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1. 发明申请

WO0010992A2 WATER-DISPERSIBLE OR WATER-SOLUBLE D-TOCOTRIENOL COMPOUNDS AND METHODS FOR MAKING THEREFOR 审中-公开
标题翻译：水分散型或水溶性D-TOCOTRIENOL化合物及其制备方法
公开(公告)号：WO0010992A2
公开(公告)日：2000-03-02
申请号：PCT/US9918138
申请日：1999-08-10
申请人： EASTMAN CHEM CO
发明人： HYATT JOHN ANTHONY
IPC分类号： C07B53/00 , C07B61/00 , C07D311/72 , C08G65/332 , C07D311/00
CPC分类号： C07D311/72
摘要： The invention relates to a water-dispersible or water-soluble compound having structure (I) wherein, R , R , and R are, independently hydrogen or methyl, and R is -(CH2CH2O)nCH2CH2OH, wherein n is from 10 to 100, wherein compound (I) is the substantially pure D-enantiomer. The invention further relates to a water-dispersible or water-soluble compound having structure (II) wherein, R , R , and R are, independently, hydrogen or methyl, or the salt thereof, wherein compound (II) is the substantially pure D-enantiomer. The invention further relates to methods for making the tocotrienol compounds of the present invention.
摘要翻译：本发明涉及具有结构（I）的水分散性或水溶性化合物，其中R 1，R 2和R 3独立地是氢或甲基，R 4是 - （ CH2CH2O）nCH2CH2OH，其中n为10至100，其中化合物（I）为基本上纯的D-对映异构体。本发明还涉及具有结构（II）的水分散性或水溶性化合物，其中R 1，R 2和R 3独立地是氢或甲基，或其盐，其中化合物（II）是基本上纯的D-对映异构体。本发明还涉及制备本发明的生育三烯酚化合物的方法。

2. 发明申请

WO9816682A3 PROCESS FOR THE CO-PRODUCTION OF DISSOLVING-GRADE PULP AND XYLAN 审中-公开
标题翻译：生产分散浆和XYLAN的方法
公开(公告)号：WO9816682A3
公开(公告)日：1998-06-25
申请号：PCT/US9718834
申请日：1997-10-10
申请人： EASTMAN CHEM CO
发明人： HYATT JOHN ANTHONY , FENGL RICHARD WILLIAM , EDGAR KEVIN JOSEPH , ALVAREZ-WRIGHT MARIA TERESA
IPC分类号： C08B37/14 , C08B37/00 , D21C5/00 , D21C9/00 , D21C11/00
CPC分类号： C08B37/0057 , D21C5/005 , D21C9/002 , D21C11/0007
摘要： Disclosed is a process for upgrading paper-grade wood pulp to dissolving grade pulp which is suitable for use in the preparation of viscose rayon, cellulose ethers and cellulose esters such as cellulose acetate. The process utilizes a sequence of caustic extraction, xylanase treatment and caustic extraction to remove most of the xylan, which may be recovered for use in the production of xylose, xylitol, and furans.

3. 发明申请

WO2007115181A3 COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：表现出EFFLUX抑制剂活性和组成的化合物及其用途
公开(公告)号：WO2007115181A3
公开(公告)日：2008-06-19
申请号：PCT/US2007065655
申请日：2007-03-30
申请人： EASTMAN CHEM CO
发明人： WEMPE MICHAEL FITZPATRICK , EDGAR KEVIN JOSEPH , ZIMA GEORGE CHESTER , HYATT JOHN ANTHONY
IPC分类号： A61K31/353 , A61K31/355 , C07D311/30 , C07D311/38 , C07D311/72
CPC分类号： A61K45/06 , A61K31/00 , A61K31/352 , A61K31/355 , A61K31/56 , C07J17/00 , A61K2300/00
摘要： At least one compound chosen from compounds of Formula 1: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each Of R 2 , R 3 , R 4 and R 5 is independently chosen from -H, alkyl, substituted aikyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z' is chosen from -O-, -N-, -NO-, - NR 4 -, -S-, -SO- and -SO 2 -, wherein R 4 is defined as above; each of X, X', Y and Z is independently chosen from -CR 4 R 5 -, -NH-, -NR 4 -, -NO-. -O-, -NOR 4 -, -S-, -SO-, -SO 2 -, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 , is chosen from any R 1 , alkyl. substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.
摘要翻译：至少一种选自式1化合物的化合物：其药学上可接受的盐或酯，其溶剂化物，其螯合物，其非共价复合物，其前药以及任何前述物质的混合物，其中：n是 1至900的数字，其中各个单元可以相同或不同; W选自烷基，取代的烷基，环烷基，取代的环烷基，芳基，取代的芳基，芳烷基和取代的芳烷基; R 2，R 3，R 4，R 5和R 5中的每一个独立地选自-H，烷基，取代的烷基，环烷基，取代的环烷基，芳基，取代的芳基，芳烷基和取代的芳烷基; Z'选自-O - ， - N - ， - NO - ， - NR 4 - ， - S - ， - SO-和-SO 2 - ，其中 R _{4 的定义如上; X，X'，Y和Z各自独立地选自-CR 4， - NR 5，， - NO-。 -O - ， - NOR 4 - ， - S - ， - SO - ， - SO 2 - ，其中R 4和R _{5 的定义如上; R SUB1选自生育酚，类固醇和类黄酮; 和R 6选自任何R 1，烷基。取代的烷基，环烷基，取代的环烷基，芳基，取代的芳基，芳烷基和取代的芳烷基。}}

4. 发明申请

WO2007115181A9 COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：化合物展示抑制剂活性及组合物及其用途
公开(公告)号：WO2007115181A9
公开(公告)日：2008-04-03
申请号：PCT/US2007065655
申请日：2007-03-30
申请人： EASTMAN CHEM CO
发明人： WEMPE MICHAEL FITZPATRICK , EDGAR KEVIN JOSEPH , ZIMA GEORGE CHESTER , HYATT JOHN ANTHONY
IPC分类号： A61B5/05
CPC分类号： A61K45/06 , A61K31/00 , A61K31/352 , A61K31/355 , A61K31/56 , C07J17/00 , A61K2300/00
摘要： At least one compound chosen from compounds of Formula 1: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each Of R 2 , R 3 , R 4 and R 5 is independently chosen from -H, alkyl, substituted aikyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z' is chosen from -O-, -N-, -NO-, - NR 4 -, -S-, -SO- and -SO 2 -, wherein R 4 is defined as above; each of X, X', Y and Z is independently chosen from -CR 4 R 5 -, -NH-, -NR 4 -, -NO-. -O-, -NOR 4 -, -S-, -SO-, -SO 2 -, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 , is chosen from any R 1 , alkyl. substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.
摘要翻译：至少一种选自式1化合物的化合物：其药学上可接受的盐或酯，其溶剂合物，螯合物，其非共价复合物，其前体药物以及上述任何一种的混合物，其中n为 1至900的数字，其中各个单元可以相同或不同; W选自烷基，取代的烷基，环烷基，取代的环烷基，芳基，取代的芳基，芳烷基和取代的芳烷基; R 2，R 3，R 4和R 5各自独立地选自-H，烷基，取代的芳基，环烷基，取代的环烷基，芳基，取代的芳基，芳烷基和取代的芳烷基; Z'选自-O - ， - N-，-NO - ， - NR 4 - ， - S - ， - SO - 和-SO 2 - ，其中 R 4如上定义; X，X'，Y和Z中的每一个独立地选自-CR 4 R 5 - ， - NH - ， - NR 4 - ，-NO-。 -O - ， - NOR 4 - ， - S - ， - SO - ， - SO 2 - ，其中R 4和R 2 < > 5 如上所定义; R 1选自生育酚，类固醇和类黄酮; 和R 6，R 6选自任何R 1，C 1-4烷基。取代的烷基，环烷基，取代的环烷基，芳基，取代的芳基，芳烷基和取代的芳烷基。

5. 发明申请

WO2006039268A3 PHARMACEUTICAL FORMULATIONS CONTAINING VITAMIN E TPGS MOLECULES THAT SOLUBILIZE LIPOPHILIC DRUGS WITHOUT SIGNIFICANT EFFLUX INHIBITION, AND USE OF SUCH FORMULATIONS 审中-公开
标题翻译：含有维生素E的药物制剂可以解决没有明显的抑制作用的脂多糖的TPGS分子，以及这些制剂的使用
公开(公告)号：WO2006039268A3
公开(公告)日：2006-07-27
申请号：PCT/US2005034587
申请日：2005-09-29
申请人： EASTMAN CHEM CO
发明人： HYATT JOHN ANTHONY , ZIMA GEORGE CHESTER , EDGAR KEVIN JOSEPH , NAVARRO LISA TONNER , LEHR CLAUS-MICHAEL , COLLNOT EVA-MARIA , SINGLETON ANDY HUGH , BALDES CHRISTIANE , SCHAFER ULRICH FRIEDRICH , WEMPE MICHAEL FITZPATRICK
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K9/48 , A61K9/50
CPC分类号： A61K9/16 , A61K9/14 , A61K9/20 , A61K9/48 , A61K9/50
摘要： Compounds and compositions are disclosed for increasing the bioavailability of lipophilic drugs, and more specifically, to solubilizing lipophilic drugs using bioenhancers that cause no efflux inhibition or a desired degree of efflux inhibition. Methods of making and using such compositions are also disclosed.
摘要翻译：公开了用于增加亲脂性药物的生物利用度的化合物和组合物，更具体地，使用不引起外排抑制或期望程度的排出抑制的生物降解剂来增溶亲脂性药物。还公开了制备和使用这些组合物的方法。

6. 发明申请

WO0196406A3 COPOLYMERIZATION OF NORBORNENE AND FUNCTIONAL NORBORNENE MONOMERS 审中-公开
标题翻译： NORBENNENE和功能NORBENNENE单体的共聚合
公开(公告)号：WO0196406A3
公开(公告)日：2002-04-04
申请号：PCT/US0117367
申请日：2001-05-29
申请人： EASTMAN CHEM CO
发明人： KILLIAN CHRISTOPHER MOORE , MACKENZIE PETER BORDEN , HYATT JOHN ANTHONY , MOODY LESLIE SHANE , LAVOIE GINO GEORGES
IPC分类号： C08F2/38 , C08F4/70 , C08F232/00 , C08F232/08
CPC分类号： C08F232/08
摘要： The present invention is directed to copolymers of norbornene and functional group containing norbornene comonomers and processes for the preparation thereof. These polymers may be random, alternating or block copolymers or terpolymers, etc. In general, the present invention describes a polymer composition of the formula: [A]S- and -[B]T wherein A is a monomer repeat unit derived from one or more norbornene or substituted norbornene monomers and B is a monomer repeat unit derived from one or more functionalized norbornene compounds.
摘要翻译：本发明涉及降冰片烯与含有降冰片烯共聚单体的官能团的共聚物及其制备方法。这些聚合物可以是无规的，交替的或嵌段共聚物或三元共聚物等。通常，本发明描述了下式的聚合物组合物：[A] S-和 - [B] T其中A是衍生自一个单体的单体重复单元或更多降冰片烯或取代的降冰片烯单体，B是衍生自一种或多种官能化降冰片烯化合物的单体重复单元。

7. 发明专利

BR9911873A 未知
公开(公告)号：BR9911873A
公开(公告)日：2001-03-27
申请号：BR9911873
申请日：1999-07-01
申请人： EASTMAN CHEM CO
发明人： HYATT JOHN ANTHONY
IPC分类号： C12P7/04 , C07B61/00 , C07C43/166 , C07C69/145 , C07D301/19 , C07D303/16 , C07D311/72 , C12P9/00
摘要： The invention provides processes for producing phytol, isophytol, and certain phytol derivatives by a method of oxidizing or epoxidizing geranylgeraniol or geranylgeraniol derivatives to form epoxygeranylgeraniol derivatives, reducing or hydrogenating the epoxygeranylgeraniol derivatives to produce epoxyphytol derivatives, and then deoxygenating the epoxyphytol derivatives to produce phytol, isophytol, phytene derivatives, isophytene derivatives, or mixtures thereof. The step of deoxygenating is carried out in the presence of deoxygenation catalysts, including rhenium trioxide compounds. The invention also provides methods for the synthesis of certain novel substituted epoxyphytyl compounds and substituted phytene compounds having removable protecting groups. The produce phytol, isophytol, phytene derivatives, isophytene derivatives, substituted epoxyphytyl compounds and substituted phytene compounds are suitable starting materials for condensation with trimethylhydroquinone derivatives in the presence of Lewis acids to give tocopherol derivatives including alpha-tocopherol, vitamin E.

8. 发明专利

BR9711899A 未知
公开(公告)号：BR9711899A
公开(公告)日：1999-08-24
申请号：BR9711899
申请日：1997-10-10
申请人： EASTMAN CHEM CO
发明人： HYATT JOHN ANTHONY , FENGL RICHARD WILLIAM , EDGAR KEVIN JOSEPH , ALVAREZ-WRIGHT MARIA TERESA
IPC分类号： C08B37/14 , C08B37/00 , D21C5/00 , D21C9/00 , D21C11/00
摘要： Disclosed is a process for upgrading paper-grade wood pulp to dissolving grade pulp which is suitable for use in the preparation of viscose rayon, cellulose ethers and cellulose esters such as cellulose acetate. The process utilizes a sequence of caustic extraction, xylanase treatment and caustic extraction to remove most of the xylan, which may be recovered for use in the production of xylose, xylitol, and furans.

9. 发明专利

CA2205813A1 POLYETHER GLYCOLS AND ALCOHOLS DERIVED FROM 3,4-EPOXY-1-BUTENE, TETRAHYDROFURAN AND AN INITIATOR 未知
公开(公告)号：CA2205813A1
公开(公告)日：1996-06-06
申请号：CA2205813
申请日：1995-11-13
申请人： EASTMAN CHEM CO
发明人： HYATT JOHN ANTHONY , MACKENZIE PETER B , MATAYABAS JAMES CHRISTOPHER JR
IPC分类号： C08G65/14 , C08G65/20 , C08G65/28 , C08G65/322
摘要： Disclosed are novel polyether compounds obtained by the reaction of polymerisation of 3,4-epoxy-1-butene in the presence of tetrahydrofuran, an acidic catalyst and a nucleophilic initiator compound. The polyether compounds comprise m units of residue (1), n units of residue (2), and p units of residue (3) wherein (i) residues (1), (2) and (3) have the structures (1), (2): -O-CH2-CH=CH-CH2-, and (3): -O-CH2-CH2-CH2-CH2-, (ii) the total value of m+n+p is 5 to 70; (iii) the value of n/(m+n+p) is in the range of 0.2 to 0.4, i.e., residue (2) constitutes from 20 to 40 mole percent of the total moles of residues (1), (2) and (3); and (iv) at least 98 percent of the terminal groups have the structure (4) or (5): HO-CH2-CH=CH-CH2-.

10. 发明专利

ZA979112B Process for the co-production of dissolving-grade pulp and xylan 未知
公开(公告)号：ZA979112B
公开(公告)日：1999-04-13
申请号：ZA979112
申请日：1997-10-10
申请人： EASTMAN CHEM CO
发明人： HYATT JOHN ANTHONY , FENGL RICHARD WILLIAM , EDGAR KEVIN JOSEPH , ALVAREZ-WRIGHT MARIA TERESA
IPC分类号： C08B20060101 , C12S20060101 , D21C20060101 , D21C , C08B , C12S

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