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1. 发明申请

WO2017117469A1 DIFFUSION RESISTANCE LAYER FOR ANALYTE SENSORS 审中-公开
标题翻译：用于分析传感器的扩散阻抗层
公开(公告)号：WO2017117469A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069342
申请日：2016-12-29
申请人： DEXCOM, INC.
发明人： ZOU, Jiong , BOOCK, Robert, J. , DENNIS, Andrew, Trinin , LEE, Ted, Tang , SURI, Jeff, T. , SZE, David , TAPSAK, Mark, A. , WANG, Shanger , ZHANG, Huashi
IPC分类号： A61B5/1473 , A61B5/1486
CPC分类号： G01N27/3273 , A61B5/0004 , A61B5/002 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B2562/12 , A61K31/045 , A61K31/137 , A61K31/46 , A61K31/465 , A61K31/485 , A61K31/515 , A61K31/56 , A61K33/00 , A61K36/185 , A61K38/28 , C08G18/0828 , C08G18/12 , C08G18/3857 , C08G18/4018 , C08G18/44 , C08G18/4833 , C08G18/755 , C08L39/06 , C08L69/00 , C08L75/04 , C12N11/08 , C12Q1/002 , C12Q1/006 , G01N27/3275 , G01N33/66 , C08G18/3234
摘要： Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.
摘要翻译：公开了用于确定分析物浓度的装置（例如葡萄糖）。这些装置包括配置为产生与分析物浓度相关的信号的传感器和位于传感器上的传感膜。传感膜包含酶层，其中酶层包含酶和包含聚氨酯和/或聚脲段和一个或多个两性离子重复单元的聚合物。酶层保护酶并防止其从传感膜渗入宿主或失活。

2. 发明申请

WO2014047631A1 MULTIPLE ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR, AND RELATED METHODS 审中-公开
标题翻译：用于连续分析仪传感器的多电极系统及相关方法
公开(公告)号：WO2014047631A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/061420
申请日：2013-09-24
申请人： DEXCOM, INC.
发明人： SIMPSON, Peter C. , BOHM, Sebastian , BOOCK, Robert J. , WIGHTLIN, Matthew D. , ZHANG, Huashi
IPC分类号： A61B5/145 , A61B5/157
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/14865 , A61B2562/125 , C12Q1/002
摘要： In one embodiment, a continuous analyte sensor having more than one working electrode, and configured to reduce or eliminate crosstalk between the working electrodes. In another embodiment, a continuous analyte sensor having more than one working electrode, and configured so that a membrane system has equal thicknesses over each of the electrodes, despite having differing numbers of layers over each of the electrodes. In another embodiment, a configuration for connecting a continuous analyte sensor to sensor electronics. In another embodiment, methods for forming precise windows in an insulator material on a multi-electrode assembly. In another embodiment, a contact assembly for a continuous analyte sensor having more than one working electrode.
摘要翻译：在一个实施例中，连续分析物传感器具有多于一个的工作电极，并被配置为减少或消除工作电极之间的串扰。在另一个实施方案中，连续的分析物传感器具有多于一个的工作电极，并且被配置为使得膜系统在每个电极上具有相同的厚度，尽管在每个电极上具有不同数量的层。在另一个实施例中，用于将连续分析物传感器连接到传感器电子器件的配置。在另一个实施例中，用于在多电极组件上形成绝缘体材料中的精确窗口的方法。在另一个实施例中，用于具有多于一个工作电极的连续分析物传感器的接触组件。

3. 发明申请

WO2011003036A2 CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME 审中-公开
标题翻译：连续分析传感器及其制作方法
公开(公告)号：WO2011003036A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040839
申请日：2010-07-01
申请人： DEXCOM, INC. , BOOCK, Robert , JACKSON, Jeff , ZHANG, Huashi , MITCHELL, Jason
发明人： BOOCK, Robert , JACKSON, Jeff , ZHANG, Huashi , MITCHELL, Jason
IPC分类号： A61B5/155 , A61B5/145 , A61B5/157
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body 510 is advanced through a pre-coating treatment station 520, through a coating station 530, through a thickness control station 540, through a drying or curing station 550, through a thickness measurement station 560, and through a post-coating treatment station 570.
摘要翻译：这里描述了用于连续制造可植入的连续分析物传感器的方法和系统的实施方案。在一些实施例中，提供了一种用于使细长导电体顺序地前进穿过多个台的方法，每个台被构造成处理细长导电体。在这些实施例中的一些实施例中，一个或多个工位被配置为使用弯液面涂覆工艺涂覆细长导电体，由此制备由聚合物和溶剂形成的溶液，该溶液被连续循环以在保持溶液的容器的顶部，并且细长导电体前进通过弯液面。该方法还可以包括通过使细长导电体通过模头孔从细长导电体去除多余涂层材料的步骤。例如，提供的细长导电体510通过预涂处理站520，穿过涂覆站530，通过厚度控制站540，穿过干燥或固化站550，穿过厚度测量站560，并通过后涂层处理站570。

4. 发明申请

WO2017117565A1 MEMBRANE LAYERS FOR ANALYTE SENSORS 审中-公开
标题翻译：用于分析传感器的膜层
公开(公告)号：WO2017117565A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069576
申请日：2016-12-30
申请人： DEXCOM, INC.
发明人： WANG, Shanger , BOOCK, Robert, J. , DENNIS, Andrew, Trinin , LEE, Ted, Tang , SURI, Jeff, T. , SZE, David , TAPSAK, Mark, A. , ZHANG, Huashi , ZHOU, Jiong
IPC分类号： A61B5/145 , A61B5/1486
CPC分类号： G01N27/3273 , A61B5/0004 , A61B5/002 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B2562/12 , A61K31/045 , A61K31/137 , A61K31/46 , A61K31/465 , A61K31/485 , A61K31/515 , A61K31/56 , A61K33/00 , A61K36/185 , A61K38/28 , C08G18/0828 , C08G18/12 , C08G18/3857 , C08G18/4018 , C08G18/44 , C08G18/4833 , C08G18/755 , C08L39/06 , C08L69/00 , C08L75/04 , C12N11/08 , C12Q1/002 , C12Q1/006 , G01N27/3275 , G01N33/66 , C08G18/3234
摘要： Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than -50C.
摘要翻译：公开了用于确定分析物浓度的装置（例如葡萄糖）。这些装置包括配置为产生与分析物浓度相关的信号的传感器和位于传感器上的传感膜。传感膜包括生物界面层，其与包含待测分析物的生物流体相接。生物界面层可以包含生物界面聚合物，其中生物界面聚合物包含聚氨酯和/或聚脲区段以及一个或多个两性离子重复单元。传感膜还可以包含酶层，其中酶层包含酶和包含聚氨酯和/或聚脲链段和一个或多个两性离子重复单元的聚合物。传感膜还可以包括扩散阻力层，其可以包含具有大于-50℃的最低Tg的基础聚合物。

5. 发明申请

WO2009121026A1 POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS 审中-公开
标题翻译：用于连续分析仪传感器的聚合物膜
公开(公告)号：WO2009121026A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038678
申请日：2009-03-27
申请人： DEXCOM, INC. , BOOCK, Robert , RIXMAN, Monica, A. , ZHANG, Huashi , ESTES, Michael, J. , LAWRENCE, Kristina
发明人： BOOCK, Robert , RIXMAN, Monica, A. , ZHANG, Huashi , ESTES, Michael, J. , LAWRENCE, Kristina
IPC分类号： G01N27/00 , G01R33/00
CPC分类号： C12Q1/002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , C12Q1/006
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise- causing species. The sensing mechanism can be a sensor 34 that includes a membrane system 32 and two electrodes, i.e., a working electrode 38 and at least one additional electrode 30, which may function as a counter or reference electrode.
摘要翻译：描述了用于提供分析物浓度的连续测量的装置和方法。在一些实施例中，该装置具有感测机构和感测膜，其包括至少一个含表面活性基团的聚合物并且位于感测机构上方。感测膜可以具有构造成基本上阻挡非恒定噪声引起物质的影响和/或影响的生物保护层。感测机构可以是传感器34，其包括膜系统32和两个电极，即工作电极38和至少一个附加电极30，其可以用作反电极或参考电极。

6. 发明公开

EP4292528A1 MEMBRANE LAYERS FOR ANALYTE SENSORS 审中-实审
公开(公告)号：EP4292528A1
公开(公告)日：2023-12-20
申请号：EP23181721.4
申请日：2016-12-30
申请人： Dexcom, Inc.
发明人： WANG, Shanger , BOOCK, Robert J. , DENNIS, Andrew Trinin , LEE, Ted Tang , SURI, Jeff T. , SZE, David , TAPSAK, Mark A. , ZHANG, Huashi , ZOU, Jiong
IPC分类号： A61B5/145 , A61B5/1486 , A61B5/00 , A61K38/28 , A61K33/00 , C08G18/48 , C08G18/75 , C12Q1/00 , C08G18/08 , A61B5/1473 , C08G18/12 , C08G18/44 , C08L39/06 , C08L75/04 , G01N27/327 , C08G18/38 , C08G18/40 , C12N11/08 , C12N11/093 , C12N11/089
摘要： Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than -50C.

7. 发明公开

EP2257794A1 POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS 有权
标题翻译：聚丙烯腈
公开(公告)号：EP2257794A1
公开(公告)日：2010-12-08
申请号：EP09723677.2
申请日：2009-03-27
申请人： Dexcom, Inc.
发明人： BOOCK, Robert , RIXMAN, Monica, A. , ZHANG, Huashi , ESTES, Michael, J. , LAWRENCE, Kristina
IPC分类号： G01N27/00 , G01R33/00
CPC分类号： C12Q1/002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , C12Q1/006
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise- causing species. The sensing mechanism can be a sensor 34 that includes a membrane system 32 and two electrodes, i.e., a working electrode 38 and at least one additional electrode 30, which may function as a counter or reference electrode.
摘要翻译：描述了用于提供分析物浓度的连续测量的装置和方法。在一些实施例中，该装置具有感测机构和感测膜，其包括至少一个含表面活性基团的聚合物并且位于传感机构之上。感测膜可以具有构造成基本上阻挡非恒定噪声产生物质的影响和/或影响的生物保护层。

8. 发明授权

EP2257794B1 POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS 有权
标题翻译：用于连续分析传感器的聚合物膜
公开(公告)号：EP2257794B1
公开(公告)日：2018-05-09
申请号：EP09723677.2
申请日：2009-03-27
申请人： Dexcom, Inc.
发明人： BOOCK, Robert , RIXMAN, Monica, A. , ZHANG, Huashi , ESTES, Michael, J. , LAWRENCE, Kristina
IPC分类号： A61B5/145 , A61B5/1486 , C12Q1/00 , G01N27/40
CPC分类号： C12Q1/002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , C12Q1/006
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

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