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1. 发明申请

WO2017117469A1 DIFFUSION RESISTANCE LAYER FOR ANALYTE SENSORS 审中-公开
标题翻译：用于分析传感器的扩散阻抗层
公开(公告)号：WO2017117469A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069342
申请日：2016-12-29
申请人： DEXCOM, INC.
发明人： ZOU, Jiong , BOOCK, Robert, J. , DENNIS, Andrew, Trinin , LEE, Ted, Tang , SURI, Jeff, T. , SZE, David , TAPSAK, Mark, A. , WANG, Shanger , ZHANG, Huashi
IPC分类号： A61B5/1473 , A61B5/1486
CPC分类号： G01N27/3273 , A61B5/0004 , A61B5/002 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B2562/12 , A61K31/045 , A61K31/137 , A61K31/46 , A61K31/465 , A61K31/485 , A61K31/515 , A61K31/56 , A61K33/00 , A61K36/185 , A61K38/28 , C08G18/0828 , C08G18/12 , C08G18/3857 , C08G18/4018 , C08G18/44 , C08G18/4833 , C08G18/755 , C08L39/06 , C08L69/00 , C08L75/04 , C12N11/08 , C12Q1/002 , C12Q1/006 , G01N27/3275 , G01N33/66 , C08G18/3234
摘要： Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.
摘要翻译：公开了用于确定分析物浓度的装置（例如葡萄糖）。这些装置包括配置为产生与分析物浓度相关的信号的传感器和位于传感器上的传感膜。传感膜包含酶层，其中酶层包含酶和包含聚氨酯和/或聚脲段和一个或多个两性离子重复单元的聚合物。酶层保护酶并防止其从传感膜渗入宿主或失活。

2. 发明申请

WO2014004450A1 DEVICES, SYSTEMS, AND METHODS TO COMPENSATE FOR EFFECTS OF TEMPERATURE ON IMPLANTABLE SENSORS 审中-公开
标题翻译：用于补偿温度对可植入传感器的影响的装置，系统和方法
公开(公告)号：WO2014004450A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/047527
申请日：2013-06-25
申请人： DEXCOM, INC.
发明人： ESTES, Michael, J. , BLACKWELL, Jennifer , BOHM, Sebastian , BOOCK, Robert, J. , PRYOR, Jack , SIMPSON, Peter, C. , WIGHTLIN, Matthew, D.
IPC分类号： A61B5/1486 , A61B5/145 , A61B5/1495
CPC分类号： G01N27/403 , A61B5/14532 , A61B5/14865 , A61B5/1495
摘要： Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration, e.g., from a dual-electrode analyte sensor comprising a reference electrode 114 and a working electrode comprising an exposed portion of a surface of an elongated body 102A having an insulating material 104A disposed thereon, such that the working electrode is exposed via a radial window 106A in the insulator.
摘要翻译：提供了用于补偿温度对植入式传感器的影响的系统和方法。在一些实施例中，提供了用于测量温度以确定传感器环境中的温度变化的系统和方法。在某些实施例中，基于传感器环境的温度变化来确定温度补偿系数。温度补偿因子可以用于处理分析物信号的原始数据以报告更精确的分析物浓度，例如，从包括参考电极114的双电极分析物传感器和包括暴露部分的工作电极的工作电极具有设置在其上的绝缘材料104A的细长体102A，使得工作电极经由绝缘体中的径向窗口106A暴露。

3. 发明申请

WO2013032940A1 POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS 审中-公开
标题翻译：用于连续分析仪传感器的聚合物膜
公开(公告)号：WO2013032940A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052365
申请日：2012-08-24
申请人： DEXCOM, INC. , BOOCK, Robert, J. , DRING, Chris, W. , HUGHES, Jonathan
发明人： BOOCK, Robert, J. , DRING, Chris, W. , HUGHES, Jonathan
IPC分类号： A61B5/1473 , A61B5/1486 , A61B5/1468
CPC分类号： A61B5/14532 , A61B5/14503 , A61B5/1486 , A61B5/14865 , A61B5/6846 , A61B5/686 , A61B2562/125 , C12Q1/00 , G01N27/3271 , G01N27/333
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the devices include a membrane that has an interference domain designed to reduce the permeation of one or more interferents. The device can be a continuous analyte sensor 34 having a sensing mechanism adapted for insertion under the host's skin, with the remaining body of the sensor residing ex vivo. The analyte sensor 34 can include a working electrode 38 and at least one additional electrode 30, which may function as a counter or reference electrode.
摘要翻译：描述了用于提供分析物浓度的连续测量的装置和方法。在一些实施方案中，所述装置包括具有设计用于减少一种或多种干扰物的渗透的干扰域的膜。该装置可以是连续的分析物传感器34，其具有适于在主体皮肤下插入的感测机构，其中传感器的剩余体积离散。分析物传感器34可以包括工作电极38和至少一个额外的电极30，其可以用作反电极或参考电极。

4. 发明申请

WO2010033724A2 PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS 审中-公开
标题翻译：用于分析物传感器的含颗粒膜和颗粒电极
公开(公告)号：WO2010033724A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057347
申请日：2009-09-17
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BOOCK, Robert, J. , WIGHTLIN, Matthew , SCHULTS, Mark
发明人： SIMPSON, Peter, C. , BOOCK, Robert, J. , WIGHTLIN, Matthew , SCHULTS, Mark
IPC分类号： G01N27/26 , G01N27/30 , G01N33/48
CPC分类号： A61B5/1473 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/6848 , A61B2562/028
摘要： Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporealIy implanted. In a preferred embodiment, the sensor includes a membrane 32 having an electrode domain 43, an interference domain 44, and enzyme domain 46, a diffusion resistance domain 48, and a particle-containing domain 50 wrapped around a working electrode 38.
摘要翻译：提供涉及具有含颗粒区域的传感器的系统和使用方法，用于在宿主中进行连续分析物测量。在一些实施例中，连续分析物测量系统被配置为全部，经皮，血管内或体外植入。在优选实施例中，传感器包括具有电极区域43，干涉区域44和酶区域46的膜32，扩散阻力区域48和围绕工作电极38缠绕的含有粒子的区域50。 >

5. 发明申请

WO2007120442A2 DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：用于连续分析仪传感器的双电极系统
公开(公告)号：WO2007120442A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/007612
申请日：2007-03-27
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BRAUKER, James, H. , GOODE, Paul, V. , KAMATH, Apurv, U. , PETISCE, James, R. , WOO, Kum Ming , NICHOLAS, Melissa, A. , BOOCK, Robert, J. , RIXMAN, Monica, A. , BURD, John , RHODES, Rathbun, K. , TAPSAK, Mark, A.
发明人： SIMPSON, Peter, C. , BRAUKER, James, H. , GOODE, Paul, V. , KAMATH, Apurv, U. , PETISCE, James, R. , WOO, Kum Ming , NICHOLAS, Melissa, A. , BOOCK, Robert, J. , RIXMAN, Monica, A. , BURD, John , RHODES, Rathbun, K. , TAPSAK, Mark, A.
IPC分类号： A61B5/05
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , B33Y70/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor (10b). One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain. The sensor (10b) can include a glucose-measuring working electrode (16), an optional auxiliary working electrode (18), and at least one additional electrode (20), which may function as a counter and/or reference electrode.
摘要翻译：本文公开了用于连续分析物传感器的系统和方法，例如连续葡萄糖传感器（10b）。一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干扰域。传感器（10b）可以包括葡萄糖测量工作电极（16），可选的辅助工作电极（18）和至少一个可用作计数器和/或参考电极的附加电极（20）。

6. 发明申请

WO2016179559A2 SYSTEM AND METHOD FOR EDUCATING USERS, INCLUDING RESPONDING TO PATTERNS 审中-公开
标题翻译：用于教育用户的系统和方法，包括对图案的响应
公开(公告)号：WO2016179559A2
公开(公告)日：2016-11-10
申请号：PCT/US2016/031348
申请日：2016-05-06
申请人： DEXCOM, INC.
发明人： SIMPSON, Peter, C. , BOOCK, Robert, J. , DERENZY, David , DUNN, Laura, J. , JOHNSON, Matthew, Lawrence , KOEHLER, Katerine, Yerre , KAMATH, Apurv, Ullas , PAL, Andrew, Attila , PRICE, David , REIHMAN, Eli , WU, Mark
IPC分类号： G06F19/00
CPC分类号： G09B19/00 , A61B5/0022 , A61B5/0077 , A61B5/1112 , A61B5/1118 , A61B5/14532 , A61B5/14546 , A61B5/1495 , A61B5/4833 , A61B5/486 , A61B5/4866 , A61B5/4872 , A61B5/742 , A61B5/7435 , A61B5/7475 , A61B2562/0219 , G06F19/00 , G06F19/3456 , G06F19/3475 , G06F19/3481 , G09B19/0092 , G16H15/00 , G16H50/50 , Y02A90/26

7. 发明申请

WO2013022775A1 SYSTEMS AND METHODS FOR DETECTING GLUCOSE LEVEL DATA PATTERNS 审中-公开
标题翻译：用于检测葡萄糖水平数据模式的系统和方法
公开(公告)号：WO2013022775A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/049579
申请日：2012-08-03
申请人： DEXCOM, INC. , MAYOU, Phil , HAMPAPURAM, Hari , PRICE, David , WEINDEL, Keri , SNISARENKO, Kostyantyn , MENSINGER, Michael, Robert , BOWMAN, Leif, N. , BOOCK, Robert, J. , KAMATH, Apurv, Ullas , REIHMAN, Eli , SIMPSON, Peter, C.
发明人： MAYOU, Phil , HAMPAPURAM, Hari , PRICE, David , WEINDEL, Keri , SNISARENKO, Kostyantyn , MENSINGER, Michael, Robert , BOWMAN, Leif, N. , BOOCK, Robert, J. , KAMATH, Apurv, Ullas , REIHMAN, Eli , SIMPSON, Peter, C.
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： A61B5/14532 , G06F19/00 , G16H15/00 , G16H50/20 , G16H50/70 , Y02A90/26
摘要： Systems and methods for detecting and reporting patterns in analyte concentration data are provided. An implantable device (8) for continuous measurement of an analyte concentration is disclosed, including a sensor (10) configured to generate a signal indicative of a concentration of an analyte in a host, and a sensor electronics modure (12) including a memory configured to store data corresponding at least one of the generated signal and user information, and a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges, and can be displayed on various display devices (14), (16), (18), and/or (20).
摘要翻译：提供了用于检测和报告分析物浓度数据模式的系统和方法。公开了一种用于连续测量分析物浓度的可植入装置（8），包括配置成产生指示主体中分析物浓度的信号的传感器（10）和包括存储器配置的传感器电子模块（12）存储对应于所生成的信号和用户信息中的至少一个的数据，以及被配置为从所述存储器和所述传感器中的至少一个接收数据的处理器，其中所述处理器被配置为基于所接收的信息来生成模式数据，以及输出模块被配置为输出生成的模式数据。模式数据可以基于在临床危险范围内检测分析物数据的频率和严重程度，并且可以显示在各种显示装置（14），（16），（18）和/或（20）上。

8. 发明申请

WO2017117565A1 MEMBRANE LAYERS FOR ANALYTE SENSORS 审中-公开
标题翻译：用于分析传感器的膜层
公开(公告)号：WO2017117565A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069576
申请日：2016-12-30
申请人： DEXCOM, INC.
发明人： WANG, Shanger , BOOCK, Robert, J. , DENNIS, Andrew, Trinin , LEE, Ted, Tang , SURI, Jeff, T. , SZE, David , TAPSAK, Mark, A. , ZHANG, Huashi , ZHOU, Jiong
IPC分类号： A61B5/145 , A61B5/1486
CPC分类号： G01N27/3273 , A61B5/0004 , A61B5/002 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B2562/12 , A61K31/045 , A61K31/137 , A61K31/46 , A61K31/465 , A61K31/485 , A61K31/515 , A61K31/56 , A61K33/00 , A61K36/185 , A61K38/28 , C08G18/0828 , C08G18/12 , C08G18/3857 , C08G18/4018 , C08G18/44 , C08G18/4833 , C08G18/755 , C08L39/06 , C08L69/00 , C08L75/04 , C12N11/08 , C12Q1/002 , C12Q1/006 , G01N27/3275 , G01N33/66 , C08G18/3234
摘要： Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than -50C.
摘要翻译：公开了用于确定分析物浓度的装置（例如葡萄糖）。这些装置包括配置为产生与分析物浓度相关的信号的传感器和位于传感器上的传感膜。传感膜包括生物界面层，其与包含待测分析物的生物流体相接。生物界面层可以包含生物界面聚合物，其中生物界面聚合物包含聚氨酯和/或聚脲区段以及一个或多个两性离子重复单元。传感膜还可以包含酶层，其中酶层包含酶和包含聚氨酯和/或聚脲链段和一个或多个两性离子重复单元的聚合物。传感膜还可以包括扩散阻力层，其可以包含具有大于-50℃的最低Tg的基础聚合物。

9. 发明申请

WO2014052080A1 ZWITTERION SURFACE MODIFICATIONS FOR CONTINUOUS SENSORS 审中-公开
标题翻译：连续传感器的ZWITTERION表面改性
公开(公告)号：WO2014052080A1
公开(公告)日：2014-04-03
申请号：PCT/US2013/059981
申请日：2013-09-16
申请人： DEXCOM, INC.
发明人： BOOCK, Robert, J. , DRING, Chris, W.
IPC分类号： A61B5/1486 , A61B5/145
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , A61B5/1486
摘要： Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a continuous analyte sensor 34 configured to generate a signal associated with a concentration of an analyte, a reference electrode 30, and a sensing membrane 32 located over the working electrode 38. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.
摘要翻译：设备用于测量分析物浓度，例如主体中的葡萄糖。该装置可以包括连续的分析物传感器34，其被配置为产生与分析物的浓度相关联的信号，参考电极30和位于工作电极38上方的感测膜32.感测膜包括被配置为控制通过其分析物的通量。扩散阻力结构域包含一种或多种两性离子化合物和包含亲水和疏水区域的基础聚合物。

10. 发明申请

WO2014004457A1 METHOD FOR PROCESSING DATA FROM A CONTINUOUS GLUCOSE SENSOR 审中-公开
标题翻译：从连续葡萄糖传感器处理数据的方法
公开(公告)号：WO2014004457A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/047537
申请日：2013-06-25
申请人： DEXCOM, INC.
发明人： BHAVARAJU, Naresh, C. , BOHM, Sebastian , BOOCK, Robert, J. , RONG, Daiting , SIMPSON, Peter, C.
IPC分类号： A61B5/145 , A61B5/1486 , A61B5/1495
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1459 , A61B5/1473 , A61B5/14865 , A61B5/7221 , A61B5/7246 , A61B5/7278 , A61B2562/04
摘要： Disclosed herein are devices, systems, and methods for a continuous analyte sensor, such as a continuous glucose sensor. In certain embodiments disclosed herein, various in vivo properties of the sensor's surroundings can be measured. In some embodiments, the measured properties can be used to identify a physiological response or condition in the body. This information can then be used by a patient, doctor, or system to respond appropriately to the identified condition. For example, after implantation of a sensor, a physiological response may occur at some time after implantation. The sensor can be used to measure one or more properties of biological tissues surrounding the implant (100), the one or more measured parameters can be processed (102), and such measurements can subsequently be used to identify a physiological condition or response of the body or a sensor failure at (104), to determine a quality score (106), and to determine a proper response to a particular condition or quality score (108).
摘要翻译：本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的装置，系统和方法。在本文公开的某些实施例中，可以测量传感器周围环境的各种体内特性。在一些实施方案中，测量的性质可用于鉴定身体中的生理反应或状况。然后，该信息可被患者，医生或系统用于适当地响应所识别的状况。例如，植入传感器后，植入后的某个时刻可能会发生生理反应。该传感器可以用于测量围绕植入物（100）的生物组织的一个或多个性质，一个或多个测量参数可以被处理（102），并且随后可以使用这样的测量来识别生理条件（104）的身体或传感器故障，以确定质量得分（106），并确定对特定状况或质量得分的适当响应（108）。

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