐惧的败血性休克的新系统。解决方案：这是一种与细菌毒素有关的配体，特别是革兰氏阳性菌的肠毒素或外毒素，并且可以选择性地与具有保留在细菌毒素中的氨基酸序列结构相互作用。本发明另外提供了一种吸附剂，其显示了与基质结合的配体，用于降低血液或血浆中细菌毒素浓度的吸附装置和包含该配体的药物组合物，特别适用于治疗和/或预防革兰氏阳性败血症休克。

7. 发明专利

JP2003159324A CENTRIFUGE 审中-公开
公开(公告)号：JP2003159324A
公开(公告)日：2003-06-03
申请号：JP2002257123
申请日：2002-09-02
申请人： FRESENIUS HEMOCARE GMBH
发明人： WITTHAUS FRIEDRICH , WEBER WOLFRAM
IPC分类号： A61M1/02 , B04B5/00 , B04B5/04
摘要： PROBLEM TO BE SOLVED: To provide an inexpensive centrifuge which can easily be manufactured in particular and whose pipeline is exposed to a relatively less mechanical load so that the number of its revolution can be enhanced. SOLUTION: The centrifuge which has a rotation frame 1 installed on a stand 2 that can be revolved and a separation unit 4 that can revolve around a central rotation axis A with twice the revolution of the rotation frame toward the same revolving direction, where the pipeline 6 that supplies or discharges a liquid is connected with the separation unit 4 and led to a static connection site 5 in a loop state around the separation unit. At least one guide element 7, 8 is provided to support the pipeline and has a support surface 10 for the pipeline. The support surface of the guide element is composed of a rotation plane curved line, while a radius R2 of each curvilinear circle contacting with the curved line at one point increases when a distance between a point of contact and the central rotation axis A is increased. An abrasion in this status is uniform over the whole surface of contact and the life span becomes longer accordingly. COPYRIGHT: (C)2003,JPO

8. 发明专利

JP2001129437A MAGNETIC DRIVING DEVICE AND CENTRIFUGAL SEPARATOR HAVING MAGNETIC DRIVING DEVICE 失效
公开(公告)号：JP2001129437A
公开(公告)日：2001-05-15
申请号：JP2000277840
申请日：2000-09-13
申请人： FRESENIUS HEMOCARE GMBH
发明人： MEISBERGER ARTHUR
IPC分类号： B04B9/02 , B04B5/00 , B04B11/02 , B08B9/08 , H02K7/14 , H02K49/10
摘要： PROBLEM TO BE SOLVED: To provide a very compact magnetic driving device for a centrifugal separator, especially for a slide sealless continuous centrifugal separator, enabling its operation hardly requiring maintenance with the high speed of revolution and with a little operation sound by relatively small power. SOLUTION: The magnetic driving device has a first and a second supporting bodies 2 and 11, and these supporting bodies carry respectively many magnets 16 and 17, and these magnets are arranged on a circle by alternating N pole and S pole and while mutually keeping a distance therebetween. Conductive liquid connecting members 18-21 are arranged at a third supporting body 6, for magnetic coupling. In the centrifugal separator for centrifuging bioliquid, especially blood, by providing such a magnetic driving device, the first supporting body 2 is arranged fixedly on a rack, and the third supporting body 6 is constituted as a rotary frame 6 arranged rotatively on the rack, and the second supporting body 11 is constituted as a separating device 12 arranged at the rotary frame 6.

9. 发明申请

WO0222253A2 ADSORBENT HAVING DIFFERENTLY MODIFIED SURFACE AREAS, METHOD FOR THE PRODUCTION THEREOF AND USE OF THE SAME 审中-公开
标题翻译：与其他的变形表面积吸附剂，方法其使用和
公开(公告)号：WO0222253A2
公开(公告)日：2002-03-21
申请号：PCT/EP0110678
申请日：2001-09-14
申请人： FRESENIUS HEMOCARE GMBH , BAUMANN HANNO , GERNER FRANZ JOSEF , HOFFMANN MICHAEL , HORRES ROLAND , KOKOTT ANDREAS , LEINENBACH HANS PETER , MATHAR GUENTER , METZGER WOLFGANG , OTTO VEIT , RUEGER WALTER , SCHIMMEL MARTIN
发明人： BAUMANN HANNO , GERNER FRANZ-JOSEF , HOFFMANN MICHAEL , HORRES ROLAND , KOKOTT ANDREAS , LEINENBACH HANS-PETER , MATHAR GUENTER , METZGER WOLFGANG , OTTO VEIT , RUEGER WALTER , SCHIMMEL MARTIN
IPC分类号： A61M1/36 , B01D15/00 , B01J20/26 , B01J20/28 , B01J20/30 , B01J20/32 , C08F2/18 , C08J9/36 , B01J20/00
CPC分类号： B01J20/3285 , A61M1/3679 , B01J20/30 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , B01J20/3272 , B01J20/3282
摘要： The invention relates to a method for producing an absorbent, comprising the following steps: (a) a particulate, porous carrier material comprising modifiable binding sites on the outer and inner surfaces thereof is provided, (b) the pores of said carrier material are filled with at least one liquid medium under the filling conditions, said medium being essentially immiscible with a solution under the modifying conditions, said solution enabling binding sites on the surfaces of the carrier material to be essentially fully modified, (c) the binding sites are essentially fully modified on the outer surfaces of the carrier material to form at least one surface modification M1, and (d) the medium which is essentially immiscible, under the modifying conditions, with a solution which enables binding sites on the surfaces of the carrier material to be essentially fully modified, is optionally removed from the pores. The invention also relates to an adsorbent for whole blood, in the form of essentially spherical, non-aggregated particles, comprising a porous carrier material having an average pore size of 1,5 mu m. The outer surfaces of the porous carrier material comprise at least one surface modification M1, and thus do not essentially interact with blood cells, and the inner surfaces of the porous carrier material, i.e. the surfaces of the pores of said porous carrier material, comprise at least one surface modification M2 which interacts with substances contained in blood.
摘要翻译：本发明涉及一种用于生产吸附剂的方法，包括以下步骤：（a）提供颗粒状的，具有外表面和内表面上的多孔载体材料可修改的结合位点，（B）填充所述载体材料的孔与当中的至少一个液体填充介质的条件，这是Mofifizierens的条件下与基本上不混溶的溶液与结合位点可以被基本上完全载体材料的表面上改性，（c）中基本上完全修饰的外表面上的结合位点所述支撑材料的至少一个表面改性M1和（d）任选地与溶液改性的条件下除去培养基中的与该支撑材料的表面上的结合位点基本上完全可以修改ändig是基本上不混溶，从毛孔。此外，本发明涉及在包含具有的平均孔径的多孔载体材料基本上为球形的，非聚集颗粒的形式用于全血的吸附剂 1.5微米的孔径，多孔载体材料的外表面包括至少一个表面改性M1，其中，外表面基本上是不与血细胞相互作用，并且所述多孔载体材料的内表面，即具有多孔载体材料的孔的表面，至少一个表面改性，其M2与存在于血液中的物质相互作用。

10. 发明申请

WO2004036212A3 METHOD FOR THE DETERMINATION OF THE ENDOTOXIN CONTENT IN LIQUIDS 审中-公开
标题翻译：测定液体中内毒素含量的方法
公开(公告)号：WO2004036212A3
公开(公告)日：2004-06-24
申请号：PCT/EP0311028
申请日：2003-10-06
申请人： FRESENIUS HEMOCARE GMBH , OTTO VEIT , ZIMMERMANN MICHAEL , SCHOEN ANDREA , HACKET FRANK , HARTUNG THOMAS
发明人： OTTO VEIT , ZIMMERMANN MICHAEL , SCHOEN ANDREA , HACKET FRANK , HARTUNG THOMAS
IPC分类号： G01N33/543 , G01N33/569 , G01N33/92
CPC分类号： G01N33/569 , G01N33/543 , G01N33/54366
摘要： The invention relates to a method for the determination of the endotoxin content in liquids, a through flow container for use in said method and the use of particular separating elements in a method for the determination of the endotoxin content in liquids.
摘要翻译：本发明涉及一种用于确定内毒素的液体中的内容，用于本发明方法中使用的Durchströmbehälter和在过程中使用某些分离元件，用于确定内毒素的液体中的内容。

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