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1. 发明授权

US08754107B2 Aminopyrrolidines as chemokine receptor antagonists 失效
标题翻译：氨基吡咯烷作为趋化因子受体拮抗剂
公开(公告)号：US08754107B2
公开(公告)日：2014-06-17
申请号：US11985724
申请日：2007-11-16
申请人： Dawn M. George , Richard W. Dixon , Michael Friedman , Adrian D. Hobson , Biqin Li , Lu Wang , Xiaoyun Wu , Neil Wishart
发明人： Dawn M. George , Richard W. Dixon , Michael Friedman , Adrian D. Hobson , Biqin Li , Lu Wang , Xiaoyun Wu , Neil Wishart
IPC分类号： A61K31/553 , A61K31/55 , A61K31/5377 , A61K31/506 , A61K31/517 , A61K31/4709 , A61K31/4545 , A61K31/454 , A61K31/4747 , A61K31/438 , A61K31/437 , C07D487/04 , C07D487/10 , C07D487/14 , C07D471/10 , C07D471/04 , C07D417/14 , C07D413/14 , C07D401/14 , C07D401/04
CPC分类号： A61K31/454 , A61K31/437 , A61K31/438 , A61K31/4545 , A61K31/4709 , A61K31/4747 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/55 , A61K31/553 , C07D207/14 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D487/14
摘要： The present invention is directed to novel aminopyrrolidines of formula I pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compounds of formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
摘要翻译：本发明涉及式I的药学上可接受的盐的新型氨基吡咯烷，其代谢物，其异构体，其立体异构体或其前体药物，其中变量如本文所定义。式（I）化合物可用作趋化因子受体拮抗剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如癌症。

2. 发明申请

US20080176883A1 Aminopyrrolidines as chemokine receptor antagonists 失效
标题翻译：氨基吡咯烷作为趋化因子受体拮抗剂
公开(公告)号：US20080176883A1
公开(公告)日：2008-07-24
申请号：US11985724
申请日：2007-11-16
申请人： Dawn M. George , Richard W. Dixon , Michael Friedman , Adrian D. Hobson , Biqin Li , Lu Wang , Xiaoyun Wu , Neil Wishart
发明人： Dawn M. George , Richard W. Dixon , Michael Friedman , Adrian D. Hobson , Biqin Li , Lu Wang , Xiaoyun Wu , Neil Wishart
IPC分类号： A61K31/438 , C07D471/04 , A61K31/4375 , C07D401/04 , A61K31/454
CPC分类号： A61K31/454 , A61K31/437 , A61K31/438 , A61K31/4545 , A61K31/4709 , A61K31/4747 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/55 , A61K31/553 , C07D207/14 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D487/14
摘要： The present invention is directed to novel aminopyrrolidines of formula I pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compounds of formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
摘要翻译：本发明涉及式I的药学上可接受的盐的新型氨基吡咯烷，其代谢物，其异构体，其立体异构体或其前体药物，其中变量如本文所定义。式（I）化合物可用作趋化因子受体拮抗剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如癌症。

3. 发明申请

US20120053345A1 Indazole Compounds 审中-公开
标题翻译：吲唑化合物
公开(公告)号：US20120053345A1
公开(公告)日：2012-03-01
申请号：US13198363
申请日：2011-08-04
申请人： Anna M. Ericson , Andrew Burchat , Kristine E. Frank , David J. Calderwood , Lily K. Abbott , Maria A. Argiriadi , David W. Borhani , Kevin P. Cusack , Richard W. Dixon , Thomas D. Gordon , Kelly D. Mullen , Robert V. Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude E. Barberis , Neil Wishart
发明人： Anna M. Ericson , Andrew Burchat , Kristine E. Frank , David J. Calderwood , Lily K. Abbott , Maria A. Argiriadi , David W. Borhani , Kevin P. Cusack , Richard W. Dixon , Thomas D. Gordon , Kelly D. Mullen , Robert V. Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude E. Barberis , Neil Wishart
IPC分类号： C07D495/04 , C07D401/14 , C07D403/14 , C07D231/54 , C07D487/04
CPC分类号： C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
摘要： Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
摘要翻译：式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

4. 发明授权

US08008481B2 Indazole compounds 有权
标题翻译：吲唑化合物
公开(公告)号：US08008481B2
公开(公告)日：2011-08-30
申请号：US11731950
申请日：2007-04-02
申请人： Anna M. Ericsson , Andrew Burchat , Kristine E. Frank , David J. Calderwood , Lily K. Abbott , Maria A. Argiriadi , David W. Borhani , Kevin P. Cusack , Richard W. Dixon , Thomas D. Gordon , Kelly D. Mullen , Robert V. Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude E. Barberis , Neil Wishart
发明人： Anna M. Ericsson , Andrew Burchat , Kristine E. Frank , David J. Calderwood , Lily K. Abbott , Maria A. Argiriadi , David W. Borhani , Kevin P. Cusack , Richard W. Dixon , Thomas D. Gordon , Kelly D. Mullen , Robert V. Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude E. Barberis , Neil Wishart
IPC分类号： C07D409/14 , C07D413/14
CPC分类号： C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
摘要： Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
摘要翻译：式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

5. 发明授权

US5560681A Seat bottom extension mechanism for passenger seats 失效
标题翻译：座椅底座延伸机构
公开(公告)号：US5560681A
公开(公告)日：1996-10-01
申请号：US407621
申请日：1995-03-21
申请人： Richard W. Dixon , Tommy G. Plant , Ralph J. Nolan, Jr.
发明人： Richard W. Dixon , Tommy G. Plant , Ralph J. Nolan, Jr.
IPC分类号： A47C1/023 , A47C7/50 , B60N2/90 , A47C3/025
CPC分类号： B60N2/4495 , B64D11/06 , B64D11/0643
摘要： A seat having a seat frame mounting a seat bottom, a seat back extending upwardly from the back of the seat bottom and a leg rest extending downwardly in an area forward of a front side of the seat bottom. The seat includes the combination of a seat bottom extension for increasing or decreasing the length of the seat bottom between the seat back and the leg rest to fit the distance between the buttocks and the back of the knees of the occupant. The seat bottom extension has a seat bottom extension assembly on which the leg rest is mounted for movement therewith and an adjustment assembly for adjustably mounting the seat bottom extension assembly to the front side of the seat bottom. The seat bottom extension is mounted for incremental movement between a first position wherein the seat bottom extension is retracted to a position adjacent the front side of the seat bottom and a second position wherein the seat bottom extension is extended to a position spaced apart from the front side of the seat bottom to thereby increase the length of the seat bottom between the seat back and the leg rest to fit the distance between the buttocks and the back of the knees of the occupant.
摘要翻译：具有安装座椅底部的座椅框架的座椅，从座椅底部的后部向上延伸的座椅靠背和在座椅底部的前侧的前方的区域中向下延伸的腿托。座椅包括座椅底部延伸部的组合，用于增加或减少座椅靠背和腿部座椅之间的座椅底部的长度，以适应臀部和乘员膝盖后部之间的距离。座椅底部延伸部具有座椅底部延伸组件，腿部支架安装在该座椅底部延伸组件上以与其一起运动，以及用于将座椅底部延伸组件可调节地安装到座椅底部的前侧的调节组件。座椅底部延伸部被安装用于在座椅底部延伸部缩回到邻近座椅底部前侧的位置的第一位置和第二位置之间进行增量运动，其中座椅底部延伸部延伸到与前部隔开的位置从而增加座椅靠背和腿部支架之间的座椅底部的长度，以适应臀部和乘员膝盖后部之间的距离。

6. 发明授权

US5272966A Method for bundling newspapers 失效
标题翻译：捆绑报纸的方法
公开(公告)号：US5272966A
公开(公告)日：1993-12-28
申请号：US53158
申请日：1993-04-27
申请人： Richard W. Dixon
发明人： Richard W. Dixon
IPC分类号： B65B27/08 , B65B13/02
CPC分类号： B65B27/083
摘要： A device for bundling newspapers and the like comprises a pair of upright walls each having an upwardly open substantially V-shaped notch formed by elements of the walls that converge downwardly and that define an interior angle of about 90.degree., the notches being in parallel alignment. In a preferred embodiment, the walls are longitudinal side walls of a box having upright end walls and having sloping top walls extending between corresponding notch-defining elements of the side walls. Newspapers are stacked on one of the top walls, with an edge thereof engaging the other top wall, and with portions extending beyond the side walls. Cords are tied around those portions to bundle the newspapers. The end walls have openings forming hand holds by which the box is lifted and which provide access to the interior of the box. The box has a shelf therein and contains a supply of cord, a cord cutter being provided along an edge of one opening. A strap may be placed over the stack centrally and is detachably engaged with portions of the top walls.
摘要翻译：用于捆扎报纸等的装置包括一对直立壁，每个竖立壁具有向上敞开的基本上为V形的凹口，该凹口由壁的元件向下收敛并限定约90度的内角，该凹口处于平行对准。在优选实施例中，壁是具有直立端壁并具有在侧壁的相应凹口限定元件之间延伸的倾斜顶壁的盒的纵向侧壁。报纸层叠在一个顶壁上，其边缘与另一个顶壁接合，并且部分延伸超出侧壁。电线捆绑在这些部分捆绑报纸。端壁具有形成手柄的开口，通过该开口，盒被提起并且提供进入箱体内部的通路。盒子里面有一个搁板，它包含一根电源线，沿着一个开口的边缘设置一个电线切割器。带子可以在中心堆放在堆叠上方并且可拆卸地与顶壁的部分接合。

7. 发明授权

US08629257B2 IL-12/p40 binding proteins 失效
标题翻译： IL-12 / p40结合蛋白
公开(公告)号：US08629257B2
公开(公告)日：2014-01-14
申请号：US12763048
申请日：2010-04-19
申请人： Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
发明人： Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
IPC分类号： C07H21/04
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.
摘要翻译：本发明包括IL-12p40结合蛋白，特别是结合人白细胞介素-12（hIL-12）和/或人IL-23（hIL-23）的抗体。具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。优选的抗体对hIL-12和/或hIL-23具有高亲和力，并在体外和体内中和h IL-12和/或hIL-23活性。本发明的抗体可以是全长抗体或其抗原结合部分。还提供了制备方法和使用本发明抗体的方法。本发明的抗体或抗体部分可用于检测hIL-12和/或hIL-23和用于抑制hIL-12和/或hIL-23活性，例如在患有hIL -12和/或hIL-23活性是有害的。

8. 发明申请

US20130004416A1 Dual Variable Domain Immunoglobulin and Uses Thereof 审中-公开
公开(公告)号：US20130004416A1
公开(公告)日：2013-01-03
申请号：US13601774
申请日：2012-08-31
申请人： Chengbin WU , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
发明人： Chengbin WU , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
IPC分类号： A61K39/395 , A61K49/00 , C12P21/02 , C12N9/96 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/19 , C12N1/11 , C12N15/63 , C07K16/00 , A61P21/02 , A61P29/00 , A61P23/00 , A61P21/00 , A61P31/04 , A61P17/06 , A61P37/06 , A61P25/24 , A61P25/18 , A61P11/06 , A61P19/02 , A61P1/00 , A61P3/10 , A61P37/08 , A61P17/00 , A61P41/00 , A61P9/10 , A61P13/12 , A61P31/12 , A61P31/00 , A61P25/16 , A61P25/28 , A61P9/00 , A61P11/00 , A61P7/06 , A61P15/00 , A61P19/04 , A61P1/16 , A61P25/32 , A61P35/00 , A61P35/02 , A61P31/18 , A61P25/06 , A61P25/00 , A61P19/10 , A61K51/00
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

9. 发明申请

US20100047245A1 IL-12/P40 BINDING PROTEINS 有权
标题翻译： IL-12 / P40结合蛋白
公开(公告)号：US20100047245A1
公开(公告)日：2010-02-25
申请号：US11478096
申请日：2006-06-29
申请人： Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
发明人： Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N15/74 , C12N1/21 , C12N5/10 , C12N1/19 , C12N5/071 , A61P37/06
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.
摘要翻译：本发明包括IL-12p40结合蛋白，特别是结合人白细胞介素-12（hIL-12）和/或人IL-23（hIL-23）的抗体。具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。优选的抗体对hIL-12和/或hIL-23具有高亲和力，并在体外和体内中和h IL-12和/或hIL-23活性。本发明的抗体可以是全长抗体或其抗原结合部分。还提供了制备方法和使用本发明抗体的方法。本发明的抗体或抗体部分可用于检测hIL-12和/或hIL-23和用于抑制hIL-12和/或hIL-23活性，例如在患有hIL -12和/或hIL-23活性是有害的。

10. 发明申请

US20100047239A1 Dual variable domain immunoglobulin and uses thereof 有权
标题翻译：双可变域免疫球蛋白及其用途
公开(公告)号：US20100047239A1
公开(公告)日：2010-02-25
申请号：US12459624
申请日：2009-07-02
申请人： Chengbin Wu , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
发明人： Chengbin Wu , Tariq Ghayur , Richard W. Dixon , Jochen G. Salfeld
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N15/63 , C12N1/21 , C12N1/15 , C12N1/19 , C12P21/06
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/48384 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
摘要翻译：本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。

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