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    • 2. 发明专利
    • Method and system for glucose regulation
    • 葡萄糖调节方法与系统
    • JP2014087681A
    • 2014-05-15
    • JP2013268765
    • 2013-12-26
    • Enteromedics Incエンテロメディクス インコーポレイテッド
    • ARNOLD W THORNTONKIM DENNIS DONG-WONKNUDSON MARK BKATHERINE S TWEDENWILSON RICHARD R
    • A61N1/05
    • A61N1/36053A61M5/00A61N1/0551A61N1/36007A61N1/36167A61N1/37211A61N1/37235
    • PROBLEM TO BE SOLVED: To provide a system and method for controlling glucose and/or treating diabete.SOLUTION: Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprise, in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulation and/or up-regulation with or without pharmaceutical agents are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus nerve and its branches, and the splanchnic nerve is used to modify the production of GLP-1 and GIP, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulation and/or up-regulation with or without pharmaceutical agents are used to modify the production of GLP-1 and GIP, to treat impaired glucose regulation.
    • 要解决的问题:提供用于控制葡萄糖和/或治疗糖尿病的系统和方法。解决方案:用于治疗与受试者的葡萄糖调节相关的病症的各种方法和装置在一个实施方案中包括将神经传导阻滞 在具有选择至少部分阻断神经脉冲的神经传导阻滞的阻断位点处的目标神经。 在另一个实施方案中,使用具有或不具有药剂的下调和/或上调的组合来治疗葡萄糖调节受损。 在其他实施方案中,使用各种神经(例如迷走神经及其分支)和内脏神经的上调或下调来改变GLP-1和GIP的产生,从而控制葡萄糖水平。 在另外的实施方案中,使用具有或不具有药剂的下调和/或上调的组合来改变GLP-1和GIP的产生,以治疗葡萄糖调节受损。