专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08725421B2 In vitro estimation of in vivo half-life binding proteins 有权
标题翻译：体外估计体内半衰期结合蛋白
公开(公告)号：US08725421B2
公开(公告)日：2014-05-13
申请号：US12386332
申请日：2009-04-16
申请人： Robert V. Talanian
发明人： Robert V. Talanian
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： C12Q1/37
摘要： The present invention discloses methods used to estimate the in vivo half-life of a binding protein of interest. The disclosed methods involve (a) determining for a binding protein of interest and for each of at least two different reference binding proteins an in vitro half-life using an in vitro protease reaction assay, wherein said reference binding proteins have known different in vivo half-lives, (b) determining the correlation between the known in vivo half-lives and the in vitro proteolytic half-lives of each of the reference binding proteins, and (c) estimating from said correlation between the known in vivo half-lives and the in vitro proteolytic half-lives of the reference binding proteins the in vivo half-life of the binding protein of interest that correlates with the in vitro proteolytic half-life of the binding protein of interest.
摘要翻译：本发明公开了用于估计感兴趣的结合蛋白的体内半衰期的方法。所公开的方法涉及（a）使用体外蛋白酶反应测定法确定感兴趣的结合蛋白和至少两种不同参考结合蛋白中的每一种具有体外半衰期，其中所述参考结合蛋白具有已知的不同体内半数（b）确定已知的体内半衰期和每个参考结合蛋白的体外蛋白水解半衰期之间的相关性，以及（c）从已知的体内半衰期和参考结合蛋白的体外蛋白水解半衰期与感兴趣的结合蛋白的体外蛋白水解半衰期相关的目的结合蛋白的体内半衰期。

2. 发明申请

US20090263833A1 In vitro estimation of in vivo half-life binding proteins 有权
标题翻译：体外估计体内半衰期结合蛋白
公开(公告)号：US20090263833A1
公开(公告)日：2009-10-22
申请号：US12386332
申请日：2009-04-16
申请人： Robert V. Talanian
发明人： Robert V. Talanian
IPC分类号： G01N33/573
CPC分类号： C12Q1/37
摘要： The present invention discloses methods used to estimate the in vivo half-life of a binding protein of interest. The disclosed methods involve (a) determining for a binding protein of interest and for each of at least two different reference binding proteins an in vitro half-life using an in vitro protease reaction assay, wherein said reference binding proteins have known different in vivo half-lives, (b) determining the correlation between the known in vivo half-lives and the in vitro proteolytic half-lives of each of the reference binding proteins, and (c) estimating from said correlation between the known in vivo half-lives and the in vitro proteolytic half-lives of the reference binding proteins the in vivo half-life of the binding protein of interest that correlates with the in vitro proteolytic half-life of the binding protein of interest.
摘要翻译：本发明公开了用于估计感兴趣的结合蛋白的体内半衰期的方法。所公开的方法涉及（a）使用体外蛋白酶反应测定法确定感兴趣的结合蛋白和至少两种不同参考结合蛋白中的每一种具有体外半衰期，其中所述参考结合蛋白具有已知的不同体内半数（b）确定已知的体内半衰期和每个参考结合蛋白的体外蛋白水解半衰期之间的相关性，以及（c）从已知的体内半衰期和参考结合蛋白的体外蛋白水解半衰期与感兴趣的结合蛋白的体外蛋白水解半衰期相关的目的结合蛋白的体内半衰期。

3. 发明授权

US5869315A Modified interleukin-1.beta. converting enzyme with increased stability 失效
标题翻译：改良的白细胞介素-1β转化酶具有增加的稳定性
公开(公告)号：US5869315A
公开(公告)日：1999-02-09
申请号：US573890
申请日：1995-12-18
申请人： Robert V. Talanian , John A. Mankovich , Tariq Ghayur , Catherine R. Ferenz
发明人： Robert V. Talanian , John A. Mankovich , Tariq Ghayur , Catherine R. Ferenz
IPC分类号： C12N9/64 , C07H21/04 , C07K1/00 , C12N9/99
CPC分类号： C12N9/6475
摘要： Modified forms of human interleukin-1.beta. converting enzyme (ICE) that display proteolytic activity and, furthermore, have increased stability compared to unmodified human ICE are disclosed. Nucleic acid molecules encoding a modified p10 subunit of ICE, and recombinant vectors and host cells incorporating such nucleic acid molecules, are also disclosed. A modified ICE protein of the invention can be used to cleave proteolytically ICE substrates and to identify modulators of ICE activity in screening assays. Moreover, due to its enhanced stability, the modified ICE of the invention is particularly suitable for use in the preparation of ICE crystals for X-ray crystallography.
摘要翻译：公开了与未修饰的人类ICE相比显示出蛋白水解活性的人白细胞介素-1β转换酶（ICE）的修饰形式，此外具有增加的稳定性。还公开了编码ICE的修饰的p10亚基的核酸分子，以及掺入了这种核酸分子的重组载体和宿主细胞。本发明的修饰的ICE蛋白质可用于切割蛋白水解的ICE底物并鉴定筛选测定中ICE活性的调节剂。此外，由于其稳定性的提高，本发明的改性ICE特别适用于制备用于X射线晶体学的ICE晶体。

4. 发明申请

US20110318349A1 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开
公开(公告)号：US20110318349A1
公开(公告)日：2011-12-29
申请号：US13167323
申请日：2011-06-23
申请人： Tariq Ghayur , Junjian Liu , James P. Jakway , Robert V. Talanian , Lorenzo Benatuil
发明人： Tariq Ghayur , Junjian Liu , James P. Jakway , Robert V. Talanian , Lorenzo Benatuil
IPC分类号： A61K39/395 , C12N9/96 , C07H21/00 , C12N15/63 , C12P21/00 , A61P35/00 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/00 , A61P29/00 , C07K16/24 , G01N33/566
CPC分类号： C07K16/2875 , C07K16/241 , C07K16/468 , C07K2317/31 , C07K2317/64
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

5. 发明授权

US06524807B2 Modified interleukin-1&bgr; converting enzyme with increased stability 失效
公开(公告)号：US06524807B2
公开(公告)日：2003-02-25
申请号：US09827708
申请日：2001-04-06
申请人： Robert V. Talanian , John A. Mankovich , Tariq Ghayur , Catherine R. Ferenz
发明人： Robert V. Talanian , John A. Mankovich , Tariq Ghayur , Catherine R. Ferenz
IPC分类号： C12Q137
CPC分类号： C12N9/6475
摘要： Modified forms of human interleukin-1&bgr; converting enzyme (ICE) that display proteolytic activity and, furthermore, have increased stability compared to unmodified human ICE are disclosed. Nucleic acid molecules encoding a modified p10 subunit of ICE, and recombinant vectors and host cells incorporating such nucleic acid molecules, are also disclosed. A modified ICE protein of the invention can be used to cleave proteolytically ICE substrates and to identify modulators of ICE activity in screening assays. Moreover, due to its enhanced stability, the modified ICE of the invention is particularly suitable for use in the preparation of ICE crystals for X-ray crystallography.

6. 发明授权

US06288037B1 Substrates and inhibitors for cysteine protease ICH-1 失效
标题翻译：半胱氨酸蛋白酶ICH-1的底物和抑制剂
公开(公告)号：US06288037B1
公开(公告)日：2001-09-11
申请号：US08665643
申请日：1996-06-18
申请人： Robert V. Talanian , Tariq Ghayur , John C. Hodges
发明人： Robert V. Talanian , Tariq Ghayur , John C. Hodges
IPC分类号： A61K3807
CPC分类号： C07K5/101 , A61K38/00 , C07K14/81
摘要： Substrates and inhibitors for the cysteine protease Ich-1 are disclosed. These compounds are designed based on an optimal minimal substrate for Ich-1 and include reversible inhibitors, irreversible inhibitors, selectively reversible inhibitors, chromogenic substrates, fluorogenic substrates and radiolabeled substrates/inhibitors. Pharmaceutical compositions comprising the compounds of the invention are also provided. Methods for inhibiting the proteolytic activity of Ich-1, methods for detecting the presence of Ich-1 and methods for isolating Ich-1 using the compounds of the invention are also disclosed.
摘要翻译：公开了半胱氨酸蛋白酶Ich-1的底物和抑制剂。这些化合物是基于Ich-1的最佳最小底物设计的，包括可逆抑制剂，不可逆抑制剂，选择性可逆抑制剂，显色底物，荧光底物和放射性标记底物/抑制剂。还提供了包含本发明化合物的药物组合物。还公开了用于抑制Ich-1的蛋白水解活性的方法，用于检测Ich-1的存在的方法和使用本发明的化合物分离Ich-1的方法。

7. 发明授权

US5492824A Ice and ice-like compositions and methods of making same 失效
标题翻译：冰和冰的组成及其制作方法
公开(公告)号：US5492824A
公开(公告)日：1996-02-20
申请号：US242663
申请日：1994-05-12
申请人： Robert V. Talanian , Leonard L. C. Dang , Nigel P. C. Walker , Tariq Ghayur
发明人： Robert V. Talanian , Leonard L. C. Dang , Nigel P. C. Walker , Tariq Ghayur
IPC分类号： C12N15/09 , C12N9/64 , C12N9/96 , C12N9/99 , C12R1/19
CPC分类号： C12N9/6475 , C12N9/96
摘要： The present invention is directed to ICE and ICE-like compositions formed by combining two subunits of ICE and folding such subunits to form an active enzyme.
摘要翻译：本发明涉及通过组合ICE的两个亚基和折叠这样的亚基形成活性酶而形成的ICE和ICE样组合物。

8. 发明申请

US20120053345A1 Indazole Compounds 审中-公开
标题翻译：吲唑化合物
公开(公告)号：US20120053345A1
公开(公告)日：2012-03-01
申请号：US13198363
申请日：2011-08-04
申请人： Anna M. Ericson , Andrew Burchat , Kristine E. Frank , David J. Calderwood , Lily K. Abbott , Maria A. Argiriadi , David W. Borhani , Kevin P. Cusack , Richard W. Dixon , Thomas D. Gordon , Kelly D. Mullen , Robert V. Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude E. Barberis , Neil Wishart
发明人： Anna M. Ericson , Andrew Burchat , Kristine E. Frank , David J. Calderwood , Lily K. Abbott , Maria A. Argiriadi , David W. Borhani , Kevin P. Cusack , Richard W. Dixon , Thomas D. Gordon , Kelly D. Mullen , Robert V. Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude E. Barberis , Neil Wishart
IPC分类号： C07D495/04 , C07D401/14 , C07D403/14 , C07D231/54 , C07D487/04
CPC分类号： C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
摘要： Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
摘要翻译：式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

9. 发明授权

US08008481B2 Indazole compounds 有权
标题翻译：吲唑化合物
公开(公告)号：US08008481B2
公开(公告)日：2011-08-30
申请号：US11731950
申请日：2007-04-02
申请人： Anna M. Ericsson , Andrew Burchat , Kristine E. Frank , David J. Calderwood , Lily K. Abbott , Maria A. Argiriadi , David W. Borhani , Kevin P. Cusack , Richard W. Dixon , Thomas D. Gordon , Kelly D. Mullen , Robert V. Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude E. Barberis , Neil Wishart
发明人： Anna M. Ericsson , Andrew Burchat , Kristine E. Frank , David J. Calderwood , Lily K. Abbott , Maria A. Argiriadi , David W. Borhani , Kevin P. Cusack , Richard W. Dixon , Thomas D. Gordon , Kelly D. Mullen , Robert V. Talanian , Xiaoyun Wu , Xiaolei Zhang , Lu Wang , Biqin Li , Claude E. Barberis , Neil Wishart
IPC分类号： C07D409/14 , C07D413/14
CPC分类号： C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
摘要： Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
摘要翻译：式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

10. 发明授权

US06242240B1 Modified interleukin-1&bgr; converting enzyme with increased stability 失效
标题翻译：改良的白介素-1beta转化酶具有增加的稳定性
公开(公告)号：US06242240B1
公开(公告)日：2001-06-05
申请号：US09248179
申请日：1999-02-09
申请人： Robert V. Talanian , John A. Mankovich , Tariq Ghayur , Catherine R. Ferenz
发明人： Robert V. Talanian , John A. Mankovich , Tariq Ghayur , Catherine R. Ferenz
IPC分类号： C12N120
CPC分类号： C12N9/6475
摘要： Modified forms of human interleukin-1&bgr; converting enzyme (ICE) that display proteolytic activity and, furthermore, have increased stability compared to unmodified human ICE are disclosed. Nucleic acid molecules encoding a modified p10 subunit of ICE, and recombinant vectors and host cells incorporating such nucleic acid molecules, are also disclosed. A modified ICE protein of the invention can be used to cleave proteolytically ICE substrates and to identify modulators of ICE activity in screening assays. Moreover, due to its enhanced stability, the modified ICE of the invention is particularly suitable for use in the preparation of ICE crystals for X-ray crystallography.
摘要翻译：公开了与未修饰的人类ICE相比显示蛋白水解活性的人白细胞介素-1β转换酶（ICE）的修饰形式，此外具有增加的稳定性。还公开了编码ICE的修饰的p10亚基的核酸分子，以及掺入了这种核酸分子的重组载体和宿主细胞。本发明的修饰的ICE蛋白质可用于切割蛋白水解的ICE底物并鉴定筛选测定中ICE活性的调节剂。此外，由于其稳定性的提高，本发明的改性ICE特别适用于制备用于X射线晶体学的ICE晶体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式