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1. 发明申请

US20060089375A1 Pyrazolo[3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors 审中-公开
标题翻译：吡唑并[3,4-b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
公开(公告)号：US20060089375A1
公开(公告)日：2006-04-27
申请号：US10527866
申请日：2003-09-12
申请人： David Allen , Diane Coe , Caroline Cook , Michael Dowle , Christophen Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Richard Knowles , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , Peter Ward
发明人： David Allen , Diane Coe , Caroline Cook , Michael Dowle , Christophen Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Richard Knowles , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , Peter Ward
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is C1-4alkyl, C1-3fluoroalkyl, —CH2CH2OH or —CH2CH2CO2C1-2alkyl; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.
摘要翻译：本发明涉及式（I）化合物或其盐：其中：R 1是C 1-4烷基，C 1-3烷基，氟代烷基，-CH 2 CH 2 OH或-CH 2 CH 2 CO 2， C 1-12烷基; R 2是氢原子（H），甲基或C 1氟代烷基; R 3是任选取代的C 3-8环烷基或任选取代的单不饱和C 5〜5-7环烯基或任选取代的杂环基子公式（aa），（bb）或（cc）; 其中n 1和n 2独立地为1或2; 并且其中Y是O，S，SO 2或NR 10; 或R 3是双环基（dd）或（ee）：其中X是NR 4 R 5或OR 5a 。这些化合物是磷酸二酯酶（PDE）抑制剂，特别是PDE4抑制剂。还提供了式（I）化合物或其药学上可接受的盐在制备用于治疗和/或预防哺乳动物例如人的炎性和/或过敏性疾病的药物中的用途，例如慢性阻塞性肺疾病（COPD），哮喘或过敏性鼻炎。

2. 发明申请

US20050023874A1 Compound stool with energy storing spring 审中-公开
标题翻译：复合凳与储能弹簧
公开(公告)号：US20050023874A1
公开(公告)日：2005-02-03
申请号：US10607935
申请日：2003-06-30
申请人： Richard Knowles
发明人： Richard Knowles
IPC分类号： A47C9/00 , A61G5/14 , A47C1/02
CPC分类号： A61G5/14 , A47C9/002
摘要： A compound stool provides a base supporting a seat structure for limited vertical motion with an energy storing spring communicating between the base and seat structure to bias the seat structure upwardly but allow its motion downward relative to the base. The seat structure moves downwardly responsive to a user's weight as the user is seated to store energy generated in the spring by its compression. The spring releases stored energy as the user exits from the stool to aid the user's exiting motion. The base provides auxiliary wheels for locomotion and peripheral supports to aid a user's motion in entering and exiting the stool. The seat structure may be locked in lowermost position, once attained by a user's weight thereon.
摘要翻译：复合凳提供支撑用于有限垂直运动的座椅结构的基座，其中能量存储弹簧在基座和座椅结构之间连通，以向上偏置座椅结构，但允许其相对于底座向下运动。当使用者坐着时，座椅结构响应于使用者的重量向下运动，以通过其压缩来储存在弹簧中产生的能量。当用户离开凳子时，弹簧释放储存的能量，以帮助用户退出运动。底座提供用于运动和外围支撑的辅助轮，以帮助用户进入和离开粪便的运动。座椅结构可以被锁定在最低位置，一旦通过使用者的重量达到。

3. 发明授权

US5779842A Forming an erosion resistant coating on an electrode 失效
标题翻译：在电极上形成耐腐蚀涂层
公开(公告)号：US5779842A
公开(公告)日：1998-07-14
申请号：US687573
申请日：1996-11-15
申请人： Nigel Fawcett , Richard Knowles
发明人： Nigel Fawcett , Richard Knowles
IPC分类号： B23K35/02 , B23K35/32 , C23C8/68 , C23C12/02 , C23C26/00 , C23C26/02 , H01T21/02 , B32B31/14
CPC分类号： C23C12/02 , B23K35/0244 , B23K35/322 , C23C26/00 , C23C26/02 , C23C8/68 , H01T21/02 , B23K35/0233 , Y10T156/1052
摘要： A method of coating an area of an electrode with an erosion resistant material. The method comprises bringing into contact with the area a web which contains the erosion resistant material and which carries an adhesive so that the web adheres to the electrode. The electrode and the adhered web are then heated to a temperature high enough to cause the adhesive to decompose, volatilize, or both such that the adhesive is substantially eliminated from the web and such that the erosion resistant material fuses and bonds to the electrode.
摘要翻译： PCT No.PCT / GB95 / 00143 Sec。 371日期1996年11月15日 102（e）1996年11月15日日期PCT 1995年1月25日PCT PCT。 WO95 / 20256 PCT公开号日期1995年7月27日一种用耐腐蚀材料涂覆电极区域的方法。该方法包括使该区域与包含抗侵蚀材料的纤维网接触并且携带粘合剂，使得纤维网粘附到电极上。然后将电极和粘合的纤维网加热到足够高的温度以使粘合剂分解，挥发或两者，使得粘合剂基本上从幅材上除去，并且使得抗侵蚀材料熔化并结合到电极。

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