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1. 发明申请

US20070167485A1 Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors 失效
标题翻译：吡唑并[3,4-b]吡啶化合物，它们用作pde4抑制剂
公开(公告)号：US20070167485A1
公开(公告)日：2007-07-19
申请号：US10598944
申请日：2005-03-15
申请人： Diane Coe , Caroline Cook , Anthony Cooper , Christopher Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , John Robinson
发明人： Diane Coe , Caroline Cook , Anthony Cooper , Christopher Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , John Robinson
IPC分类号： A61K31/44
CPC分类号： C07D471/04
摘要： The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is Et, n-Pr, i-Pr, C2fluoroalkyl, or —CH2CH2OH; R2 is H, Me, Et, n-Pr, i-Pr, C1-2fluoroalkyl, cyclopropyl or (cyclopropyl)methyl-; and NHR3 has the sub-formula (nhr3): wherein R3a is methyl or ethyl; R3b is H, methyl or ethyl; R3c is H, methyl or ethyl, R3d is H, methyl or ethyl, and R3e is H or methyl, provided that: (a) R3b is methyl or ethyl; and/or (b) R3c and R3d are independently methyl or ethyl; and provided that: (c) when R3c is ethyl and/or when R3d is ethyl and/or when R3e is methyl, then: R3a is methyl and/or R3b is hydrogen or methyl. These compounds are PDE4 inhibitors.
摘要翻译：本发明涉及式（I）化合物或其盐：其中：R 1是Et，n-Pr，i-Pr，C 2氟代烷基，或 -CH 2 CH 2 CH 2 OH; R 2是H，Me，Et，n-Pr，i-Pr，C 1-12氟代烷基，环丙基或（环丙基）甲基; 和NHR 3具有子式（nhr3）：其中R 3a是甲基或乙基; R 3b是H，甲基或乙基; R 3c是H，甲基或乙基，R 3d是H，甲基或乙基，R 3e是H或甲基，条件是：（a）R 3b是甲基或乙基; 和/或（b）R 3c和R 3d独立地是甲基或乙基; 并且条件是：（c）当R 3c为乙基时，和/或当R 3d为乙基时，和/或当R 3e为甲基时，那么：R 3a是甲基，和/或R 3b是氢或甲基。这些化合物是PDE4抑制剂。

2. 发明申请

US20080021058A1 Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors 审中-公开
标题翻译： Pyrazolo'3,4-B！吡啶化合物及其用作磷酸二酯酶4（Pde4）抑制剂
公开(公告)号：US20080021058A1
公开(公告)日：2008-01-24
申请号：US10598940
申请日：2005-03-15
申请人： David Allen , Diane Coe , Caroline Cook , Michael Dowle , Christopher Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , Naimisha Trivedi
发明人： David Allen , Diane Coe , Caroline Cook , Michael Dowle , Christopher Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , Naimisha Trivedi
IPC分类号： A61K31/437 , A61P29/00 , A61P37/08 , C07D221/04
CPC分类号： C07D471/04
摘要： The invention provides a compound of formula (I) or a salt thereof: wherein W is Ar, —CR4R5Ar or a group (y) or (y1), wherein Ar is (x) or (z): R1 is C1-4alkyl, C1-3fluoroalkyl or —CH2CH2OH. R2 is C2-6alkyl, C3-6cycloalkyl or —(CH2)n4-C3-6cycloalkyl; and R3 is optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, an optionally substituted heterocyclic group (aa), (bb) or (cc) (in which Y is O, S, SO2, or NR10), or a bicyclic group (ee): These compounds are PDE4 inhibitors.
摘要翻译：本发明提供式（I）化合物或其盐：其中W为Ar，-CR 4 R 5或Ar或基团（y）或（y1）其中Ar是（x）或（z）：R 1是C 1-4烷基，C 1-3 - 氟代烷基或-CH 2 CH 2 OH。 R 2是C 2-6 - 烷基，C 3-6环烷基或 - （CH 2 CH 2）_{n + 4-C 3-6环烷基; 且R 3是任选取代的C 3-8环烷基，任选取代的单不饱和C 5〜5-7环烯基，任意取代的杂环基（aa），（bb）或（cc）（其中Y为O，S，SO 2或NR 10）或双环基团（ee）这些化合物是PDE4抑制剂。}

3. 发明申请

US20060089375A1 Pyrazolo[3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors 审中-公开
标题翻译：吡唑并[3,4-b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
公开(公告)号：US20060089375A1
公开(公告)日：2006-04-27
申请号：US10527866
申请日：2003-09-12
申请人： David Allen , Diane Coe , Caroline Cook , Michael Dowle , Christophen Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Richard Knowles , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , Peter Ward
发明人： David Allen , Diane Coe , Caroline Cook , Michael Dowle , Christophen Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Richard Knowles , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , Peter Ward
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is C1-4alkyl, C1-3fluoroalkyl, —CH2CH2OH or —CH2CH2CO2C1-2alkyl; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.
摘要翻译：本发明涉及式（I）化合物或其盐：其中：R 1是C 1-4烷基，C 1-3烷基，氟代烷基，-CH 2 CH 2 OH或-CH 2 CH 2 CO 2， C 1-12烷基; R 2是氢原子（H），甲基或C 1氟代烷基; R 3是任选取代的C 3-8环烷基或任选取代的单不饱和C 5〜5-7环烯基或任选取代的杂环基子公式（aa），（bb）或（cc）; 其中n 1和n 2独立地为1或2; 并且其中Y是O，S，SO 2或NR 10; 或R 3是双环基（dd）或（ee）：其中X是NR 4 R 5或OR 5a 。这些化合物是磷酸二酯酶（PDE）抑制剂，特别是PDE4抑制剂。还提供了式（I）化合物或其药学上可接受的盐在制备用于治疗和/或预防哺乳动物例如人的炎性和/或过敏性疾病的药物中的用途，例如慢性阻塞性肺疾病（COPD），哮喘或过敏性鼻炎。

4. 发明申请

US20070142373A1 Quinoline derivatives as phosphodiesterase inhibitors 失效
标题翻译：喹啉衍生物作为磷酸二酯酶抑制剂
公开(公告)号：US20070142373A1
公开(公告)日：2007-06-21
申请号：US10557079
申请日：2004-05-19
申请人： Ian Baldwin , Michael Barker , Anthony Dean , Colin Eldred , Brian Evans , Sharon Gough , Stephen Guntrip , Julie Hamblin , Stuart Holman , Paul Jones , Mika Lindvall , Christopher Lunniss , Tracy Redfern , Alison Redgrave , John Robinson , Michael Woodrow
发明人： Ian Baldwin , Michael Barker , Anthony Dean , Colin Eldred , Brian Evans , Sharon Gough , Stephen Guntrip , Julie Hamblin , Stuart Holman , Paul Jones , Mika Lindvall , Christopher Lunniss , Tracy Redfern , Alison Redgrave , John Robinson , Michael Woodrow
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4709 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D401/12 , C07D215/54 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译：根据本发明提供新的式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 19，R 20和R 34如说明书中所述，其制备方法，含有他们及其在治疗炎症性疾病中的应用。

5. 发明申请

US20070280971A1 Pyrazolo[3,4-B]Pyridine Compound, and Its Use as a Pde4 Inhibitor 失效
标题翻译：吡唑并[3,4-B]吡啶化合物及其作为Pde4抑制剂的用途
公开(公告)号：US20070280971A1
公开(公告)日：2007-12-06
申请号：US10598838
申请日：2005-03-15
申请人： Siegfried Christensen , Caroline Cook , Christopher Edlin , Martin Johnson , Paul Jones , Mika Lindvall , Amyn Sayani , Naimisha Trivedi , Lionel Trottet
发明人： Siegfried Christensen , Caroline Cook , Christopher Edlin , Martin Johnson , Paul Jones , Mika Lindvall , Amyn Sayani , Naimisha Trivedi , Lionel Trottet
IPC分类号： A61K31/437 , A61K9/06 , A61K9/107 , A61P17/00 , A61P29/00 , A61P37/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention provides 4-{[1-(aminocarbonyl)-4-piperidinyl]amino}-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, which is the compound of formula (I): or a salt thereof.
摘要翻译：本发明提供4 - {[1-（氨基羰基）-4-哌啶基]氨基} -N - [（3,4-二甲基苯基）甲基] -1-乙基-1H-吡唑并[3,4-b]吡啶-5 甲酰胺，其为式（I）的化合物或其盐。

6. 发明申请

US20170006823A1 Pet Feeding Apparatus 审中-公开
标题翻译：宠物喂养器具
公开(公告)号：US20170006823A1
公开(公告)日：2017-01-12
申请号：US14792299
申请日：2015-07-06
申请人： Paul Jones
发明人： Paul Jones
IPC分类号： A01K5/01
CPC分类号： A01K1/0356 , A01K1/034 , A01K5/01 , A01K5/0135 , A01K5/0225
摘要： A gravity-fed, animal feeding apparatus is equipped with a funnel, a food chute, and at least one feeding pan. The food chute of the apparatus preferably includes a transport tube configured to extend through a conventional chain-link fence gap via a diamond-shaped fitting, and terminate at the feeding pan disposed on the floor within the fenced pen area. The apparatus is configured to direct dry pet food fed into the funnel disposed on the exterior of the fenced pen area to the feeding pan on the interior of the fence. Gravity causes the food in the funnel to fall into the food chute, passing through the fence, and outputting the food to the feeding pan. The feeding pan is equipped with drainage holes to ensure that the dry food does not get wet, and that water does not collect in the feeding pan.
摘要翻译：重力饲养的动物饲养装置配备有漏斗，食物槽和至少一个饲料盘。该装置的食物槽优选地包括运送管，该输送管构造成经由菱形配件延伸穿过常规的链节栅栏间隙，并终止在设置在围栏笔区域内的地板上的供给盘上。该装置被构造成将供给到设置在围栏笔区域的外部的漏斗中的干燥宠物食物引导到围栏内部的供给盘上。重力导致漏斗中的食物落入食物槽中，穿过围栏，并将食物输送到喂食盘。进料盘配有排水孔，以确保干燥的食物不会变湿，并且水不会在进料盘中收集。

7. 发明授权

US08168668B2 Compounds 有权
标题翻译：化合物
公开(公告)号：US08168668B2
公开(公告)日：2012-05-01
申请号：US12578730
申请日：2009-10-14
申请人： Yevgeni Besidski , Martin Nylof , Inger Kers , Karin Skogholm , Shawn Johnstone , Paul Jones , Denis Labrecque , Andrew Griffin
发明人： Yevgeni Besidski , Martin Nylof , Inger Kers , Karin Skogholm , Shawn Johnstone , Paul Jones , Denis Labrecque , Andrew Griffin
IPC分类号： A61K31/4184 , C07D235/04
CPC分类号： C07D401/12 , C07D235/08 , C07D405/12 , C07D409/12
摘要： The present invention relates to new compounds or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译：本发明涉及新化合物或其盐，溶剂化物或溶剂化盐，其制备方法和用于制备其的新中间体，含有所述化合物的药物组合物和所述化合物在治疗中的用途。

8. 发明申请

US20090278696A1 SYSTEM AND METHOD FOR PROVIDING ENHANCED WEIGHT ALERT NOTIFICATION DURING AUTOMATED PATIENT MANAGEMENT 有权
标题翻译：在自动化患者管理期间提供增强体重警报通知的系统和方法
公开(公告)号：US20090278696A1
公开(公告)日：2009-11-12
申请号：US12432939
申请日：2009-04-30
申请人： Par Lindh , Donovan Benton Fellows , Timothy E. Meyer , Paul Jones , Kenneth T. Tobacman
发明人： Par Lindh , Donovan Benton Fellows , Timothy E. Meyer , Paul Jones , Kenneth T. Tobacman
IPC分类号： G08B23/00
CPC分类号： A61B5/0002 , G01G19/4146 , G01G19/44 , G01G23/3735 , G01G23/3742 , G06F19/00 , G06F19/3418 , G06F19/3475 , G16H50/20
摘要： A system and method for providing enhanced weight alert notification during automated patient management is presented. A plurality of weight measurements in an automated patient environment from a weight monitoring device for a patient during an observation period is remotely obtained. A raw baseline weight for the patient is determined based on a function of the weight measurements. Irregularities in the weight measurements are identified. The raw baseline weight is processed into a baseline weight by application of a correction coefficient to the irregularities. Weight remotely measured in the automated patient environment for the patient on a substantially regular basis is obtained. Changes in the weight are identified by periodic comparison to the baseline weight. An alert notification is generated in response to the change in weight.
摘要翻译：提出了一种在自动化患者管理过程中提供增强重量警报通知的系统和方法。远程获得在观察期间患者体重监测装置的自动化患者环境中的多个体重测量。基于体重测量的函数确定患者的原始基线重量。确定重量测量中的不规则性。通过对不规则应用校正系数将原始基线权重处理为基线权重。获得了在患者自动化患者环境中基本上定期地对患者进行远程测量的重量。通过与基线重量的周期性比较来确定体重的变化。响应于重量的变化产生警报通知。

9. 发明申请

US20080278604A1 Apparatus, System and Method for Processing and Transferring Captured Video Data 审中-公开
标题翻译：用于处理和传输捕获的视频数据的装置，系统和方法
公开(公告)号：US20080278604A1
公开(公告)日：2008-11-13
申请号：US11915649
申请日：2006-04-18
申请人： David Watkins , Anita Briginshaw , Evangelos Pappas-Katsiafas , Xing Yu , Michael Rowbothom , Ben Henricksen , Paul Jones
发明人： David Watkins , Anita Briginshaw , Evangelos Pappas-Katsiafas , Xing Yu , Michael Rowbothom , Ben Henricksen , Paul Jones
IPC分类号： H04N5/76
CPC分类号： H04N21/8405 , G06F16/71 , G06F16/783 , H04N21/235 , H04N21/2353 , H04N21/435 , H04N21/4725 , H04N21/4728 , H04N21/4821 , H04N21/4823 , H04N21/6125 , H04N21/6131
摘要： A method of transferring video data comprises obtaining a stream of video frames from an video capture device and identifying at least one characteristic in at least one frame of the stream of video frames. Lookup data is generated which associates the at least one characteristic with its at least one identified video frame. At least one video frame in the stream of video frames having a given characteristic is determined and notification or at least one of the determined video frames is transmitted to a client. A video transfer system, video processing device and method of image identification are also described.
摘要翻译：传输视频数据的方法包括从视频捕捉设备获取视频帧流，并且识别视频帧流的至少一帧中的至少一个特性。生成将至少一个特征与其至少一个识别的视频帧相关联的查找数据。确定具有给定特性的视频帧流中的至少一个视频帧，并将确定的视频帧中的至少一个传送给客户端。还描述了视频传输系统，视频处理设备和图像识别方法。

10. 发明授权

US07290589B2 Control of deposition and other processes 失效
标题翻译：控制沉积和其他工艺
公开(公告)号：US07290589B2
公开(公告)日：2007-11-06
申请号：US10469738
申请日：2002-03-05
申请人： Stephen Richard Duncan , Patrick Grant , Paul Jones , Timothy Rayment
发明人： Stephen Richard Duncan , Patrick Grant , Paul Jones , Timothy Rayment
IPC分类号： B22D11/00 , B05B7/06
CPC分类号： C23C4/12
摘要： Material is incrementally deposited using material directed toward a deposition zone. The scan path of the directed material is controlled according to a path plan derived to reduce derivation from an ideal uniform temperature profile for the deposition during the deposition process. A path plan having angled scan passes that intersect (or overcross one another), for example in a mirrorbox path plan, is preferred.
摘要翻译：使用指向沉积区的材料来递增地沉积材料。定向材料的扫描路径根据导出的路径计划来控制，以减少在沉积过程期间用于沉积的理想均匀温度分布的推导。具有相交（或彼此跨越）的成角度的扫描遍历的路径计划是优选的，例如在镜像框路径规划中。

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