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1. 发明授权

US06506414B2 Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof 失效
标题翻译：鲨鱼软骨的低分子量组分，其制备方法及其治疗用途
公开(公告)号：US06506414B2
公开(公告)日：2003-01-14
申请号：US09751111
申请日：2000-12-29
申请人： Eric Dupont , Yves Lachance , Denis Lessard , Serge Auger
发明人： Eric Dupont , Yves Lachance , Denis Lessard , Serge Auger
IPC分类号： A61K3512
CPC分类号： A61K35/60
摘要： This invention relates to a process by which organic solvent-containing solutions are used in lieu of pure water for the preparation of cartilage extracts and fractions thereof. Different organic solvents have been tested for the preparation of extracts containing biologically active components possessing at least an activity against a matrix metalloprotease (anti-MMP). This invention also relates to a process by which a total liquid extract of shark cartilage composed of molecules having molecular weights less than about 500kDa (0-500 fraction) is purified into two well separated fractions composed of molecules having molecular weights less than about 1 kDa (0-1 fraction) and between about 1 to 500 kDa (1-500 fraction). In order to prevent the formation of aggregates, to improve the dissolution and the stability of active components, sucrose or other stabilizing agents can be added. The 0-500 fraction, the 0-1 fraction and the 1-500 fraction as well as their equivalents containing 1% w/v sucrose possess have anti-MMP and anti-tumor activities. The invention also provides a component which has at least anti-MMP and anti-tumor activities, and which has a mass of 244 amu (atomic mass unit). The use of the above extracts, derived fractions or components for inhibiting MMP enzyme, neovascularization and/or metastase formation is also described.
摘要翻译：本发明涉及使用含有机溶剂的溶液代替纯水来制备软骨提取物及其级分的方法。已经测试了不同的有机溶剂来制备含有至少对基质金属蛋白酶（抗-MMP）具有活性的生物活性组分的提取物。本发明还涉及由具有小于约500kDa（0-500级分）的分子组成的鲨鱼软骨的总液体提取物被纯化成由分子量小于约1kDa的分子组成的两个良好分离的级分（0-1分数）和约1至500kDa（1-500分数）之间。为了防止聚集体的形成，为了改善活性组分的溶解和稳定性，可以加入蔗糖或其它稳定剂。 0-500级分，0-1级分和1-500级分以及其含有1％w / v蔗糖的当量具有抗MMP和抗肿瘤活性。本发明还提供了具有至少抗MMP和抗肿瘤活性，并且质量为244amu（原子质量单位）的组分。还描述了上述提取物，衍生级分或组分用于抑制MMP酶，新血管形成和/或转移形成的用途。

2. 发明授权

US06168807A Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof 失效
标题翻译：鲨鱼软骨的低分子量组分，其制备方法及其治疗用途
公开(公告)号：US06168807A
公开(公告)日：2001-01-02
申请号：US09122481
申请日：1998-07-23
申请人： {acute over (E)}ric Dupont , Yves Lachance , Denis Lessard , Serge Auger
发明人： {acute over (E)}ric Dupont , Yves Lachance , Denis Lessard , Serge Auger
IPC分类号： C01B3104
CPC分类号： A61K35/60
摘要： This invention relates to a process by which organic solvent-containing solutions are used in lieu of pure water for the preparation of cartilage extracts and fractions thereof. Different organic solvents have been tested for the preparation of extracts containing biologically active components possessing at least an activity against a matrix metalloprotease (anti-MMP). This invention also relates to a process by which a total liquid extract of shark cartilage composed of molecules having molecular weights less than about 500 kDa (0-500 fraction) is purified into two well separated fractions composed of molecules having molecular weights less than about 1 kDa (0-1 fraction) and between about 1 to 500 kDa (1-500 fraction). In order to prevent the formation of aggregates, to improve the dissolution and the stability of active components, sucrose or other stabilizing agents can be added. The 0-500 fraction, the 0-1 fraction and the 1-500 fraction as well as their equivalents containing 1% w/v sucrose possess have anti-MMP and anti-tumor activities. The invention also provides a component which has at least anti-MMP and anti-tumor activities, and which has a mass of 244 amu (atomic mass unit). The use of the above extracts, derived fractions or components for inhibiting MMP enzyme, neovascularization and/or metastase formation is also described.
摘要翻译：本发明涉及使用含有机溶剂的溶液代替纯水来制备软骨提取物及其级分的方法。已经测试了不同的有机溶剂来制备含有至少对基质金属蛋白酶（抗-MMP）具有活性的生物活性组分的提取物。本发明还涉及一种由分子量小于约500kDa（0-500级分）组成的鲨鱼软骨的总液体提取物被纯化成由分子量小于约1的分子组成的两个井分离的级分 kDa（0-1分数）和约1至500kDa（1-500分数）之间。为了防止聚集体的形成，为了改善活性组分的溶解和稳定性，可以加入蔗糖或其它稳定剂。 0-500级分，0-1级分和1-500级分以及其含有1％w / v蔗糖的当量具有抗MMP和抗肿瘤活性。本发明还提供了具有至少抗MMP和抗肿瘤活性，并且质量为244amu（原子质量单位）的组分。还描述了上述提取物，衍生级分或组分用于抑制MMP酶，新血管形成和/或转移形成的用途。

3. 发明授权

US06250961B1 Hermetic connection assembly 失效
标题翻译：密封连接组件
公开(公告)号：US06250961B1
公开(公告)日：2001-06-26
申请号：US09391832
申请日：1999-09-08
申请人： Gerard Boiret , Serge Auger , Olivier Bourgeois
发明人： Gerard Boiret , Serge Auger , Olivier Bourgeois
IPC分类号： H01R1340
CPC分类号： H01R13/523
摘要： In order to create a hermetic connection assembly (1, 2) with a female insert (2), the insert provided with double-female (5, 27) receptacles (4) is placed on a hermetic male connector (1). In order to assure a good electrical connection, clips or sockets (7, 26), preferably truncated, are positioned inside the receptacles, taking support and assuring an electrical contact, on the one hand, with an inner wall of a receptacle and on the other hand, with an outer wall of a pin (8) when such a pin is inserted in the receptacle.
摘要翻译：为了创建具有阴插入物（2）的气密连接组件（1,2），设置有双阴（5,27）插座（4）的插入件被放置在密封的公连接器（1）上。为了确保良好的电气连接，夹具或插座（7,26）（优选截短的）位于插座内部，一方面支撑并确保电接触与容器的内壁，并且另一方面，当这种销插入插座时，具有销（8）的外壁。

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