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1. 发明授权

US07340297B2 Kit, device and method for controlled delivery of oxidizing agent into the skin 失效
标题翻译：用于将氧化剂控制递送到皮肤中的试剂盒，装置和方法
公开(公告)号：US07340297B2
公开(公告)日：2008-03-04
申请号：US10858045
申请日：2004-06-02
申请人： Dov Tamarkin , Daniela Mavor , Zvi Nitzan , Giora Arbel , Nurit Harel , Shalom Luski , Yossi Gross
发明人： Dov Tamarkin , Daniela Mavor , Zvi Nitzan , Giora Arbel , Nurit Harel , Shalom Luski , Yossi Gross
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61K9/0009
摘要： A kit, device and method for delivering an oxidizing agent onto and/or into the body are disclosed. Moreover, a dermal patch device, which delivers an oxidizing agent using iontophoresis and or electroosmosis onto and/or into the body is disclosed. Furthermore, use of a dermal patch device for treatment of a body area with an oxidizing agent is disclosed. The device may be a thin and flexible dermal patch. A method of using such a device/kit for treatment of a disorder of a body area with an oxidizing agent is also disclosed.
摘要翻译：公开了用于将氧化剂递送到身体和/或进入身体的套件，装置和方法。此外，公开了一种使用离子电渗疗法和/或电沉积递送至身体的氧化剂的皮肤贴剂装置。此外，公开了使用用氧化剂处理身体区域的真皮贴剂装置。该装置可以是薄而柔软的皮肤贴剂。还公开了使用这种装置/试剂盒用于用氧化剂治疗身体区域紊乱的方法。

2. 发明申请

US20050085751A1 Disposable electric bandage 失效
标题翻译：一次性电绷带
公开(公告)号：US20050085751A1
公开(公告)日：2005-04-21
申请号：US10936540
申请日：2004-09-09
申请人： Shalom Daskal , Dov Tamarkin , Zvi Nitzan , Nurit Harel , Daniela Mavor , Giora Arbel , Shalom Luski , Noam Emanuel , Dalia Jayes
发明人： Shalom Daskal , Dov Tamarkin , Zvi Nitzan , Nurit Harel , Daniela Mavor , Giora Arbel , Shalom Luski , Noam Emanuel , Dalia Jayes
IPC分类号： A61F5/00 , A61N1/30 , A61N1/32
CPC分类号： A61N1/326 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/325
摘要： The present invention provides a device and kit and method of use thereof for wound treatment of a subject. The device may include an electrically operated patch or other means of delivery of electrical current and a connected moist surface. Optionally, the device may include a composition comprising an active substance useful in wound treatment. Preferably, the means of delivery of electrical current includes a power source and a plurality of electrodes disposed in a suitable conformation on a base substrate layer, which readily facilitates electrical contact with the body area of the subject. Preferably, the kit may include a means of delivery of electrical current and a moist surface provided as separate components. The present invention further provides a thin and flexible device for galvanic treatment to treat wounds with electrical stimulation. Preferably, the device is made using a printing technique.
摘要翻译：本发明提供了一种用于受试者的伤口治疗的装置和试剂盒及其使用方法。该装置可以包括电操作的贴片或电流的其它输送装置和连接的潮湿表面。任选地，装置可以包括包含可用于伤口治疗的活性物质的组合物。优选地，电流传递装置包括电源和在基底层上以适当构型设置的多个电极，其容易地促进与受试者身体区域的电接触。优选地，套件可以包括递送电流的装置和作为单独部件提供的潮湿表面。本发明还提供了一种薄而灵活的电气处理装置，用电刺激来治疗伤口。优选地，使用印刷技术制造该装置。

3. 发明授权

US07922676B2 Disposable electric bandage 失效
标题翻译：一次性电绷带
公开(公告)号：US07922676B2
公开(公告)日：2011-04-12
申请号：US10936540
申请日：2004-09-09
申请人： Shalom Daskal , Dov Tamarkin , Zvi Nitzan , Nurit Harel , Daniela Mavor , Giora Arbel , Shalom Luski , Noam Emanuel , Dalia Jayes
发明人： Shalom Daskal , Dov Tamarkin , Zvi Nitzan , Nurit Harel , Daniela Mavor , Giora Arbel , Shalom Luski , Noam Emanuel , Dalia Jayes
IPC分类号： A61F5/00
CPC分类号： A61N1/326 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/325
摘要： The present invention provides a device and kit and method of use thereof for wound treatment of a subject. The device may include an electrically operated patch or other means of delivery of electrical current and a connected moist surface. Optionally, the device may include a composition comprising an active substance useful in wound treatment. Preferably, the means of delivery of electrical current includes a power source and a plurality of electrodes disposed in a suitable conformation on a base substrate layer, which readily facilitates electrical contact with the body area of the subject. Preferably, the kit may include a means of delivery of electrical current and a moist surface provided as separate components.The present invention further provides a thin and flexible device for galvanic treatment to treat wounds with electrical stimulation. Preferably, the device is made using a printing technique.
摘要翻译：本发明提供了一种用于受试者的伤口治疗的装置和试剂盒及其使用方法。该装置可以包括电操作的贴片或电流的其它输送装置和连接的潮湿表面。任选地，装置可以包括包含可用于伤口治疗的活性物质的组合物。优选地，电流传递装置包括电源和在基底层上以适当构型设置的多个电极，其容易地促进与受试者身体区域的电接触。优选地，套件可以包括递送电流的装置和作为单独部件提供的潮湿表面。本发明还提供了一种薄而灵活的电气处理装置，用电刺激来治疗伤口。优选地，使用印刷技术制造该装置。

4. 发明授权

US07979117B2 Device and method for controlled delivery of active substance into the skin 失效
标题翻译：用于将活性物质控制递送到皮肤中的装置和方法
公开(公告)号：US07979117B2
公开(公告)日：2011-07-12
申请号：US10493386
申请日：2002-10-23
申请人： Daniela Mavor , Zvi Nitzan , Dov Tamarkin , Giora Arbel , Nurit Harel , Yossi Gross
发明人： Daniela Mavor , Zvi Nitzan , Dov Tamarkin , Giora Arbel , Nurit Harel , Yossi Gross
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044
摘要： An apparatus for dermal treatment of an active substance having certain physical properties having a flexible, wearable patch conformable to the contour of a skin surface and having: a first electrode adapted to communicate the active substance into the skin by application of an electrical current on the skin surface, a second electrode capable of closing an electrical circuit with the skin surface, a power source for providing a current and voltage connected through a conductive media to the first and second electrode, and an apparatus for substantially controlling penetration depth of the active substance by selecting at least one variable from a plurality of variables.
摘要翻译：一种用于对具有某些物理性质的活性物质进行真皮处理的装置，其具有柔软的，可穿戴的贴片，其符合皮肤表面的轮廓，并且具有：第一电极，其适于通过将电流施加到皮肤上而将活性物质传递到皮肤中皮肤表面，能够与皮肤表面封闭电路的第二电极，用于将通过导电介质连接的电流和电压提供给第一和第二电极的电源，以及用于基本上控制活性物质的穿透深度的装置通过从多个变量中选择至少一个变量。

5. 发明授权

US07483738B2 Combination stimulating and exothermic heating device and method of use thereof 失效
标题翻译：组合刺激放热加热装置及其使用方法
公开(公告)号：US07483738B2
公开(公告)日：2009-01-27
申请号：US10724054
申请日：2003-12-01
申请人： Dov Tamarkin , Zvi Nitzan , Giora Arbel , Daniela Mavor , Yossif Gross , Shalom Luski
发明人： Dov Tamarkin , Zvi Nitzan , Giora Arbel , Daniela Mavor , Yossif Gross , Shalom Luski
IPC分类号： A61N1/30
CPC分类号： A61N1/323 , A61N1/0428 , A61N1/30 , A61N1/325 , A61N1/328 , A61N1/36021
摘要： The present invention is of an apparatus and method for enhancing skin, muscle and nerve stimulation and controlled delivery of an active substance to a subject's skin. Moreover, the present invention is of an apparatus, featuring a combination of a stimulating device and an exothermic heating source. Preferably, the stimulating device is an iontophoretic device, or an electrical stimulation device, such as, but not limited to TENS, IFC and GC devices or a combination thereof. The present invention also provides a method of using such an apparatus for enhancing skin, muscle and nerve stimulation. Furthermore, the present invention provides a method of use of such an apparatus for enhancing controlled delivery of an active substance.
摘要翻译：本发明是一种用于增强皮肤，肌肉和神经刺激并将活性物质控制递送到受试者的皮肤的装置和方法。此外，本发明是一种以刺激装置和放热加热源的组合为特征的装置。优选地，刺激装置是离子电渗疗法装置或电刺激装置，例如但不限于TENS，IFC和GC装置或其组合。本发明还提供了一种使用这种装置来增强皮肤，肌肉和神经刺激的方法。此外，本发明提供了一种使用这种用于增强活性物质的受控递送的装置的方法。

6. 发明申请

US20100030129A1 DERMAL PATCH 审中-公开
公开(公告)号：US20100030129A1
公开(公告)日：2010-02-04
申请号：US12575630
申请日：2009-10-08
申请人： Zvi NITZAN , Yossi Gross , Daniela Mavor , Dov Tamarkin
发明人： Zvi NITZAN , Yossi Gross , Daniela Mavor , Dov Tamarkin
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/042 , A61N1/0424 , A61N1/0436 , A61N1/044 , A61N1/325
摘要： The invention is generally directed to a kit and patch for transdermal or intradermal delivery of at least one substance into the skin. The kit includes a dermal patch having an electrochemical cell with two electrodes and a retainer for retaining a conductive fluid which further includes an active substance. The conductive fluid can be deposited on at least one of the two electrodes. Alternatively, the conductive fluid can be applied topically to the skin.
摘要翻译：本发明通常涉及用于将至少一种物质透皮或皮内递送至皮肤的试剂盒和贴剂。该试剂盒包括具有具有两个电极的电化学电池的皮肤贴片和用于保持进一步包含活性物质的导电流体的保持器。导电流体可以沉积在两个电极中的至少一个上。或者，导电流体可以局部施用于皮肤。

7. 发明授权

US07643874B2 Dermal patch 失效
标题翻译：皮肤贴片
公开(公告)号：US07643874B2
公开(公告)日：2010-01-05
申请号：US10757414
申请日：2004-01-15
申请人： Zvi Nitzan , Yossi Gross , Daniela Mavor , Dov Tamarkin
发明人： Zvi Nitzan , Yossi Gross , Daniela Mavor , Dov Tamarkin
IPC分类号： A61M1/30
CPC分类号： A61N1/0448 , A61N1/042 , A61N1/0424 , A61N1/0436 , A61N1/044 , A61N1/325
摘要： The invention is generally directed to a kit and patch for transdermal or intradermal delivery of at least one substance into the skin. The kit includes a dermal patch having an electrochemical cell with two electrodes and a retainer for retaining a conductive fluid which further includes an active substance. The conductive fluid can be deposited on at least one of the two electrodes. Alternatively, the conductive fluid can be applied topically to the skin.
摘要翻译：本发明通常涉及用于将至少一种物质透皮或皮内递送至皮肤的试剂盒和贴剂。该试剂盒包括具有具有两个电极的电化学电池的皮肤贴片和用于保持进一步包含活性物质的导电流体的保持器。导电流体可以沉积在两个电极中的至少一个上。或者，导电流体可以局部施用于皮肤。

8. 发明授权

US07647100B2 Method, apparatus, and kit for onychomycosis treatment 失效
标题翻译：用于甲真菌病治疗的方法，仪器和试剂盒
公开(公告)号：US07647100B2
公开(公告)日：2010-01-12
申请号：US10890297
申请日：2004-07-14
申请人： Zvika Nitzan , Dov Tamarkin , Daniela Mavor , Nurit Harel , Noam Emanuel
发明人： Zvika Nitzan , Dov Tamarkin , Daniela Mavor , Nurit Harel , Noam Emanuel
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： Methods, apparatus, and kits for onychomycosis treatment are presented. In one embodiment, a kit for treatment includes an anti-fungal agent, in a composition, and an electrically powered patch. Exemplary embodiments of the patch include a first electrode, a power source having a first and second terminal, a second electrode coupled to the second terminal of the power source, and a base member supporting the first electrode, the second electrode, and the power source. Embodiments include those where the first and second electrode and power source are printed on the base member. Anti-fungal agents may be unionized while the composition includes an ionizing agent. Home use may be practiced, as embodiments include those in which the voltage or current of the power source cannot be adjusted by a user. Exemplary methods include the selection of a nail or diseased area to which treatment is desired and administering the kit as described.
摘要翻译：提出了用于甲真菌病治疗的方法，仪器和试剂盒。在一个实施方案中，用于治疗的试剂盒包括组合物中的抗真菌剂和电动贴剂。贴片的示例性实施例包括第一电极，具有第一和第二端子的电源，耦合到电源的第二端子的第二电极和支撑第一电极，第二电极和电源的基座部件。实施例包括将第一和第二电极和电源印刷在基底构件上的那些。抗真菌剂可以团聚，而组合物包含电离剂。可以实施家庭使用，因为实施例包括其中电源的电压或电流不能由用户调整的实施例。示例性方法包括选择需要治疗的指甲或患病区域，并如所述施用试剂盒。

9. 发明授权

US07652188B2 Adhesive bandage with display 失效
标题翻译：胶带绷带与显示
公开(公告)号：US07652188B2
公开(公告)日：2010-01-26
申请号：US10741435
申请日：2003-12-22
申请人： Baruch Levanon , Zvi Nitzan , Daniela Mavor , Nurit Harel
发明人： Baruch Levanon , Zvi Nitzan , Daniela Mavor , Nurit Harel
IPC分类号： A61F13/00
CPC分类号： A61F13/0226 , A61F13/0206
摘要： An adhesive bandage is provided. The adhesive bandage includes: (a) an absorbent pad having an absorbent surface; (b) an adhesive tape attached to the absorbent pad, the adhesive tape being configured for attaching to a skin region so as to position the absorbent surface against a portion of the skin region; (c) a display being positioned on an outer surface of the adhesive bandage the display being configured and positioned so as to be viewable by an individual when the adhesive tape is attached to the skin region; and (d) a power source attached to or integrated with the adhesive tape, the power source being for powering the display, the display being for increasing an acceptability of use of the adhesive bandage by the individual when powered. Furthermore, the present invention provides an adhesive bandage with a display, the display being for displaying a skin condition value and for increasing an acceptability of use of the adhesive bandage by the individual when powered.
摘要翻译：提供胶粘绷带。胶粘绷带包括：（a）具有吸收表面的吸收垫; （b）附着在所述吸收垫上的粘合带，所述粘合带被构造成附接到皮肤区域，以将所述吸收表面定位在所述皮肤区域的一部分上; （c）显示器被定位在所述粘合绷带的外表面上，所述显示器被构造和定位成当所述胶带被附接到所述皮肤区域时被个人可视; 和（d）附着到胶带上或与该胶带一体的电源，该电源用于为显示器供电，该显示器用于在通电时提高该个体在使用粘合绷带的可接受性。此外，本发明提供具有显示器的粘合绷带，所述显示器用于显示皮肤状况值，并且用于当通电时增加个人使用粘合绷带的可接受性。

10. 发明申请

US20050010146A1 Adhesive bandage with display 失效
标题翻译：胶带绷带与显示
公开(公告)号：US20050010146A1
公开(公告)日：2005-01-13
申请号：US10741435
申请日：2003-12-22
申请人： Baruch Levanon , Zvi Nitzan , Daniela Mavor , Nurit Harel
发明人： Baruch Levanon , Zvi Nitzan , Daniela Mavor , Nurit Harel
IPC分类号： A61F13/02 , A61F5/00
CPC分类号： A61F13/0226 , A61F13/0206
摘要： An adhesive bandage is provided. The adhesive bandage includes: (a) an absorbent pad having an absorbent surface; (b) an adhesive tape attached to the absorbent pad, the adhesive tape being configured for attaching to a skin region so as to position the absorbent surface against a portion of the skin region; (c) a display being positioned on an outer surface of the adhesive bandage the display being configured and positioned so as to be viewable by an individual when the adhesive tape is attached to the skin region; and (d) a power source attached to or integrated with the adhesive tape, the power source being for powering the display, the display being for increasing an acceptability of use of the adhesive bandage by the individual when powered. Furthermore, the present invention provides an adhesive bandage with a display, the display being for displaying a skin condition value and for increasing an acceptability of use of the adhesive bandage by the individual when powered.
摘要翻译：提供胶粘绷带。胶粘绷带包括：（a）具有吸收表面的吸收垫; （b）附着在所述吸收垫上的粘合带，所述粘合带被构造成附接到皮肤区域，以将所述吸收表面定位在所述皮肤区域的一部分上; （c）显示器被定位在所述粘合绷带的外表面上，所述显示器被构造和定位成当所述胶带被附接到所述皮肤区域时被个人可视; 和（d）附着到胶带上或与该胶带一体的电源，该电源用于为显示器供电，该显示器用于在通电时提高该个体在使用粘合绷带的可接受性。此外，本发明提供具有显示器的粘合绷带，所述显示器用于显示皮肤状况值，并且用于当通电时增加个人使用粘合绷带的可接受性。

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