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1. 发明申请

WO2007021534A1 NEURAL ELECTRODE TREATMENT 审中-公开
标题翻译：神经电极治疗
公开(公告)号：WO2007021534A1
公开(公告)日：2007-02-22
申请号：PCT/US2006/029926
申请日：2006-08-01
申请人： ENTEROMEDICS INC. , DONDERS, Adrianus, P. , WEIJAND, Koen, J. , KNUDSON, Mark, B.
发明人： DONDERS, Adrianus, P. , WEIJAND, Koen, J. , KNUDSON, Mark, B.
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61N1/36053 , A61N1/36085 , A61N1/36114
摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.
摘要翻译：用于向神经施加信号以用于治疗病症的装置包括第一电极和第二电极。每个电极适于固定到患者的神经。信号发生器电连接到第一和第二电极中的每一个。信号发生器适于产生在第一电极处具有第一波形的信号和在第二电极处的第二波形。波形具有选择的参数以阻止神经动作电位的传播。这些波形具有脉冲周期的重复模式，其中延迟周期至少在所选择的脉冲之间。在一个实施例中，在另一个波形的延迟周期期间，波形中的一个波形的周期是第一和第二波形异相。

2. 发明申请

WO2008151059A2 IMPLANTABLE THERAPY SYSTEM 审中-公开
标题翻译：可植入治疗系统
公开(公告)号：WO2008151059A2
公开(公告)日：2008-12-11
申请号：PCT/US2008/065386
申请日：2008-05-30
申请人： ENTEROMEDICS, INC. , DONDERS, Adrianus, P. , WEIJAND, Koen, J. , LAMBERT, Scott, Anthony , SPAR, Gregory, Pat , STULTZ, Mark, Raymond , VALLAPUREDDY, Vineel , LAUGHLIN, John, Charles
发明人： DONDERS, Adrianus, P. , WEIJAND, Koen, J. , LAMBERT, Scott, Anthony , SPAR, Gregory, Pat , STULTZ, Mark, Raymond , VALLAPUREDDY, Vineel , LAUGHLIN, John, Charles
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0556 , A61N1/0558 , A61N1/37229 , A61N1/3752 , A61N1/3787
摘要： Example embodiments of therapy systems may include an implantable component and an external component that can be configured into one of multiple selectable operating modes. Plugging an external antenna into the external component can automatically configure the external component into one of the operating modes. Initial values for the parameters of a therapy program can be incremented or decremented after a predetermined period of time by a predetermined amount to obtain a subsequent value of the parameter and therapy can be applied using the subsequent value. The implantable component can be adapted to be selectively configured into one of a training mode and a delivery mode. The implantable component is configured to simulate application of therapy when configured in the training mode.
摘要翻译：治疗系统的示例性实施例可以包括可植入组件和可以配置成多种可选操作模式之一的外部组件。将外部天线插入外部组件可以将外部组件自动配置为其中一种工作模式。治疗程序的参数的初始值可以在预定时间段之后增加或减少预定量，以获得参数的后续值，并且可以使用随后的值来应用治疗。可植入部件可以适于选择性地配置成训练模式和递送模式之一。可植入组件被配置为在训练模式下配置时模拟治疗的应用。

3. 发明申请

WO2013134121A3 DEVICES FOR REGULATION OF BLOOD PRESSURE AND HEART RATE 审中-公开
公开(公告)号：WO2013134121A3
公开(公告)日：2013-09-12
申请号：PCT/US2013/028865
申请日：2013-03-04
申请人： ENTEROMEDICS INC.
发明人： DONDERS, Adrianus, P. , TWEDEN, Katherine, S. , KNUDSON, Mark, B. , THORNTON, Arnold, W.
IPC分类号： A61N1/36 , A61N1/378 , A61N1/372
摘要： A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses. In embodiments, the apparatus provides a first therapy program to provide a downregulating signal to one or more nerves including renal artery, renal nerve, vagus nerve, celiac plexus, a splanchnic nerve, cardiac sympathetic nerves, spinal nerves originating between T10 to L5. In embodiments, the apparatus provides a third therapy program to provide an upregulating signal to one or more nerves including a glossopharyngeal nerve and/ or a tissue containing baroreceptors.

4. 发明申请

WO2011156439A2 NEURAL MODULATION DEVICES AND METHODS 审中-公开
标题翻译：神经调制装置及方法
公开(公告)号：WO2011156439A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039540
申请日：2011-06-08
申请人： ENTEROMEDICS INC. , TWEDEN, Katherine, S. , WAATAJA, Jonathan, J. , DONDERS, Adrianus, P. , KNUDSON, Mark, B.
发明人： TWEDEN, Katherine, S. , WAATAJA, Jonathan, J. , DONDERS, Adrianus, P. , KNUDSON, Mark, B.
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/0551 , A61N1/36053 , A61N1/36085 , A61N1/36117 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/3787
摘要： A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
摘要翻译：一种用于设计用于治疗或治疗与受试者相关的胃肠疾病或与体重过重相关的病症的系统，所述系统包括被配置为植入患者体内并置于迷走神经的至少一个电极，所述电极还被配置为施加在向电极施加治疗周期时对迷走神经进行治疗; 可植入神经调节器，用于放置在皮肤层下面的患者体内，所述可植入神经调节器被配置为产生治疗周期，其中所述治疗周期包括传递电信号的导通时间，所述电信号包括：a）以大约150-10,000Hz的第一选定频率施加的一组脉冲，其中脉冲组的每个脉冲具有至少0.01毫秒且小于第一选定频率的周期的脉冲宽度。

5. 发明公开

EP2579941A2 NEURAL MODULATION DEVICES AND METHODS 审中-公开
标题翻译：神经调制装置和方法
公开(公告)号：EP2579941A2
公开(公告)日：2013-04-17
申请号：EP11726593.4
申请日：2011-06-08
申请人： Enteromedics Inc.
发明人： TWEDEN, Katherine, S. , WAATAJA, Jonathan, J. , DONDERS, Adrianus, P. , KNUDSON, Mark, B.
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/0551 , A61N1/36053 , A61N1/36085 , A61N1/36117 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/3787
摘要： A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
摘要翻译：一种用于设计治疗或用于治疗对象中的胃肠病症或与体重过重相关的病症的系统，包括至少一个被配置为植入患者体内并放置在迷走神经处的电极，所述电极还被配置为应用在对电极施加治疗周期后对迷走神经进行治疗; 植入式神经调节器，其用于放置在皮肤层下方的患者体内，所述植入式神经调节器被配置为产生治疗周期，其中所述治疗周期包括传递电信号的开启时间，所述电信号包括：a）以约150-10,000Hz的第一选定频率施加的一组脉冲，其中该组脉冲中的每个脉冲具有至少0.01毫秒并且小于第一选定频率的周期的脉冲宽度。

6. 发明授权

EP2167187B1 IMPLANTABLE THERAPY SYSTEM 有权
标题翻译：植入式治疗系统
公开(公告)号：EP2167187B1
公开(公告)日：2016-08-17
申请号：EP08756557.8
申请日：2008-05-30
申请人： Enteromedics Inc.
发明人： DONDERS, Adrianus, P. , WEIJAND, Koen, J. , LAMBERT, Scott, Anthony , SPAR, Gregory, Pat , STULTZ, Mark, Raymond , VALLAPUREDDY, Vineel , LAUGHLIN, John, Charles
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36007 , A61N1/0556 , A61N1/0558 , A61N1/37229 , A61N1/3752 , A61N1/3787

7. 发明公开

EP1922111A1 NEURAL ELECTRODE TREATMENT 有权
标题翻译：设备的神经ELECTRODES治疗
公开(公告)号：EP1922111A1
公开(公告)日：2008-05-21
申请号：EP06789104.4
申请日：2006-08-01
申请人： Enteromedics Inc.
发明人： DONDERS, Adrianus, P. , WEIJAND, Koen, J. , KNUDSON, Mark, B.
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61N1/36053 , A61N1/36085 , A61N1/36114
摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.

8. 发明申请

WO2017136552A1 HIGH-FREQUENCY LOW DUTY CYCLE PATTERNS FOR NEURAL REGULATION 审中-公开
标题翻译：用于神经调节的高频低占空比模式
公开(公告)号：WO2017136552A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/016218
申请日：2017-02-02
申请人： ENTEROMEDICS INC.
发明人： WAATAJA, Jonathan, J. , DONDERS, Adrianus, P.
IPC分类号： A61N1/36
CPC分类号： A61N1/36171 , A61N1/36007 , A61N1/3606 , A61N1/36117 , A61N1/36153 , A61N1/36175 , A61N1/36178
摘要： A method of downregulating and/or upregulating neural activity by applying a high frequency alternating current electrical signal to a nerve in a subject is disclosed. The signal comprises more than one microsecond cycle comprising one or more periods, each period comprising a charge recharge phase, and optionally, a pulse delay, each period having a frequency of at least 1000 Hz; and a microsecond inactive phase. In embodiments, an electrical signal treatment comprises more than one microsecond cycle to form a millisecond cycle, each millisecond cycle separated by a millisecond inactive phase during an on time. In embodiments, the electrical signal patterns can differ in amplitude.
摘要翻译：公开了一种通过向对象的神经施加高频交流电信号来下调和/或上调神经活动的方法。该信号包括多于一个微秒周期，其包括一个或多个周期，每个周期包括充电再充电阶段和可选的脉冲延迟，每个周期具有至少1000Hz的频率; 和一个微秒无效阶段。在实施例中，电信号处理包括多于一个微秒周期以形成毫秒循环，每个毫秒循环在开启时间期间由毫秒无效阶段分开。在实施例中，电信号图案的幅度可以不同。

9. 发明申请

WO2008112430A3 REMOTE MONITORING AND CONTROL OF IMPLANTABLE DEVICES 审中-公开
公开(公告)号：WO2008112430A3
公开(公告)日：2008-09-18
申请号：PCT/US2008/055098
申请日：2008-02-27
申请人： ENTEROMEDICS, INC. , VALLAPUREDDY, Vineel , DONDERS, Adrianus, P. , RAMADHYANI, Satish , WANG, Wu , CHAN, Hang
发明人： VALLAPUREDDY, Vineel , DONDERS, Adrianus, P. , RAMADHYANI, Satish , WANG, Wu , CHAN, Hang
IPC分类号： A61N1/372
摘要： A treatment system includes a regulator implanted within a patient, a computing device storing at least one patient database associated with the patient in whom the regulator is implanted, and a data transfer device. The data transfer device provides bi-directional communication ( e.g. , voice communication) and a data exchange ( e.g. , a treatment history, a patient database, and operational instructions) between the regulator and the computing device. A programmer can obtain patient reports and/or default treatment values from the computing device based on the data exchange.

10. 发明申请

WO2014116938A1 ENERGY EFFICIENT NEUROMODULATION 审中-公开
标题翻译：能量有效的神经网络
公开(公告)号：WO2014116938A1
公开(公告)日：2014-07-31
申请号：PCT/US2014/012933
申请日：2014-01-24
申请人： ENTEROMEDICS INC. , WAATAJA, Jonathan, J. , DONDERS, Adrianus, P.
发明人： WAATAJA, Jonathan, J. , DONDERS, Adrianus, P.
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/3605 , A61N1/37247
摘要： A therapy system for applying an electrical signal to a target nerve includes an electrode, an implantable component and an external component. The electrode has an impedance of at least about 2000 ohms. The electrical signal is applied using constant current or constant voltage.
摘要翻译：用于向目标神经施加电信号的治疗系统包括电极，可植入部件和外部部件。该电极具有至少约2000欧姆的阻抗。使用恒定电流或恒定电压施加电信号。

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