专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06967196B1 Sulfonamide compounds and uses thereof 失效
标题翻译：磺酰胺化合物及其用途
公开(公告)号：US06967196B1
公开(公告)日：2005-11-22
申请号：US09890927
申请日：2000-02-22
申请人： David W. Smith , Benito Munoz , Kumar Srinivasan , Carl P. Bergstrom , Prasad V. Chaturvedula , Milind S. Deshpande , Daniel J. Keavy , Wai Yu Lau , Michael F. Parker , Charles P. Sloan , Owen B. Wallace , Henry Hui Wang
发明人： David W. Smith , Benito Munoz , Kumar Srinivasan , Carl P. Bergstrom , Prasad V. Chaturvedula , Milind S. Deshpande , Daniel J. Keavy , Wai Yu Lau , Michael F. Parker , Charles P. Sloan , Owen B. Wallace , Henry Hui Wang
IPC分类号： A61K31/40 , A61K31/407 , A61K31/47 , A61K31/4965 , A61K31/54 , A61P25/00 , C07C311/21 , C07C323/41
CPC分类号： C07D285/06 , C07C311/21 , C07C323/41 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/12 , C07D207/20 , C07D207/48 , C07D211/22 , C07D211/24 , C07D211/46 , C07D211/70 , C07D213/30 , C07D213/76 , C07D217/04 , C07D233/61 , C07D277/06 , C07D277/46 , C07D295/088 , C07D295/12 , C07D295/205 , C07D311/20 , C07D333/48 , C07D491/10
摘要： In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the sulfur atom and nitrogen atom of the sulfonamide group include substituted or unsubstituted hydrocarbyl moieties, substituted or unsubstituted heterocycle moieties, polycyclic moieties, halogen, alkoxy, ether, ester, amide, sulfonyl, sulfonamidyl, sulfide, carbamate, and the like. Invention compounds are capable of a wide variety of uses. For example sulfonamide compounds can act to modulate production of amyloid β protein and are useful in the prevention or treatment of a variety of diseases. Pharmaceutical compositions containing invention compounds are also provided. Such compositions have wide utility for the prevention or treatment of a variety of diseases.
摘要翻译：根据本发明，提供了一类新型的磺酰胺化合物。本发明的化合物含有核心磺酰胺基团。连接到磺酰胺基团的硫原子和氮原子的可变部分包括取代或未取代的烃基部分，取代或未取代的杂环部分，多环部分，卤素，烷氧基，醚，酯，酰胺，磺酰基，磺酰胺基，硫醚，氨基甲酸酯，和喜欢。本发明化合物能够具有多种用途。例如，磺酰胺化合物可以起到调节淀粉样蛋白β蛋白的产生的作用，并且可用于预防或治疗各种疾病。还提供含有本发明化合物的药物组合物。这样的组合物可广泛用于预防或治疗各种疾病。

2. 发明授权

US5472966A Antidepressant heteroarylaminoalkyl derivatives of naphthyl-monazines 失效
标题翻译：萘基 - 单子的抗抑郁药杂芳基氨基烷基衍生物
公开(公告)号：US5472966A
公开(公告)日：1995-12-05
申请号：US412625
申请日：1995-03-29
申请人： Charles P. Sloan , David W. Smith
发明人： Charles P. Sloan , David W. Smith
IPC分类号： C07D211/14 , A61K31/4427 , A61K31/445 , A61K31/451 , A61K31/495 , A61K31/505 , A61P25/24 , A61P25/26 , C07D211/22 , C07D211/70 , C07D401/12
CPC分类号： C07D401/12 , C07D211/70
摘要： Certain aminoalkyl derivatives of naphthyl-piperidines and tetrahydro-pyridines of Formula (I) are useful antidepressant agents. ##STR1## The symbol (Aryl) denotes phenyl, naphthyl, pyridinyl, pyrimidinyl and pyrazinyl ring systems with n being an integer of 2-4.
摘要翻译：式（I）的萘基哌啶和四氢吡啶的某些氨基烷基衍生物是有用的抗抑郁剂。（I）符号（芳基）表示n为2-4的整数的苯基，萘基，吡啶基，嘧啶基和吡嗪基环体系。

3. 发明授权

US5703129A 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production 失效
标题翻译： 5-氨基-6-环己基-4-羟基 - 己酰胺衍生物作为β-淀粉样蛋白生产的抑制剂
公开(公告)号：US5703129A
公开(公告)日：1997-12-30
申请号：US723488
申请日：1996-09-30
申请人： Kevin Felsenstein , David W. Smith , Michael A. Poss , Prasad Chaturvedula , Charles P. Sloan
发明人： Kevin Felsenstein , David W. Smith , Michael A. Poss , Prasad Chaturvedula , Charles P. Sloan
IPC分类号： C07C237/14 , C07C323/41 , C07D307/33 , A61K31/17
CPC分类号： C07D307/33 , C07C237/14 , C07C323/41 , C07C2101/02 , C07C2101/08 , C07C2101/14
摘要： A series of 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives of Formula I have been synthesized. ##STR1## As inhibitors of the production of .beta.-amyloid protein from .beta.-amyloid precursor protein, these compounds are expected to be effective in treating patients suffering from or susceptible to conditions or disorders linked to brain accumulation of .beta.-amyloid protein; e.g., Alzheimer's Disease and Down's Syndrome.
摘要翻译：已经合成了一系列式I的5-氨基-6-环己基-4-羟基 - 己酰胺衍生物。（I）作为从β-淀粉样蛋白前体蛋白生产β-淀粉样蛋白的抑制剂，预期这些化合物可有效治疗患有或易于与β-淀粉样蛋白的脑积聚相关的病症或障碍的患者 ; 例如阿尔茨海默病和唐氏综合症。

4. 发明授权

US06989399B2 Antiamyloid phenylsulfonamides: N-alkanol derivatives 有权
标题翻译：抗氨基苯基磺酰胺：N-烷醇衍生物
公开(公告)号：US06989399B2
公开(公告)日：2006-01-24
申请号：US10626299
申请日：2003-07-24
申请人： David W. Smith , Michael F. Parker
发明人： David W. Smith , Michael F. Parker
IPC分类号： A61K31/4164 , C07D233/54
CPC分类号： C07C311/21 , C07C2601/08 , C07C2601/14
摘要： A series of N-alkanol-N-phenyl benzenesulfonamide and related derivatives of the Formula I are disclosed, wherein R1, R2, R3, X, and Y are defined herein. The compounds are inhibitors of β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions characterized by aberrant extracellular deposition of amyloid. Pharmaceutical compositions and methods of treatment are also disclosed.
摘要翻译：公开了一系列N-烷醇-N-苯基苯磺酰胺和式I的相关衍生物，其中R 1，R 2，R 3， >，X和Y在本文中定义。这些化合物是β-淀粉样蛋白肽（β-AP）产生的抑制剂，并且可用于治疗阿尔茨海默氏病和以淀粉样蛋白异常细胞外沉积为特征的其它病症。还公开了药物组合物和治疗方法。

5. 发明授权

US09302065B2 Patient interface device with adjustable headgear and frame 有权
标题翻译：患者接口装置，带有可调式头带和框架
公开(公告)号：US09302065B2
公开(公告)日：2016-04-05
申请号：US13503102
申请日：2010-08-31
申请人： David W. Smith , Gregory John Jablonski , Derrick Blake Andrews , Harold Allen Lockhart
发明人： David W. Smith , Gregory John Jablonski , Derrick Blake Andrews , Harold Allen Lockhart
IPC分类号： A61M16/06 , A61M16/00
CPC分类号： A61M16/0683 , A61M16/06 , A61M16/0633 , A61M16/0672 , A61M2210/0618
摘要： A patient interface device includes a main frame and a headgear. The main frame includes a central support portion for supporting a cushion component and first and second arms extending from the central support portion. The headgear includes a support portion, and first and second straps extending therefrom. The first strap has a first pocket and the second strap has a second pocket, wherein the first arm is received and moveable within the first pocket along a longitudinal axis of the first strap and the second arm is received and moveable within the second pocket along a longitudinal axis of the second strap. The headgear also includes first and second fastening mechanisms for securing the headgear to the main frame, holding the first arm in a selected position within the first pocket and holding the second arm in a selected position within the second pocket.
摘要翻译：患者接口装置包括主框架和头盔。主框架包括用于支撑缓冲部件的中心支撑部分和从中心支撑部分延伸的第一和第二臂。头带包括支撑部分，以及从其延伸的第一和第二条带。所述第一带具有第一袋，所述第二带具有第二袋，其中所述第一臂被容纳并沿着所述第一带的纵向轴线在所述第一袋内可移动，并且所述第二臂沿着所述第一袋接收并在所述第二袋内沿着第二条带的纵向轴线。头套还包括用于将头带固定到主框架的第一和第二紧固机构，将第一臂保持在第一袋内的选定位置并将第二臂保持在第二袋内的选定位置。

6. 发明授权

US09078685B2 Method and system for performing invasive medical procedures using a surgical robot 有权
标题翻译：使用外科手术机器人进行侵入性医疗手术的方法和系统
公开(公告)号：US09078685B2
公开(公告)日：2015-07-14
申请号：US13542560
申请日：2012-07-05
申请人： David W. Smith , Regina DeSanctis-Smith , Alan M. Pitt , Nicholas Theodore , Neil Crawford
发明人： David W. Smith , Regina DeSanctis-Smith , Alan M. Pitt , Nicholas Theodore , Neil Crawford
IPC分类号： A61B5/055 , A61B5/06 , A61B19/00 , A61B17/34
CPC分类号： A61B34/30 , A61B5/06 , A61B17/3478 , A61B34/20 , A61B34/25 , A61B34/73 , A61B90/10 , A61B90/11 , A61B90/36 , A61B2034/107 , A61B2034/2051 , A61B2034/301
摘要： A method and system for performing invasive procedures includes a surgical robot which is controlled by a guidance system that uses time of flight calculations from RF transmitters embedded in the robot, surgical instrument, and patient anatomy. Sensors around the room detect RF transmissions emitted by the RF transmitters and drive the robot according to a preprogrammed trajectory entered into the guidance system.
摘要翻译：用于执行侵入性手术的方法和系统包括由引导系统控制的手术机器人，所述引导系统利用嵌入在机器人中的RF发射器，外科器械和患者解剖结构中的飞行时间计算。房间周围的传感器检测射频发射器发射的射频发射器，并根据输入引导系统的预编程轨迹驱动机器人。

7. 发明授权

US08997736B2 Interface apparatus identification system and method and differentiating feature therefor 有权
标题翻译：接口设备识别系统及其方法及其特征
公开(公告)号：US08997736B2
公开(公告)日：2015-04-07
申请号：US13131630
申请日：2009-11-21
申请人： David W. Smith
发明人： David W. Smith
IPC分类号： A61M16/00 , A62B9/00 , A62B27/00 , G08B3/00 , G08B5/00 , A61M16/06 , A61M16/08
CPC分类号： A61M16/06 , A61M16/0816 , A61M16/0825 , A61M16/0875 , A61M2205/6018 , A61M2205/6081
摘要： An interface apparatus identification system for a respiration machine such as, for example, a medical ventilator, includes a detection element which is adapted to communicate with the ventilator, a patient interface assembly including a patient interface apparatus for delivering a flow of gas from the ventilator to an airway of a patient, and a differentiating feature which is incorporated into the patient interface assembly. The patient interface apparatus is selected from a predetermined category such as, for example, a specific make or brand. The differentiating feature is detectable by the detection element to distinguish patient interface apparatus that fall within the predetermined category from those that do not. Operation of the respiration machine in conjunction with the patient interface apparatus is dependent upon detection of the differentiating feature by the detection element. An associated identification method is also disclosed.
摘要翻译：用于呼吸机例如医疗呼吸机的接口装置识别系统包括适于与呼吸机通信的检测元件，患者接口组件，包括用于从呼吸机输送气流的患者接口装置到患者的气道，以及结合到患者接口组件中的微分特征。患者接口装置从预定类别中选择，例如特定品牌或品牌。检测元件可以检测微分特征，以区分属于预定类别的患者接口设备与不具有预定类别的患者接口设备。与患者接口装置一起操作呼吸机取决于检测元件对差分特征的检测。还公开了相关的识别方法。

8. 发明申请

US20140123981A1 SKIN-CONTACT PRODUCT HAVING MOISTURE AND MICROCLIMATE CONTROL 审中-公开
标题翻译：具有水分和微量控制的皮肤接触产品
公开(公告)号：US20140123981A1
公开(公告)日：2014-05-08
申请号：US14127538
申请日：2012-06-25
申请人： Nicolaas Petrus Willard , Mareike Klee , Lucas Johannes Anna Maria Beckers , Dirk Burdinski , Joyce Vanzanten , Willem Franke Pasveer , Biju Kumar Sreedharan Nair , David W. Smith , Cornelis Petrus Hendriks , Sima Asvadi
发明人： Nicolaas Petrus Willard , Mareike Klee , Lucas Johannes Anna Maria Beckers , Dirk Burdinski , Joyce Vanzanten , Willem Franke Pasveer , Biju Kumar Sreedharan Nair , David W. Smith , Cornelis Petrus Hendriks , Sima Asvadi
IPC分类号： A61M16/06 , A61M16/00
CPC分类号： C08G77/28 , A61M16/0057 , A61M16/06 , A61M16/0605 , A61M16/0616 , A61M16/0633 , A61M16/0683 , A61M16/0816 , A61M2205/0205 , A61M2205/0238 , A61M2205/7527 , A61M2205/7536 , C08G77/08 , C08J9/00 , C08J2207/10 , C08J2383/08
摘要： Skin-contact products with a transpiration function such as medical devices or medicinal products, of which face masks, aspirators, ventilators, breast pumps or wound dressings are examples are described especially a skin-contact product with a transpiration function with an improved microclimate at a patient interface material-skin contact area. In an embodiment a material system (10, 20, 30) is described that comprises a hydrophobic silicone base material (11, 21, 31) and a hydrophilic silicone material (12, 22, 32) that is combined with the hydrophobic base material (11, 21, 31). At least a part of the hydrophilic material (12, 22, 32) is in contact with a moist surface (50). The hydrophobic base material (11, 21, 31) provides mechanical and dynamical stability of the material system (10, 20, 30). The hydrophilic material (12, 22, 32) allows for uptake or for diffusion of moisture away from moist surface (50). The material system (10, 20, 30) is utilized to fabricate a patient interface material (41) and forehead pad (42) of a user or patient interface, such as face mask (40), for example, a patient interface mask for positive air pressure therapy. Furthermore, a novel composition for the preparation of hydrophilic silicone materials, suitable for use in the material system (10, 20, 30), is disclosed.
摘要翻译：具有蒸发功能的皮肤接触产品，例如面罩，抽吸器，呼吸机，吸乳器或伤口敷料等医疗设备或医药产品，是具有蒸发功能的皮肤接触产品，具有改善的小气候患者界面材料 - 皮肤接触面积。在一个实施例中，描述了一种材料系统（10,20,30），其包括疏水性硅氧烷基材料（11,21,31）和亲水性硅氧烷材料（12,22,32），其与疏水基础材料 11,21,31）。至少一部分亲水性材料（12,22,32）与潮湿的表面（50）接触。疏水基材（11,21,31）提供材料体系（10,20,30）的机械和动力学稳定性。亲水材料（12,22,32）允许摄取或使湿气从潮湿表面（50）扩散。材料系统（10,20,30）用于制造用户或患者接口（例如面罩（40））的患者接口材料（41）和前额垫（42），例如患者接口面罩，用于正压气疗此外，公开了一种用于制备适用于材料体系（10,20,30）的亲水硅氧烷材料的新型组合物。

9. 发明授权

US08528315B2 Air cooling apparatus for a purge valve 有权
标题翻译：用于清洗阀的空气冷却装置
公开(公告)号：US08528315B2
公开(公告)日：2013-09-10
申请号：US12289573
申请日：2008-10-30
申请人： David W. Smith , Doug Byrd , Michael P. Black , Swapnil Tiwari
发明人： David W. Smith , Doug Byrd , Michael P. Black , Swapnil Tiwari
IPC分类号： F02C7/12
CPC分类号： F16K49/005 , Y10T137/6525 , Y10T137/7062
摘要： A cooling enclosure for a valve includes an elongated housing body having a pair of housing portions and a pair of removable end plates, the pair of housing portions separable along at least one longitudinally-extending seam. Fastener devices are provided for securing the pair of housing portions engaged along the at least one longitudinal extending seam. One or more apertures are provided for accommodating a like number of valve fittings, and cooling air inlet and outlet openings are also provided in the housing body for supplying and removing cooling air to the housing body.
摘要翻译：用于阀的冷却外壳包括细长的壳体，其具有一对壳体部分和一对可移除的端板，所述一对壳体部分沿着至少一个纵向延伸的接缝可分离。提供紧固件装置用于固定沿着至少一个纵向延伸接缝接合的一对壳体部分。提供一个或多个孔以容纳相同数量的阀配件，并且冷却空气入口和出口也设置在壳体中，用于向壳体提供和去除冷却空气。

10. 发明授权

US08219178B2 Method and system for performing invasive medical procedures using a surgical robot 有权
标题翻译：使用外科手术机器人进行侵入性医疗手术的方法和系统
公开(公告)号：US08219178B2
公开(公告)日：2012-07-10
申请号：US11845557
申请日：2007-08-27
申请人： David W. Smith , Regina DeSanctis-Smith , Alan M. Pitt , Nicholas Theodore , Neil R. Crawford
发明人： David W. Smith , Regina DeSanctis-Smith , Alan M. Pitt , Nicholas Theodore , Neil R. Crawford
IPC分类号： A61B5/05
CPC分类号： A61B34/30 , A61B5/06 , A61B17/3478 , A61B34/20 , A61B34/25 , A61B34/73 , A61B90/10 , A61B90/11 , A61B90/36 , A61B2034/107 , A61B2034/2051 , A61B2034/301
摘要： A method and system for performing invasive procedures includes a surgical robot which is controlled by a guidance system that uses time of flight calculations from RF transmitters embedded in the robot, surgical instrument, and patient anatomy. Sensors around the room detect RF transmissions emitted by the RF transmitters and drive the robot according to a preprogrammed trajectory entered into the guidance system.
摘要翻译：用于执行侵入性手术的方法和系统包括由引导系统控制的手术机器人，所述引导系统利用嵌入在机器人中的RF发射器，外科器械和患者解剖结构中的飞行时间计算。房间周围的传感器检测射频发射器发射的射频发射器，并根据输入引导系统的预编程轨迹驱动机器人。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式