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1. 发明申请

WO2012142502A3 ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION 审中-公开
公开(公告)号：WO2012142502A3
公开(公告)日：2012-10-18
申请号：PCT/US2012/033645
申请日：2012-04-13
申请人： DEXCOM INC. , ESTES, Michael, J. , SIMPSON, Peter, C. , KAMATH, Apurv, Ullas , BOHM, Sebastian , RONG, Daiting
发明人： ESTES, Michael, J. , SIMPSON, Peter, C. , KAMATH, Apurv, Ullas , BOHM, Sebastian , RONG, Daiting
IPC分类号： G01N33/66 , A61B5/157
摘要： Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self- calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity (110) of the analyte sensor is determined by applying an estimative algorithm (120) that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

2. 发明申请

WO2015156966A1 SENSORS FOR CONTINUOUS ANALYTE MONITORING, AND RELATED METHODS 审中-公开
标题翻译：用于连续分析监测的传感器及相关方法
公开(公告)号：WO2015156966A1
公开(公告)日：2015-10-15
申请号：PCT/US2015/020796
申请日：2015-03-16
申请人： DEXCOM, INC.
发明人： SIMPSON, Peter, C. , BLACKWELL, Jennifer , BOHM, Sebastian , ESTES, Michael, J. , JACKSON, Jeff , MITCHELL, Jason , PRYOR, Jack , RONG, Daiting , SAINT, Sean, T. , SHETH, Disha, B. , WANG, Shanger
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1486
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6849 , A61B5/688 , A61B2562/02 , A61B2562/12
摘要： Sensor devices including dissolvable tissue-piercing tips can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.
摘要翻译：包括可溶组织穿刺尖端的传感器装置可以与被配置用于将传感器装置插入主机的可溶解针结合使用。还提供用于加强传感器装置上的膜的硬化剂。还提供了使用和制造传感器装置的方法。

3. 发明申请

WO2009120240A1 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2009120240A1
公开(公告)日：2009-10-01
申请号：PCT/US2008/082905
申请日：2008-11-07
申请人： DEXCOM, INC. , KAMATH, Apurv, U. , LEACH, Jacob, S. , ESTES, Michael, J. , SHARIATI, Mohammad, Ali , NEALE, Paul, V. , SIMPSON, Peter, C. , YANG, Richard, C. , BOOCK, Robert , LI, Ying
发明人： KAMATH, Apurv, U. , LEACH, Jacob, S. , ESTES, Michael, J. , SHARIATI, Mohammad, Ali , NEALE, Paul, V. , SIMPSON, Peter, C. , YANG, Richard, C. , BOOCK, Robert , LI, Ying
IPC分类号： A61B5/0245
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/412 , A61B5/7275 , A61M39/10 , A61M2039/1077 , A61M2205/3303
摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system (10) includes a vascular access device (12), a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
摘要翻译：提供了用于宿主血管系统的连续分析物测量的系统和方法。在一些实施例中，连续葡萄糖测量系统（10）包括血管进入装置（12），传感器和传感器电子装置，所述系统被配置为插入与主机的循环系统的通信。

5. 发明申请

WO2014004450A1 DEVICES, SYSTEMS, AND METHODS TO COMPENSATE FOR EFFECTS OF TEMPERATURE ON IMPLANTABLE SENSORS 审中-公开
标题翻译：用于补偿温度对可植入传感器的影响的装置，系统和方法
公开(公告)号：WO2014004450A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/047527
申请日：2013-06-25
申请人： DEXCOM, INC.
发明人： ESTES, Michael, J. , BLACKWELL, Jennifer , BOHM, Sebastian , BOOCK, Robert, J. , PRYOR, Jack , SIMPSON, Peter, C. , WIGHTLIN, Matthew, D.
IPC分类号： A61B5/1486 , A61B5/145 , A61B5/1495
CPC分类号： G01N27/403 , A61B5/14532 , A61B5/14865 , A61B5/1495
摘要： Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration, e.g., from a dual-electrode analyte sensor comprising a reference electrode 114 and a working electrode comprising an exposed portion of a surface of an elongated body 102A having an insulating material 104A disposed thereon, such that the working electrode is exposed via a radial window 106A in the insulator.
摘要翻译：提供了用于补偿温度对植入式传感器的影响的系统和方法。在一些实施例中，提供了用于测量温度以确定传感器环境中的温度变化的系统和方法。在某些实施例中，基于传感器环境的温度变化来确定温度补偿系数。温度补偿因子可以用于处理分析物信号的原始数据以报告更精确的分析物浓度，例如，从包括参考电极114的双电极分析物传感器和包括暴露部分的工作电极的工作电极具有设置在其上的绝缘材料104A的细长体102A，使得工作电极经由绝缘体中的径向窗口106A暴露。

6. 发明申请

WO2013138369A1 SYSTEMS AND METHODS FOR PROCESSING ANALYTE SENSOR DATA 审中-公开
标题翻译：用于处理分析仪传感器数据的系统和方法
公开(公告)号：WO2013138369A1
公开(公告)日：2013-09-19
申请号：PCT/US2013/030583
申请日：2013-03-12
申请人： DEXCOM, INC.
发明人： ESTES, Michael, J. , VANSLYKE, Stephen, J. , KAMATH, Apurv, Ullas , PEYSER, Thomas, A. , BOHNETT, Lucas , MAHALINGAM, Aarthi , GARCIA, Arturo , SIMPSON, Peter, C. , RACK-GOMER, Anna, Leigh , BOHM, Sebastian
IPC分类号： A61B5/1495
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14503 , A61B5/14532 , A61B5/7203 , A61B2560/0223 , A61B2562/02 , G01D3/022 , G06F19/3468
摘要： Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously.
摘要翻译：将时间依赖算法补偿功能应用于从连续分析物传感器输出的数据的系统和方法。一些实施例确定了自传感器植入之后的时间和/或先前已经使用了新初始化的传感器。

7. 发明申请

WO2015187366A1 FAULT DISCRIMINATION AND RESPONSIVE PROCESSING BASED ON DATA AND CONTEXT 审中-公开
标题翻译：基于数据和背景的故障辨别和响应处理
公开(公告)号：WO2015187366A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/031710
申请日：2015-05-20
申请人： DEXCOM, INC.
发明人： VANSLYKE, Stephen, J. , BHAVARAJU, Naresh, C. , BOHM, Sebastian , BOWMAN, Leif, N. , ESTES, Michael, J. , GARCIA, Arturo , KAMATH, Apurv, Ullas , PAL, Andrew, Attila , PEYSER, Thomas, A. , RACK-GOMER, Anna, Leigh , RONG, Daiting , SHETH, Disha, B. , SIMPSON, Peter, C. , SOKOLVSKY, Dmytro
IPC分类号： A61B5/00 , A61B5/145
CPC分类号： A61B5/1495 , A61B5/01 , A61B5/053 , A61B5/1118 , A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/4833 , A61B5/4839 , A61B5/4848 , A61B5/4866 , A61B5/6898 , A61B5/7203 , A61B5/7221 , A61B5/7275 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B5/746 , A61B2560/0247 , A61B2560/0252 , A61B2560/0276 , A61B2560/0475 , A61B2562/0247 , A61M5/1723 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/52 , A61M2230/201 , G06F19/00
摘要： Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.
摘要翻译：这里公开的系统和方法提供了区分分析物传感器和系统中遇到的故障类型的方法，并进一步提供了基于传感器数据，临床上下文信息以及关于患者或患者环境的其它数据来响应地处理这种被辨别的故障的方法。因此，系统和方法利用临床上下文来检测和/或响应与分析物传感器系统相关的错误或故障，以及区分故障类型及其根本原因，特别是因为故障动态可能类似于生理系统的动力学强调区分错误并提供适当的响应处理的重要性。因此，所公开的系统和方法在确定如何应对故障时考虑患者的健康状况或状态的上下文。

8. 发明申请

WO2011003035A2 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2011003035A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040838
申请日：2010-07-01
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BOOCK, Robert , KAMATH, Apurv, Ullas , WIGHTLIN, Matthew , ESTES, Michael, J.
发明人： SIMPSON, Peter, C. , BOOCK, Robert , KAMATH, Apurv, Ullas , WIGHTLIN, Matthew , ESTES, Michael, J.
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104, and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.
摘要翻译：提供了用于连续测量分析物浓度的装置和方法。该装置可以包括具有多个传感器元件的传感器，每个传感器元件具有与装置的其它传感器不同的至少一个特性。在一些实施例中，多个传感器元件各自被调谐以测量分析物浓度的不同范围，从而为器件提供在生理学相关范围内实现基本一致的测量精度水平的能力。在其他实施例中，该装置包括多个传感器元件，每个传感器元件在插入或植入之后的不同时间期间被调整以测量，从而为传感器提供在宽范围的时间段内连续且精确地测量分析物浓度的能力。例如，传感器系统180被提供有具有包括第一传感器元件102的第一工作电极150和包括第二传感器元件104的第二工作电极160以及用于提供用于测量工作电极电位的参考值的参考电极108 的传感器元件102,104。

9. 发明申请

WO2009121026A1 POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS 审中-公开
标题翻译：用于连续分析仪传感器的聚合物膜
公开(公告)号：WO2009121026A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038678
申请日：2009-03-27
申请人： DEXCOM, INC. , BOOCK, Robert , RIXMAN, Monica, A. , ZHANG, Huashi , ESTES, Michael, J. , LAWRENCE, Kristina
发明人： BOOCK, Robert , RIXMAN, Monica, A. , ZHANG, Huashi , ESTES, Michael, J. , LAWRENCE, Kristina
IPC分类号： G01N27/00 , G01R33/00
CPC分类号： C12Q1/002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , C12Q1/006
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise- causing species. The sensing mechanism can be a sensor 34 that includes a membrane system 32 and two electrodes, i.e., a working electrode 38 and at least one additional electrode 30, which may function as a counter or reference electrode.
摘要翻译：描述了用于提供分析物浓度的连续测量的装置和方法。在一些实施例中，该装置具有感测机构和感测膜，其包括至少一个含表面活性基团的聚合物并且位于感测机构上方。感测膜可以具有构造成基本上阻挡非恒定噪声引起物质的影响和/或影响的生物保护层。感测机构可以是传感器34，其包括膜系统32和两个电极，即工作电极38和至少一个附加电极30，其可以用作反电极或参考电极。

10. 发明授权

EP2257794B1 POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS 有权
标题翻译：用于连续分析传感器的聚合物膜
公开(公告)号：EP2257794B1
公开(公告)日：2018-05-09
申请号：EP09723677.2
申请日：2009-03-27
申请人： Dexcom, Inc.
发明人： BOOCK, Robert , RIXMAN, Monica, A. , ZHANG, Huashi , ESTES, Michael, J. , LAWRENCE, Kristina
IPC分类号： A61B5/145 , A61B5/1486 , C12Q1/00 , G01N27/40
CPC分类号： C12Q1/002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , C12Q1/006
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

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