专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4883861A Cysteine-rich peptides having gamma-glutamic acid and beta-alanine units, a process for their preparation and their use 失效
标题翻译：具有γ-谷氨酸和β-丙氨酸单元的富含半胱氨酸的肽，其制备方法及其应用
公开(公告)号：US4883861A
公开(公告)日：1989-11-28
申请号：US026833
申请日：1987-03-17
申请人： Erwin Grill , Ernst-Ludwig Winnacker , Meinhart H. Zenk
发明人： Erwin Grill , Ernst-Ludwig Winnacker , Meinhart H. Zenk
IPC分类号： C07K14/415 , A61K38/00 , A61P39/02 , C07K1/00 , C07K5/02 , C07K7/02
CPC分类号： C07K5/0215
摘要： Disclosed are peptides which have the following amino acid sequence:(.gamma.-Glu-Cys).sub.n -.beta.-Alan being an integer from 2 to 11;.gamma.-Glu represents .gamma.-glutamic acid;Cys represents cysteine; and.beta.-Ala represents .beta.-alanine.A process for the preparation of these peptides is disclosed as well as processes for their use for the maintenance of hemeostasis in physiological systems, the diagnosis of tumors, and the removal of heavy metals from a chemical or physiological system which has been contaminated with heavy metal.
摘要翻译：公开了具有以下氨基酸序列的肽：（γ-Glu-Cys）n-β-Ala n为2至11的整数; γ-Glu表示γ-谷氨酸; Cys代表半胱氨酸; β-Ala代表β-丙氨酸。公开了一种制备这些肽的方法，以及其用于维持生理系统中的血管平衡，肿瘤诊断和从重金属被污染的化学或生理系统中去除重金属的方法。

2. 发明授权

US4725670A High-cysteine peptides with alpha-glutamic acid units, process for their production and application of same 失效
标题翻译：具有α-谷氨酸单元的高半胱氨酸肽，其生产和应用的过程
公开(公告)号：US4725670A
公开(公告)日：1988-02-16
申请号：US829317
申请日：1986-02-14
申请人： Erwin Grill , Ernst-Ludwig Winnacker , Meinhart H. Zenk
发明人： Erwin Grill , Ernst-Ludwig Winnacker , Meinhart H. Zenk
IPC分类号： C07K14/415 , A61K36/00 , A61K36/18 , A61K36/23 , A61K36/24 , A61K36/28 , A61K36/29 , A61K36/71 , A61K36/73 , A61K36/81 , A61K38/00 , A61P39/02 , C02F1/62 , C07K5/02 , C07K7/02 , C07K7/06 , C07K7/08 , C09K3/00 , C12P21/02
CPC分类号： C07K5/0215
摘要： A high-cysteine polypeptide having an amino acid sequence of the formula:-(.gamma.-Glu-Cys).sub.n -Glyin which,n is an integer from 4 to 7,.gamma.-Glu represents .gamma.-glutamic acid,Cys represents cysteine, andGly represents glycine,for use in pharmaceutical preparations for treating acute and chronic heavy metal poisoning. Alternatively, the polypeptides may be employed in the treatment of metal deficiency phenomena or for maintaining the homeostasis in physiological systems with respect to such metals as iron or zinc. Processes for producing the polypeptides of the invention are also disclosed.
摘要翻译：具有下式的氨基酸序列的高半胱氨酸多肽： - （γ-Glu-Cys）n-Gly，其中n是4至7的整数，γ-Glu表示γ-谷氨酸，Cys表示半胱氨酸， Gly代表甘氨酸，用于治疗急性和慢性重金属中毒的药物制剂。或者，多肽可用于治疗金属缺乏现象或用于维持生理系统中相对于诸如铁或锌的金属的体内平衡。还公开了用于制备本发明多肽的方法。

3. 发明授权

US07037674B1 Cytochrome P450 reductases from poppy plants 失效
公开(公告)号：US07037674B1
公开(公告)日：2006-05-02
申请号：US09486757
申请日：1998-08-28
申请人： Toni M. Kutchan , Meinhart H. Zenk , David G. Atkins , Anthony J. Fist
发明人： Toni M. Kutchan , Meinhart H. Zenk , David G. Atkins , Anthony J. Fist
IPC分类号： C12P21/06 , C12N15/82 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12N9/0042 , C12N15/8205 , C12N15/8243
摘要： The present invention relates to production of alkaloids from poppy plants and in particular togenes encoding enzymes in the alkaloid pathway, to proteins encoded by the gens, to plants transformed or transfected with the genes and to methods of altering alkaloid content or blend of poppy plants.

4. 发明授权

US07288367B2 Non-mevalonate isoprenoid pathway 失效
标题翻译：非甲羟戊酸类异戊二烯通路
公开(公告)号：US07288367B2
公开(公告)日：2007-10-30
申请号：US10296416
申请日：2001-06-01
申请人： Adelbert Bacher , Meinhart H. Zenk , Petra Adam , Wolfgang Eisenreich , Monika Fellermeier , Stefan Hecht , Felix Rohdich , Christoph A. Schuhr , Juraithip Wungsintaweekul
发明人： Adelbert Bacher , Meinhart H. Zenk , Petra Adam , Wolfgang Eisenreich , Monika Fellermeier , Stefan Hecht , Felix Rohdich , Christoph A. Schuhr , Juraithip Wungsintaweekul
IPC分类号： C12Q1/00
CPC分类号： C12N9/00 , C12N15/52 , C12N15/8274 , C12P9/00
摘要： The present invention is directed to enzymes and intermediates of the non-mevalonate isoprenoid pathway downstream of 2C-methyl-D-erythritol 2,4-cyclopyrophosphate and upstream of isopentenyl pyrophosphate or dimethylallyl pyrophosphate. These are used as a basis for a screening method for inhibitors of these enzymes, and a method for identifying inhibitor-resistant variants thereof. Further disclosures refer to DNA coding for said enzymes and for inhibitor-resistant variants thereof, vectors containing said DNA, cells containing said vector, and plant seeds comprising cells containing said vector. This invention is useful for the inhibition of the biosynthesis of isoprenoids in plants, bacteria and protozoa, for confering herbicide-resistance to plants, as well as for weed control in agriculture using a crop containing a herbicide-resistant gene and an effective amount of a suitable herbicide.
摘要翻译：本发明涉及2-甲基-D-赤藓糖醇2,4-环丙基磷酸酯和异戊烯基焦磷酸或二甲基烯丙基焦磷酸的上游的非甲羟戊酸异戊二烯通路的酶和中间体。这些用作这些酶的抑制剂的筛选方法的基础，以及用于鉴定其抑制剂抗性变体的方法。还涉及编码所述酶和其抑制剂抗性变体的DNA，含有所述DNA的载体，含有所述载体的细胞，以及含有所述载体的细胞的植物种子。本发明可用于抑制植物，细菌和原生动物中的类异戊二烯的生物合成，以赋予对植物的除草剂抗性，以及在使用含有除草剂抗性基因的作物和有效量的合适的除草剂。

5. 发明授权

US4857512A Immunostimulating polysaccharides, method for using such, and pharmaceutical preparations containing them 失效
标题翻译：免疫刺激多糖，使用方法和含有它们的药物制剂
公开(公告)号：US4857512A
公开(公告)日：1989-08-15
申请号：US933482
申请日：1986-11-21
申请人： Hildebert Wagner , Meinhart H. Zenk , Holger Ott
发明人： Hildebert Wagner , Meinhart H. Zenk , Holger Ott
IPC分类号： C12N5/06 , A61K31/715 , A61K36/28 , A61P35/00 , A61P37/00 , A61P37/04 , C08B37/00 , C08B37/14 , C12N5/00 , C12P19/04 , C12R1/91
CPC分类号： C12P19/04 , C08B37/0087 , Y10S514/885
摘要： The present invention pertains to plant polysaccharides acting on the immune system and a process for isolating the polysaccharides from plant cell cultures. The purified polysaccharides can be used as drugs, specifically as immunomodulators or immune mediators, in animal medicine.
摘要翻译：本发明涉及作用于免疫系统的植物多糖和从植物细胞培养物中分离多糖的方法。纯化的多糖可以用作动物药物中的药物，特别是作为免疫调节剂或免疫介质。

6. 发明授权

US07534742B2 Isoprenoid biosynthesis 失效
标题翻译：异戊二烯生物合成
公开(公告)号：US07534742B2
公开(公告)日：2009-05-19
申请号：US11526318
申请日：2006-09-25
申请人： Wolfgang Eisenreich , Monika Fellermeier , Markus Fischer , Stefan Hecht , Stefan Herz , Klaus Kis , Holger Lüttgen , Felix Rohdich , Silvia Sagner , Christoph A. Schuhr , Jurathip Wungsintaweekul , Adelbert Bacher , Meinhart H. Zenk
发明人： Wolfgang Eisenreich , Monika Fellermeier , Markus Fischer , Stefan Hecht , Stefan Herz , Klaus Kis , Holger Lüttgen , Felix Rohdich , Silvia Sagner , Christoph A. Schuhr , Jurathip Wungsintaweekul , Adelbert Bacher , Meinhart H. Zenk
IPC分类号： C40B30/04
CPC分类号： C12N9/1229 , C12N9/1205 , C12N9/88 , C12P23/00
摘要： The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as purified isolated DNA coding for such proteins. Moreover, the present invention relates to novel inhibitors detectable by said screening methods as well as compositions and processes for inhibiting the synthesis of isoprenoids and for controlling the growth of organisms based on said inhibitors. The invention relates also to the development of inhibitor-resistant plant enzymes and plants, plant tissues, plant seeds and plant cells.
摘要翻译：本发明涉及涉及类异戊二烯生物合成的酶活性以及在类异戊二烯的生物合成中用于酶的抑制剂，特别是除草剂。更具体地，本发明涉及用于检测这些抑制剂的筛选方法和用于进行所述方法的酶活性蛋白质以及编码这种蛋白质的纯化的分离的DNA。此外，本发明涉及可通过所述筛选方法检测的新型抑制剂，以及用于抑制类异戊二烯的合成和基于所述抑制剂控制生物体的生长的组合物和方法。本发明还涉及抑制剂抗性植物酶和植物，植物组织，植物种子和植物细胞的发展。

7. 发明授权

US07390642B2 Salutaridinol 7-O-acetyltransferase and derivatives thereof 失效
标题翻译： salutaridinol 7-O-乙酰转移酶及其衍生物
公开(公告)号：US07390642B2
公开(公告)日：2008-06-24
申请号：US10167603
申请日：2002-06-11
申请人： Toni M. Kutchan , Meinhart H. Zenk , Torsten Grothe
发明人： Toni M. Kutchan , Meinhart H. Zenk , Torsten Grothe
IPC分类号： C12N15/54 , C12N9/10
CPC分类号： C12N9/1029 , C12N15/8243 , C12P17/188 , C12Y203/0115
摘要： This invention provides: (A) a protein the sequence of which is in FIG. 8 (SEQ. ID n° 14), or a fragment thereof having at least 15 amino acids, or a variant thereof, having at least 70% identity with FIG. 8 (SEQ. ID n° 14) over a length of at least 400 amino acids; (B) a peptide comprising a fragment of salutaridinol 7-O-acetyltransferase of at least 6 consecutive amino acids not present in other plant acetyltransferases as in FIG. 2 (SEQ. IDs n° 8 to 12); (C) a nucleic acid (i) the sequence of which is in FIG. 9 (SEQ. ID n° 13) or FIG. 10 (SEQ. ID n° 15), or (ii) a fragment thereof of at least 45 nucleotides, or (iii) a variant thereof, having at least 70% identity with FIG. 9 (SEQ. ID n° 13) or FIG. 10 (SEQ. ID n° 15) over a length of at least 1200 bases, or (iv) a sequence complementary to (i), (ii) or (iii); or (v) the RNA equivalent of any of (i), (ii), or (iii); (D) a nucleic acid comprising a fragment of a salutaridinol 7-O-acetyltransferase gene of at least 18 consecutive nucleotides unique to the salutaridinol 7-O-acetyltransferase gene from the 5′ or 3′ untranslated regions in FIG. 9 (SEQ. ID n° 13), or a sequence complementary thereto. This invention also provides methods for producing pentacyclic morphinan alkaloids and thebaine.
摘要翻译：本发明提供：（A）其序列在图1中的蛋白质。 8（SEQ ID NO 14）或其具有至少15个氨基酸的片段，或其变体与图1至少具有70％的同一性。 8（SEQ ID NO：14），长度至少为400个氨基酸; （B）包含不存在于如图1所示的其它植物乙酰转移酶中的至少6个连续氨基酸的salutaridinol 7-O-乙酰转移酶片段的肽。 2（SEQ ID NO 8至12）; （C）核酸（i）其序列在图1中。 9（SEQ ID NO：13）或图9。 10（SEQ ID NO：15），或（ii）至少45个核苷酸的片段，或（iii）其变体与图1至少具有70％的同一性。 9（SEQ ID NO：13）或图9。 10（SEQ ID NO：15），长度至少为1200个碱基，或（iv）与（i），（ii）或（iii）互补的序列; 或（v）（i），（ii）或（iii）中任何一种的RNA当量; （D）包含图5中5'或3'非翻译区的salutaridinol 7-O-乙酰转移酶基因独特的至少18个连续核苷酸的salutaridinol 7-O-乙酰转移酶基因片段的核酸。 9（SEQ ID NO：13）或其互补序列。本发明还提供了生产五环吗啡生物碱和蒂巴因的方法。

8. 发明授权

US07122331B1 Isoprenoid biosynthesis 失效
标题翻译：异戊二烯生物合成
公开(公告)号：US07122331B1
公开(公告)日：2006-10-17
申请号：US10048874
申请日：2000-08-03
申请人： Wolfgang Eisenreich , Monika Fellermeier , Markus Fischer , Stefan Hecht , Stefan Herz , Klaus Kis , Holger Lüttgen , Felix Rohdich , Silvia Sagner-Grehn , Christoph A. Schuhr , Jurathip Wungsintaweekul , Adelbert Bacher , Meinhart H. Zenk
发明人： Wolfgang Eisenreich , Monika Fellermeier , Markus Fischer , Stefan Hecht , Stefan Herz , Klaus Kis , Holger Lüttgen , Felix Rohdich , Silvia Sagner-Grehn , Christoph A. Schuhr , Jurathip Wungsintaweekul , Adelbert Bacher , Meinhart H. Zenk
IPC分类号： G01N33/573
CPC分类号： C12N9/1229 , C12N9/1205 , C12N9/88 , C12P23/00
摘要： The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as purified isolated DNA coding for such proteins. Moreover, the present invention relates to novel inhibitors detectable by said screening methods as well as compositions and processes for inhibiting the synthesis of isoprenoids and for controlling the growth of organisms based on said inhibiors. The invention relates also to the development of inhibitor-resistant plant enzymes and plants, plant tissues, plant seeds and plant cells.
摘要翻译：本发明涉及涉及类异戊二烯生物合成的酶活性以及在类异戊二烯的生物合成中用于酶的抑制剂，特别是除草剂。更具体地，本发明涉及用于检测这些抑制剂的筛选方法和用于进行所述方法的酶活性蛋白质以及编码这种蛋白质的纯化的分离的DNA。此外，本发明涉及可通过所述筛选方法检测的新型抑制剂以及用于抑制类异戊二烯的合成和基于所述抑制剂控制生物体的生长的组合物和方法。本发明还涉及抑制剂抗性植物酶和植物，植物组织，植物种子和植物细胞的发展。

9. 发明申请

US20090199313A1 Non-mevalonate isoprenoid pathway 审中-公开
标题翻译：非甲羟戊酸类异戊二烯通路
公开(公告)号：US20090199313A1
公开(公告)日：2009-08-06
申请号：US11977973
申请日：2007-10-26
申请人： Adelbert Bacher , Meinhart H. Zenk , Petra Adam , Wolfgang Eisenreich , Monika Fellermeier , Stefan Hecht , Felix Rohdich , Christoph A. Schuhr , Juraithip Wungsintaweekul
发明人： Adelbert Bacher , Meinhart H. Zenk , Petra Adam , Wolfgang Eisenreich , Monika Fellermeier , Stefan Hecht , Felix Rohdich , Christoph A. Schuhr , Juraithip Wungsintaweekul
IPC分类号： A01H5/00 , G01N33/48 , C12Q1/00 , C12N9/00 , C12N15/11 , C12N15/00 , C12N5/06 , C12N1/21 , C12N1/19 , C12N5/04 , C12N1/11
CPC分类号： C12N9/00 , C12N15/52 , C12N15/8274 , C12P9/00
摘要： The present invention is directed to enzymes and intermediates of the non-mevalonate isoprenoid pathway downstream of 2C-methyl-D-erythritol 2,4-cyclopyrophosphate and upstream of isopentenyl pyrophosphate or dimethylallyl pyrophosphate. These are used as a basis for a screening method for inhibitors of these enzymes, and a method for identifying inhibitor-resistant variants thereof. Further disclosures refer to DNA coding for said enzymes and for inhibitor-resistant variants thereof, vectors containing said DNA, cells containing said vector, and plant seeds comprising cells containing said vector. This invention is useful for the inhibition of the biosynthesis of isoprenoids in plants, bacteria and protozoa, for conferring herbicide-resistance to plants, as well as for weed control in agriculture using a crop containing a herbicide-resistant gene and an effective amount of a suitable herbicide.
摘要翻译：本发明涉及2-甲基-D-赤藓糖醇2,4-环丙基磷酸酯和异戊烯基焦磷酸或二甲基烯丙基焦磷酸的上游的非甲羟戊酸异戊二烯通路的酶和中间体。这些用作这些酶的抑制剂的筛选方法的基础，以及用于鉴定其抑制剂抗性变体的方法。还涉及编码所述酶和其抑制剂抗性变体的DNA，含有所述DNA的载体，含有所述载体的细胞，以及含有所述载体的细胞的植物种子。本发明可用于抑制植物，细菌和原生动物中的类异戊二烯的生物合成，以赋予对植物的除草剂抗性，以及使用含有除草剂抗性基因的作物和有效量的合适的除草剂。

10. 发明授权

US6153401A Microorganisms and plasmids for 2,4-dichlorophenoxyacetic acid (2,4-D) monooxygenase formation and process for the production of these plasmids and strains 失效
标题翻译：用于2,4-二氯苯氧基乙酸（2,4-D）单加氧酶形成的微生物和质粒以及用于生产这些质粒和菌株的方法
公开(公告)号：US6153401A
公开(公告)日：2000-11-28
申请号：US322604
申请日：1989-03-10
申请人： Wolfgang R. Streber , Kenneth N. Timmis , Meinhart H. Zenk
发明人： Wolfgang R. Streber , Kenneth N. Timmis , Meinhart H. Zenk
IPC分类号： C12N15/09 , A01H1/04 , A61K39/395 , C12N1/20 , C12N1/21 , C12N9/02 , C12N15/00 , C12N15/01 , C12N15/31 , C12N15/82 , C12Q1/68 , C12R1/05 , C12R1/19 , C12R1/38
CPC分类号： C12N9/0004 , C12N15/8209 , C12N15/8274 , C12N9/0071 , C12R1/05
摘要： The disclosure relates to the production and the use, by genetic engineering, of plasmids and bacterial strains containing, on a short, precisely characterizable DNA segment, the gene tfda or a gene almost identical to tfdA. The novel plasmids and microorganisms are suitable for the production of 2,4-D (2,4-dichlorophenoxyacetic acid)-monooxygenase, and as starting materials for the transfer, by genetic engineering of the 2,4-D-degrading property of this enzyme to various organisms.
摘要翻译：本公开涉及通过基因工程生产和使用质粒和细菌菌株，其在短的，精确表征的DNA片段上含有基因tfda或与tfdA几乎相同的基因。新型质粒和微生物适用于生产2,4-D（2,4-二氯苯氧基乙酸） - 单加氧酶，并且作为转移的起始原料，通过遗传工程对其进行2,4-D降解性能酶到各种生物体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式