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1. 发明授权

US06967196B1 Sulfonamide compounds and uses thereof 失效
标题翻译：磺酰胺化合物及其用途
公开(公告)号：US06967196B1
公开(公告)日：2005-11-22
申请号：US09890927
申请日：2000-02-22
申请人： David W. Smith , Benito Munoz , Kumar Srinivasan , Carl P. Bergstrom , Prasad V. Chaturvedula , Milind S. Deshpande , Daniel J. Keavy , Wai Yu Lau , Michael F. Parker , Charles P. Sloan , Owen B. Wallace , Henry Hui Wang
发明人： David W. Smith , Benito Munoz , Kumar Srinivasan , Carl P. Bergstrom , Prasad V. Chaturvedula , Milind S. Deshpande , Daniel J. Keavy , Wai Yu Lau , Michael F. Parker , Charles P. Sloan , Owen B. Wallace , Henry Hui Wang
IPC分类号： A61K31/40 , A61K31/407 , A61K31/47 , A61K31/4965 , A61K31/54 , A61P25/00 , C07C311/21 , C07C323/41
CPC分类号： C07D285/06 , C07C311/21 , C07C323/41 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/12 , C07D207/20 , C07D207/48 , C07D211/22 , C07D211/24 , C07D211/46 , C07D211/70 , C07D213/30 , C07D213/76 , C07D217/04 , C07D233/61 , C07D277/06 , C07D277/46 , C07D295/088 , C07D295/12 , C07D295/205 , C07D311/20 , C07D333/48 , C07D491/10
摘要： In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the sulfur atom and nitrogen atom of the sulfonamide group include substituted or unsubstituted hydrocarbyl moieties, substituted or unsubstituted heterocycle moieties, polycyclic moieties, halogen, alkoxy, ether, ester, amide, sulfonyl, sulfonamidyl, sulfide, carbamate, and the like. Invention compounds are capable of a wide variety of uses. For example sulfonamide compounds can act to modulate production of amyloid β protein and are useful in the prevention or treatment of a variety of diseases. Pharmaceutical compositions containing invention compounds are also provided. Such compositions have wide utility for the prevention or treatment of a variety of diseases.
摘要翻译：根据本发明，提供了一类新型的磺酰胺化合物。本发明的化合物含有核心磺酰胺基团。连接到磺酰胺基团的硫原子和氮原子的可变部分包括取代或未取代的烃基部分，取代或未取代的杂环部分，多环部分，卤素，烷氧基，醚，酯，酰胺，磺酰基，磺酰胺基，硫醚，氨基甲酸酯，和喜欢。本发明化合物能够具有多种用途。例如，磺酰胺化合物可以起到调节淀粉样蛋白β蛋白的产生的作用，并且可用于预防或治疗各种疾病。还提供含有本发明化合物的药物组合物。这样的组合物可广泛用于预防或治疗各种疾病。

2. 发明授权

US06638529B2 Amide-based cationic lipids 失效
标题翻译：酰胺类阳离子脂质
公开(公告)号：US06638529B2
公开(公告)日：2003-10-28
申请号：US10046332
申请日：2002-01-14
申请人： David Aaron Schwartz , William J. Daily , Brian Patrick Dwyer , Kumar Srinivasan , Bob Dale Brown
发明人： David Aaron Schwartz , William J. Daily , Brian Patrick Dwyer , Kumar Srinivasan , Bob Dale Brown
IPC分类号： A61K9127
CPC分类号： B82Y5/00 , A61K9/1272 , C07C237/06 , C07C237/10 , C07C237/22 , C07K5/0215 , C07K5/06086 , C07K5/0815
摘要： The present invention provides novel amide-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof wherein; (a) Y is a direct link or an alkylene of 1 to about 20 carbon atoms; (b) R1 is H or a lipophilic moiety; (c) R2, R3, and R4 are positively charged moieties, or at least one but not all of R2, R3, or R4 is a positive moiety and the remaining are independently selected from H, an alkyl moiety of 1 to about 6 carbon atoms, or a heterocyclic moiety of about 5 to about 10 carbon atoms; (d) n and p are independently selected integers from 0 to 8, such that the sum of n and o is from 1 to 16; (e) X− is an anion or polyanion and (f) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid; provided that if Y is a direct link and the sum of n and p is 1 then one of either R3 or R4 must have an alkyl moiety of at least 10 carbon atoms. The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
摘要翻译：本发明提供了一般结构的新型酰胺类阳离子脂质：或其盐或溶剂合物或其对映体，其中：（a）Y是1至约20个碳原子的直链或亚烷基; （b）R 1为H或亲油部分; （c）R 2，R 3和R 4为带正电荷的部分，或至少一个但不全部为R 2，R 3或R 4为正部分，其余为独立选自H，1至约6个碳原子的烷基部分原子或约5至约10个碳原子的杂环部分; （d）n和p独立地选自0至8的整数，使得n和o的和为1至16; （e）X 1是阴离子或聚阴离子，（f）m是0至等于脂质上存在的正电荷数的整数; 条件是如果Y是直链，n和p的和为1，则R3或R4中的一个必须具有至少10个碳原子的烷基部分。本发明还提供这些脂质与聚阴离子大分子的组合物，方法用于干扰利用这些组合物的细胞中的蛋白质表达和用于制备其的试剂盒。

3. 发明授权

US6034135A Dimeric cationic lipids 失效
标题翻译：二聚阳离子脂质
公开(公告)号：US6034135A
公开(公告)日：2000-03-07
申请号：US812771
申请日：1997-03-06
申请人： David Aaron Schwartz , Brian Patrick Dwyer , William J. Daily , Kumar Srinivasan , Bob Dale Brown
发明人： David Aaron Schwartz , Brian Patrick Dwyer , William J. Daily , Kumar Srinivasan , Bob Dale Brown
IPC分类号： A61K38/00 , A61K48/00 , C07C323/60 , C07K5/068 , C12N15/87 , A61K31/16 , A61K31/195
CPC分类号： A61K48/00 , C07C323/60 , C07K5/06086 , C12N15/87 , A61K38/00
摘要： The present invention provides novel dimeric cationic lipids. The present invention further provides compositions of these lipids with anionic or polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
摘要翻译：本发明提供新的二聚阳离子脂质。本发明还提供这些脂质与阴离子或聚阴离子大分子的组合物，利用这些组合物干扰细胞中蛋白质表达的方法和用于制备该组合物的试剂盒。

4. 发明授权

US6020526A Amide-based cationic lipids 失效
标题翻译：酰胺类阳离子脂质
公开(公告)号：US6020526A
公开(公告)日：2000-02-01
申请号：US681297
申请日：1996-07-22
申请人： David Aaron Schwartz , William J. Daily , Brian Patrick Dwyer , Kumar Srinivasan , Bob Dale Brown
发明人： David Aaron Schwartz , William J. Daily , Brian Patrick Dwyer , Kumar Srinivasan , Bob Dale Brown
IPC分类号： C12N15/09 , A61K9/127 , C07C237/06 , C07C237/10 , C07C237/22 , C07K5/06 , C07K5/068 , C07K5/09 , C07C233/05
CPC分类号： B82Y5/00 , A61K9/1272 , C07C237/06 , C07C237/10 , C07C237/22 , C07K5/06086 , C07K5/0815
摘要： The present invention provides novel amide-based cationic lipids of the general structure: ##STR1## or a salt, or solvate, or enantiomers thereof wherein; (a) Y is a direct link or an alkylene of 1 to about 20 carbon atoms; (b) R.sub.1 is H or a lipophilic moiety; (c) R.sub.2, R.sub.3, and R.sub.4 are positively charged moieties, or at least one but not all of R.sub.2, R.sub.3, or R.sub.4 is a positive moiety and the remaining are independently selected from H, an alkyl moiety of 1 to about 6 carbon atoms, or a heterocyclic moiety of about 5 to about 10 carbon atoms; (d) n and p are independently selected integers from 0 to 8, such that the sum of n and o is from 1 to 16; (e) X.sup.- is an anion or polyanion and (f) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid; provided that if Y is a direct link and the sum of n and p is 1 then one of either R.sub.3 or R.sub.4 must have an alkyl moiety of at least 10 carbon atoms.The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
摘要翻译：本发明提供了一般结构的新型酰胺类阳离子脂质：或其盐或溶剂合物或其对映体，其中：（a）Y是1至约20个碳原子的直链或亚烷基; （b）R 1为H或亲油部分; （c）R 2，R 3和R 4为带正电荷的部分，或至少一个但不全部为R 2，R 3或R 4为正部分，其余独立地选自H，1至约6个碳原子的烷基部分原子或约5至约10个碳原子的杂环部分; （d）n和p独立地选自0至8的整数，使得n和o的和为1至16; （e）X-是阴离子或聚阴离子，（f）m是0至等于脂质上存在的正电荷数的整数; 条件是如果Y是直链，并且n和p之和为1，则R3或R4之一必须具有至少10个碳原子的烷基部分。本发明还提供了这些脂质与聚阴离子大分子的组合物，利用这些组合物干扰细胞中的蛋白质表达的方法和用于制备该组合物的试剂盒。

5. 发明授权

US5877220A Amide-based oligomeric cationic lipids 失效
标题翻译：酰胺类低聚阳离子脂质
公开(公告)号：US5877220A
公开(公告)日：1999-03-02
申请号：US812775
申请日：1997-03-06
申请人： David Aaron Schwartz , Brian Patrick Dwyer , William J. Daily , Kumar Srinivasan , Bob Dale Brown
发明人： David Aaron Schwartz , Brian Patrick Dwyer , William J. Daily , Kumar Srinivasan , Bob Dale Brown
IPC分类号： C07C237/22 , C07K5/068 , C12N15/87 , A01N37/18 , A01N47/10 , C07C233/05
CPC分类号： C07C237/22 , C07K5/06086 , C12N15/87
摘要： The present invention provides amide-based oligomeric cationic lipids. The present invention further provides compositions of these amide-based cationic lipids with anionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
摘要翻译：本发明提供了酰胺类低聚阳离子脂质。本发明还提供了这些基于阴离子大分子的酰胺类阳离子脂质的组合物，利用这些组合物干扰细胞中蛋白质表达的方法和用于制备该组合物的试剂盒。

6. 发明申请

US20130071694A1 INTERLAYERS FOR MAGNETIC RECORDING MEDIA 有权
标题翻译：磁记录介质层
公开(公告)号：US20130071694A1
公开(公告)日：2013-03-21
申请号：US13234399
申请日：2011-09-16
申请人： Kumar Srinivasan , B. Ramamurthy Acharya
发明人： Kumar Srinivasan , B. Ramamurthy Acharya
IPC分类号： G11B5/66 , C23C14/34
CPC分类号： C23C14/165 , C23C14/025 , G11B5/7325 , G11B5/8404
摘要： Embodiments of the present invention include a recording medium comprising: a hard magnetic recording layer and an interlayer disposed under the hard magnetic recording layer, wherein the interlayer comprises an upper layer of Ru-based alloy and a lower layer of RuCo or ReCo alloy. Generally for embodiments of the present invention, the lower layer of RuCo or ReCo alloy is formed over a seed layer using a low-pressure sputter process, and the upper layer of Ru-based alloy is formed over the lower layer using a high-pressure sputter process.
摘要翻译：本发明的实施例包括记录介质，包括：硬磁记录层和设置在硬磁记录层下面的中间层，其中中间层包含Ru基合金的上层和RuCo或ReCo合金的下层。通常对于本发明的实施方案，使用低压溅射工艺在种子层上形成RuCo或ReCo合金的下层，并且使用高压在低层上形成上层Ru基合金溅射工艺。

7. 发明授权

US08758912B2 Interlayers for magnetic recording media 有权
标题翻译：磁记录介质中间层
公开(公告)号：US08758912B2
公开(公告)日：2014-06-24
申请号：US13234399
申请日：2011-09-16
申请人： Kumar Srinivasan , B. Ramamurthy Acharya
发明人： Kumar Srinivasan , B. Ramamurthy Acharya
IPC分类号： G11B5/66
CPC分类号： C23C14/165 , C23C14/025 , G11B5/7325 , G11B5/8404
摘要： Embodiments of the present invention include a recording medium comprising: a hard magnetic recording layer and an interlayer disposed under the hard magnetic recording layer, wherein the interlayer comprises an upper layer of Ru-based alloy and a lower layer of RuCo or ReCo alloy. Generally for embodiments of the present invention, the lower layer of RuCo or ReCo alloy is formed over a seed layer using a low-pressure sputter process, and the upper layer of Ru-based alloy is formed over the lower layer using a high-pressure sputter process.
摘要翻译：本发明的实施例包括记录介质，包括：硬磁记录层和设置在硬磁记录层下面的中间层，其中中间层包含Ru基合金的上层和RuCo或ReCo合金的下层。通常对于本发明的实施方案，使用低压溅射工艺在种子层上形成RuCo或ReCo合金的下层，并且使用高压在低层上形成上层Ru基合金溅射工艺。

8. 发明申请

US20090226764A1 Magnetic Recording Medium with Iridum-Manganese Based Intermediate Layer and Method of Manufacturing Same 审中-公开
标题翻译：具有铱基锰中间层的磁记录介质及其制造方法相同
公开(公告)号：US20090226764A1
公开(公告)日：2009-09-10
申请号：US12398574
申请日：2009-04-17
申请人： Kumar Srinivasan , Rachid Sbiaa , S.N. Piramanayagam
发明人： Kumar Srinivasan , Rachid Sbiaa , S.N. Piramanayagam
IPC分类号： G11B5/706 , C23C14/34
CPC分类号： G11B5/667 , C23C14/165 , G11B5/65 , G11B5/8404
摘要： A magnetic recording medium and a method of making a magnetic recording medium are disclosed. The magnetic recording medium comprises an Iridium-Manganese based intermediate layer formed over a base structure and a magnetic recording layer formed over the Iridium-Manganese based intermediate layer.
摘要翻译：公开了磁记录介质和制造磁记录介质的方法。磁记录介质包括在基础结构上形成的基于铱 - 锰的中间层和形成在基于铱 - 锰的中间层上的磁记录层。

9. 发明授权

US06339173B1 Amide-based cationic lipids 失效
标题翻译：酰胺类阳离子脂质
公开(公告)号：US06339173B1
公开(公告)日：2002-01-15
申请号：US09327392
申请日：1999-06-07
申请人： David Aaron Schwartz , William J. Daily , Brian Patrick Dwyer , Kumar Srinivasan , Bob Dale Brown
发明人： David Aaron Schwartz , William J. Daily , Brian Patrick Dwyer , Kumar Srinivasan , Bob Dale Brown
IPC分类号： C07C23305
CPC分类号： B82Y5/00 , A61K9/1272 , C07C237/06 , C07C237/10 , C07C237/22 , C07K5/0215 , C07K5/06086 , C07K5/0815
摘要： The present invention provides novel amide-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof wherein; (a) Y is a direct link or an alkylene of 1 to about 20 carbon atoms; (b) R1 is H or a lipophilic moiety; (c) R2, R3, and R4 are positively charged moieties, or at least one but not all of R2,R3, or R4 is a positive moiety and the remaining are independently selected from H, an alkyl moiety of 1 to about 6 carbon atoms, or a heterocyclic moiety of about 5 to about 10 carbon atoms; (d) n and p are independently selected integers from 0 to 8, such that the sum of n and o is from 1 to 16; (e) X− is an anion or polyanion and (f) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid; provided that if Y is a direct link and the sum of n and p is 1 then one of either R3 or R4 must have an alkyl moiety of at least 10 carbon atoms. The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
摘要翻译：本发明提供了一般结构的新型酰胺类阳离子脂质：或其盐或溶剂合物或其对映体，其中：（a）Y是1至约20个碳原子的直链或亚烷基; （b）R 1为H或亲油部分; （c）R 2，R 3和R 4为带正电荷的部分，或至少一个但不全部为R 2，R 3或R 4为正部分，其余独立地选自H，1至约6个碳原子的烷基部分原子或约5至约10个碳原子的杂环部分; （d）n和p独立地选自0至8的整数，使得n和o的和为1至16; （e）X-是阴离子或聚阴离子，（f）m是0至等于脂质上存在的正电荷数的整数; 条件是如果Y是直链，n和p的和为1，则R3或R4中的一个必须具有至少10个碳原子的烷基部分。本发明还提供这些脂质与聚阴离子大分子的组合物，方法用于干扰利用这些组合物的细胞中的蛋白质表达和用于制备其的试剂盒。

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