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1. 发明申请

WO2010033724A2 PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS 审中-公开
标题翻译：用于分析物传感器的含颗粒膜和颗粒电极
公开(公告)号：WO2010033724A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057347
申请日：2009-09-17
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BOOCK, Robert, J. , WIGHTLIN, Matthew , SCHULTS, Mark
发明人： SIMPSON, Peter, C. , BOOCK, Robert, J. , WIGHTLIN, Matthew , SCHULTS, Mark
IPC分类号： G01N27/26 , G01N27/30 , G01N33/48
CPC分类号： A61B5/1473 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/6848 , A61B2562/028
摘要： Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporealIy implanted. In a preferred embodiment, the sensor includes a membrane 32 having an electrode domain 43, an interference domain 44, and enzyme domain 46, a diffusion resistance domain 48, and a particle-containing domain 50 wrapped around a working electrode 38.
摘要翻译：提供涉及具有含颗粒区域的传感器的系统和使用方法，用于在宿主中进行连续分析物测量。在一些实施例中，连续分析物测量系统被配置为全部，经皮，血管内或体外植入。在优选实施例中，传感器包括具有电极区域43，干涉区域44和酶区域46的膜32，扩散阻力区域48和围绕工作电极38缠绕的含有粒子的区域50。 >

2. 发明申请

WO2007120442A2 DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：用于连续分析仪传感器的双电极系统
公开(公告)号：WO2007120442A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/007612
申请日：2007-03-27
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BRAUKER, James, H. , GOODE, Paul, V. , KAMATH, Apurv, U. , PETISCE, James, R. , WOO, Kum Ming , NICHOLAS, Melissa, A. , BOOCK, Robert, J. , RIXMAN, Monica, A. , BURD, John , RHODES, Rathbun, K. , TAPSAK, Mark, A.
发明人： SIMPSON, Peter, C. , BRAUKER, James, H. , GOODE, Paul, V. , KAMATH, Apurv, U. , PETISCE, James, R. , WOO, Kum Ming , NICHOLAS, Melissa, A. , BOOCK, Robert, J. , RIXMAN, Monica, A. , BURD, John , RHODES, Rathbun, K. , TAPSAK, Mark, A.
IPC分类号： A61B5/05
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , B33Y70/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor (10b). One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain. The sensor (10b) can include a glucose-measuring working electrode (16), an optional auxiliary working electrode (18), and at least one additional electrode (20), which may function as a counter and/or reference electrode.
摘要翻译：本文公开了用于连续分析物传感器的系统和方法，例如连续葡萄糖传感器（10b）。一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干扰域。传感器（10b）可以包括葡萄糖测量工作电极（16），可选的辅助工作电极（18）和至少一个可用作计数器和/或参考电极的附加电极（20）。

3. 发明申请

WO2013022775A1 SYSTEMS AND METHODS FOR DETECTING GLUCOSE LEVEL DATA PATTERNS 审中-公开
标题翻译：用于检测葡萄糖水平数据模式的系统和方法
公开(公告)号：WO2013022775A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/049579
申请日：2012-08-03
申请人： DEXCOM, INC. , MAYOU, Phil , HAMPAPURAM, Hari , PRICE, David , WEINDEL, Keri , SNISARENKO, Kostyantyn , MENSINGER, Michael, Robert , BOWMAN, Leif, N. , BOOCK, Robert, J. , KAMATH, Apurv, Ullas , REIHMAN, Eli , SIMPSON, Peter, C.
发明人： MAYOU, Phil , HAMPAPURAM, Hari , PRICE, David , WEINDEL, Keri , SNISARENKO, Kostyantyn , MENSINGER, Michael, Robert , BOWMAN, Leif, N. , BOOCK, Robert, J. , KAMATH, Apurv, Ullas , REIHMAN, Eli , SIMPSON, Peter, C.
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： A61B5/14532 , G06F19/00 , G16H15/00 , G16H50/20 , G16H50/70 , Y02A90/26
摘要： Systems and methods for detecting and reporting patterns in analyte concentration data are provided. An implantable device (8) for continuous measurement of an analyte concentration is disclosed, including a sensor (10) configured to generate a signal indicative of a concentration of an analyte in a host, and a sensor electronics modure (12) including a memory configured to store data corresponding at least one of the generated signal and user information, and a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges, and can be displayed on various display devices (14), (16), (18), and/or (20).
摘要翻译：提供了用于检测和报告分析物浓度数据模式的系统和方法。公开了一种用于连续测量分析物浓度的可植入装置（8），包括配置成产生指示主体中分析物浓度的信号的传感器（10）和包括存储器配置的传感器电子模块（12）存储对应于所生成的信号和用户信息中的至少一个的数据，以及被配置为从所述存储器和所述传感器中的至少一个接收数据的处理器，其中所述处理器被配置为基于所接收的信息来生成模式数据，以及输出模块被配置为输出生成的模式数据。模式数据可以基于在临床危险范围内检测分析物数据的频率和严重程度，并且可以显示在各种显示装置（14），（16），（18）和/或（20）上。

4. 发明申请

WO2012050926A2 ADVANCED CONTINUOUS ANALYTE MONITORING SYSTEM 审中-公开
标题翻译：先进的连续分析监测系统
公开(公告)号：WO2012050926A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/053777
申请日：2011-09-28
申请人： DEXCOM, INC. , BOHM, Sebastian , DERVAES, Mark , JOHNSON, Eric , KAMATH, Apurv, Ullas , LARVENZ, Shawn , LEACH, Jacob, S. , LIEU, Phong , MAHALINGAM, Aarthi , MILLER, Tom , NEALE, Paul, V. , PRYOR, Jack , PEYSER, Thomas, A. , RONG, Daiting , SAN VICENTE, Ken , SHARIATI, Mohammad, Ali , SIMPSON, Peter, C. , WIGHTLIN, Matthew
发明人： BOHM, Sebastian , DERVAES, Mark , JOHNSON, Eric , KAMATH, Apurv, Ullas , LARVENZ, Shawn , LEACH, Jacob, S. , LIEU, Phong , MAHALINGAM, Aarthi , MILLER, Tom , NEALE, Paul, V. , PRYOR, Jack , PEYSER, Thomas, A. , RONG, Daiting , SAN VICENTE, Ken , SHARIATI, Mohammad, Ali , SIMPSON, Peter, C. , WIGHTLIN, Matthew
IPC分类号： A61B5/145 , A61B5/157 , H04B7/24
CPC分类号： A61B5/14532 , A61B5/14507 , A61B5/1451 , G06F1/3203
摘要： The present invention relates generally to systems and methods for processing, transmitting, and displaying data received from continuous analyte sensor (10), such as a glucose sensor. In some embodiments, the continuous analyte sensor system (8) comprises a sensor electronics module (12) that includes power saving features. One feature includes a low power measurement circuit that can be switched between a measurement mode and a low power mode, in which charging circuitry continues to apply power to electrodes of a sensor during the low power mode. In addition, the sensor electronics module can be switched between in a low power storage mode higher power operational mode via a switch. The switch can include a reed switch or optical switch, for example. A validation routine can also be implemented to ensure an interrupt signal sent from the switch is valid. The continuous analyte sensor (10) can be physically connected to a sensor electronics module (12), which is in direct wireless communication with a plurality of different display devices (14, 16, 18), and/or (20).
摘要翻译：本发明总体上涉及处理，传输和显示从连续分析物传感器（10）例如葡萄糖传感器接收的数据的系统和方法。在一些实施例中，连续分析物传感器系统（8）包括包含省电特征的传感器电子模块（12）。一种功能包括可在测量模式和低功率模式之间切换的低功率测量电路，其中充电电路在低功率模式期间继续向传感器的电极施加功率。另外，传感器电子模块可以通过开关在低功率存储模式的高功率操作模式之间切换。例如，开关可以包括簧片开关或光开关。还可以实施验证程序以确保从交换机发送的中断信号有效。连续分析物传感器（10）可以物理连接到与多个不同显示装置（14,16,18）和/或（20）直接无线通信的传感器电子模块（12）。 p>

5. 发明申请

WO2011003039A2 ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME 审中-公开
标题翻译：分析传感器及其制造方法
公开(公告)号：WO2011003039A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040842
申请日：2010-07-01
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BOOCK, Robert , NEALE, Paul, V. , BOHM, Sebastian , WIGHTLIN, Matthew , PRYOR, Jack , MITCHELL, Jason , JACKSON, Jeff , PATEL, Kaushik , LLEVARES, Antonio, C.
发明人： SIMPSON, Peter, C. , BOOCK, Robert , NEALE, Paul, V. , BOHM, Sebastian , WIGHTLIN, Matthew , PRYOR, Jack , MITCHELL, Jason , JACKSON, Jeff , PATEL, Kaushik , LLEVARES, Antonio, C.
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies El, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies El, E2, and working electrodes 802', 802" formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies El, E2.
摘要翻译：提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成;绝缘层810，其将导电层820与细长主体分离;膜层，通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。

6. 发明申请

WO2011003035A2 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2011003035A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040838
申请日：2010-07-01
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BOOCK, Robert , KAMATH, Apurv, Ullas , WIGHTLIN, Matthew , ESTES, Michael, J.
发明人： SIMPSON, Peter, C. , BOOCK, Robert , KAMATH, Apurv, Ullas , WIGHTLIN, Matthew , ESTES, Michael, J.
IPC分类号： A61B5/145 , A61B5/1468
CPC分类号： A61B5/1473 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2560/0223 , A61B2562/0209 , A61B2562/043 , A61B2562/125 , B05C3/10
摘要： Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104, and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.
摘要翻译：提供了用于连续测量分析物浓度的装置和方法。该装置可以包括具有多个传感器元件的传感器，每个传感器元件具有与装置的其它传感器不同的至少一个特性。在一些实施例中，多个传感器元件各自被调谐以测量分析物浓度的不同范围，从而为器件提供在生理学相关范围内实现基本一致的测量精度水平的能力。在其他实施例中，该装置包括多个传感器元件，每个传感器元件在插入或植入之后的不同时间期间被调整以测量，从而为传感器提供在宽范围的时间段内连续且精确地测量分析物浓度的能力。例如，传感器系统180被提供有具有包括第一传感器元件102的第一工作电极150和包括第二传感器元件104的第二工作电极160以及用于提供用于测量工作电极电位的参考值的参考电极108 的传感器元件102,104。

7. 发明申请

WO2011041463A2 TRANSCUTANEOUS ANALYTE SENSOR 审中-公开
标题翻译：经皮分析传感器
公开(公告)号：WO2011041463A2
公开(公告)日：2011-04-07
申请号：PCT/US2010/050788
申请日：2010-09-29
申请人： DEXCOM, INC. , NEALE, Paul, V. , BOOCK, Robert , BOHM, Sebastian , SIMPSON, Peter, C. , BRAUKER, James
发明人： NEALE, Paul, V. , BOOCK, Robert , BOHM, Sebastian , SIMPSON, Peter, C. , BRAUKER, James
IPC分类号： A61B5/151 , A61B5/157
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译：提供经配置用于连续测量宿主中的分析物浓度的经皮传感器装置。在一些实施例中，经皮传感器装置100包括被配置用于插入宿主的皮肤180下方的体内部分160和被配置为在传感器插入到主体的传感器之后保持在宿主的皮肤180的表面上方的离体部分170 体内部分。体内部分可以包括被配置用于刺穿主体的皮肤180的组织刺穿元件110和包括材料或支撑构件130的传感器主体120，该传感器主体120提供足够的柱强度以允许传感器主体可以在宿主组织中大量屈曲。离体部分170可以被配置成包括（或可操作地连接到）传感器电子单元并且可以包括安装单元150.这里还描述了传感器主体和组织穿透元件的各种配置，其可以用于保护传感器主体的膜。

8. 发明申请

WO2005057173A2 SYSTEMS AND METHODS FOR IMPROVING ELECTROCHEMICAL ANALYTE SENSORS 审中-公开
标题翻译：改进电化学分析仪传感器的系统和方法
公开(公告)号：WO2005057173A2
公开(公告)日：2005-06-23
申请号：PCT/US2004/040913
申请日：2004-12-07
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BRAUKER, James, H. , CARR-BRENDEL, Victoria , GOODE, JR., Paul, V. , TAPSAK, Mark
发明人： SIMPSON, Peter, C. , BRAUKER, James, H. , CARR-BRENDEL, Victoria , GOODE, JR., Paul, V. , TAPSAK, Mark
IPC分类号： G01N
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/14865 , C12Q1/006 , G01N27/3274
摘要： An analyte-measuring device, particularly an electrochemical sensor, is provided for measuring current values at multiple bias potential settings to assess the quality of the analyte measurement, identify interference in the signal, and calculate substantially interference-free analyte concentration measurements. The device and method are suitable for calculating substantially interference-free analyte concentration measurements when glucose is the analyte and acetaminophen is an interfering species.
摘要翻译：提供分析物测量装置，特别是电化学传感器，用于在多个偏置电位设置下测量电流值，以评估分析物测量的质量，识别信号中的干扰，并计算基本无干扰的分析物浓度测量。当葡萄糖是分析物和对乙酰氨基酚是干扰物质时，该装置和方法适合于计算基本无干扰的分析物浓度测定。

9. 发明申请

WO2009120240A1 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2009120240A1
公开(公告)日：2009-10-01
申请号：PCT/US2008/082905
申请日：2008-11-07
申请人： DEXCOM, INC. , KAMATH, Apurv, U. , LEACH, Jacob, S. , ESTES, Michael, J. , SHARIATI, Mohammad, Ali , NEALE, Paul, V. , SIMPSON, Peter, C. , YANG, Richard, C. , BOOCK, Robert , LI, Ying
发明人： KAMATH, Apurv, U. , LEACH, Jacob, S. , ESTES, Michael, J. , SHARIATI, Mohammad, Ali , NEALE, Paul, V. , SIMPSON, Peter, C. , YANG, Richard, C. , BOOCK, Robert , LI, Ying
IPC分类号： A61B5/0245
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/412 , A61B5/7275 , A61M39/10 , A61M2039/1077 , A61M2205/3303
摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system (10) includes a vascular access device (12), a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
摘要翻译：提供了用于宿主血管系统的连续分析物测量的系统和方法。在一些实施例中，连续葡萄糖测量系统（10）包括血管进入装置（12），传感器和传感器电子装置，所述系统被配置为插入与主机的循环系统的通信。

10. 发明申请

WO2007002189A2 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2007002189A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/024132
申请日：2006-06-20
申请人： DEXCOM, INC. , DOBBLES, J., Michael , BRISTER, Mark , BRAUKER, James, H. , KAMATH, Apurv, Ullas , KLINE, Daniel, S. , MASTERSON, Steve , MENSINGER, Michael, Robert , SAINT, Sean , SIMPSON, Peter, C.
发明人： DOBBLES, J., Michael , BRISTER, Mark , BRAUKER, James, H. , KAMATH, Apurv, Ullas , KLINE, Daniel, S. , MASTERSON, Steve , MENSINGER, Michael, Robert , SAINT, Sean , SIMPSON, Peter, C.
IPC分类号： A61B5/05
CPC分类号： A61B5/1451 , A61B5/0031 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/6832 , A61B5/6833 , A61B5/6848 , A61B5/6849 , A61B5/7264 , A61B5/742 , A61B2560/0223 , A61B2560/0276 , A61B2560/028 , A61L2/12 , A61L2/206 , G06F19/00 , Y02A90/22 , Y02A90/26 , Y10T29/49004
摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. The system can include an applicator 12, a mounting unit 14, and an electronics unit 16.
摘要翻译：本发明一般涉及用于测量宿主中分析物的系统和方法。更具体地说，本发明涉及用于经皮测量宿主中的葡萄糖的系统和方法。该系统可以包括施加器12，安装单元14和电子单元16。

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