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1. 发明申请

WO2009134701A3 DEVICE AND METHOD FOR REPLACING MITRAL VALVE 审中-公开
标题翻译：用于更换麻药阀的装置和方法
公开(公告)号：WO2009134701A3
公开(公告)日：2010-02-11
申请号：PCT/US2009041754
申请日：2009-04-27
申请人： EDWARDS LIFESCIENCES CORP , ROWE STANTON J , CHAU MARK , NGUYEN SON V
发明人： ROWE STANTON J , CHAU MARK , NGUYEN SON V
IPC分类号： A61F2/90 , A61F2/24
CPC分类号： A61F2/2418 , A61B17/0401 , A61B2017/00243 , A61B2017/0417 , A61B2017/0496 , A61F2/2427 , A61F2/2436 , A61F2/2457 , A61F2/90 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , A61L27/3625 , A61L27/50 , A61L2430/20
摘要： A prosthetic mitral valve assembly is disclosed. In certain disclosed embodiments, the prosthetic mitral valve assembly has a flared upper end and a tapered portion to fit the contours of the native mitral valve. The prosthetic mitral valve assembly includes a stent or outer support frame with a valve mounted therein. The assembly can be adapted to expand radially outwardly and into contact with the native tissue to create a pressure fit. The mitral valve assembly further includes tension members between the leaflets of the valve assembly and a suitable location on the heart.
摘要翻译：公开了一种假体二尖瓣组件。在某些公开的实施例中，假体二尖瓣组件具有扩张的上端和锥形部分以适应天然二尖瓣的轮廓。假体二尖瓣组件包括其中安装有阀的支架或外部支撑框架。组件可以适于径向向外膨胀并与天然组织接触以产生压力配合。二尖瓣组件还包括在阀组件的传单和心脏上的适当位置之间的张力构件。

2. 发明申请

WO2010099032A3 MITRAL VALVE REPLACEMENT WITH ATRIAL ANCHORING 审中-公开
标题翻译：麻醉阀更换与ATRIAL锚固
公开(公告)号：WO2010099032A3
公开(公告)日：2011-01-06
申请号：PCT/US2010024665
申请日：2010-02-19
申请人： EDWARDS LIFESCIENCES CORP , CHAU MARK , YI SEUNG , CORSO PHILLIP , POPP MICHAEL J , OLIN JANE , NGUYEN SON V , GOLEMO KEVIN
发明人： CHAU MARK , YI SEUNG , CORSO PHILLIP , POPP MICHAEL J , OLIN JANE , NGUYEN SON V , GOLEMO KEVIN
IPC分类号： A61F2/24 , A61F2/84 , A61F2/86 , A61L27/04 , A61L27/14 , A61M29/00
CPC分类号： A61F2/2457 , A61F2/2418 , A61F2/2436 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/0078 , A61F2250/0039
摘要： A prosthetic mitral valve assembly and method of inserting the same is disclosed. In certain disclosed embodiments, the prosthetic mitral valve assembly includes a stent and valve combination. The stent is designed so that the anchoring portion is positioned above the annulus of the mitral valve and in the left atrium. The stent is radially expandable so that it can expand into position against the walls of the left atrium and accommodate a wide range of anatomies. Contact between the stent and the native tissue in the left atrium reduces paravalvular leakage and prevents migration of the stent once in place.
摘要翻译：公开了一种假体二尖瓣组件及其插入方法。在某些公开的实施例中，假体二尖瓣组件包括支架和瓣膜组合。支架被设计成使得锚固部分位于二尖瓣环和左心房的环上。支架是径向可扩张的，使得其能够相对于左心房的壁膨胀到适当的位置并适应宽范围的解剖结构。支架与左心房中的天然组织之间的接触减少了瓣膜渗漏，并防止了支架移动到位。

3. 发明专利

IL288452D0 Systems and methods for heart valve leaflet repair 未知
公开(公告)号：IL288452D0
公开(公告)日：2022-01-01
申请号：IL28845221
申请日：2021-11-28
申请人： EDWARDS LIFESCIENCES CORP , CHAU MARK , SHAFIGH SAM , OBA TRAVIS ZENYO , GUERRERO MAURICIO , SPARGIAS KONSTANTINOS , FELDMAN TED ELIOT , KHUU NANCY HOANG , RABBAH JEAN PIERRE MICHEL
发明人： CHAU MARK , SHAFIGH SAM , OBA TRAVIS ZENYO , GUERRERO MAURICIO , SPARGIAS KONSTANTINOS , FELDMAN TED ELIOT , KHUU NANCY HOANG , RABBAH JEAN-PIERRE MICHEL
摘要： An implant (100) includes an interface (110), and a wing (120) that is coupled to the interface and has a contact face. A catheter (40) is transluminally advanceable to a chamber (6) of a heart of a subject and houses the implant. A delivery tool comprises a shaft (60) and a driver (70). Via engagement with the interface, the shaft is configured to (i) deploy the implant out of the catheter such that, within the chamber, the wing extends away from the interface; and (ii) position the implant in a position in which the interface is at a site in the heart, the wing extends over the first leaflet toward the opposing leaflet, and the contact face faces the first leaflet. The driver is configured to secure the implant in the position by using an anchor to anchor the interface. Other embodiments are also described.

4. 发明申请

WO2010065265A3 APPARATUS AND METHOD FOR IN SITU EXPANSION OF PROSTHETIC DEVICE 审中-公开
标题翻译：用于原位扩张假体装置的装置和方法
公开(公告)号：WO2010065265A3
公开(公告)日：2010-09-30
申请号：PCT/US2009064412
申请日：2009-11-13
申请人： EDWARDS LIFESCIENCES CORP , CHAU MARK , OBA TRAVIS , HUNTLEY TAMMY , ZENG QUINGGANG , YAMBAO AUGUST , PINTOR RAFAEL
发明人： CHAU MARK , OBA TRAVIS , HUNTLEY TAMMY , ZENG QUINGGANG , YAMBAO AUGUST , PINTOR RAFAEL
IPC分类号： A61M29/02 , A61F2/82
CPC分类号： A61F2/2433 , A61F2/2418 , A61F2/243 , A61F2220/0008 , A61F2230/0054 , A61F2250/0003
摘要： A system for expanding a device in a conduit or orifice of a human body includes an expansion device that is movable from a first configuration to a second configuration. External surfaces of the expansion device can collectively have a non-cylindrical cross-section relative to a main axis of the expansion device, such that the external surfaces of the expansion device generally conform to the anatomical shape of the conduit or orifice when the expansion device is in the second configuration.
摘要翻译：用于在人体的导管或孔口中扩张装置的系统包括可从第一构造移动到第二构造的扩张装置。扩张装置的外表面可相对于扩张装置的主轴共同具有非圆柱形横截面，使得扩张装置的外表面大致符合导管或孔口的解剖形状，当扩张装置处于第二种配置。

5. 发明申请

WO2010080594A8 QUICK-CONNECT PROSTHETIC HEART VALVE AND METHODS 审中-公开
标题翻译：快速连接心脏瓣膜和方法
公开(公告)号：WO2010080594A8
公开(公告)日：2011-06-09
申请号：PCT/US2009068693
申请日：2009-12-18
申请人： EDWARDS LIFESCIENCES CORP , PINTOR RAFAEL , CHAU MARK , OBA TRAVIS , YAMBAO AUGUST , CAMPBELL LOUIS , HUNTLEY TAMMY , ZENG QINGGANG , CRISTEA CAREY , KALAM FAISAL
发明人： PINTOR RAFAEL , CHAU MARK , OBA TRAVIS , YAMBAO AUGUST , CAMPBELL LOUIS , HUNTLEY TAMMY , ZENG QINGGANG , CRISTEA CAREY , KALAM FAISAL
IPC分类号： A61F2/24 , A61F2/82 , A61M29/00 , A61M39/22
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/0054 , A61F2230/0067 , A61F2230/0069 , A61F2230/0078 , A61F2250/006
摘要： A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve has a base stent that is deployed at a treatment site, and a valve component configured to quickly connect to the base stent. The base stent may take the form of a self- or balloon-expandable stent that expands outward against the native valve with or without leaflet excision. The valve component has a non-expandable prosthetic valve and a self- or balloon-expandable coupling stent for attachment to the base stent, thereby fixing the position of the valve component relative to the base stent. The prosthetic valve may be a commercially available to valve with a sewing ring and the coupling stent attaches to the sewing ring. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment. A catheter-based system and method for deployment is provided.
摘要翻译：提供了可以在外科手术过程中快速且容易地植入的心脏瓣膜假体。假体瓣膜具有部署在治疗部位的基部支架和构造成快速连接到基部支架的阀部件。基底支架可以采取自体或球囊扩张的支架的形式，其在具有或不具有小叶切除的情况下相对于天然瓣膜向外扩张。阀组件具有不可扩张的假体瓣膜和用于附接到基底支架的自支撑或球囊可扩张的联接支架，从而固定阀部件相对于基底支架的位置。人造瓣膜可以是市售的，具有缝合环的阀门，并且联接支架附接到缝合环。该系统特别适用于在常规开心手术环境中快速部署心脏瓣膜。提供了基于导管的系统和部署方法。

6. 发明申请

WO2010151617A3 UNITARY QUICK-CONNECT PROSTHETIC HEART VALVE AND DEPLOYMENT SYSTEM AND METHODS 审中-公开
标题翻译：单位快速连接心脏瓣膜和部署系统和方法
公开(公告)号：WO2010151617A3
公开(公告)日：2011-05-19
申请号：PCT/US2010039746
申请日：2010-06-24
申请人： EDWARDS LIFESCIENCES CORP , PINTOR RAFAEL , CHAU MARK , OBA TRAVIS , YAMBAO AUGUST , CAMPBELL LOUIS A , HUNTLEY TAMMY , ZENG QINGGANG , CRISTEA CAREY , KALAM FAISAL
发明人： PINTOR RAFAEL , CHAU MARK , OBA TRAVIS , YAMBAO AUGUST , CAMPBELL LOUIS A , HUNTLEY TAMMY , ZENG QINGGANG , CRISTEA CAREY , KALAM FAISAL
IPC分类号： A61F2/24 , A61F2/82 , A61M25/02 , A61M25/10 , A61M29/00
CPC分类号： A61F2/2427 , A61F2/2409 , A61F2/2418 , A61F2/2433 , A61F2/2439 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/005 , A61F2250/006
摘要： A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable coupling stent, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the coupling stent attached thereto. The coupling stent may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes a hollow two-piece handle through which a balloon catheter passes. A valve holder is stored with the heart valve and the handle easily attaches thereto to improve valve preparation steps.
摘要翻译：提供了一种快速连接的心脏瓣膜假体，可以在手术过程中快速方便地植入。心脏瓣膜包括基本上不可膨胀的不可压缩的人造瓣膜和塑性可扩张的联接支架，从而使得能够在不缝合的情况下连接到环形空间。可以提供少量的导向缝线用于主动脉瓣取向。假体瓣膜可以是具有连接有联接支架的缝合环的市售阀。联接支架可以从锥形展开形状扩展到圆锥形膨胀形状，并且可以包括连接在轴向延伸柱之间的腹板状支柱。用于展开的系统和方法包括气球导管通过的中空两件式手柄。与心脏瓣膜一起存储阀保持器，并且手柄容易地附接到其上以改善阀门准备步骤。

7. 发明申请

WO2010117609A2 PROSTHETIC HEART VALVE SYSTEM WITH POSITONING MARKERS 审中-公开
标题翻译：具有定位标记的前置心脏瓣膜系统
公开(公告)号：WO2010117609A2
公开(公告)日：2010-10-14
申请号：PCT/US2010028151
申请日：2010-03-22
申请人： EDWARDS LIFESCIENCES CORP , CHAU MARK , ZENG QINGGANG
发明人： CHAU MARK , ZENG QINGGANG
IPC分类号： A61B17/00 , A61B19/00 , A61F2/24 , A61F2/82 , A61M29/02 , G01N33/58
CPC分类号： A61F2/243 , A61F2/2418 , A61F2/2427 , A61F2/2433 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/0054 , A61F2230/008 , A61F2250/0063 , A61F2250/0097 , A61F2250/0098
摘要： An exemplary two-stage prosthetic heart valve system has a radially expandable base stent implanted within a native valve annulus. The base stent desirably has three position markers projecting in the axial direction from the outflow end of the base stent to assist in aligning the stent with respect to the commissures of the native valve. The two-stage heart valve system also has a valve component that is delivered to and mounted within the base stent in a separate or sequential operation after the base stent has been anchored within the annulus. The valve component in certain embodiments comprises a hybrid valve component that includes a conventional, non-expandable surgical valve that is modified to include an expandable coupling stent that can be expanded to engage the inner surface of the base stent, thereby anchoring the valve component to the base stent.
摘要翻译：示例性的两级假体心脏瓣膜系统具有植入在天然瓣膜环内的径向可扩展的基底支架。基底支架理想地具有从基部支架的流出端在轴向上突出的三个位置标记，以帮助相对于天然瓣膜的连合来对准支架。两级心脏瓣膜系统还具有阀组件，其在基础支架已经被锚定在环空中之后以单独的或顺序的操作被输送并安装在基础支架内。在某些实施方案中，阀部件包括混合阀部件，其包括常规的不可扩张的外科手术阀，其被修改为包括可膨胀以可接合基部支架的内表面的可扩张联接支架，从而将阀部件固定到基础支架。

8. 发明申请

WO2010080594A3 QUIK-CONNECT PROSTHETIC HEART VALVE AND METHODS 审中-公开
标题翻译： QUIK连接前置心脏瓣膜和方法
公开(公告)号：WO2010080594A3
公开(公告)日：2010-10-14
申请号：PCT/US2009068693
申请日：2009-12-18
申请人： EDWARDS LIFESCIENCES CORP , PINTOR RAFAEL , CHAU MARK , OBA TRAVIS , YAMBAO AUGUST , CAMPBELL LOUIS , HUNTLEY TAMMY , ZENG QINGGANG , CRISTEA CAREY , KALAM FAISAL
发明人： PINTOR RAFAEL , CHAU MARK , OBA TRAVIS , YAMBAO AUGUST , CAMPBELL LOUIS , HUNTLEY TAMMY , ZENG QINGGANG , CRISTEA CAREY , KALAM FAISAL
IPC分类号： A61F2/24 , A61F2/82 , A61M29/00 , A61M39/22
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/0054 , A61F2230/0067 , A61F2230/0069 , A61F2230/0078 , A61F2250/006
摘要： A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve has a base stent that is deployed at a treatment site, and a valve component configured to quickly connect to the base stent. The base stent may take the form of a self- or balloon-expandable stent that expands outward against the native valve with or without leaflet excision. The valve component has a non-expandable prosthetic valve and a self- or balloon-expandable coupling stent for attachment to the base stent, thereby fixing the position of the valve component relative to the base stent. The prosthetic valve may be a commercially available to valve with a sewing ring and the coupling stent attaches to the sewing ring. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment. A catheter-based system and method for deployment is provided.
摘要翻译：提供了可以在手术过程中快速且容易地植入的心脏瓣膜假体。假体瓣膜具有部署在治疗部位的基部支架和构造成快速连接到基部支架的阀部件。基底支架可以采取自体或球囊扩张的支架的形式，其在具有或不具有小叶切除的情况下相对于天然瓣膜向外扩张。阀部件具有不可扩张的假体瓣膜和用于附接到基底支架的自支撑或球囊扩张的联接支架，由此固定阀部件相对于基底支架的位置。人造瓣膜可以是市售的，具有缝合环的阀门，并且联接支架附接到缝合环。该系统特别适用于在常规开心手术环境中快速部署心脏瓣膜。提供了基于导管的系统和部署方法。

9. 发明申请

WO2007067820A3 IMPROVED ANCHORING SYSTEM FOR MEDICAL IMPLANT 审中-公开
标题翻译：改进的医疗植入锚定系统
公开(公告)号：WO2007067820A3
公开(公告)日：2007-09-07
申请号：PCT/US2006047272
申请日：2006-12-11
申请人： EDWARDS LIFESCIENCES CORP , BOBO DONALD E JR , BOURANG HENRY , CORSO CHIP , WERTENBERG WILLIAM R , CHAU MARK , POPP MIKE
发明人： BOBO DONALD E JR , BOURANG HENRY , CORSO CHIP , WERTENBERG WILLIAM R , CHAU MARK , POPP MIKE
IPC分类号： A61F2/24
CPC分类号： A61F2/2451
摘要： Embodiments of the invention provide a medical implant, and method for deploying the same, configured for placement in a body lumen such as a coronary sinus, as may be desired to treat a regurgitant mitral valve. The implant includes a proximal anchor, a distal anchor, and an elongate bridge extending between the proximal and distal anchors. The anchors are configured to be delivered to a desired deployment site within the body lumen in a collapsed or contracted condition and then expanded to engage the walls of the body lumen. The bridge is preferably a shape-changing member configured to contract after delivery into the coronary sinus for applying a compressive force to the annulus of the mitral valve. The proximal and distal anchoring mechanisms preferably overlap the proximal and distal end portions of the bridge, thereby providing the implant with a longer bridge having greater contraction.
摘要翻译：本发明的实施例提供一种医学植入物和用于展开它的方法，该医学植入物和方法被配置用于放置在诸如冠状窦的体腔中，如可能希望治疗反流二尖瓣的。植入物包括近端锚定件，远端锚定件和在近端和远端锚定件之间延伸的细长桥。锚定件被构造成在塌缩或收缩状态下被递送到体腔内的期望的展开部位，然后扩张以接合体腔的壁。所述桥优选为形状改变构件，所述形状改变构件构造成在递送到冠状窦内之后收缩以向所述二尖瓣的瓣膜环施加压缩力。近端锚固机构和远端锚固机构优选地与桥的近端和远端部分重叠，由此为植入物提供具有更大收缩的更长的桥。

10. 发明公开

EP2892469A4 HEART VALVE SEALING DEVICES 审中-实审
标题翻译： HERZKLAPPENVERSCHLUSSVORRICHTUNGEN
公开(公告)号：EP2892469A4
公开(公告)日：2016-06-15
申请号：EP13834484
申请日：2013-08-30
申请人： EDWARDS LIFESCIENCES CORP
发明人： CHAU MARK , OBA TRAVIS , DELGADO SERGIO , TAFT ROBERT C , ROWE STANTON J , COOPER ALEXANDER H
IPC分类号： A61F2/24 , A61F2/82 , A61M39/22
CPC分类号： A61F2/2436 , A61F2/2412 , A61F2/243 , A61F2/2433 , A61F2/2442 , A61F2/2445 , A61F2/2454 , A61F2/2457 , A61F2/246 , A61F2/2463 , A61F2/2466 , A61F2230/0069 , A61F2250/0003
摘要： This disclosure pertains generally to prosthetic devices and related methods for helping to seal native heart valves and prevent or reduce regurgitation therethrough, as well as devices and related methods for implanting such prosthetic devices. In some cases, a spacer having a single anchor can be implanted within a native heart valve. In some cases, a spacer having dual anchors can be implanted within a native heart valve. In some cases, devices can be used to extend the effective length of a native heart valve leaflet.
摘要翻译：本公开总体上涉及用于帮助密封天然心脏瓣膜并防止或减少穿过其的反流的假体装置和相关方法，以及用于植入这种假体装置的装置和相关方法。在一些情况下，具有单个锚的间隔物可以植入天然心脏瓣膜内。在一些情况下，具有双重锚固件的间隔件可以植入天然心脏瓣膜内。在某些情况下，可以使用装置来延长天然心脏瓣膜小叶的有效长度。

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