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1. 发明授权

US5582705A Multiplexed capillary electrophoresis system 失效
标题翻译：多重毛细管电泳系统
公开(公告)号：US5582705A
公开(公告)日：1996-12-10
申请号：US444565
申请日：1995-05-19
申请人： Edward S. Yeung , Huan-Tsang Chang , Eliza N. Fung , Qingbo Li , Xiandan Lu
发明人： Edward S. Yeung , Huan-Tsang Chang , Eliza N. Fung , Qingbo Li , Xiandan Lu
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44782 , G01N27/44721
摘要： The invention provides a side-entry optical excitation geometry for use in a multiplexed capillary electrophoresis system. A charge-injection device is optically coupled to capillaries in the array such that the interior of a capillary is imaged onto only one pixel. In Sanger-type 4-label DNA sequencing reactions, nucleotide identification ("base calling") is improved by using two long-pass filters to split fluorescence emission into two emission channels. A binary poly(ethyleneoxide) matrix is used in the electrophoretic separations.
摘要翻译：本发明提供了用于多路复用毛细管电泳系统中的侧入光激发几何形状。电荷注入装置光学耦合到阵列中的毛细管，使得毛细管的内部成像到仅一个像素上。在Sanger型4标记DNA测序反应中，通过使用两个长通滤波器将荧光发射分解成两个发射通道来改善核苷酸鉴定（“碱基呼叫”）。在电泳分离中使用二元聚（环氧乙烷）基质。

2. 发明授权

US5741411A Multiplexed capillary electrophoresis system 失效
公开(公告)号：US5741411A
公开(公告)日：1998-04-21
申请号：US665800
申请日：1996-06-18
申请人： Edward S. Yeung , Qingbo Li , Xiandan Lu
发明人： Edward S. Yeung , Qingbo Li , Xiandan Lu
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44782 , G01N27/44721
摘要： The invention provides a side-entry optical excitation geometry for use in a multiplexed capillary electrophoresis system. A charge-injection device is optically coupled to capillaries in the array such that the interior of a capillary is imaged onto only one pixel. In Sanger-type 4-label DNA sequencing reactions, nucleotide identification ("base calling") is improved by using two long-pass filters to split fluorescence emission into two emission channels. A binary poly(ethyleneoxide) matrix is used in the electrophoretic separations.

3. 发明授权

US06788414B1 Method of analyzing multiple sample simultaneously by detecting absorption and systems for use in such a method 有权
标题翻译：通过检测吸收和同时使用这种方法的系统同时分析多个样品的方法
公开(公告)号：US06788414B1
公开(公告)日：2004-09-07
申请号：US10070531
申请日：2002-06-05
申请人： Edward S. Yeung , Xiaoyi Gong
发明人： Edward S. Yeung , Xiaoyi Gong
IPC分类号： G01N2159
CPC分类号： G01N30/95 , B01J2219/00522 , B01J2219/00585 , B01J2219/00659 , B01J2219/00707 , G01N21/253 , G01N21/31 , G01N27/44721 , G01N27/44782 , G01N30/74 , G01N30/466
摘要： The present invention provides a method of analyzing multiple samples simultaneously by absorption detection. The method comprises: (i) providing a planar array of multiple containers, each of which contains a sample comprising at least one absorbing species, (ii) irradiating the planar array of multiple containers with a light source and (iii) detecting absorption of light with a detetion means that is in line with the light source at a distance of at leaat about 10 times a cross-sectional distance of a container in the planar array of multiple containers. The absorption of light by a sample indicates the presence of an absorbing species in it. The method can further comprise: (iv) measuring the amount of absorption of light detected in (iii) indicating the amount of the absorbing species in the sample. Also provided by the present invention is a system for use in the abov metho.The system comprises; (i) a light source comrnpising or consisting essentially of at leaat one wavelength of light, the absorption of which is to be detected, (ii) a planar array of multiple containers, and (iii) a detection means that is in line with the light source and is positioned in line with and parallel to the planar array of multiple contiainers at a distance of at least about 10 times a cross-sectional distance of a container.
摘要翻译：本发明提供了通过吸收检测同时分析多个样品的方法。该方法包括：（i）提供多个容器的平面阵列，每个容器包含包含至少一个吸收物质的样品，（ii）用光源照射多个容器的平面阵列，以及（iii）检测光的吸收具有与多个容器的平面阵列中的容器的横截面距离的至少约10倍的距离与光源一致的检测装置。样品对光的吸收表明其中存在吸收物质。该方法还可以包括：（iv）测量在（iii）中检测到的光的吸收量，指示样品中吸收物质的量。本发明还提供了一种在上述方法中使用的系统。（i）光源，其包括或基本上由至少一个波长的光，其吸收被检测，（ii）多个容器的平面阵列，以及（iii）检测装置，其符合光源并且与容器的横截面距离的至少约10倍的距离定位成与多个容器的平面阵列成直线并平行。

4. 发明授权

US5540825A Noise suppressing capillary separation system 失效
标题翻译：噪声抑制毛细管分离系统
公开(公告)号：US5540825A
公开(公告)日：1996-07-30
申请号：US406714
申请日：1995-03-20
申请人： Edward S. Yeung , Yongjun Xue
发明人： Edward S. Yeung , Yongjun Xue
IPC分类号： G01N27/447 , G01N30/62 , G01N30/74 , G01N27/26 , G01N21/85
CPC分类号： G01N30/74 , G01N27/44721 , G01N2030/621
摘要： A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that generates a beam which is split into a reference beam and a sample beam that irradiate the capillary, and a detector for detecting the reference beam and the sample beam light that transmits through the capillary. The laser beam is of a wavelength effective to be absorbed by a chromophore in the capillary. The system includes a noise suppressing system to improve performance and accuracy without signal averaging or multiple scans.
摘要翻译：提供了用于检测样品中分析物的实时存在或浓度的噪声抑制毛细管分离系统。该系统包含毛细管分离装置，分析物通过该分离装置移动，相干光源产生分成参考光束的光束和照射毛细管的样品光束，以及用于检测参考光束和样品光束的检测器透过毛细管的光。激光束具有有效地被毛细管中的发色团吸收的波长。该系统包括噪声抑制系统，以提高性能和精度，而不需要信号平均或多次扫描。

5. 发明授权

US5695626A Capillaries for use in a multiplexed capillary electrophoresis system 失效
标题翻译：用于复用毛细管电泳系统的毛细血管
公开(公告)号：US5695626A
公开(公告)日：1997-12-09
申请号：US667950
申请日：1996-06-18
申请人： Edward S. Yeung , Huan-Tsang Chang , Eliza N. Fung
发明人： Edward S. Yeung , Huan-Tsang Chang , Eliza N. Fung
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44782 , G01N27/44721
摘要： The invention provides a side-entry optical excitation geometry for use in a multiplexed capillary electrophoresis system. A charge-injection device is optically coupled to capillaries in the array such that the interior of a capillary is imaged onto only one pixel. In Sanger-type 4-label DNA sequencing reactions, nucleotide identification ("base calling") is improved by using two long-pass filters to split fluorescence emission into two emission channels. A binary poly(ethyleneoxide) matrix is used in the electrophoretic separations.
摘要翻译：本发明提供了用于多路复用毛细管电泳系统中的侧入光激发几何形状。电荷注入装置光学耦合到阵列中的毛细管，使得毛细管的内部成像到仅一个像素上。在Sanger型4标记DNA测序反应中，通过使用两个长通滤波器将荧光发射分解成两个发射通道来改善核苷酸鉴定（“碱基呼叫”）。在电泳分离中使用二元聚（环氧乙烷）基质。

6. 发明授权

US4575433A Method of generating chemiluminescent light 失效
标题翻译：产生化学发光光的方法
公开(公告)号：US4575433A
公开(公告)日：1986-03-11
申请号：US688553
申请日：1985-01-03
申请人： Stanford R. Spurlin , Edward S. Yeung
发明人： Stanford R. Spurlin , Edward S. Yeung
IPC分类号： G01N21/76 , C09K11/07 , C09K11/56 , C09K11/61 , F21K2/06
CPC分类号： G01N21/766 , Y10T436/182 , Y10T436/184
摘要： A method of chemiluminescently determining a sulfide which is either hydrogen sulfide or methyl mercaptan by reacting the sulfide with chlorine dioxide at low pressure and under conditions which allow a longer reaction time in emission of a single photon for every two sulfide containing species, and thereafter, chemiluminescently detecting and determining the sulfide. The invention also relates not only to the detection method, but the novel chemical reaction that generates chemiluminescent light and a specifically designed chemiluminescence detection cell for the reaction.
摘要翻译：一种化学发光测定硫化物的方法，该硫化物是硫化氢或甲硫醇，其通过使硫化物与二氧化氯在低压下和允许每两个硫化物物质发射单个光子的反应时间更长的条件下反应，化学发光检测和测定硫化物。本发明不仅涉及检测方法，而且还涉及产生化学发光的新型化学反应和用于反应的专门设计的化学发光检测电池。

7. 发明授权

US4455089A Refractive index and absorption detector for liquid chromatography based on Fabry-Perot interferometry 失效
$Refractive index and absorption detector for liquid chromatography based on Fabry-Perot interferometry$
标题翻译：基于法布里 - 珀罗干涉法的液相色谱折射率和吸收检测器
公开(公告)号：US4455089A
公开(公告)日：1984-06-19
申请号：US460467
申请日：1983-01-24
申请人： Edward S. Yeung , Steven D. Woodruff
发明人： Edward S. Yeung , Steven D. Woodruff
IPC分类号： G01B9/02 , G01N21/05 , G01N21/45 , G01N30/74
CPC分类号： G01N30/74 , G01N21/45 , G01N2030/746 , G01N21/05
摘要： A refractive index and absorption detector for liquid chromatography. It is based in part on a Fabry-Perot interferometer and is used for the improved detection of refractive index and absorption. It includes a Fabry-Perot interferometer having a normally fixed first partially reflecting mirror and a movable second partially reflecting mirror. A chromatographic flow-cell is positioned between the mirrors along the optical axis of a monochromatic laser beam passing through the interferometer. A means for deriving information about the interference fringes coming out of the interferometer is used with a mini-computer to compute the refractive index of the specimen injected into the flow cell. The minicomputer continuously scans the interferometer for continuous refractive index readings and outputs the continuous results of the scans on a chart recorder. The absorption of the specimen can concurrently be scanned by including a second optical path for an excitation laser which will not interfere with the first laser, but will affect the specimen so that absorption properties can be detected. By first scanning for the refractive index of the specimen, and then immediately adding the excitation laser and subsequently scanning for the refractive index again, the absorption of the specimen can be computed and recorded.
摘要翻译：液相色谱的折射率和吸收检测器。它部分基于法布里 - 珀罗干涉仪，用于改进折射率和吸收的检测。它包括具有通常固定的第一部分反射镜和可动第二部分反射镜的法布里 - 珀罗干涉仪。色谱流动池位于通过干涉仪的单色激光束的光轴之间的反射镜之间。与微型计算机一起使用用于导出关于从干涉仪出来的干涉条纹的信息的装置来计算注入到流动池中的样本的折射率。小型计算机连续扫描干涉仪以获得连续折射率读数，并在图表记录仪上输出扫描的连续结果。可以通过包括不会干扰第一激光的激发激光器的第二光路来同时扫描样品的吸收，但会影响样品，从而可以检测吸收特性。首先扫描样品的折射率，然后立即加入激发激光，然后再次扫描折射率，可以计算和记录样品的吸收。

8. 发明授权

US06878254B2 Size separation of analytes using monomeric surfactants 失效
标题翻译：使用单体表面活性剂大小分离分析物
公开(公告)号：US06878254B2
公开(公告)日：2005-04-12
申请号：US10085656
申请日：2002-02-27
申请人： Edward S. Yeung , Wei Wei
发明人： Edward S. Yeung , Wei Wei
IPC分类号： B01D15/34 , G01N27/447 , G01N27/453
CPC分类号： B01D15/34 , G01N27/44721 , G01N27/44747 , G01N27/44782
摘要： A sieving medium for use in the separation of analytes in a sample containing at least one such analyte comprises a monomeric non-ionic surfactant of the of the general formula, B-A, wherein A is a hydrophilic moiety and B is a hydrophobic moiety, present in a solvent at a concentration forming a self-assembled micelle configuration under selected conditions and having an aggregation number providing an equivalent weight capable of effecting the size separation of the sample solution so as to resolve a target analyte(s) in a solution containing the same, the size separation taking place in a chromatography or electrophoresis separation system.
摘要翻译：用于分离含有至少一种此类分析物的样品中的分析物的筛分介质包含通式BA的单体非离子表面活性剂，其中A是亲水部分，B是疏水部分，存在于在选定条件下形成自组装胶束构型的浓度的溶剂，并且具有提供能够实现样品溶液的尺寸分离的当量的聚集数，以便在含有该样品溶液的溶液中分辨目标分析物，在色谱或电泳分离系统中发生尺寸分离。

9. 发明授权

US4984857A Linearization of scan velocity of resonant vibrating-mirror beam deflectors 失效
标题翻译：谐振式振镜光束偏转器扫描速度的线性化
公开(公告)号：US4984857A
公开(公告)日：1991-01-15
申请号：US297483
申请日：1989-01-17
申请人： Edward S. Yeung , Shun-Le Chen
发明人： Edward S. Yeung , Shun-Le Chen
IPC分类号： G02B27/00
CPC分类号： G02B27/0031 , Y10S359/90
摘要： A means and method for producing linerization of scan velocity of resonant vibrating-mirror beam deflectors in laser scanning system including presenting an elliptical convex surface to the scanning beam to reflect the scanning beam to the focal plane of the scanning line. The elliptical surface is shaped to produce linear velocity of the reflective scanning beam at the focal plane. Maximization of linerization is accomplished by considering sets of criteria for different scanning applications.
摘要翻译：一种用于在激光扫描系统中产生共振振镜反射镜偏转器的扫描速度的线性化的方法和方法，包括向扫描光束呈现椭圆形的凸面以将扫描光束反射到扫描线的焦平面。椭圆形表面被成形为在焦平面处产生反射扫描光束的线速度。通过考虑不同扫描应用的标准集来实现最大化的线性化。

10. 发明授权

US4921348A Method and means for a spatial and temporal probe for laser-generated plumes based on density gradients 失效
标题翻译：用于基于密度梯度的激光产生羽流的空间和时间探针的方法和装置
公开(公告)号：US4921348A
公开(公告)日：1990-05-01
申请号：US301485
申请日：1989-01-26
申请人： Edward S. Yeung , Guoying Chen
发明人： Edward S. Yeung , Guoying Chen
IPC分类号： G01N21/17 , G01N21/41
CPC分类号： G01N21/41 , G01N21/171
摘要： A method and means for a spatial and temporal probe for laser generated plumes based on density gradients includes generation of a plume of vaporized material from a surface by an energy source. The probe laser beam is positioned so that the plume passes through the probe laser beam. Movement of the probe laser beam caused by refraction from the density gradient of the plume is monitored. Spatial and temporal information, correlated to one another, is then derived.
摘要翻译：用于基于密度梯度的激光产生羽流的空间和时间探针的方法和装置包括通过能量源从表面生成蒸发物质的羽流。探针激光束被定位成使得羽流通过探针激光束。监测由羽流的密度梯度折射引起的探针激光束的移动。然后导出彼此相关的空间和时间信息。

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