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1. 发明申请

WO2004075781A3 BIOACTIVE STENTS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：生物手术及其使用方法
公开(公告)号：WO2004075781A3
公开(公告)日：2006-08-03
申请号：PCT/US2004005940
申请日：2004-02-26
申请人： MEDIVAS LLC , CARPENTER KENNETH W , ZHANG HUASHI , MCCARTHY BRENDAN J , SZINAI ISTVAN , TURNELL WILLIAM GORDON , GOPALAN SINDHU M
发明人： CARPENTER KENNETH W , ZHANG HUASHI , MCCARTHY BRENDAN J , SZINAI ISTVAN , TURNELL WILLIAM GORDON , GOPALAN SINDHU M
IPC分类号： A61F2/00 , A61K31/685 , A61K31/7048 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61K31/685 , A61K31/7048 , A61L31/10 , A61L31/148 , A61L2300/25 , A61L2300/604 , A61L2300/80
摘要： The present invention is based on the discovery that stents can be coated with biodegradable, bioactive polymers that promote endogenous healing processes at a site of stent implantation. The polymers biodegrade over time, releasing agents which establish or re-establish the natural healing process in an artery. Preferably, the stent is implanted at the time an artery is damaged, such at the time of angioplasty to protect the damaged artery against deleterious blood-borne factors that initiate proliferation of smooth muscle cells.
摘要翻译：本发明基于以下发现：支架可以涂覆有促进支架植入部位的内源性愈合过程的可生物降解的生物活性聚合物。聚合物随时间生物降解，释放在动脉中建立或重建自然愈合过程的药剂。优选地，在动脉损伤时植入支架，例如在血管成形术时，为了保护损伤的动脉免受引起平滑肌细胞增殖的有害的血液传导因素的侵害。

2. 发明申请

WO2004075781A2 BIOACTIVE STENTS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：生物手术及其使用方法
公开(公告)号：WO2004075781A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/005940
申请日：2004-02-26
申请人： MEDIVAS, LLC , CARPENTER, Kenneth, W. , ZHANG, Huashi , McCARTHY, Brendan, J. , SZINAI, Istvan , TURNELL, William, Gordon , GOPALAN, Sindhu, M.
发明人： CARPENTER, Kenneth, W. , ZHANG, Huashi , McCARTHY, Brendan, J. , SZINAI, Istvan , TURNELL, William, Gordon , GOPALAN, Sindhu, M.
IPC分类号： A61F
CPC分类号： A61L31/16 , A61K31/685 , A61K31/7048 , A61L31/10 , A61L31/148 , A61L2300/25 , A61L2300/604 , A61L2300/80
摘要： The present invention is based on the discovery that stents can be coated with biodegradable, bioactive polymers that promote endogenous healing processes at a site of stent implantation. The polymers biodegrade over time, releasing agents which establish or re-establish the natural healing process in an artery. Preferably, the stent is implanted at the time an artery is damaged, such at the time of angioplasty to protect the damaged artery against deleterious blood-borne factors that initiate proliferation of smooth muscle cells.
摘要翻译：本发明基于以下发现：支架可以涂覆有促进支架植入部位的内源性愈合过程的可生物降解的生物活性聚合物。聚合物随时间生物降解，释放在动脉中建立或重建自然愈合过程的药剂。优选地，在动脉损伤时植入支架，例如在血管成形术时，为了保护损伤的动脉免受引起平滑肌细胞增殖的有害的血液传导因素的侵害。

3. 发明申请

WO2011003036A3 CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME 审中-公开
标题翻译：连续分析仪传感器及其制作方法
公开(公告)号：WO2011003036A3
公开(公告)日：2011-04-14
申请号：PCT/US2010040839
申请日：2010-07-01
申请人： DEXCOM INC , BOOCK ROBERT , JACKSON JEFF , ZHANG HUASHI , MITCHELL JASON
发明人： BOOCK ROBERT , JACKSON JEFF , ZHANG HUASHI , MITCHELL JASON
IPC分类号： A61B5/155 , A61B5/145 , A61B5/157
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body (510) is advanced through a pre-coating treatment station (520), through a coating station 530, through a thickness control station (540), through a drying or curing station (550), through a thickness measurement station (560), and through a post-coating treatment station (570).
摘要翻译：这里描述了用于连续制造可植入的连续分析物传感器的方法和系统的实施方案。在一些实施例中，提供了一种方法，用于顺序地将细长导电体穿过多个工位，每个工位都构造成处理细长导电体。在这些实施例中的一些实施例中，一个或多个工位被配置为使用弯液面涂覆工艺涂覆细长导电体，由此制备由聚合物和溶剂形成的溶液，所述溶液被连续循环以在保持溶液的容器的顶部，并且细长导电体前进通过弯液面。该方法还可以包括通过使细长导电体通过模头孔从细长导电体去除多余涂层材料的步骤。例如，所提供的细长导电体（510）穿过预涂处理站（520），穿过涂覆站530穿过厚度控制站（540），通过干燥或固化站（550），通过厚度测量站（560），并通过后涂层处理站（570）。

4. 发明申请

WO2011003036A2 CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME 审中-公开
标题翻译：连续分析传感器及其制作方法
公开(公告)号：WO2011003036A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040839
申请日：2010-07-01
申请人： DEXCOM, INC. , BOOCK, Robert , JACKSON, Jeff , ZHANG, Huashi , MITCHELL, Jason
发明人： BOOCK, Robert , JACKSON, Jeff , ZHANG, Huashi , MITCHELL, Jason
IPC分类号： A61B5/155 , A61B5/145 , A61B5/157
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body 510 is advanced through a pre-coating treatment station 520, through a coating station 530, through a thickness control station 540, through a drying or curing station 550, through a thickness measurement station 560, and through a post-coating treatment station 570.
摘要翻译：这里描述了用于连续制造可植入的连续分析物传感器的方法和系统的实施方案。在一些实施例中，提供了一种用于使细长导电体顺序地前进穿过多个台的方法，每个台被构造成处理细长导电体。在这些实施例中的一些实施例中，一个或多个工位被配置为使用弯液面涂覆工艺涂覆细长导电体，由此制备由聚合物和溶剂形成的溶液，该溶液被连续循环以在保持溶液的容器的顶部，并且细长导电体前进通过弯液面。该方法还可以包括通过使细长导电体通过模头孔从细长导电体去除多余涂层材料的步骤。例如，提供的细长导电体510通过预涂处理站520，穿过涂覆站530，通过厚度控制站540，穿过干燥或固化站550，穿过厚度测量站560，并通过后涂层处理站570。

5. 发明申请

WO2005112587A2 WOUND HEALING POLYMER COMPOSITIONS AND METHODS FOR USE THEREOF 审中-公开
标题翻译： WOUND HEALING POLYMER组合物及其使用方法
公开(公告)号：WO2005112587A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/016678
申请日：2005-05-12
申请人： MEDIVAS, LLC , CARPENTER, Kenneth, W. , ZHANG, Huashi , McCARTHY, Brendan, J. , SZINAI, Istvan , TURNELL, William, G. , GOPALAN, Sindhu, M.
发明人： CARPENTER, Kenneth, W. , ZHANG, Huashi , McCARTHY, Brendan, J. , SZINAI, Istvan , TURNELL, William, G. , GOPALAN, Sindhu, M.
IPC分类号： A61K35/44
CPC分类号： A61K35/44 , A61K9/0024 , A61K38/00 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/595 , A61L15/26 , A61L15/44 , A61L15/60 , A61L15/64 , A61L26/0019 , A61L26/0066 , A61L31/10 , A61L31/148 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/416 , A61L2300/604 , A61L2300/64 , C08L77/12 , C08L79/02
摘要： The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and/or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyratevalerate copolymers, and copolymers of the cyclic diester monomer, 3(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and ε-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.
摘要翻译：本发明提供生物活性聚合物组合物，其可配制成通过调节组合物的各种组分以受控的速率释放伤口愈合剂。组合物可用于外部伤口敷料中，作为用于将伤口愈合剂递送至内部身体部位的聚合物植入物，或作为可植入手术装置的表面上的涂层，以递送共价连接到生物相容的可生物降解聚合物和/或嵌入在水凝胶内。还提供了使用本发明生物活性聚合物组合物促进伤口，特别是慢性伤口的自然愈合的方法。可用于形成血液相容的亲水层或涂层的可生物降解的共聚物聚酯的实例包括共聚酯酰胺，共聚酯氨基甲酸酯，乙交酯 - 丙交酯共聚物，乙交酯 - 己内酯共聚物，聚-3-羟基丁酸戊酯共聚物和环状二酯单体的共聚物， 3（S）[（烷氧基羰基）甲基] -1,4-二恶烷-2,5-二酮与L-丙交酯。乙交酯 - 丙交酯共聚物包括使用乙醇酸与L-乳酸的单体摩尔比在5:95至95:5范围内形成的聚（乙交酯-L-丙交酯）共聚物，优选乙醇酸与L-乳酸的单体摩尔比，乳酸范围为45:65至95:5。乙交酯 - 己内酯共聚物包括乙交酯和ε-己内酯嵌段共聚物，例如Monocryl或Poliglecaprone。

6. 发明申请

WO2009121026A1 POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS 审中-公开
标题翻译：用于连续分析仪传感器的聚合物膜
公开(公告)号：WO2009121026A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038678
申请日：2009-03-27
申请人： DEXCOM, INC. , BOOCK, Robert , RIXMAN, Monica, A. , ZHANG, Huashi , ESTES, Michael, J. , LAWRENCE, Kristina
发明人： BOOCK, Robert , RIXMAN, Monica, A. , ZHANG, Huashi , ESTES, Michael, J. , LAWRENCE, Kristina
IPC分类号： G01N27/00 , G01R33/00
CPC分类号： C12Q1/002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , C12Q1/006
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise- causing species. The sensing mechanism can be a sensor 34 that includes a membrane system 32 and two electrodes, i.e., a working electrode 38 and at least one additional electrode 30, which may function as a counter or reference electrode.
摘要翻译：描述了用于提供分析物浓度的连续测量的装置和方法。在一些实施例中，该装置具有感测机构和感测膜，其包括至少一个含表面活性基团的聚合物并且位于感测机构上方。感测膜可以具有构造成基本上阻挡非恒定噪声引起物质的影响和/或影响的生物保护层。感测机构可以是传感器34，其包括膜系统32和两个电极，即工作电极38和至少一个附加电极30，其可以用作反电极或参考电极。

7. 发明申请

WO2008098011A1 METHOD FOR POLYMERIZING A MONOMER SOLUTION WITHIN A CAVITY TO GENERATE A SMOOTH POLYMER SURFACE 审中-公开
标题翻译：用于聚合孔中的单体溶液以生成平滑聚合物表面的方法
公开(公告)号：WO2008098011A1
公开(公告)日：2008-08-14
申请号：PCT/US2008/053097
申请日：2008-02-05
申请人： GLUMETRICS, INC. , MARKLE, David, R. , ZHANG, Huashi , ROMEY, Matthew, A. , WESSLING, Ritchie, A.
发明人： MARKLE, David, R. , ZHANG, Huashi , ROMEY, Matthew, A. , WESSLING, Ritchie, A.
IPC分类号： G01N21/77
CPC分类号： G01N21/7703 , G01N2021/6434 , G01N2021/773 , G01N2021/7786
摘要： IThe present invention relates to methods for polymerizing a monomer solution (15) comprising a polymerization initiator and an analyte indicator within a cavity (6) in an optical fiber covered by a porous membrane (14) to generate a smooth polymer surface. More specifically, the method can be used to provide a medical device or sensor (2) with a smooth polymer surface.
摘要翻译：本发明涉及用于在由多孔膜（14）覆盖的光纤中的空腔（6）内聚合包含聚合引发剂和分析物指示剂的单体溶液（15）的方法，以产生光滑的聚合物表面。更具体地，该方法可用于提供具有光滑聚合物表面的医疗装置或传感器（2）。

8. 发明申请

WO2006088647A1 POLYMER PARTICLE DELIVERY COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：聚合物颗粒递送组合物和使用方法
公开(公告)号：WO2006088647A1
公开(公告)日：2006-08-24
申请号：PCT/US2006/003575
申请日：2006-01-31
申请人： MEDIVAS, LLC , TURNELL, William, G. , LI, Hong , GOMURASHVILI, Zaza, D. , HUGHES, Jonathan, Macferran , DA, Jie , ZHANG, Huashi , KATSARAVA, Ramaz
发明人： TURNELL, William, G. , LI, Hong , GOMURASHVILI, Zaza, D. , HUGHES, Jonathan, Macferran , DA, Jie , ZHANG, Huashi , KATSARAVA, Ramaz
IPC分类号： A61K9/50
CPC分类号： A61K9/1075 , A61K9/1647 , A61K9/5031 , A61K9/5153 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/595 , C07K16/2821 , C08L77/12 , C12N15/88
摘要： The present invention provides biodegradable polymer particle delivery compositions based on polymers, such as polyester amide (PEA) and polyester urethane (PEUR) polymers, that contain amino acids in the polymer. The polymer particle delivery compositions can be formulated as a liquid dispersion of polymer particles with the bioactive agents dispersed in the particle or conjugated attached to polymer molecules or particle surfaces. The bioactive agents can include drugs, polypeptides, DNA and cells for cell-based therapies using particles sized for local, mucosal or circulatory delivery. Methods of treating a disease by administering to a subject the polymer particle delivery composition, which incorporates a bioactive agent suitable for treatment of the disease, or its symptoms, are also included.
摘要翻译：本发明提供了基于在聚合物中含有氨基酸的聚合物如聚酯酰胺（PEA）和聚酯聚氨酯（PEUR）聚合物的可生物降解的聚合物颗粒递送组合物。聚合物颗粒递送组合物可以配制成聚合物颗粒的液体分散体，其中分散在颗粒中的生物活性剂或缀合在聚合物分子或颗粒表面上。生物活性剂可以包括药物，多肽，DNA和细胞用于基于细胞的疗法，使用尺寸适合局部，粘膜或循环递送的颗粒。还包括通过向受试者施用包含适合于治疗该疾病的生物活性剂的聚合物颗粒递送组合物或其症状来治疗疾病的方法。

9. 发明申请

WO2005112587A3 WOUND HEALING POLYMER COMPOSITIONS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：创伤治疗聚合物组合物及其使用方法
公开(公告)号：WO2005112587A3
公开(公告)日：2009-04-09
申请号：PCT/US2005016678
申请日：2005-05-12
申请人： MEDIVAS LLC , CARPENTER KENNETH W , ZHANG HUASHI , MCCARTHY BRENDAN J , SZINAI ISTVAN , TURNELL WILLIAM G , GOPALAN SINDHU M , KATSARAVA RAMAZ
发明人： CARPENTER KENNETH W , ZHANG HUASHI , MCCARTHY BRENDAN J , SZINAI ISTVAN , TURNELL WILLIAM G , GOPALAN SINDHU M , KATSARAVA RAMAZ
IPC分类号： A61K47/00
CPC分类号： A61K35/44 , A61K9/0024 , A61K38/00 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/595 , A61L15/26 , A61L15/44 , A61L15/60 , A61L15/64 , A61L26/0019 , A61L26/0066 , A61L31/10 , A61L31/148 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/416 , A61L2300/604 , A61L2300/64 , C08L77/12 , C08L79/02
摘要： The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and/or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyratevalerate copolymers, and copolymers of the cyclic diester monomer, 3(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and e-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.
摘要翻译：本发明提供生物活性聚合物组合物，其可配制成通过调节组合物的各种组分以受控的速率释放伤口愈合剂。组合物可以用作外部伤口敷料，作为用于将伤口愈合剂递送到内部身体部位的聚合物植入物，或者作为可植入手术装置的表面上的涂层，以递送共价连接到生物相容的，可生物降解的聚合物和/或嵌入在水凝胶内。还提供了使用本发明生物活性聚合物组合物促进伤口，特别是慢性伤口的自然愈合的方法。可用于形成血液相容的亲水层或涂层的可生物降解的共聚物聚酯的实例包括共聚酯酰胺，共聚酯氨基甲酸酯，乙交酯 - 丙交酯共聚物，乙交酯 - 己内酯共聚物，聚-3-羟基丁酸戊酯共聚物，以及环状二酯单体的共聚物， 3（S）[（烷氧基羰基）甲基] -1,4-二恶烷-2,5-二酮与L-丙交酯。乙交酯 - 丙交酯共聚物包括使用乙醇酸与L-乳酸的单体摩尔比为5:95至95:5的聚（乙交酯-L-丙交酯）共聚物，优选乙醇酸与L-乳酸的单体摩尔比，乳酸范围为45:65至95:5。乙交酯 - 己内酯共聚物包括乙交酯和ε-己内酯嵌段共聚物，例如Monocryl或Poliglecaprone。

10. 发明申请

WO2007146119A3 BIODEGRADABLE POLYMER ADHESION BARRIERS 审中-公开
公开(公告)号：WO2007146119A3
公开(公告)日：2007-12-21
申请号：PCT/US2007/013501
申请日：2007-06-08
申请人： MEDIVAS, LLC , CARPENTER, Kenneth, W. , ZHANG, Huashi
发明人： CARPENTER, Kenneth, W. , ZHANG, Huashi
IPC分类号： A61K8/72
摘要： The present invention provides adhesion barrier compositions based on a solution of at least one of a biodegradable polyester amide (PEA), polyester urethane (PEUR), or polyester urea (PEU) polymers, dissolved in a biocompatible solvent. The compositions can be applied to a tissue surface, such as in open surgery, as a viscous liquid which forms an adhesive film upon being sprayed or painted onto the tissue surface. Alternatively, the composition can be applied to the tissue surface as a preformed solid layer or double layer (either porous or non-porous) that adheres to the tissue surface. In open surgery, the invention adhesion barrier compositions are used to separate opposing tissue surfaces or tissue-organ surfaces while injured tissues heal, for example in the abdomen or pelvis.

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