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1. 发明申请

WO2004069331A2 NEURAL STIMULATION TREATMENT 审中-公开
标题翻译：神经刺激治疗
公开(公告)号：WO2004069331A2
公开(公告)日：2004-08-19
申请号：PCT/US2004/002847
申请日：2004-01-30
申请人： ENTEROMEDICS INC. , KNUDSON, Mark, B. , CONRAD, Timothy, R. , EVNIN, Luke, B. , WILSON, Richard, R. , TWEDEN, Katherine, S.
发明人： KNUDSON, Mark, B. , CONRAD, Timothy, R. , EVNIN, Luke, B. , WILSON, Richard, R. , TWEDEN, Katherine, S.
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： A plurality of disorders are treated by neural stimulation with optional neural blocking. These include gastrointestinal disorders as well as neuropsychiatric and cardio-respiratory disorders. The apparatus includes stimulating and blocking electrodes. Stimulating electrodes proving a stimulation signal on a nerve. Blocking electrodes at least partially block nerve impulses at a blocking site.
摘要翻译：通过具有任选的神经阻滞的神经刺激来治疗多种疾病。这些包括胃肠道疾病以及神经精神和心脏呼吸障碍。该装置包括刺激和阻断电极。刺激电极证明神经上的刺激信号。阻塞电极至少部分阻断阻塞部位的神经冲动。

2. 发明申请

WO2004069330A1 ELECTRODE BAND 审中-公开
标题翻译：电极带
公开(公告)号：WO2004069330A1
公开(公告)日：2004-08-19
申请号：PCT/US2004/002841
申请日：2004-01-30
申请人： ENTEROMEDICS INC. , KNUDSON, Mark, B. , CONRAD, Timothy, R. , EVNIN, Luke, B. , WILSON, Richard, R. , TWEDEN, Katherine, S.
发明人： KNUDSON, Mark, B. , CONRAD, Timothy, R. , EVNIN, Luke, B. , WILSON, Richard, R. , TWEDEN, Katherine, S.
IPC分类号： A61N1/36
CPC分类号： A61N1/321 , A61N1/05 , A61N1/36007 , A61N1/36071
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.
摘要翻译：通过包括以下步骤的方法来治疗患者的多种病症中的至少一种：至少部分表现为神经支配患者的多个器官中的至少一个的迷走神经活动，所述方法包括将神经刺激器载体在患者的身体器官周围，器官由至少迷走神经干支配。电极设置在载体上并定位在迷走神经干。将电信号施加至电极以调节迷走神经活性的量达选择治疗该病症的量。该信号可以是阻塞信号或刺激信号。

3. 发明公开

EP2349462A1 SYSTEMS FOR REGULATION OF BLOOD PRESSURE AND HEART RATE 审中-公开
标题翻译：系统的血压调节和心率
公开(公告)号：EP2349462A1
公开(公告)日：2011-08-03
申请号：EP09791276.0
申请日：2009-08-07
申请人： Enteromedics Inc.
发明人： TWEDEN, Katherine, S. , WILSON, Richard, R. , KNUDSON, Mark, B. , KIM, Dennis, Dong-Won , BHOLE, Deepak
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36117 , A61N1/36053 , A61N1/36114 , A61N1/36139 , A61N1/37211 , A61N1/3787
摘要： A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.

4. 发明申请

WO2009102969A1 TREATMENT OF EXCESS WEIGHT BY NEURAL DOWNREGULATION IN COMBINATION WITH COMPOSITIONS 审中-公开
标题翻译：通过与组合物组合的神经衰弱来治疗超重
公开(公告)号：WO2009102969A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/034080
申请日：2009-02-13
申请人： ENTEROMEDICS, INC. , KIM, Dennis, Dong-Won , KNUDSON, Mark, B.
发明人： KIM, Dennis, Dong-Won , KNUDSON, Mark, B.
IPC分类号： A61N1/36 , A61N1/372 , A61M5/142
CPC分类号： A61N1/36007 , A61M5/14276 , A61M2205/3515 , A61M2205/3523 , A61M2205/353 , A61M2210/105 , A61M2210/1053 , A61N1/36053 , A61N1/36114 , A61N1/37223 , A61N1/37264
摘要： A method and system for designing a therapy or for treating a condition associated with excess weight in a subject comprising applying a neural conduction block to the vagus nerve at a blocking site with the neural conduction block selected to at least partially block nerve impulses on the vagus nerve at the blocking site and administering a composition comprising an effective amount of an agent that alters the energy balance of the subject.
摘要翻译：一种用于设计治疗或用于治疗与受试者中的超重相关的病症的方法和系统，其包括将神经传导阻滞在阻塞位点处的迷走神经中，所述神经传导阻滞被选择为至少部分阻断迷走神经脉冲上的神经传导阻滞并且施用包含改变受试者的能量平衡的有效量的药剂的组合物。

5. 发明公开

EP2579941A2 NEURAL MODULATION DEVICES AND METHODS 审中-公开
标题翻译：神经调制装置和方法
公开(公告)号：EP2579941A2
公开(公告)日：2013-04-17
申请号：EP11726593.4
申请日：2011-06-08
申请人： Enteromedics Inc.
发明人： TWEDEN, Katherine, S. , WAATAJA, Jonathan, J. , DONDERS, Adrianus, P. , KNUDSON, Mark, B.
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/0551 , A61N1/36053 , A61N1/36085 , A61N1/36117 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/3787
摘要： A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
摘要翻译：一种用于设计治疗或用于治疗对象中的胃肠病症或与体重过重相关的病症的系统，包括至少一个被配置为植入患者体内并放置在迷走神经处的电极，所述电极还被配置为应用在对电极施加治疗周期后对迷走神经进行治疗; 植入式神经调节器，其用于放置在皮肤层下方的患者体内，所述植入式神经调节器被配置为产生治疗周期，其中所述治疗周期包括传递电信号的开启时间，所述电信号包括：a）以约150-10,000Hz的第一选定频率施加的一组脉冲，其中该组脉冲中的每个脉冲具有至少0.01毫秒并且小于第一选定频率的周期的脉冲宽度。

6. 发明公开

EP1603634A1 ELECTRODE BAND 有权
标题翻译： LEAD BAND
公开(公告)号：EP1603634A1
公开(公告)日：2005-12-14
申请号：EP04707111.3
申请日：2004-01-30
申请人： Enteromedics Inc.
发明人： KNUDSON, Mark, B. , CONRAD, Timothy, R. , EVNIN, Luke, B. , WILSON, Richard, R. , TWEDEN, Katherine, S.
IPC分类号： A61N1/36 , A61N1/32
CPC分类号： A61N1/321 , A61N1/05 , A61N1/36007 , A61N1/36071
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.

7. 发明申请

WO2010017457A1 SYSTEMS FOR REGULATION OF BLOOD PRESSURE AND HEART RATE 审中-公开
标题翻译：用于调节血压和心率的系统
公开(公告)号：WO2010017457A1
公开(公告)日：2010-02-11
申请号：PCT/US2009/053114
申请日：2009-08-07
申请人： ENTEROMEDICS INC. , TWEDEN, Katherine, S. , WILSON, Richard, R. , KNUDSON, Mark, B. , KIM, Dennis, Dong-Won , BHOLE, Deepak
发明人： TWEDEN, Katherine, S. , WILSON, Richard, R. , KNUDSON, Mark, B. , KIM, Dennis, Dong-Won , BHOLE, Deepak
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36117 , A61N1/36053 , A61N1/36114 , A61N1/36139 , A61N1/37211 , A61N1/3787
摘要： A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.
摘要翻译：一种用于治疗与受试者的血压和/或心率受损相关的病症的方法和装置，包括施加电治疗信号，其中所述电治疗信号被选择为至少部分阻断神经冲动，或在一些实施例中增加神经冲动

8. 发明申请

WO2007021534A1 NEURAL ELECTRODE TREATMENT 审中-公开
标题翻译：神经电极治疗
公开(公告)号：WO2007021534A1
公开(公告)日：2007-02-22
申请号：PCT/US2006/029926
申请日：2006-08-01
申请人： ENTEROMEDICS INC. , DONDERS, Adrianus, P. , WEIJAND, Koen, J. , KNUDSON, Mark, B.
发明人： DONDERS, Adrianus, P. , WEIJAND, Koen, J. , KNUDSON, Mark, B.
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61N1/36053 , A61N1/36085 , A61N1/36114
摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.
摘要翻译：用于向神经施加信号以用于治疗病症的装置包括第一电极和第二电极。每个电极适于固定到患者的神经。信号发生器电连接到第一和第二电极中的每一个。信号发生器适于产生在第一电极处具有第一波形的信号和在第二电极处的第二波形。波形具有选择的参数以阻止神经动作电位的传播。这些波形具有脉冲周期的重复模式，其中延迟周期至少在所选择的脉冲之间。在一个实施例中，在另一个波形的延迟周期期间，波形中的一个波形的周期是第一和第二波形异相。

9. 发明申请

WO2004069332A1 INTRALUMINAL ELECTRODE 审中-公开
标题翻译：阴极电极
公开(公告)号：WO2004069332A1
公开(公告)日：2004-08-19
申请号：PCT/US2004/002849
申请日：2004-01-30
申请人： ENTEROMEDICS INC. , KNUDSON, Mark, B. , CONRAD, Timothy, R. , EVNIN, Luke, B. , WILSON, Richard, R. , TWEDEN, Katherine, S.
发明人： KNUDSON, Mark, B. , CONRAD, Timothy, R. , EVNIN, Luke, B. , WILSON, Richard, R. , TWEDEN, Katherine, S.
IPC分类号： A61N1/36
CPC分类号： A61N1/36007
摘要： At least one of a plurality of disorders of a patient associated with vagal activity innervating at least one of a plurality of organs of the patient at an innervation site are treated by positioning a neurostimulator carrier within a body lumen of the patient. An electrode disposed on the carrier is positioned at a mucosal layer of the lumen. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.
摘要翻译：通过将神经刺激器载体定位在体腔内来治疗与在神经支配部位支配患者的多个器官中的至少一个器官的迷走神经活动相关的多种病症中的至少一种病症的病人。设置在载体上的电极位于内腔的粘膜层。将电信号施加至电极以调节迷走神经活性的量达选择治疗该病症的量。信号可能是阻塞信号或刺激信号。

10. 发明申请

WO2013134121A3 DEVICES FOR REGULATION OF BLOOD PRESSURE AND HEART RATE 审中-公开
公开(公告)号：WO2013134121A3
公开(公告)日：2013-09-12
申请号：PCT/US2013/028865
申请日：2013-03-04
申请人： ENTEROMEDICS INC.
发明人： DONDERS, Adrianus, P. , TWEDEN, Katherine, S. , KNUDSON, Mark, B. , THORNTON, Arnold, W.
IPC分类号： A61N1/36 , A61N1/378 , A61N1/372
摘要： A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses. In embodiments, the apparatus provides a first therapy program to provide a downregulating signal to one or more nerves including renal artery, renal nerve, vagus nerve, celiac plexus, a splanchnic nerve, cardiac sympathetic nerves, spinal nerves originating between T10 to L5. In embodiments, the apparatus provides a third therapy program to provide an upregulating signal to one or more nerves including a glossopharyngeal nerve and/ or a tissue containing baroreceptors.

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