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1. 发明授权

US07483738B2 Combination stimulating and exothermic heating device and method of use thereof 失效
标题翻译：组合刺激放热加热装置及其使用方法
公开(公告)号：US07483738B2
公开(公告)日：2009-01-27
申请号：US10724054
申请日：2003-12-01
申请人： Dov Tamarkin , Zvi Nitzan , Giora Arbel , Daniela Mavor , Yossif Gross , Shalom Luski
发明人： Dov Tamarkin , Zvi Nitzan , Giora Arbel , Daniela Mavor , Yossif Gross , Shalom Luski
IPC分类号： A61N1/30
CPC分类号： A61N1/323 , A61N1/0428 , A61N1/30 , A61N1/325 , A61N1/328 , A61N1/36021
摘要： The present invention is of an apparatus and method for enhancing skin, muscle and nerve stimulation and controlled delivery of an active substance to a subject's skin. Moreover, the present invention is of an apparatus, featuring a combination of a stimulating device and an exothermic heating source. Preferably, the stimulating device is an iontophoretic device, or an electrical stimulation device, such as, but not limited to TENS, IFC and GC devices or a combination thereof. The present invention also provides a method of using such an apparatus for enhancing skin, muscle and nerve stimulation. Furthermore, the present invention provides a method of use of such an apparatus for enhancing controlled delivery of an active substance.
摘要翻译：本发明是一种用于增强皮肤，肌肉和神经刺激并将活性物质控制递送到受试者的皮肤的装置和方法。此外，本发明是一种以刺激装置和放热加热源的组合为特征的装置。优选地，刺激装置是离子电渗疗法装置或电刺激装置，例如但不限于TENS，IFC和GC装置或其组合。本发明还提供了一种使用这种装置来增强皮肤，肌肉和神经刺激的方法。此外，本发明提供了一种使用这种用于增强活性物质的受控递送的装置的方法。

2. 发明申请

US20050085751A1 Disposable electric bandage 失效
标题翻译：一次性电绷带
公开(公告)号：US20050085751A1
公开(公告)日：2005-04-21
申请号：US10936540
申请日：2004-09-09
申请人： Shalom Daskal , Dov Tamarkin , Zvi Nitzan , Nurit Harel , Daniela Mavor , Giora Arbel , Shalom Luski , Noam Emanuel , Dalia Jayes
发明人： Shalom Daskal , Dov Tamarkin , Zvi Nitzan , Nurit Harel , Daniela Mavor , Giora Arbel , Shalom Luski , Noam Emanuel , Dalia Jayes
IPC分类号： A61F5/00 , A61N1/30 , A61N1/32
CPC分类号： A61N1/326 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/325
摘要： The present invention provides a device and kit and method of use thereof for wound treatment of a subject. The device may include an electrically operated patch or other means of delivery of electrical current and a connected moist surface. Optionally, the device may include a composition comprising an active substance useful in wound treatment. Preferably, the means of delivery of electrical current includes a power source and a plurality of electrodes disposed in a suitable conformation on a base substrate layer, which readily facilitates electrical contact with the body area of the subject. Preferably, the kit may include a means of delivery of electrical current and a moist surface provided as separate components. The present invention further provides a thin and flexible device for galvanic treatment to treat wounds with electrical stimulation. Preferably, the device is made using a printing technique.
摘要翻译：本发明提供了一种用于受试者的伤口治疗的装置和试剂盒及其使用方法。该装置可以包括电操作的贴片或电流的其它输送装置和连接的潮湿表面。任选地，装置可以包括包含可用于伤口治疗的活性物质的组合物。优选地，电流传递装置包括电源和在基底层上以适当构型设置的多个电极，其容易地促进与受试者身体区域的电接触。优选地，套件可以包括递送电流的装置和作为单独部件提供的潮湿表面。本发明还提供了一种薄而灵活的电气处理装置，用电刺激来治疗伤口。优选地，使用印刷技术制造该装置。

3. 发明授权

US07340297B2 Kit, device and method for controlled delivery of oxidizing agent into the skin 失效
标题翻译：用于将氧化剂控制递送到皮肤中的试剂盒，装置和方法
公开(公告)号：US07340297B2
公开(公告)日：2008-03-04
申请号：US10858045
申请日：2004-06-02
申请人： Dov Tamarkin , Daniela Mavor , Zvi Nitzan , Giora Arbel , Nurit Harel , Shalom Luski , Yossi Gross
发明人： Dov Tamarkin , Daniela Mavor , Zvi Nitzan , Giora Arbel , Nurit Harel , Shalom Luski , Yossi Gross
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61K9/0009
摘要： A kit, device and method for delivering an oxidizing agent onto and/or into the body are disclosed. Moreover, a dermal patch device, which delivers an oxidizing agent using iontophoresis and or electroosmosis onto and/or into the body is disclosed. Furthermore, use of a dermal patch device for treatment of a body area with an oxidizing agent is disclosed. The device may be a thin and flexible dermal patch. A method of using such a device/kit for treatment of a disorder of a body area with an oxidizing agent is also disclosed.
摘要翻译：公开了用于将氧化剂递送到身体和/或进入身体的套件，装置和方法。此外，公开了一种使用离子电渗疗法和/或电沉积递送至身体的氧化剂的皮肤贴剂装置。此外，公开了使用用氧化剂处理身体区域的真皮贴剂装置。该装置可以是薄而柔软的皮肤贴剂。还公开了使用这种装置/试剂盒用于用氧化剂治疗身体区域紊乱的方法。

4. 发明授权

US07922676B2 Disposable electric bandage 失效
标题翻译：一次性电绷带
公开(公告)号：US07922676B2
公开(公告)日：2011-04-12
申请号：US10936540
申请日：2004-09-09
申请人： Shalom Daskal , Dov Tamarkin , Zvi Nitzan , Nurit Harel , Daniela Mavor , Giora Arbel , Shalom Luski , Noam Emanuel , Dalia Jayes
发明人： Shalom Daskal , Dov Tamarkin , Zvi Nitzan , Nurit Harel , Daniela Mavor , Giora Arbel , Shalom Luski , Noam Emanuel , Dalia Jayes
IPC分类号： A61F5/00
CPC分类号： A61N1/326 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/325
摘要： The present invention provides a device and kit and method of use thereof for wound treatment of a subject. The device may include an electrically operated patch or other means of delivery of electrical current and a connected moist surface. Optionally, the device may include a composition comprising an active substance useful in wound treatment. Preferably, the means of delivery of electrical current includes a power source and a plurality of electrodes disposed in a suitable conformation on a base substrate layer, which readily facilitates electrical contact with the body area of the subject. Preferably, the kit may include a means of delivery of electrical current and a moist surface provided as separate components.The present invention further provides a thin and flexible device for galvanic treatment to treat wounds with electrical stimulation. Preferably, the device is made using a printing technique.
摘要翻译：本发明提供了一种用于受试者的伤口治疗的装置和试剂盒及其使用方法。该装置可以包括电操作的贴片或电流的其它输送装置和连接的潮湿表面。任选地，装置可以包括包含可用于伤口治疗的活性物质的组合物。优选地，电流传递装置包括电源和在基底层上以适当构型设置的多个电极，其容易地促进与受试者身体区域的电接触。优选地，套件可以包括递送电流的装置和作为单独部件提供的潮湿表面。本发明还提供了一种薄而灵活的电气处理装置，用电刺激来治疗伤口。优选地，使用印刷技术制造该装置。

5. 发明授权

US07979117B2 Device and method for controlled delivery of active substance into the skin 失效
标题翻译：用于将活性物质控制递送到皮肤中的装置和方法
公开(公告)号：US07979117B2
公开(公告)日：2011-07-12
申请号：US10493386
申请日：2002-10-23
申请人： Daniela Mavor , Zvi Nitzan , Dov Tamarkin , Giora Arbel , Nurit Harel , Yossi Gross
发明人： Daniela Mavor , Zvi Nitzan , Dov Tamarkin , Giora Arbel , Nurit Harel , Yossi Gross
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044
摘要： An apparatus for dermal treatment of an active substance having certain physical properties having a flexible, wearable patch conformable to the contour of a skin surface and having: a first electrode adapted to communicate the active substance into the skin by application of an electrical current on the skin surface, a second electrode capable of closing an electrical circuit with the skin surface, a power source for providing a current and voltage connected through a conductive media to the first and second electrode, and an apparatus for substantially controlling penetration depth of the active substance by selecting at least one variable from a plurality of variables.
摘要翻译：一种用于对具有某些物理性质的活性物质进行真皮处理的装置，其具有柔软的，可穿戴的贴片，其符合皮肤表面的轮廓，并且具有：第一电极，其适于通过将电流施加到皮肤上而将活性物质传递到皮肤中皮肤表面，能够与皮肤表面封闭电路的第二电极，用于将通过导电介质连接的电流和电压提供给第一和第二电极的电源，以及用于基本上控制活性物质的穿透深度的装置通过从多个变量中选择至少一个变量。

6. 发明授权

US06567706B2 Electrode for muscle stimulation 有权
标题翻译：电极用于肌肉刺激
公开(公告)号：US06567706B2
公开(公告)日：2003-05-20
申请号：US09811613
申请日：2001-03-20
申请人： Jonathan Bar-Or , Giora Arbel
发明人： Jonathan Bar-Or , Giora Arbel
IPC分类号： A61N100
CPC分类号： A61N1/0452 , A61N1/0472 , A61N1/0492 , A61N1/0496
摘要： The invention provides an electrode kit for muscle stimulation to be used in conjunction with a splint, the kit including an electrode carrier attachable to an interior surface of the splint and consisting of a relatively thin, flexible, tray-like member; a thin, flexible electrode member fixedly attached to the electrode carrier, and a skin-contacting pad member consisting of a piece of medium-absorptive material fixedly mounted on a rigidifying frame attachable to, and removable from, the electrode carrier.
摘要翻译：本发明提供了一种用于肌肉刺激的电极套件，其与夹板一起使用，该套件包括可附接到夹板的内表面并由相对薄的，柔性的托盘状构件构成的电极载体; 固定地附接到电极载体上的薄而柔性的电极部件，以及皮肤接触垫部件，其由固定地安装在可附接到电极载体上并可从电极载体移除的刚性框架上的一块介质吸收材料构成。

7. 发明授权

US10661081B2 Non-invasive device and method for treating gastro esophageal reflux disease (GERD) and the digestive system 有权
公开(公告)号：US10661081B2
公开(公告)日：2020-05-26
申请号：US15915255
申请日：2018-03-08
申请人： Mordechay Esh , Giora Arbel
发明人： Mordechay Esh , Giora Arbel
IPC分类号： A61N1/00 , A61N1/36 , A61N1/04 , A61N1/18 , A61N1/32
摘要： A non-invasive method and device for treating gastroesophageal reflux disease (GERD) in a patient are disclosed. The method calls for positioning electrodes, and applying electrical symmetrical bursts. In particular, positioning step requires positioning a plurality of electrodes in electrical contact with the skin of a target region of the abdomen of the patient. The application step calls for applying a series of electrical symmetrical bursts to said electrodes. That application step generates contractions of abdominal muscles thereby generating movements of a digestive system of said patient wherein said movements are for causing the content of the esophagus to return to the stomach and to relieve GERD symptoms of said patient.

8. 发明申请

US20100286588A1 MAGNETIC PATCH COUPLING 有权
标题翻译：磁性配线接头
公开(公告)号：US20100286588A1
公开(公告)日：2010-11-11
申请号：US12682291
申请日：2008-10-12
申请人： Yossi Bar-El , Giora Arbel
发明人： Yossi Bar-El , Giora Arbel
IPC分类号： A61N1/20
CPC分类号： A61N1/327 , A61N1/0424 , A61N1/044
摘要： Apparatus is described for facilitating delivery of a substance through skin (70) of a subject. A skin preparation device (50), and a patch assembly (20) that comprises the substance and is magnetically couplable to the skin preparation device, are described. Other embodiments are also described.
摘要翻译：描述了用于促进物质通过受试者的皮肤（70）递送的装置。描述了皮肤制备装置（50）和包括该物质并且与皮肤准备装置可磁耦合的补片组件（20）。还描述了其它实施例。

9. 发明授权

US09925375B2 Non-invasive device and method for treating gastro esophageal reflux disease (GERD) and the digestive system 有权
公开(公告)号：US09925375B2
公开(公告)日：2018-03-27
申请号：US15132270
申请日：2016-04-19
申请人： Mordechay Esh , Giora Arbel
发明人： Mordechay Esh , Giora Arbel
IPC分类号： A61N1/00 , A61N1/36 , A61N1/18 , A61N1/04 , A61N1/32
CPC分类号： A61N1/36007 , A61N1/0452 , A61N1/0476 , A61N1/0484 , A61N1/18 , A61N1/321 , A61N1/36 , A61N1/36014
摘要： A non-invasive device for facilitating therapy of patient suffering from the gastrointestinal system diseases or symptoms, and in particular suffering Gastroesophageal reflux disease (GERD). The device is positioned by the patient on the skin of the patient abdomen and electrically stimulates the abdomen muscles. This treating results in dynamic motions of the digestive system, which causes the treatment of various digestive symptoms or diseases.

10. 发明申请

US20130211347A1 STIFFENER FOR USE WITH A DRUG PATCH 审中-公开
标题翻译：使用与药物配合使用的强化剂
公开(公告)号：US20130211347A1
公开(公告)日：2013-08-15
申请号：US13572612
申请日：2012-08-10
申请人： Giora Arbel , Yossi Bar-El
发明人： Giora Arbel , Yossi Bar-El
IPC分类号： A61K9/70
CPC分类号： A61K9/7084 , A61K9/7023 , A61M35/00 , A61M2037/0007
摘要： Apparatus and methods are provided including a patch assembly (20) configured to deliver a substance through a subject's skin. A frame (26) surrounds at least in part an open portion of the patch assembly, such that a region of the skin is exposed through the open portion when the frame is placed on the skin. A substance support area (28) is foldably coupled to the frame at a foldable joint (27). A substance delivery area (23) is adapted to be placed in contact with at least a portion of the region of skin, by the substance support area being folded with respect to the frame. A stiffener (29), disposed on the substance support area between the foldable joint and the substance delivery area, is configured to facilitate the placement of the substance delivery area on the portion of the region of skin. Other applications are also described.
摘要翻译：提供的装置和方法包括配置成将物质输送通过受试者皮肤的补片组件（20）。框架（26）至少部分地包围贴片组件的开口部分，使得当框架放置在皮肤上时，皮肤的区域通过开口部分露出。物质支撑区域（28）在可折叠接头（27）处可折叠地联接到框架。物质输送区域（23）适于通过相对于框架折叠的物质支撑区域与皮肤区域的至少一部分接触放置。设置在可折叠接头和物质输送区域之间的物质支撑区域上的加强件（29）构造成便于将物质输送区域放置在皮肤区域的该部分上。还描述了其它应用。

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