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1. 发明申请

US20060089375A1 Pyrazolo[3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors 审中-公开
标题翻译：吡唑并[3,4-b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
公开(公告)号：US20060089375A1
公开(公告)日：2006-04-27
申请号：US10527866
申请日：2003-09-12
申请人： David Allen , Diane Coe , Caroline Cook , Michael Dowle , Christophen Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Richard Knowles , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , Peter Ward
发明人： David Allen , Diane Coe , Caroline Cook , Michael Dowle , Christophen Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Richard Knowles , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , Peter Ward
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is C1-4alkyl, C1-3fluoroalkyl, —CH2CH2OH or —CH2CH2CO2C1-2alkyl; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.
摘要翻译：本发明涉及式（I）化合物或其盐：其中：R 1是C 1-4烷基，C 1-3烷基，氟代烷基，-CH 2 CH 2 OH或-CH 2 CH 2 CO 2， C 1-12烷基; R 2是氢原子（H），甲基或C 1氟代烷基; R 3是任选取代的C 3-8环烷基或任选取代的单不饱和C 5〜5-7环烯基或任选取代的杂环基子公式（aa），（bb）或（cc）; 其中n 1和n 2独立地为1或2; 并且其中Y是O，S，SO 2或NR 10; 或R 3是双环基（dd）或（ee）：其中X是NR 4 R 5或OR 5a 。这些化合物是磷酸二酯酶（PDE）抑制剂，特别是PDE4抑制剂。还提供了式（I）化合物或其药学上可接受的盐在制备用于治疗和/或预防哺乳动物例如人的炎性和/或过敏性疾病的药物中的用途，例如慢性阻塞性肺疾病（COPD），哮喘或过敏性鼻炎。

2. 发明申请

US20080021058A1 Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors 审中-公开
标题翻译： Pyrazolo'3,4-B！吡啶化合物及其用作磷酸二酯酶4（Pde4）抑制剂
公开(公告)号：US20080021058A1
公开(公告)日：2008-01-24
申请号：US10598940
申请日：2005-03-15
申请人： David Allen , Diane Coe , Caroline Cook , Michael Dowle , Christopher Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , Naimisha Trivedi
发明人： David Allen , Diane Coe , Caroline Cook , Michael Dowle , Christopher Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , Naimisha Trivedi
IPC分类号： A61K31/437 , A61P29/00 , A61P37/08 , C07D221/04
CPC分类号： C07D471/04
摘要： The invention provides a compound of formula (I) or a salt thereof: wherein W is Ar, —CR4R5Ar or a group (y) or (y1), wherein Ar is (x) or (z): R1 is C1-4alkyl, C1-3fluoroalkyl or —CH2CH2OH. R2 is C2-6alkyl, C3-6cycloalkyl or —(CH2)n4-C3-6cycloalkyl; and R3 is optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, an optionally substituted heterocyclic group (aa), (bb) or (cc) (in which Y is O, S, SO2, or NR10), or a bicyclic group (ee): These compounds are PDE4 inhibitors.
摘要翻译：本发明提供式（I）化合物或其盐：其中W为Ar，-CR 4 R 5或Ar或基团（y）或（y1）其中Ar是（x）或（z）：R 1是C 1-4烷基，C 1-3 - 氟代烷基或-CH 2 CH 2 OH。 R 2是C 2-6 - 烷基，C 3-6环烷基或 - （CH 2 CH 2）_{n + 4-C 3-6环烷基; 且R 3是任选取代的C 3-8环烷基，任选取代的单不饱和C 5〜5-7环烯基，任意取代的杂环基（aa），（bb）或（cc）（其中Y为O，S，SO 2或NR 10）或双环基团（ee）这些化合物是PDE4抑制剂。}

3. 发明申请

US20060252790A1 Pyrazolo [3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors 失效
标题翻译：吡唑并[3,4-b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
公开(公告)号：US20060252790A1
公开(公告)日：2006-11-09
申请号：US10540371
申请日：2003-12-19
申请人： David Allen , Diane Coe
发明人： David Allen , Diane Coe
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is C1-4alkyl, C1-3fluoroalkyl or —(CH2)2OH; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3a is a hydrogen atom (H) or C1-3alkyl; R3 is optionally substituted branched C3-6alkyl, optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, optionally substituted phenyl, or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc): in which n1 and n2 independently are 1 or 2; and Y is O, S, SO2, or NR4; and wherein Het is of sub-formula (i), (ii), (iii), (iv) or (v): The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.
摘要翻译：本发明涉及式（I）化合物或其盐：其中：R 1是C 1-4烷基，C 1-3烷基，氟代烷基或 - （CH 2 CH 2）2 OH; R 2是氢原子（H），甲基或C 1氟代烷基; R 3a是氢原子（H）或C 1-3烷基; R 3是任选取代的支链C 3-6 - 烷基，任选取代的C 3-8环烷基，任选取代的单不饱和-C _{2 独立为1或2; Y是O，S，SO 2或NR 4; 并且其中Het为亚式（i），（ii），（iii），（iv）或（v）：所述化合物是磷酸二酯酶（PDE）抑制剂，特别是PDE4抑制剂。还提供了式（I）化合物或其药学上可接受的盐在制备用于治疗和/或预防哺乳动物例如人的炎性和/或过敏性疾病的药物中的用途，例如慢性阻塞性肺疾病（COPD），哮喘或过敏性鼻炎。}

4. 发明授权

US09091027B2 Asphalt composition 有权
标题翻译：沥青组成
公开(公告)号：US09091027B2
公开(公告)日：2015-07-28
申请号：US13512183
申请日：2009-11-30
申请人： David Allen , Flavio Souza , Yong-Rak Kim , Roberto Soares
发明人： David Allen , Flavio Souza , Yong-Rak Kim , Roberto Soares
IPC分类号： G06F7/60 , G06G7/48 , E01C1/00 , G06F17/50
CPC分类号： E01C1/002 , G06F17/5018 , G06F2217/44 , G06F2217/76
摘要： A computational method is provided for predicting roadway failure due to degradation of the roadway over time as a function of the input loads, the roadway geometry, the material properties of the constituents in the asphaltic pavement, the shape, distribution, orientation and volume fractions of the constituents, and environmental conditions. The unique and new feature of the method is that it employs several physically based predictive methodologies simultaneously.
摘要翻译：提供了一种计算方法，用于根据输入载荷，道路几何形状，沥青路面中组分的材料性质，形状，分布，取向和体积分数的函数，预测道路巷道随着时间的退化而导致的道路失效成分和环境条件。该方法的独特和新特征是它同时采用了几种基于物理的预测方法。

5. 发明申请

US20140091610A1 VEHICLE SEAT TRACK COVER 有权
标题翻译：车辆座椅履带盖
公开(公告)号：US20140091610A1
公开(公告)日：2014-04-03
申请号：US14009094
申请日：2012-04-05
申请人： Kenneth Clark , David Allen
发明人： Kenneth Clark , David Allen
IPC分类号： B60N2/07 , B60N2/44
CPC分类号： B60N2/07 , B60N2/0725 , B60N2/90 , Y10T156/1052
摘要： According to various embodiments, a vehicle seat track cover includes a substrate configured to be positioned over a seat track and a slot formed along the substrate. The slot is configured to facilitate passage of a seat support from the seat track to a vehicle seat.
摘要翻译：根据各种实施例，车辆座椅轨道盖包括被配置为定位在座椅轨道和沿着衬底形成的狭槽的衬底。槽被构造成便于将座椅支撑件从座椅轨道通过到车辆座椅。

6. 发明授权

US08437904B2 Systems and methods for health monitoring of complex systems 有权
标题翻译：复杂系统健康监测系统和方法
公开(公告)号：US08437904B2
公开(公告)日：2013-05-07
申请号：US11864717
申请日：2007-09-28
申请人： Ali R. Mansouri , John L. Vian , Krzysztof Wojtek Przytula , David Allen
发明人： Ali R. Mansouri , John L. Vian , Krzysztof Wojtek Przytula , David Allen
IPC分类号： G01M17/00 , G06F11/30 , B64D17/00 , G05B9/02
CPC分类号： G07C5/0816 , G07C5/0808
摘要： Systems and methods for health monitoring of complex systems are disclosed. In one embodiment, a method includes receiving a plurality of signals indicative of observation states of plurality of operating variables, performing a combined probability analysis of the plurality of signals using a diagnostic model of a monitored system to provide a health prognosis of the monitored system, and providing an indication of the health prognosis of the monitored system. In some embodiments, the monitored system may be an onboard system of an aircraft.
摘要翻译：公开了用于复杂系统的健康监测的系统和方法。在一个实施例中，一种方法包括：接收指示多个操作变量的观察状态的多个信号，使用被监视系统的诊断模型执行所述多个信号的组合概率分析以提供所监视的系统的健康预测，并提供所监测系统的健康预后的指示。在一些实施例中，所监视的系统可以是飞行器的车载系统。

7. 发明申请

US20130010475A1 JACKETED LED ASSEMBLIES AND LIGHT STRINGS CONTAINING SAME 有权
标题翻译：封装的LED组件和包含相同的灯串
公开(公告)号：US20130010475A1
公开(公告)日：2013-01-10
申请号：US13490140
申请日：2012-06-06
申请人： David Allen , Mark Allen
发明人： David Allen , Mark Allen
IPC分类号： F21V5/04
CPC分类号： H01L33/56 , F21S4/10 , F21V5/04 , F21V15/01 , F21V19/0005 , F21V23/001 , F21V31/005 , F21V31/04 , F21W2121/00 , F21W2121/04 , F21Y2115/10 , H01L33/58 , H01L33/62 , H01L2224/48247 , H01L2924/181 , H01L2924/30107 , H01L2924/3011 , H05B33/0803 , H05B33/0809 , H05B33/0821 , Y02B20/383 , Y10S362/80 , H01L2224/48091 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
摘要： A jacketed light emitting diode assembly is provided, which includes a light emitting diode including a set of positive and negative contacts, and a lens body containing a semiconductor chip and end portions of the contacts. An electrical wire set of first and second electrical wires are connected to the positive contact and the negative contact, respectively. A light transmissive cover receives the lens body, and has an opening through which at least one of the contact set and the electrical wire set passes. An integrally molded plastic jacket at the opening of the light transmissive cover provides a seal at the opening against moisture and airborne contaminants. A waterproof light string including one or more of the jacketed light emitting diode assemblies is also provided, as are related methods.
摘要翻译：提供了一种夹套的发光二极管组件，其包括包括一组正和负触点的发光二极管，以及包含半导体芯片和触头端部的透镜体。第一和第二电线的电线组分别连接到正触点和负触点。透光盖接收透镜体，并且具有开口，触点组和电线组中的至少一个通过该开口。在透光盖的开口处的整体模制的塑料护套在开口处提供防水和空气污染物的密封。还提供了包括一个或多个夹套发光二极管组件的防水光串，如相关方法。

8. 发明授权

US08321378B2 Method and apparatus for managing information related to storage activities of data storage systems 有权
标题翻译：用于管理与数据存储系统的存储活动有关的信息的方法和装置
公开(公告)号：US08321378B2
公开(公告)日：2012-11-27
申请号：US12008376
申请日：2008-01-10
申请人： Jeffrey Phillips , David Allen , Brett Serkez , Peter Bouchard
发明人： Jeffrey Phillips , David Allen , Brett Serkez , Peter Bouchard
IPC分类号： G06F17/30
CPC分类号： G06F11/1464 , G06F11/1458 , Y10S707/99939 , Y10S707/99955
摘要： Methods and apparatus for managing information related to backup storage activities of data storage systems. In a computer system having one or more independent backup data storage systems coupled to each other and each serving one or more clients, a user may obtain information related to backup activities of any of the backup storage systems from a single location. Through a user interface associated with any of the backup storage systems, or through a stand alone user interface, a user may manage (e.g., organize, display, print) information related to backup activities of any or all of the backup storage systems. System administrators can design and store a variety of report formats that may be utilized by any user to display or print various parameters associated with backup activities in a particular manner. Report formats may be edited by users, and displayed parameters may be dynamically updated to provide for active monitoring of one or more backup storage systems. Additionally, periodic backup activity reports can be generated and automatically sent to designated locations, for example to one or more printers and/or to one or more designated recipients via E-mail.
摘要翻译：用于管理与数据存储系统的备份存储活动有关的信息的方法和装置。在具有彼此耦合并且每个服务于一个或多个客户端的一个或多个独立备份数据存储系统的计算机系统中，用户可以从单个位置获得与任何备份存储系统的备份活动相关的信息。通过与任何备份存储系统相关联的用户界面，或通过独立的用户界面，用户可以管理（例如，组织，显示，打印）与任何或所有备份存储系统的备份活动相关的信息。系统管理员可以设计和存储各种报告格式，任何用户可以利用它们以特定的方式显示或打印与备份活动相关的各种参数。报告格式可以由用户编辑，并且显示的参数可以被动态地更新以提供一个或多个备份存储系统的主动监视。此外，定期备份活动报告可以生成并自动发送到指定位置，例如通过电子邮件发送到一个或多个打印机和/或一个或多个指定的收件人。

9. 发明申请

US20120248730A1 BICYCLE CHAIN GUIDE ASSEMBLY 失效
标题翻译：自行链指南大会
公开(公告)号：US20120248730A1
公开(公告)日：2012-10-04
申请号：US13079316
申请日：2011-04-04
申请人： Brandon Dale Sloan , David Allen , Jan Talavasek , Joseph Edward Buckley
发明人： Brandon Dale Sloan , David Allen , Jan Talavasek , Joseph Edward Buckley
IPC分类号： B62K19/44
CPC分类号： B62J13/00 , B62M9/16
摘要： A bicycle having a wheel and a frame supported by the wheel. The frame includes a wheel support and a stay extending from the wheel support. A stay protector engages the stay, and a chain guide member is coupled to the stay protector to support and align the chain. The chain guide member comprises a guide mount and a guide carriage. The guide mount is secured to the stay protector, and the guide carriage is supported by the guide mount. The bicycle chain passes through a channel formed on the guide carriage.
摘要翻译：具有车轮和由车轮支撑的框架的自行车。框架包括车轮支撑件和从车轮支撑件延伸的撑杆。保持架与托架接合，并且链条导向件联接到撑杆保护器以支撑和对齐链条。链条导向件包括导向架和导向架。导向架固定在支撑保护器上，导向架由导向架支撑。自行车链条穿过形成在导向架上的通道。

10. 发明申请

US20080133624A1 Method and apparatus for managing information related to storage activities of data storage systems 有权
公开(公告)号：US20080133624A1
公开(公告)日：2008-06-05
申请号：US12008376
申请日：2008-01-10
申请人： Jeffrey Phillips , David Allen , Brett Serkez , Peter Bouchard
发明人： Jeffrey Phillips , David Allen , Brett Serkez , Peter Bouchard
IPC分类号： G06F17/30
CPC分类号： G06F11/1464 , G06F11/1458 , Y10S707/99939 , Y10S707/99955
摘要： Methods and apparatus for managing information related to backup storage activities of data storage systems. In a computer system having one or more independent backup data storage systems coupled to each other and each serving one or more clients, a user may obtain information related to backup activities of any of the backup storage systems from a single location. Through a user interface associated with any of the backup storage systems, or through a stand alone user interface, a user may manage (e.g., organize, display, print) information related to backup activities of any or all of the backup storage systems. System administrators can design and store a variety of report formats that may be utilized by any user to display or print various parameters associated with backup activities in a particular manner. Report formats may be edited by users, and displayed parameters may be dynamically updated to provide for active monitoring of one or more backup storage systems. Additionally, periodic backup activity reports can be generated and automatically sent to designated locations, for example to one or more printers and/or to one or more designated recipients via E-mail.

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