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1. 发明申请

WO2015156966A1 SENSORS FOR CONTINUOUS ANALYTE MONITORING, AND RELATED METHODS 审中-公开
标题翻译：用于连续分析监测的传感器及相关方法
公开(公告)号：WO2015156966A1
公开(公告)日：2015-10-15
申请号：PCT/US2015/020796
申请日：2015-03-16
申请人： DEXCOM, INC.
发明人： SIMPSON, Peter, C. , BLACKWELL, Jennifer , BOHM, Sebastian , ESTES, Michael, J. , JACKSON, Jeff , MITCHELL, Jason , PRYOR, Jack , RONG, Daiting , SAINT, Sean, T. , SHETH, Disha, B. , WANG, Shanger
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1486
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6849 , A61B5/688 , A61B2562/02 , A61B2562/12
摘要： Sensor devices including dissolvable tissue-piercing tips can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.
摘要翻译：包括可溶组织穿刺尖端的传感器装置可以与被配置用于将传感器装置插入主机的可溶解针结合使用。还提供用于加强传感器装置上的膜的硬化剂。还提供了使用和制造传感器装置的方法。

2. 发明申请

WO2019213428A3 AUTOMATIC ANALYTE SENSOR CALIBRATION AND ERROR DETECTION 审中-公开
公开(公告)号：WO2019213428A3
公开(公告)日：2019-11-07
申请号：PCT/US2019/030450
申请日：2019-05-02
申请人： DEXCOM, INC.
发明人： BHAVARAJU, Naresh, C. , CLARK, Becky, L. , CRABTREE, Vincent, P. , DRING, Chris, W. , GARCIA, Arturo , HALAC, Jason , HUGHES, Jonathan , JACKSON, Jeff , JEPSON, Lauren, Hruby , LEE, David, I-Chun , LEE, Ted, Tang , MA, Rui , MCDANIEL, Zebediah, L. , MITCHELL, Jason , PAL, Andrew, Attila , RONG, Daiting , SHETH, Disha, B. , SIMPSON, Peter, C. , VANSLYKE, Stephen, J. , WIGHTLIN, Matthew, D. , DAVIS, Anna, Leigh , HAMPAPURAM, Hari , MANDAPAKA, Aditya, Sagar , TEETER, Alexander, Leroy , WANG, Lian
IPC分类号： A61B5/00 , A61B5/0245
摘要： Systems and methods are provided that address the need to frequently calibrate analyte sensors, according to implementation. In more detail, systems and methods provide a preconnected analyte sensor system that physically combines an analyte sensor to measurement electronics during the manufacturing phase of the sensor and in some cases in subsequent life phases of the sensor, so as to allow an improved recognition of sensor environment over time to improve subsequent calibration of the sensor.

3. 发明申请

WO2011003036A2 CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME 审中-公开
标题翻译：连续分析传感器及其制作方法
公开(公告)号：WO2011003036A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040839
申请日：2010-07-01
申请人： DEXCOM, INC. , BOOCK, Robert , JACKSON, Jeff , ZHANG, Huashi , MITCHELL, Jason
发明人： BOOCK, Robert , JACKSON, Jeff , ZHANG, Huashi , MITCHELL, Jason
IPC分类号： A61B5/155 , A61B5/145 , A61B5/157
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body 510 is advanced through a pre-coating treatment station 520, through a coating station 530, through a thickness control station 540, through a drying or curing station 550, through a thickness measurement station 560, and through a post-coating treatment station 570.
摘要翻译：这里描述了用于连续制造可植入的连续分析物传感器的方法和系统的实施方案。在一些实施例中，提供了一种用于使细长导电体顺序地前进穿过多个台的方法，每个台被构造成处理细长导电体。在这些实施例中的一些实施例中，一个或多个工位被配置为使用弯液面涂覆工艺涂覆细长导电体，由此制备由聚合物和溶剂形成的溶液，该溶液被连续循环以在保持溶液的容器的顶部，并且细长导电体前进通过弯液面。该方法还可以包括通过使细长导电体通过模头孔从细长导电体去除多余涂层材料的步骤。例如，提供的细长导电体510通过预涂处理站520，穿过涂覆站530，通过厚度控制站540，穿过干燥或固化站550，穿过厚度测量站560，并通过后涂层处理站570。

4. 发明申请

WO2019213428A2 AUTOMATIC ANALYTE SENSOR CALIBRATION AND ERROR DETECTION 审中-公开
公开(公告)号：WO2019213428A2
公开(公告)日：2019-11-07
申请号：PCT/US2019/030450
申请日：2019-05-02
申请人： DEXCOM, INC.
发明人： BHAVARAJU, Naresh C. , CLARK, Becky L. , CRABTREE, Vincent P. , DRING, Chris W. , GARCIA, Arturo , HALAC, Jason , HUGHES, Jonathan , JACKSON, Jeff , JEPSON, Lauren Hruby , LEE, David I-Chun , LEE, Ted Tang , MA, Rui , MCDANIEL, Zebediah L. , MITCHELL, Jason , PAL, Andrew Attila , RONG, Daiting , SHETH, Disha B. , SIMPSON, Peter C. , VANSLYKE, Stephen J. , WIGHTLIN, Matthew D. , DAVIS, Anna Leigh , HAMPAPURAM, Hari , MANDAPAKA, Aditya Sagar , TEETER, Alexander Leroy , WANG, Lian
IPC分类号： A61B5/00 , A61B5/0245 , G01N27/3274
摘要： Systems and methods are provided that address the need to frequently calibrate analyte sensors, according to implementation. In more detail, systems and methods provide a preconnected analyte sensor system that physically combines an analyte sensor to measurement electronics during the manufacturing phase of the sensor and in some cases in subsequent life phases of the sensor, so as to allow an improved recognition of sensor environment over time to improve subsequent calibration of the sensor.

5. 发明申请

WO2018081749A3 TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2018081749A3
公开(公告)日：2018-05-03
申请号：PCT/US2017/059112
申请日：2017-10-30
申请人： DEXCOM, INC.
发明人： SIMPSON, Peter C. , SHI, Minglian , BOHM, Sebastian , WELLS, Maria Neol Brown , MAJEWSKI, John Patrick , EDRA, Leah Morta , SHETH, Disha B. , GRAY, John Michael , WANG, Shanger , LEE, Ted Tang , MOORE, Michael L. , MITCHELL, Jason , BLACKWELL, Jennifer , SHAH, Neel Narayan , NEWHOUSE, Todd Andrew , HALAC, Jason , SCHOONMAKER, Ryan Everett , NEALE, Paul V. , ZOU, Jiong , SAINT, Sean T.
IPC分类号： A61B5/05 , A61B5/00
摘要： Sensor systems can be used to measure an analyte concentration. Sensor systems can include a base having a distal side configured to face towards a person's skin. An adhesive can couple the base to the skin. A transcutaneous analyte measurement sensor can be coupled to the base and can be located at least partially in the host. A transmitter can be coupled to the base and can transmit analyte measurement data to a remote device.

6. 发明申请

WO2019083939A1 PRE-CONNECTED ANALYTE SENSORS 审中-公开
公开(公告)号：WO2019083939A1
公开(公告)日：2019-05-02
申请号：PCT/US2018/057011
申请日：2018-10-23
申请人： DEXCOM, INC.
发明人： HALAC, Jason , BARRY, John Charles , CLARK, Becky L. , DRING, Chris W. , GRAY, John Michael , HIGLEY, Kris Elliot , JACKSON, Jeff , KELLER, David A. , LEE, Ted Tang , MITCHELL, Jason , PIRONDINI, Kenneth , REGO, David , SCHOONMAKER, Ryan Everett , SIMPSON, Peter C. , GADD, Craig Thomas , STEWART, Kyle Thomas
IPC分类号： A61B5/05 , A61B5/145 , A61B5/1468 , C12Q1/54 , G01N27/327
摘要： Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

7. 发明申请

WO2018081749A2 TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS 审中-公开
标题翻译：经皮分析传感器系统和方法
公开(公告)号：WO2018081749A2
公开(公告)日：2018-05-03
申请号：PCT/US2017/059112
申请日：2017-10-30
申请人： DEXCOM, INC.
发明人： SIMPSON, Peter C. , SHI, Minglian , BOHM, Sebastian , WELLS, Maria Neol Brown , MAJEWSKI, John Patrick , EDRA, Leah Morta , SHETH, Disha B. , GRAY, John Michael , WANG, Shanger , LEE, Ted Tang , MOORE, Michael L. , MITCHELL, Jason , BLACKWELL, Jennifer , SHAH, Neel Narayan , NEWHOUSE, Todd Andrew , HALAC, Jason , SCHOONMAKER, Ryan Everett , NEALE, Paul V. , ZOU, Jiong , SAINT, Sean T.
摘要： Sensor systems can be used to measure an analyte concentration. Sensor systems can include a base having a distal side configured to face towards a person's skin. An adhesive can couple the base to the skin. A transcutaneous analyte measurement sensor can be coupled to the base and can be located at least partially in the host. A transmitter can be coupled to the base and can transmit analyte measurement data to a remote device.
摘要翻译：传感器系统可用于测量分析物浓度。传感器系统可以包括具有被构造成朝向人的皮肤的远侧的基部。粘合剂可以将基底连接到皮肤上。经皮分析物测量传感器可以连接到基座并且可以至少部分地位于主机中。发射器可以连接到基座，并可以将分析物测量数据传输到远程设备。

8. 发明申请

WO2011003039A2 ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME 审中-公开
标题翻译：分析传感器及其制造方法
公开(公告)号：WO2011003039A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040842
申请日：2010-07-01
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BOOCK, Robert , NEALE, Paul, V. , BOHM, Sebastian , WIGHTLIN, Matthew , PRYOR, Jack , MITCHELL, Jason , JACKSON, Jeff , PATEL, Kaushik , LLEVARES, Antonio, C.
发明人： SIMPSON, Peter, C. , BOOCK, Robert , NEALE, Paul, V. , BOHM, Sebastian , WIGHTLIN, Matthew , PRYOR, Jack , MITCHELL, Jason , JACKSON, Jeff , PATEL, Kaushik , LLEVARES, Antonio, C.
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies El, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies El, E2, and working electrodes 802', 802" formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies El, E2.
摘要翻译：提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成;绝缘层810，其将导电层820与细长主体分离;膜层，通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。

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