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    • 6. 发明申请
    • REFRIGERATING ASSEMBLY
    • 制冷装置
    • WO2011000118A1
    • 2011-01-06
    • PCT/CA2010/001067
    • 2010-07-02
    • CONSTRUCTION YVES LACHANCE INC.LACHANCE, Yves
    • LACHANCE, Yves
    • B65D81/18B65D81/38F25D23/08F25D3/08
    • B65D81/38B65D81/382B65D81/3825F25D3/08F25D31/00F25D2303/08221F25D2303/0831F25D2331/812
    • There is provided a refrigerating assembly for temporarily storing an item at a first temperature lower than an ambient temperature. The refrigerating assembly comprises a container for receiving the item and a shell adapted for removably receiving the container therein. The container comprises a sidewall having therein defined a cavity containing an amount of a refrigerant medium having a second temperature lower than the ambient temperature for temporarily maintaining the item received in the container at the first temperature. The shell has an outer surface which is at the ambient temperature and an inner surface which has a layer of thermally insulating material mounted thereon for thermally insulating the shell from the container, thereby maintaining the outer surface at the ambient temperature. There is further provided a method for temporarily storing an item at a first temperature lower than an ambient temperature.
    • 提供了一种用于在低于环境温度的第一温度下临时存储物品的制冷组件。 制冷组件包括用于容纳物品的容器和适于在其中可移除地容纳容器的壳体。 容器包括侧壁,其中限定有一个空腔,该空腔包含一定量的制冷剂介质,其具有低于环境温度的第二温度,用于将容纳在容器中的物品临时保持在第一温度。 壳体具有处于环境温度的外表面和安装在其上的绝热材料层的内表面,用于使壳体与容器热绝缘,从而将外表面保持在环境温度。 还提供了一种在低于环境温度的第一温度下临时存储物品的方法。
    • 9. 发明授权
    • Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof
    • 鲨鱼软骨的低分子量组分,其制备方法及其治疗用途
    • US06506414B2
    • 2003-01-14
    • US09751111
    • 2000-12-29
    • Eric DupontYves LachanceDenis LessardSerge Auger
    • Eric DupontYves LachanceDenis LessardSerge Auger
    • A61K3512
    • A61K35/60
    • This invention relates to a process by which organic solvent-containing solutions are used in lieu of pure water for the preparation of cartilage extracts and fractions thereof. Different organic solvents have been tested for the preparation of extracts containing biologically active components possessing at least an activity against a matrix metalloprotease (anti-MMP). This invention also relates to a process by which a total liquid extract of shark cartilage composed of molecules having molecular weights less than about 500kDa (0-500 fraction) is purified into two well separated fractions composed of molecules having molecular weights less than about 1 kDa (0-1 fraction) and between about 1 to 500 kDa (1-500 fraction). In order to prevent the formation of aggregates, to improve the dissolution and the stability of active components, sucrose or other stabilizing agents can be added. The 0-500 fraction, the 0-1 fraction and the 1-500 fraction as well as their equivalents containing 1% w/v sucrose possess have anti-MMP and anti-tumor activities. The invention also provides a component which has at least anti-MMP and anti-tumor activities, and which has a mass of 244 amu (atomic mass unit). The use of the above extracts, derived fractions or components for inhibiting MMP enzyme, neovascularization and/or metastase formation is also described.
    • 本发明涉及使用含有机溶剂的溶液代替纯水来制备软骨提取物及其级分的方法。 已经测试了不同的有机溶剂来制备含有至少对基质金属蛋白酶(抗-MMP)具有活性的生物活性组分的提取物。 本发明还涉及由具有小于约500kDa(0-500级分)的分子组成的鲨鱼软骨的总液体提取物被纯化成由分子量小于约1kDa的分子组成的两个良好分离的级分 (0-1分数)和约1至500kDa(1-500分数)之间。 为了防止聚集体的形成,为了改善活性组分的溶解和稳定性,可以加入蔗糖或其它稳定剂。 0-500级分,0-1级分和1-500级分以及其含有1%w / v蔗糖的当量具有抗MMP和抗肿瘤活性。 本发明还提供了具有至少抗MMP和抗肿瘤活性,并且质量为244amu(原子质量单位)的组分。 还描述了上述提取物,衍生级分或组分用于抑制MMP酶,新血管形成和/或转移形成的用途。
    • 10. 发明申请
    • REFRIGERATING ASSEMBLY
    • 制冷装置
    • US20140345315A1
    • 2014-11-27
    • US14456368
    • 2014-08-11
    • Construction Yves Lachance Inc.
    • Yves Lachance
    • B65D81/38F25D31/00
    • B65D81/38B65D81/382B65D81/3825F25D3/08F25D31/00F25D2303/08221F25D2303/0831F25D2331/812
    • There is provided a refrigerating assembly for temporarily storing an item at a first temperature lower than an ambient temperature. The refrigerating assembly comprises a container for receiving the item and a shell adapted for removably receiving the container therein. The container comprises a sidewall having therein defined a cavity containing an amount of a refrigerant medium having a second temperature lower than the ambient temperature for temporarily maintaining the item received in the container at the first temperature. The shell has an outer surface which is at the ambient temperature and an inner surface which has a layer of thermally insulating material mounted thereon for thermally insulating the shell from the container, thereby maintaining the outer surface at the ambient temperature. There is further provided a method for temporarily storing an item at a first temperature lower than an ambient temperature.
    • 提供了一种用于在低于环境温度的第一温度下临时存储物品的制冷组件。 制冷组件包括用于容纳物品的容器和适于在其中可移除地容纳容器的壳体。 容器包括侧壁,其中限定有一个空腔,该空腔包含一定量的制冷剂介质,其具有低于环境温度的第二温度,用于将容纳在容器中的物品临时保持在第一温度。 壳体具有处于环境温度的外表面和安装在其上的绝热材料层的内表面,用于将壳体与容器隔热,从而将外表面保持在环境温度。 还提供了一种在低于环境温度的第一温度下临时存储物品的方法。