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1. 发明授权

US06180288B2 Gel sensors and method of use thereof 失效
标题翻译：凝胶传感器及其使用方法
公开(公告)号：US06180288B2
公开(公告)日：2001-01-30
申请号：US08821464
申请日：1997-03-21
申请人： Dennis S. Everhart , Rosann M. Kaylor , Mark L. Jones
发明人： Dennis S. Everhart , Rosann M. Kaylor , Mark L. Jones
IPC分类号： G03F716
CPC分类号： G03F7/00 , B82Y10/00 , B82Y40/00 , G01N33/54373 , G03F7/0002 , G03F7/165 , G03H2001/0033
摘要： The present invention comprises an optically diffracting sensing device whose diffraction pattern changes upon exposure to some stimuli. The diffraction pattern may be two or three dimensional, and in one embodiment the change in diffraction patterns is recognizable to the untrained eye. The device comprises one or more gels coated onto patterned, self-assembling monolayers of alkanethiolates, carboxylic acids, hydroxamic acids, and phosphonic acids printed onto a variety of substrates, including glass, silicon, aluminum oxide, and thermoplastic films metallized with gold, or with an alloy such as nickel/gold. The present invention also comprises the method of making this device, and the use of this device.
摘要翻译：本发明包括一种光学衍射感测装置，其衍射图案在暴露于一些刺激物时改变。衍射图案可以是二维或三维，并且在一个实施例中，未经训练的眼睛可以识别衍射图案的变化。该装置包括一个或多个涂布在图案化的自组装单链烷烃硫醇盐，羧酸，异羟肟酸和膦酸上的凝胶，印刷在各种基材上，包括用金金属化的玻璃，硅，氧化铝和热塑性薄膜，或使用镍/金等合金。本发明还包括制造该装置的方法以及该装置的使用。

2. 发明授权

US06573040B2 Patterned binding of functionalized microspheres for optical diffraction-based biosensors 有权
$Patterned binding of functionalized microspheres for optical diffraction-based biosensors$
标题翻译：用于光学衍射的生物传感器的官能化微球的图案化结合
公开(公告)号：US06573040B2
公开(公告)日：2003-06-03
申请号：US09733204
申请日：2000-12-08
申请人： Dennis S. Everhart , Rosann M. Kaylor , Kevin McGrath
发明人： Dennis S. Everhart , Rosann M. Kaylor , Kevin McGrath
IPC分类号： G01N33567
CPC分类号： G01N33/54346 , B01J2219/00382 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , C40B60/14 , G01N21/4788 , G01N33/54373 , G01N33/553
摘要： The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as functionalized microspheres, which are modified such that they are capable of binding with a target analyte. Additionally, the system comprises a polymer film, which may include a metal coating, upon which is printed a specific, predetermined pattern of a analyte-specific receptors. Upon attachment of a target analyte to select areas of the polymer film, either directly or with the diffraction enhancing element, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.
摘要翻译：本发明提供了用于检测介质中存在的分析物的廉价且敏感的系统和方法。该系统包括衍射增强元件，例如功能化微球，其被修饰使得它们能够与靶分析物结合。此外，该系统包括聚合物膜，其可以包括金属涂层，在其上印刷特定的预定图案的分析物特异性受体。当将目标分析物直接或与衍射增强元件连接到聚合物膜的选择区域时，透射和/或反射光的衍射通过物理尺寸和限定的精确放置分析物而发生。产生可以用眼睛或可选地用感测装置容易地看到的衍射图像。

3. 发明授权

US5603830A Caffeine adsorbent liquid filter with integrated adsorbent 失效
标题翻译：咖啡因吸附剂液体过滤器与集成吸附剂
公开(公告)号：US5603830A
公开(公告)日：1997-02-18
申请号：US448801
申请日：1995-05-24
申请人： Dennis S. Everhart , Rosann M. Kaylor , Kenneth R. Smith
发明人： Dennis S. Everhart , Rosann M. Kaylor , Kenneth R. Smith
IPC分类号： A23F3/38 , A23F5/22 , B01J20/28 , B01D39/00
CPC分类号： B01J20/28028 , A23F3/385 , A23F5/223 , B01J20/28033
摘要： An adsorbent filter for removing caffeine from liquids. The filter is composed of a matrix of fibrous material; and adsorbent particulate material integrated within the matrix of fibrous material, so that passage of a liquid having a caffeine concentration ranging from about 20 to about 100 mg per 100 mL of liquid through the matrix for a contact time of less than about 2 minutes results in at least a 40 percent reduction in the caffeine concentration of the liquid. The matrix of fibrous material may be selected from woven fabrics, knit fabrics and nonwoven fabrics. The adsorbent material may be clay minerals such as, for example, smectite clay minerals. Examples of smectite clay minerals include, bentonite clays and montmorillonite clays. Generally speaking, the filter can be adapted to provide at least a 40 percent reduction in the caffeine concentration for about 1 cup to about 40 cups of a liquid.
摘要翻译：用于从液体中去除咖啡因的吸附剂过滤器。过滤器由纤维材料基体组成; 以及整合在纤维材料基质内的吸附剂颗粒材料，使得咖啡因浓度范围为每100mL液体约20至约100mg的液体通过基质，接触时间小于约2分钟，导致咖啡因浓度至少降低40％。纤维材料的基质可以选自机织织物，针织织物和非织造织物。吸附剂材料可以是粘土矿物，例如蒙脱石粘土矿物。蒙皂石粘土矿物的实例包括膨润土和蒙脱石粘土。一般来说，过滤器可以适合于提供约1杯至约40杯液体的咖啡因浓度的至少40％的降低。

4. 发明授权

US06579673B2 Patterned deposition of antibody binding protein for optical diffraction-based biosensors 有权
$Patterned deposition of antibody binding protein for optical diffraction-based biosensors$
标题翻译：用于光学衍射的生物传感器的抗体结合蛋白的图案沉积
公开(公告)号：US06579673B2
公开(公告)日：2003-06-17
申请号：US09213713
申请日：1998-12-17
申请人： Kevin McGrath , Rosann M. Kaylor , Dennis S. Everhart
发明人： Kevin McGrath , Rosann M. Kaylor , Dennis S. Everhart
IPC分类号： G01N33543
CPC分类号： G01N21/4788 , B01J19/0046 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , C40B60/14 , G01N33/54353 , G01N33/54373 , Y10S435/817 , Y10S436/805 , Y10S436/807
摘要： The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of an antibody-binding proteins. Upon attachment of a target analyte to select areas of the plastic film upon which the protein is printed, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.
摘要翻译：本发明提供了用于检测和定量存在于介质中的分析物的廉价且敏感的装置和方法。该装置包括金属化膜，在其上印刷特定的预定图案的抗体结合蛋白。当将目标分析物附着到选择蛋白质印刷的塑料膜的区域时，通过物理尺寸和分析物的精确放置进行发射和/或反射光的衍射。产生可以用眼睛或可选地用感测装置容易地看到的衍射图像。

5. 发明授权

US06221579B1 Patterned binding of functionalized microspheres for optical diffraction-based biosensors 有权
$Patterned binding of functionalized microspheres for optical diffraction-based biosensors$
公开(公告)号：US06221579B1
公开(公告)日：2001-04-24
申请号：US09210016
申请日：1998-12-11
申请人： Dennis S. Everhart , Rosann M. Kaylor , Kevin McGrath
发明人： Dennis S. Everhart , Rosann M. Kaylor , Kevin McGrath
IPC分类号： G01N33567
CPC分类号： G01N33/54346 , B01J2219/00382 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , C40B60/14 , G01N21/4788 , G01N33/54373 , G01N33/553
摘要： The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as functionalized microspheres, which are modified such that they are capable of binding with a target analyte. Additionally, the system comprises a polymer film, which may include a metal coating, upon which is printed a specific, predetermined pattern of a analyte-specific receptors. Upon attachment of a target analyte to select areas of the polymer film, either directly or with the diffraction enhancing element, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.

6. 发明授权

US06436651B1 Optical diffraction biosensor 有权
$Optical diffraction biosensor$
标题翻译：光学衍射生物传感器
公开(公告)号：US06436651B1
公开(公告)日：2002-08-20
申请号：US09503554
申请日：2000-02-11
申请人： Dennis S. Everhart , Mark L. Jones , Rosann Marie Kaylor
发明人： Dennis S. Everhart , Mark L. Jones , Rosann Marie Kaylor
IPC分类号： G01N3353
CPC分类号： A61F13/42 , C23F1/02 , C23F1/40 , G01N21/4788 , G03H1/0244 , G03H1/182 , G03H2001/0044 , G03H2001/0491 , G03H2001/2655 , G03H2270/55 , Y10S435/808 , Y10S436/805
摘要： The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of analyte-specific receptors. Upon attachment of a target analyte to select areas of the plastic film upon which the receptor is printed, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.
摘要翻译：本发明提供了用于检测和定量存在于介质中的分析物的廉价且敏感的装置和方法。该装置包括金属化膜，在其上印刷特定的预定图案的分析物特异性受体。在将目标分析物附着到选择受体的塑料薄膜的选择区域时，透射和/或反射光的衍射通过分析物的物理尺寸和定义的精确放置而发生。产生可以用眼睛或可选地用感测装置容易地看到的衍射图像。

7. 发明授权

US6060256A Optical diffraction biosensor 失效
$Optical diffraction biosensor$
公开(公告)号：US6060256A
公开(公告)日：2000-05-09
申请号：US991644
申请日：1997-12-16
申请人： Dennis S. Everhart , Mark L. Jones , Rosann Marie Kaylor
发明人： Dennis S. Everhart , Mark L. Jones , Rosann Marie Kaylor
IPC分类号： A61F13/42 , B41M3/00 , G01N21/47 , G01N33/567 , G01N21/00 , G01N33/48 , G01N33/566
CPC分类号： A61F13/42 , G01N21/4788 , G03H1/0244 , G03H1/182 , G03H2001/0044 , G03H2001/0491 , G03H2001/2655 , G03H2270/55 , Y10S435/808 , Y10S436/805
摘要： The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of analyte-specific receptors. Upon attachment of a target analyte to select areas of the plastic film upon which the receptor is printed, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.

8. 发明授权

US06626961B1 Nonwovens modified with petrolatum 有权
标题翻译：用凡士林改性的无纺布
公开(公告)号：US06626961B1
公开(公告)日：2003-09-30
申请号：US09559566
申请日：2000-04-27
申请人： Dennis S. Everhart , Ali Yahiaoui
发明人： Dennis S. Everhart , Ali Yahiaoui
IPC分类号： D06Q102
CPC分类号： A61K8/062 , A61K8/0208 , A61K8/31 , A61K8/342 , A61K8/86 , A61L15/34 , A61L15/48 , A61Q19/00 , D06M13/02 , D06M13/144 , D06M13/165 , D06M13/224 , D06M15/03 , D06M23/04
摘要： A lotion alternative, namely a nonwoven fabric treated with an aqueous-based petrolatum-surfactant mixture, simultaneously imparts fluid handling and skin health benefits during product use. The petrolatum-surfactant mixture can be applied to the nonwoven fabric by a foaming process. The foaming process is compatible with existing commercial nonwoven production equipment and in-line high production rates.
摘要翻译：乳液替代品，即用水性凡士林 - 表面活性剂混合物处理的非织造织物，同时在产品使用期间赋予流体处理和皮肤健康益处。凡士林 - 表面活性剂混合物可以通过发泡法施加到无纺织物上。发泡过程与现有的商业非织造布生产设备兼容，并且生产率高。

9. 发明授权

US5500254A Coated polymeric fabric having durable wettability and reduced adsorption of protein 失效
公开(公告)号：US5500254A
公开(公告)日：1996-03-19
申请号：US170598
申请日：1993-12-21
申请人： Roger B. Quincy, III , Ronald S. Nohr , John G. MacDonald , Elizaeth D. Gadsby , Dennis S. Everhart
发明人： Roger B. Quincy, III , Ronald S. Nohr , John G. MacDonald , Elizaeth D. Gadsby , Dennis S. Everhart
IPC分类号： A61F13/511 , A61F5/44 , A61F13/15 , A61F13/20 , A61F13/49 , A61L15/48 , B32B27/32 , C09D183/12 , D06M15/643 , D06M15/647 , B32B27/00 , B32B9/00
CPC分类号： D06M15/647 , A61L15/48 , C09D183/12 , Y10S428/903 , Y10T442/2484 , Y10T442/2492 , Y10T442/2549 , Y10T442/291
摘要： A method of durably rendering a polymeric fabric, e.g., a polyolefin fabric, wettable and resistant to protein adsorption. The method involves providing a polymeric fabric having a surface, applying to the surface of the polymeric fabric a composition which includes water and a surfactant adapted to durably render the polymeric fabric resistant to protein adsorption, and drying the polymeric fabric. The surfactant has a solubility in water at 20.degree. C. no greater than about 5 percent by weight, based on the weight of the water, and is present on the polymeric fabric in an amount of the surfactant sufficient to reduce the adsorption of the protein by the fabric. The coated fabric not only exhibits durable reduced adsorption of protein but also has durable wettability by aqueous liquids. The coated fabric is especially suited for incorporation in such disposable absorbent articles as diapers, feminine care products, such as sanitary napkins and tampons, incontinent care products, training pants, wipes, and the like.

10. 发明授权

US5534335A Nonwoven fabric formed from alloy fibers 失效
标题翻译：由合金纤维形成的无纺布
公开(公告)号：US5534335A
公开(公告)日：1996-07-09
申请号：US320098
申请日：1994-10-07
申请人： Dennis S. Everhart , Mary L. Delucia , Terry K. Timmons , Robert D. Wright
发明人： Dennis S. Everhart , Mary L. Delucia , Terry K. Timmons , Robert D. Wright
IPC分类号： D01F8/06 , D01F8/12 , D04H1/42 , D04H1/54 , D03D3/00
CPC分类号： D04H1/54 , D01F8/06 , D01F8/12 , D04H1/4291 , D04H1/4334 , D04H1/4374 , D04H1/4382 , Y10T428/2929 , Y10T428/2933 , Y10T442/622 , Y10T442/66 , Y10T442/68 , Y10T442/681
摘要： A nonwoven fabric is provided which is made from fibers comprising at least two thermoplastic polymers and a compatibilizer. One of the thermoplastic polymers is present as a dominant continuous phase and the other one or more polymers are present as a non-continuous phase or phases. The polymer of the non-continuous phase or phases has a polymer melt temperature less than 30.degree. C. below the polymer melt temperature of the continuous phase. The polymer of the dominant phase may be, for example, polypropylene and the non-continuous phase may be, for example, polyamide. The compatibilizer may be one of several such as zinc ionomers of ethylenemethacrylic acid or modified polypropylene with maleic anhydride. The fibers from which the fabric is made are generally between about 5 and 50 microns in diameter and the non-continuous phase may exist within the continuous phase as fibrils with a cross-sectional area at least 0.1% of the cross-sectional area of the fiber.
摘要翻译：提供由包含至少两种热塑性聚合物和增容剂的纤维制成的非织造织物。一种热塑性聚合物作为显性连续相存在，而另一种或多种聚合物作为非连续相或相存在。非连续相或聚合物的聚合物的聚合物熔体温度低于连续相聚合物熔体温度30℃以下。主要相的聚合物可以是例如聚丙烯，非连续相可以是例如聚酰胺。增容剂可以是几种之一，例如乙烯·甲基丙烯酸的锌离聚物或具有马来酸酐的改性聚丙烯。制造织物的纤维通常在直径约5至50微米之间，并且非连续相可以作为原纤维存在于连续相中，其中横截面积为截面面积的至少0.1％纤维。

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