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1. 发明申请

US20050020484A1 Compositions for improving lipid metabolism 审中-公开
标题翻译：用于改善脂质代谢的组合物
公开(公告)号：US20050020484A1
公开(公告)日：2005-01-27
申请号：US10500245
申请日：2002-12-27
申请人： Etsumori Harada , Takashi Takeuchi , Kunio Ando , Hirohiko Shimizu
发明人： Etsumori Harada , Takashi Takeuchi , Kunio Ando , Hirohiko Shimizu
IPC分类号： A61K38/01 , A61K38/40 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12
CPC分类号： A61K38/38 , A23L33/19 , A23V2002/00 , A61K38/40 , A23V2250/54248 , A23V2250/5424 , A23V2250/304 , A23V2200/332 , A23V2200/328 , A61K2300/00
摘要： The present invention provides a pharmaceutical composition having at least one kind to be selected from the group consisting of a lactoferrin group protein comprising lactoferrin and conalbumin, and an enzymatically decomposed product of the lactoferrin group protein comprising peptides corresponding to lactoferricin and lactoferricin of conalbumin an active ingredient. The composition of the present invention can be used as an agent for improving lipid metabolism. Further, it is useful for treating hypercholesterolemia, hyper-neutral lipidemia, hyper-low density lipoprotein (LDL) cholesterolemia, hypo-high density lipoprotein (HDL) cholesterolemia, obesity, fatty liver and cholesterol gallstone and lifestyle-related diseases such as severe obesity, hyperlipidemia, hypertension and type II diabetes. The composition of the present invention can improve basal metabolic rate.
摘要翻译：本发明提供一种药物组合物，其具有至少一种选自包含乳铁蛋白和对照蛋白的乳铁蛋白基团蛋白质的组合物，以及乳铁蛋白基团蛋白质的酶促分解产物，其包含对应于乳酸铁蛋白的乳铁蛋白和乳铁蛋白的活性成分成分。本发明的组合物可以用作改善脂质代谢的药剂。此外，它可用于治疗高胆固醇血症，超中性脂质血症，高低密度脂蛋白（LDL）胆固醇血症，低密度脂蛋白（HDL）胆固醇血症，肥胖症，脂肪肝和胆固醇胆结石以及生活方式相关疾病如严重肥胖，高脂血症，高血压和II型糖尿病。本发明的组合物可以改善基础代谢率。

2. 发明授权

US08399414B2 Analgesics 有权
标题翻译：止痛药
公开(公告)号：US08399414B2
公开(公告)日：2013-03-19
申请号：US10502209
申请日：2003-01-17
申请人： Etsumori Harada , Takashi Takeuchi , Kenichiro Hayashida , Kunio Ando , Hirohiko Shimizu
发明人： Etsumori Harada , Takashi Takeuchi , Kenichiro Hayashida , Kunio Ando , Hirohiko Shimizu
IPC分类号： A61K38/40 , C07K14/79
CPC分类号： A61K9/2866 , A61K9/19 , A61K9/2013 , A61K9/205 , A61K9/282 , A61K31/485 , A61K38/40 , A61K2300/00
摘要： The object of this invention is to provide a novel pharmaceutical composition for getting rid of pains and anxiety in patients. This invention relates to a pharmaceutical composition containing lactoferrin as an active ingredient. The composition of this invention is useful for treatment of at least one disease or condition selected from the group consisting of pains, including the phase 1 pain and the phase 2 pain, anxiety and stress. The composition is particularly beneficial to alleviating or getting rid of the pain and anxiety which significantly lower quality of life of patients with end-stage cancer. The composition of this invention is also useful for treatment of pains, including the phase 1 pain and the phase 2 pain, and inflammation which accompany arthritis or diseases in the junctions of bones (e.g. rheumatoid arthritis, osteoarthritis, frozen shoulder, sports injuries such as tennis elbow and baseball shoulder, and low back pain).
摘要翻译：本发明的目的是提供一种用于消除患者的疼痛和焦虑的新型药物组合物。本发明涉及含有乳铁蛋白作为活性成分的药物组合物。本发明的组合物可用于治疗选自疼痛，包括1期疼痛和2期疼痛，焦虑和压力的至少一种疾病或病症。该组合物特别有利于缓解或消除显着降低终末期癌症患者生活质量的疼痛和焦虑。本发明的组合物还可用于治疗疼痛，包括1期疼痛和2期疼痛，以及伴随关节炎或骨骼关节疾病的炎症（例如类风湿性关节炎，骨关节炎，冷冻肩部，运动损伤如网球肘和棒球肩膀，腰痛）。

3. 发明申请

US20080014270A1 METHODS FOR IMPROVED LIPID METABOLISM AND BASAL METABOLIC RATE WITH LACTOFERRIN 审中-公开
标题翻译：改进脂质代谢和基础代谢率的方法与LACTOFERRIN
公开(公告)号：US20080014270A1
公开(公告)日：2008-01-17
申请号：US11832387
申请日：2007-08-01
申请人： Etsumori HARADA , Takashi Takeuchi , Kunio Ando , Hirohiko Shimizu
发明人： Etsumori HARADA , Takashi Takeuchi , Kunio Ando , Hirohiko Shimizu
IPC分类号： A61K9/30 , A61K38/40 , A61P1/16 , A61P3/06 , C07K14/79
CPC分类号： A61K38/38 , A23L33/19 , A23V2002/00 , A61K38/40 , A23V2250/54248 , A23V2250/5424 , A23V2250/304 , A23V2200/332 , A23V2200/328 , A61K2300/00
摘要： A pharmaceutical composition is provided having at least one kind to be selected from the group consisting of a lactoferrin group protein having lactoferrin and conalbumin, and an enzymatically decomposed product of the lactoferrin group protein having peptides corresponding to lactoferricin and lactoferricin of conalbumin as an active ingredient. The composition of the present invention can be used as an agent for improving lipid metabolism. Further, it is useful for treating hypercholesterolemia, hyper-neutral lipidemia, hyper-low density lipoprotein (LDL) cholesterolemia, hypo-high density lipoprotein (HDL) cholesterolemia, obesity, fatty liver and cholesterol gallstone and lifestyle-related diseases such as severe obesity, hyperlipidemia, hypertension and type II diabetes. The composition of the present invention can improve basal metabolic rate.
摘要翻译：提供一种药物组合物，其具有至少一种选自具有乳铁蛋白和氨聚糖蛋白的乳铁蛋白基蛋白和乳铁蛋白基蛋白的酶促分解产物，所述乳铁蛋白基蛋白具有与对照乳头蛋白的乳铁蛋白和乳铁蛋白作为活性成分的肽。本发明的组合物可以用作改善脂质代谢的药剂。此外，它可用于治疗高胆固醇血症，超中性脂质血症，高低密度脂蛋白（LDL）胆固醇血症，低密度脂蛋白（HDL）胆固醇血症，肥胖症，脂肪肝和胆固醇胆结石以及生活方式相关疾病如严重肥胖，高脂血症，高血压和II型糖尿病。本发明的组合物可以改善基础代谢率。

4. 发明申请

US20050119162A1 Novel analgesics 有权
标题翻译：新型镇痛药
公开(公告)号：US20050119162A1
公开(公告)日：2005-06-02
申请号：US10502209
申请日：2003-01-17
申请人： Etsumori Harada , Takashi Takeuchi , Kenichiro Hayashida , Kunio Ando , Hirohiko Shimizu
发明人： Etsumori Harada , Takashi Takeuchi , Kenichiro Hayashida , Kunio Ando , Hirohiko Shimizu
IPC分类号： A61K9/19 , A61K9/20 , A61K9/28 , A61K31/485 , A61K38/40 , A61P25/00 , A61P25/04 , A61P25/22 , A61P29/00 , A61P41/00 , A61P43/00
CPC分类号： A61K9/2866 , A61K9/19 , A61K9/2013 , A61K9/205 , A61K9/282 , A61K31/485 , A61K38/40 , A61K2300/00
摘要： The object of this invention is to provide a novel pharmaceutical composition for getting rid of pains and anxiety in patients. This invention relates to a pharmaceutical composition containing lactoferrin as an active ingredient. The composition of this invention is useful for treatment of at least one disease or condition selected from the group consisting of pains, including the phase 1 pain and the phase 2 pain, anxiety and stress. The composition is particularly beneficial to alleviating or getting rid of the pain and anxiety which significantly lower quality of life of patients with end-stage cancer. The composition of this invention is also useful for treatment of pains, including the phase 1 pain and the phase 2 pain, and inflammation which accompany arthritis or diseases in the junctions of bones (e.g. rheumatoid arthritis, osteoarthritis, frozen shoulder, sports injuries such as tennis elbow and baseball shoulder, and low back pain).
摘要翻译：本发明的目的是提供一种用于消除患者的疼痛和焦虑的新型药物组合物。本发明涉及含有乳铁蛋白作为活性成分的药物组合物。本发明的组合物可用于治疗选自疼痛，包括1期疼痛和2期疼痛，焦虑和压力的至少一种疾病或病症。该组合物特别有利于缓解或消除显着降低终末期癌症患者生活质量的疼痛和焦虑。本发明的组合物还可用于治疗疼痛，包括1期疼痛和2期疼痛，以及伴随关节炎或骨骼关节疾病的炎症（例如类风湿性关节炎，骨关节炎，冷冻肩部，运动损伤如网球肘和棒球肩膀，腰痛）。

5. 发明授权

US5793564A Auto-loading system for interfacing a magazine of recording medium cartridges with a recording/reproducing apparatus 失效
标题翻译：用于将记录介质盒的盒与记录/再现装置接口的自动加载系统
公开(公告)号：US5793564A
公开(公告)日：1998-08-11
申请号：US595484
申请日：1996-02-01
申请人： Hideo Nakase , Jo Nakagawa , Hirohiko Shimizu , Tsuyoshi Umemura , Akira Saito
发明人： Hideo Nakase , Jo Nakagawa , Hirohiko Shimizu , Tsuyoshi Umemura , Akira Saito
IPC分类号： G11B15/68
CPC分类号： G11B15/6885
摘要： An auto-loading system for recording medium cartridges is provided which permits the simple and reliable operation of rotating the recording medium cartridges between a magazine and a drive. The auto-loading system has a cartridge tray of an elevator which is moved upward and downward between a cartridge port of the drive and a cartridge insertion port and a cartridge ejection port of the magazine within an autoloader body so that a plurality of recording medium cartridges are rotated between the magazine and the drive by the operation of ejecting the recording medium cartridges into the cartridge tray from the cartridge ejection port of the magazine by a first cartridge ejecting mechanism and the operation of ejecting the recording medium cartridges into the cartridge port of the drive or the cartridge insertion port of the magazine from the cartridge tray by a second cartridge ejecting mechanism.
摘要翻译：提供了用于记录介质盒的自动装载系统，其允许在盒和驱动器之间旋转记录介质盒的简单和可靠的操作。自动装载系统具有电梯的盒托盘，其在自动装载机主体内在驱动器的盒端口和盒插入口与盒的弹出口之间向上和向下移动，使得多个记录介质盒通过利用第一盒式排出机构从盒的盒排出口将记录介质盒排出到盒托架中，并且将记录介质盒排出到盒式存储器盒的盒式端口中的操作，在盒和驱动器之间旋转驱动器或药筒插入口通过第二药筒排出机构从药筒托盘中取出。

6. 发明申请

US20100032554A1 Neutron Polarization Apparatus 审中-公开
标题翻译：中子极化仪
公开(公告)号：US20100032554A1
公开(公告)日：2010-02-11
申请号：US11992848
申请日：2006-11-01
申请人： Hirohiko Shimizu , Jun-ichi Suzuki , Takayuki Oku
发明人： Hirohiko Shimizu , Jun-ichi Suzuki , Takayuki Oku
IPC分类号： H05H3/02
CPC分类号： H05H3/06 , G21K1/093 , G21K1/16
摘要： A neutron polarization apparatus is provided that provides a neutron beam polarized by an interaction between a spin of a neutron in an incident neutron beam and a magnetic field. The apparatus includes a quadrupole magnet (2) disposed around a passage of a neutron beam, a tubular neutron absorber (3) provided in the quadrupole magnet (2) along am axial direction of the neutron beam, and a solenoid coil (4) disposed at an exit of the quadrupole magnet (2), adiabatically coupling the quadrupole magnetic field produced by the quadrupole magnet (2) and applying a bipolar magnetic field. The neutron polarization apparatus can polarize a neutron with a high polarization unavailable in the prior art.
摘要翻译：提供一种中子极化装置，其提供通过入射中子束中的中子的自旋与磁场之间的相互作用而偏振的中子束。该装置包括围绕中子束的通道设置的四极磁体（2），沿着中子束的轴向方向设置在四极磁体（2）中的管状中子吸收体（3），以及设置在电磁线圈在四极磁体（2）的出口处，绝缘地耦合由四极磁铁（2）产生的四极磁场并施加双极磁场。中子极化装置可以使现有技术中不可用的高极化的中子偏振。

7. 发明授权

US07450299B2 Broadband telescope 失效
标题翻译：宽带望远镜
公开(公告)号：US07450299B2
公开(公告)日：2008-11-11
申请号：US10499968
申请日：2002-12-25
申请人： Yoshiyuki Takizawa , Yoshiyuki Takahashi , Hirohiko Shimizu , Chiko Otani , Toshikazu Ebisuzaki
发明人： Yoshiyuki Takizawa , Yoshiyuki Takahashi , Hirohiko Shimizu , Chiko Otani , Toshikazu Ebisuzaki
IPC分类号： G02B23/06
CPC分类号： B82Y10/00 , G02B23/02 , G02B23/06 , G21K2201/061
摘要： The light of a broad energy band can be observed by reflecting the light of the broad energy band, for example, the light from the visible light region to the x-ray region at a high reflectance respectively, by a composite telescope including a normal incidence optical system and an oblique incidence optical system. A broadband telescope comprise an oblique incidence optical system unit in which the light is obliquely incident on a surface part for reflecting the incident light, a normal incidence optical system unit in which the light is substantially vertically incident on a surface part for reflecting the incident light, and an analyzer for spectrum analysis of the light reflected by the surface part of the obliquely incidence optical system unit and the light reflected by the surface part of the normal incidence optical system unit.
摘要翻译：通过复合望远镜，通过将包括正常入射的宽能带的光例如以可见光区域的光反射到高反射率的X射线区域，能够观察到宽能带的光光学系统和倾斜入射光学系统。宽带望远镜包括倾斜入射光学系统单元，其中光倾斜地入射在用于反射入射光的表面部分上;法线入射光学系统单元，其中光基本垂直地入射在表面部分上以反射入射光以及用于对由倾斜入射光学系统单元的表面部分反射的光和由入射光学系统单元的表面部分反射的光进行光谱分析的分析仪。

8. 发明申请

US20060226350A1 Neutron beam control device and method manufacturing the control device 失效
标题翻译：中子束控制装置及方法制造控制装置
公开(公告)号：US20060226350A1
公开(公告)日：2006-10-12
申请号：US10516449
申请日：2003-06-03
申请人： Shinya Morita , Hitoshi Ohmori , Yutaka Yamagata , Hirohiko Shimizu , Takayuki Oku
发明人： Shinya Morita , Hitoshi Ohmori , Yutaka Yamagata , Hirohiko Shimizu , Takayuki Oku
IPC分类号： H05H3/02
CPC分类号： G21K1/06 , G21K2201/068
摘要： An apparatus for controlling a neutron beam includes a plurality of columnar prisms 1 that are made of a material having a refractive index of less than 1 for a neutron beam, and are arranged so as to be multi-layered. The columnar prisms 1 each have an approximately right-triangle-shaped section, and are three-dimensionally multi-layered such that respective surfaces 1a, 1b, 1c of the columnar prisms are in parallel to one another. Stick-shaped members 5 are made of the above material, the stick-shaped members 5 are set in a plurality of grooves formed on a jig 6 that have the same shape, and upper surfaces of the grooves are flattened at the same time.
摘要翻译：用于控制中子束的装置包括多个柱状棱镜1，其由中子束的折射率小于1的材料制成，并且被布置为多层。柱状棱镜1各自具有近似三角形的截面，并且是三维多层的，使得柱状棱镜的各个表面1a，1b，1c彼此平行。棒状构件5由上述材料制成，棒状构件5被设置在形成于具有相同形状的夹具6上的多个槽中，并且槽的上表面同时被平坦化。

9. 发明授权

US4024073A Hydrogel and production thereof 失效
标题翻译：水凝胶及其制造
公开(公告)号：US4024073A
公开(公告)日：1977-05-17
申请号：US551669
申请日：1975-02-21
申请人： Hirohiko Shimizu , Hitoshi Ozawa
发明人： Hirohiko Shimizu , Hitoshi Ozawa
IPC分类号： A61K47/34 , A61K47/36 , A61K47/38 , B01J13/00 , C08B15/10 , C08B31/00 , C08B33/00 , C08B37/00 , C08H1/00 , C08L77/04 , C08L3/02
CPC分类号： A61K47/36 , A61K47/34 , A61K47/38 , A61K9/0019 , B01J13/0065 , C08B15/10 , C08B31/003 , C08B33/00 , C08B37/00 , C08H1/00 , C08L77/04
摘要： A novel and stable hydrogel contains a water-soluble polymer containing a chelating agent bound to the polymer chain, and a polyvalent metal ion cross-linking the polymer molecules through the chelating agent. The hydrogel is a carrier for timed release of drugs and medicaments.
摘要翻译：一种新颖且稳定的水凝胶含有含有与聚合物链结合的螯合剂的水溶性聚合物，多价金属离子通过螯合剂交联聚合物分子。水凝胶是药物和药物定时释放的载体。

10. 发明授权

US06580080B1 Neutron beam controlling apparatus, and neutron energy measuring apparatus 失效
标题翻译：中子束控制装置和中子能量测量装置
公开(公告)号：US06580080B1
公开(公告)日：2003-06-17
申请号：US09520154
申请日：2000-03-07
申请人： Hirohiko Shimizu , Takayuki Oku , Yuji Kawabata
发明人： Hirohiko Shimizu , Takayuki Oku , Yuji Kawabata
IPC分类号： G21K106
CPC分类号： B82Y10/00 , G01T3/00 , G21K1/062 , G21K2201/068
摘要： A neutron beam controlling apparatus includes a plurality of multilayered plate members, each having on one or both of its surfaces, one or more minute protruding portions. Each of the protruding portions is a long and narrow protrusion extending in an area-wise direction and having both an inclined surface that is inclined against the beam axis of neutron beam and serves as an incident plane or an outgoing plane for the neutron beam and a surface approximately normal to the plate member.
摘要翻译：中子束控制装置包括多个多层板构件，每个多层板构件在其一个或两个表面上具有一个或多个微小突出部分。每个突出部分是沿着区域方向延伸的长而窄的突起，并且具有相对于中子束的束轴倾斜的倾斜表面并且用作中子束的入射面或出射面，并且大致垂直于板件的表面。

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