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1. 发明授权

US06725081B2 Intravascular radiation delivery device 失效
标题翻译：血管内辐射输送装置
公开(公告)号：US06725081B2
公开(公告)日：2004-04-20
申请号：US09876481
申请日：2001-06-06
申请人： Jay P. Ciezki , Eugene J. Jung, Jr. , Eric J. Lee , Emin M. Tuzcu , James D. Savage , Martin S. Weinhous
发明人： Jay P. Ciezki , Eugene J. Jung, Jr. , Eric J. Lee , Emin M. Tuzcu , James D. Savage , Martin S. Weinhous
IPC分类号： A61B505
CPC分类号： A61N5/1002 , A61N2005/1005
摘要： A device and method for precisely delivering dosage of radiation from a radiation source to a treatment site of a vessel is provided herein. In one embodiment, the device includes a catheter which inserts into a vessel lumen of the body. The catheter includes an adjuster section for altering a portion of the radiation emitting radially from the radiation source so that the radiation source delivers an asymmetrical radiation profile to the vessel. The device can also include a catheter supporter which inhibits rotational deformation in the catheter between a catheter distal end and a catheter proximal end. This allows the delivery section to be precisely rotated to properly position the adjuster section within the vessel lumen.
摘要翻译：本文提供了一种用于将辐射源的辐射剂量准确地输送到容器的处理部位的装置和方法。在一个实施例中，该装置包括插入身体的血管腔的导管。导管包括调节器部分，用于改变从辐射源径向辐射的辐射的一部分，使得辐射源将不对称辐射轮廓传送到血管。该装置还可以包括导管支撑件，其阻止导管在导管远端和导管近端之间的旋转变形。这允许输送部分被精确地旋转以将调节器部分适当地定位在血管内腔内。

2. 发明授权

US06387035B1 Catheter with swivel tip 有权
标题翻译：导管带旋转头
公开(公告)号：US06387035B1
公开(公告)日：2002-05-14
申请号：US09436666
申请日：1999-11-10
申请人： Eugene J. Jung, Jr. , James D. Savage
发明人： Eugene J. Jung, Jr. , James D. Savage
IPC分类号： A61M3604
CPC分类号： A61N5/1002 , A61N2005/1005
摘要： A device and method for precisely delivering dosage of radiation from a radiation source to a treatment site of a vessel is provided herein. In one embodiment, the device includes a catheter which inserts into a vessel lumen of the body. The catheter includes an adjuster section for altering a portion of the radiation emitting radially from the radiation source so that the radiation source delivers an asymmetrical radiation profile to the vessel. The device can also include a catheter supporter which inhibits rotational deformation in the catheter between a catheter distal end and a catheter proximal end. This allows the delivery section to be precisely rotated to properly position the adjuster section within the vessel lumen.
摘要翻译：本文提供了一种用于将辐射源的辐射剂量准确地输送到容器的处理部位的装置和方法。在一个实施例中，该装置包括插入身体的血管腔的导管。导管包括调节器部分，用于改变从辐射源径向辐射的辐射的一部分，使得辐射源将不对称辐射轮廓传送到血管。该装置还可以包括导管支撑件，其阻止导管在导管远端和导管近端之间的旋转变形。这允许输送部分被精确地旋转以将调节器部分适当地定位在血管内腔内。

3. 发明授权

US06309339B1 Intravascular radiation delivery device 失效
标题翻译：血管内辐射输送装置
公开(公告)号：US06309339B1
公开(公告)日：2001-10-30
申请号：US09118308
申请日：1998-07-16
申请人： Jay P Ciezki , Eugene J. Jung, Jr. , Eric J. Lee , Emin M. Tuzcu , James D. Savage , Martin S. Weinhous
发明人： Jay P Ciezki , Eugene J. Jung, Jr. , Eric J. Lee , Emin M. Tuzcu , James D. Savage , Martin S. Weinhous
IPC分类号： A61M2902
CPC分类号： A61N5/1002 , A61N2005/1005
摘要： A device and method for precisely delivering dosage of radiation from a radiation source to a treatment site of a vessel is provided herein. In one embodiment, the device includes a catheter which inserts into a vessel lumen of the body. The catheter includes an adjuster section for altering a portion of the radiation emitting radially from the radiation source so that the radiation source delivers an asymmetrical radiation profile to the vessel. The device can also include a catheter supporter which inhibits rotational deformation in the catheter between a catheter distal end and a catheter proximal end. This allows the delivery section to be precisely rotated to properly position the adjuster section within the vessel lumen.
摘要翻译：本文提供了一种用于将辐射源的辐射剂量准确地输送到容器的处理部位的装置和方法。在一个实施例中，该装置包括插入身体的血管腔的导管。导管包括调节器部分，用于改变从辐射源径向辐射的辐射的一部分，使得辐射源将不对称辐射轮廓传送到血管。该装置还可以包括导管支撑件，其阻止导管在导管远端和导管近端之间的旋转变形。这允许输送部分被精确地旋转以将调节器部分适当地定位在血管内腔内。

4. 发明授权

US06626816B1 Intravascular radiation delivery device 失效
标题翻译：血管内辐射输送装置
公开(公告)号：US06626816B1
公开(公告)日：2003-09-30
申请号：US09614662
申请日：2000-07-12
申请人： Jay P. Ciezki , Eugene J. Jung, Jr.
发明人： Jay P. Ciezki , Eugene J. Jung, Jr.
IPC分类号： A61M3612
CPC分类号： A61N5/1002 , A61N2005/1005
摘要： A delivery device and method for delivering a dosage of radiation from a radiation source to a treatment site of a vessel is provided herein. The delivery device includes a catheter and a delivery area. The catheter is suitable for being inserted into a vessel lumen of the vessel and includes a delivery lumen for receiving the radiation source. The delivery area also receives the radiation source. The delivery area includes an attenuator section for attenuating a portion of the radiation emitting from the radioactive area so that the delivery area emits an eccentric radiation profile. The delivery device can also include a catheter supporter which inhibits rotational deformation in the catheter between a catheter distal end and a catheter proximal end. This allows the delivery area to be precisely rotated to properly position the attenuator section within the vessel lumen.
摘要翻译：本文提供了用于将辐射源的辐射剂量递送到容器的处理部位的递送装置和方法。输送装置包括导管和输送区域。该导管适于插入容器的血管腔，并且包括用于接收辐射源的输送腔。输送区域也接收辐射源。输送区域包括用于衰减从放射性区域发射的辐射的一部分的衰减器部分，使得输送区域发射偏心辐射轮廓。输送装置还可以包括导管支撑件，其阻止导管在导管远端和导管近端之间的旋转变形。这允许输送区域被精确地旋转以将衰减器部分适当地定位在血管内腔内。

5. 发明授权

US06033357A Intravascular radiation delivery device 失效
公开(公告)号：US06033357A
公开(公告)日：2000-03-07
申请号：US827489
申请日：1997-03-28
申请人： Jay P. Ciezki , Eugene J. Jung, Jr.
发明人： Jay P. Ciezki , Eugene J. Jung, Jr.
IPC分类号： A61M25/00 , A61M25/01 , A61M36/04 , A61M36/12 , A61N5/10
CPC分类号： A61N5/1002 , A61N2005/1005
摘要： A delivery device and method for delivering a dosage of radiation from a radiation source to a treatment site of a vessel is provided herein. The delivery device includes a catheter and a delivery area. The catheter is suitable for being inserted into a vessel lumen of the vessel and includes a delivery lumen for receiving the radiation source. The delivery area also receives the radiation source. The delivery area includes an attenuator section for attenuating a portion of the radiation emitting from the radioactive area so that the delivery area emits an eccentric radiation profile. The delivery device can also include a catheter supporter which inhibits rotational deformation in the catheter between a catheter distal end and a catheter proximal end. This allows the delivery area to be precisely rotated to properly position the attenuator section within the vessel lumen.

6. 发明授权

US06696121B2 Balloon for a dilation catheter and method for manufacturing a balloon 有权
标题翻译：用于扩张导管的气球和用于制造球囊的方法
公开(公告)号：US06696121B2
公开(公告)日：2004-02-24
申请号：US09918684
申请日：2001-07-27
申请人： Eugene J. Jung, Jr. , Leo R. Roucher, Jr.
发明人： Eugene J. Jung, Jr. , Leo R. Roucher, Jr.
IPC分类号： A61M2900
CPC分类号： A61M25/1029 , A61M2025/1086 , B29C49/18 , Y10T428/1334 , Y10T428/1345 , Y10T428/1352
摘要： A method for forming a balloon for a dilation catheter is provided herein. The method includes the steps of: (i) positioning a tube in a preconditioned mold; (ii) expanding the tube in a preconditioned mold to form a parison; (iii) positioning the parison in a balloon mold; and (iv) expanding the parison within the balloon mold to form the balloon. Thus, the tube is initially expanded into a parison in the preconditioned mold. Subsequently, the parison is expanded into a balloon in the balloon mold. Because of this unique manufacturing process, polyester block copolymers can be formed into balloons. Some of these polyester block copolymers could not be formed into a balloon using prior art blow molding processes. The resulting balloon exhibits superior characteristics, including relatively thin and consistent walls, soft texture, low uninflated crossing profile, expansion in a predictable fashion, and good tensile strength.
摘要翻译：本文提供了一种用于形成用于扩张导管的球囊的方法。该方法包括以下步骤：（i）将管定位在预调模中; （ii）在预处理的模具中膨胀管以形成型坯; （iii）将型坯定位在气球模具中; 和（iv）在气球模具内扩展型坯以形成气球。因此，管最初在预处理的模具中膨胀成型坯。随后，型坯在气球模具中膨胀成气球。由于这种独特的制造工艺，聚酯嵌段共聚物可以形成气球。这些聚酯嵌段共聚物中的一些不能使用现有技术的吹塑方法形成气囊。所得到的气球表现出优异的特性，包括相对薄且一致的壁，柔软的质地，低未膨胀的交叉轮廓，以可预测的方式膨胀，以及良好的拉伸强度。

7. 发明授权

US5735872A Stent 失效
标题翻译：支架
公开(公告)号：US5735872A
公开(公告)日：1998-04-07
申请号：US720714
申请日：1996-10-02
申请人： Kenneth W. Carpenter , Leo R. Roucher, Jr. , Eugene J. Jung, Jr. , Erich H. Wolf , Thomas A. Steinke
发明人： Kenneth W. Carpenter , Leo R. Roucher, Jr. , Eugene J. Jung, Jr. , Erich H. Wolf , Thomas A. Steinke
IPC分类号： A61F2/82 , A61F2/92 , A61M29/00
CPC分类号： A61F2/93 , A61F2/958
摘要： The present invention is a stent for insertion into an artery or other vessel. The stent is formed from a series of tubular shaped bands each formed with a first end which overlaps a second end. The overlap between the first and second ends is variable and allows each band to move between a contracted configuration and a fully expanded configuration which are within the elastic limits of the band. Each band includes a plurality of receivers and a first tab on a first edge of the band to secure each band at or near the fully expanded configuration and allow the stent to conform to the contours of the vessel. The bands are distributed along a substantially common axis to form a tube interconnected by a pair of elongated strips. In use, the stent is placed over a balloon catheter and compressed to adopt the contracted configuration. The stent is maintained in the contracted configuration by a retainer. The balloon catheter and stent are then advanced through a placement catheter to a target site where the balloon is partially inflated to free the stent for expansion to an equilibrium configuration. The balloon may then be more fully inflated to further expand any of the bands in the stent to suit the needs of the patient. The balloon is then deflated and removed, leaving the expanded stent to support that target site.
摘要翻译：本发明是用于插入动脉或其他血管的支架。支架由一系列管状带形成，每个管状带形成有与第二端重叠的第一端。第一和第二端之间的重叠是可变的，并且允许每个带在收缩构型和处于该带的弹性极限内的完全展开构型之间移动。每个带包括多个接收器和在带的第一边缘上的第一接头，以将每个带固定在完全展开的构型处或附近，并允许支架符合容器的轮廓。带沿着基本上共同的轴线分布以形成通过一对细长带相互连接的管。在使用中，将支架放置在气囊导管上并压缩以采用收缩构造。支架通过保持器保持在收缩构型中。气球导管和支架然后通过放置导管前进到目标部位，其中气囊被部分充气以释放支架用于扩张至平衡构型。然后，气球可以被更充分地充气以进一步扩张支架中的任何带以满足患者的需要。然后将气囊放气并除去，留下扩张的支架以支持该靶位点。

8. 发明授权

US6077213A Intravascular radiation delivery device 失效
公开(公告)号：US6077213A
公开(公告)日：2000-06-20
申请号：US114594
申请日：1998-07-13
申请人： Jay P. Ciezki , Eugene J. Jung, Jr.
发明人： Jay P. Ciezki , Eugene J. Jung, Jr.
IPC分类号： A61M25/00 , A61M25/01 , A61M36/04 , A61M36/12 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1002 , A61N2005/1005
摘要： A delivery device and method for delivering a dosage of radiation from a radiation source to a treatment site of a vessel is provided herein. The delivery device includes a catheter and a delivery area. The catheter is suitable for being inserted into a vessel lumen of the vessel and includes a delivery lumen for receiving the radiation source. The delivery area also receives the radiation source. The delivery area includes an attenuator section for attenuating a portion of the radiation emitting from the radioactive area so that the delivery area emits an eccentric radiation profile. The delivery device can also include a catheter supporter which inhibits rotational deformation in the catheter between a catheter distal end and a catheter proximal end. This allows the delivery area to be precisely rotated to properly position the attenuator section within the vessel lumen.

9. 发明授权

US5643314A Self-expanding stent 失效
标题翻译：自扩张支架
公开(公告)号：US5643314A
公开(公告)日：1997-07-01
申请号：US557725
申请日：1995-11-13
申请人： Kenneth W. Carpenter , Leo R. Roucher, Jr. , Eugene J. Jung, Jr.
发明人： Kenneth W. Carpenter , Leo R. Roucher, Jr. , Eugene J. Jung, Jr.
IPC分类号： A61F2/82 , A61F2/92 , A61M29/00
CPC分类号： A61F2/82 , A61F2/92 , A61F2/958
摘要： The present invention provides a self-expanding stent for insertion into an artery or other internal vessel. The stent is formed from a series of radial bands each formed with overlapping first and second ends. The overlap between the first and second ends is variable, allowing each band to move between a contracted configuration and an expanded configuration. The first and second ends of each band are both formed to include a tab which is folded to hold the first and second end against the band. The bands are distributed along a common axis to form a cylinder and interconnected by a pair of elongated strips. In use, the stent is placed over a balloon catheter and compressed to adopt the contracted configuration. The balloon catheter and stent are then advanced through a placement catheter and to a target site where the balloon is partially inflated to free the stent for self-expansion. The balloon may then be more fully inflated to further expand any of the radial bands in the stent. The balloon is then deflated and removed, leaving the expanded stent to support that target site.
摘要翻译：本发明提供一种用于插入动脉或其他内部血管的自扩张支架。支架由一系列径向带形成，每个径向带形成有重叠的第一和第二端。第一和第二端之间的重叠是可变的，允许每个带在收缩配置和扩展配置之间移动。每个带的第一和第二端都形成为包括折叠片，以将第一和第二端保持抵靠带。带沿着公共轴线分布以形成圆柱体并且通过一对细长条带互连。在使用中，将支架放置在气囊导管上并压缩以采用收缩构造。气囊导管和支架然后通过放置导管前进到靶部位，其中气囊被部分充气以释放支架以进行自我扩张。然后可以使球囊充分充气以进一步扩张支架中的任何径向带。然后将气囊放气并除去，留下扩张的支架以支持该靶位点。

10. 发明授权

US06645422B2 Method for manufacturing a balloon for a dilation catheter 有权
标题翻译：膨胀导管用球囊的制造方法
公开(公告)号：US06645422B2
公开(公告)日：2003-11-11
申请号：US09918599
申请日：2001-07-27
申请人： Eugene J. Jung, Jr. , Leo R. Roucher, Jr.
发明人： Eugene J. Jung, Jr. , Leo R. Roucher, Jr.
IPC分类号： B29C4908
CPC分类号： A61M25/1029 , A61M2025/1086 , B29C49/18
摘要： A method for forming a balloon for a dilation catheter is provided herein. The method includes the steps of: (i) positioning a tube in a preconditioned mold; (ii) expanding the tube in a preconditioned mold to form a parison; (iii) positioning the parison in a balloon mold; and (iv) expanding the parison within the balloon mold to form the balloon. Thus, the tube is initially expanded into a parison in the preconditioned mold. Subsequently, the parison is expanded into a balloon in the balloon mold. Because of this unique manufacturing process, polyester block copolymers can be formed into balloons. Some of these polyester block copolymers could not be formed into a balloon using prior art blow molding processes. The resulting balloon exhibits superior characteristics, including relatively thin and consistent walls, soft texture, low uninflated crossing profile, expansion in a predictable fashion, and good tensile strength.
摘要翻译：本文提供了一种用于形成用于扩张导管的球囊的方法。该方法包括以下步骤：（i）将管定位在预调模中; （ii）在预处理的模具中膨胀管以形成型坯; （iii）将型坯定位在气球模具中; 和（iv）在气球模具内扩展型坯以形成气球。因此，管最初在预处理的模具中膨胀成型坯。随后，型坯在气球模具中膨胀成气球。由于这种独特的制造工艺，聚酯嵌段共聚物可以形成气球。这些聚酯嵌段共聚物中的一些不能使用现有技术的吹塑方法形成气囊。所得到的气球表现出优异的特性，包括相对薄且一致的壁，柔软的质地，低未膨胀的交叉轮廓，以可预测的方式膨胀，以及良好的拉伸强度。

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