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1. 发明申请

US20080051395A1 2-Pyrimidinyl Pyrazolopyridine Erbb Kinase Inhibitors 失效
标题翻译： 2-嘧啶基吡唑并吡啶Erbb激酶抑制剂
公开(公告)号：US20080051395A1
公开(公告)日：2008-02-28
申请号：US11721504
申请日：2005-12-06
申请人： David Uehling , Kirk Stevens , Scott Dickerson , Alex Waterson , Philip Harris , Douglas Sammond , Robert Hubbard , Holly Emerson , Joseph Wilson
发明人： David Uehling , Kirk Stevens , Scott Dickerson , Alex Waterson , Philip Harris , Douglas Sammond , Robert Hubbard , Holly Emerson , Joseph Wilson
IPC分类号： A61K31/506 , A61K31/5377 , A61P35/00 , C07D239/24 , C07D413/14
CPC分类号： C07D471/04
摘要： The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.
摘要翻译：本发明提供2-嘧啶基吡唑并吡啶化合物，含有它们的组合物，以及制备方法及其作为药剂的用途。

2. 发明申请

US20050090507A1 Pyrazolopyridazine derivatves 失效
标题翻译：吡唑并哒嗪衍生物
公开(公告)号：US20050090507A1
公开(公告)日：2005-04-28
申请号：US10499179
申请日：2002-12-11
申请人： Jennifer Badiang , Scott Dickerson , Philip Harris , David Jung , Michael Peel , Michael Reno , Tara Rheault , Kirk Stevens , Francis Tavares , James Veal
发明人： Jennifer Badiang , Scott Dickerson , Philip Harris , David Jung , Michael Peel , Michael Reno , Tara Rheault , Kirk Stevens , Francis Tavares , James Veal
IPC分类号： A61K31/506 , A61K31/5377 , A61K45/00 , A61P35/00 , A61P43/00 , C07D487/04 , A61K31/519
CPC分类号： C07D487/04
摘要： Fused pyradazine derivatives, which are useful as CDK inhibitors are described herein. The described invention also includes methods of making such fused pyradazines derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译：本文描述了可用作CDK抑制剂的稠合的哒嗪衍生物。所述的发明还包括制备这种稠合吡嗪嗪衍生物的方法以及使用其来治疗过度增殖性疾病的方法。

3. 发明申请

US20050009845A1 Thienopyrimidine compounds as protein tyrosine kinase inhibitors 审中-公开
标题翻译：噻吩并嘧啶化合物作为蛋白酪氨酸激酶抑制剂
公开(公告)号：US20050009845A1
公开(公告)日：2005-01-13
申请号：US10499247
申请日：2002-12-13
申请人： Thomas Caferro , Stanley Chamberlain , Kelly Donaldson , Philip Harris , Michael Gaul , David Uehling , Dana Vanderwall
发明人： Thomas Caferro , Stanley Chamberlain , Kelly Donaldson , Philip Harris , Michael Gaul , David Uehling , Dana Vanderwall
IPC分类号： A61K31/337 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/7072 , A61K45/00 , A61P11/08 , A61P17/06 , A61P29/00 , A61P35/00 , A61P43/00 , C07D495/04 , C07D498/02
CPC分类号： C07D495/04
摘要： The present invention relates to thienopyrmidine compounds of formula (I) (one of A1 and A2 is S and the other is CH), salts thereof, as well as use and preparation of the same. These compounds are inhibitors of various protein tyrosine kinases (PTKs) of the ErbB family and consequently are useful in the treatment of disorders mediated by aberrant activity of such kinases.
摘要翻译：本发明涉及式（I）的噻吩并嘧啶化合物（A 1和A 2之一是S，另一个是CH），其盐，以及其用途和制备。这些化合物是ErbB家族的各种蛋白酪氨酸激酶（PTK）的抑制剂，因此可用于治疗由这种激酶的异常活性介导的病症。

4. 发明申请

US20070142437A1 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：US20070142437A1
公开(公告)日：2007-06-21
申请号：US11670498
申请日：2007-02-02
申请人： Matthew Brown , Mui Cheung , Scott Dickerson , Cassandra Gauthier , Philip Harris , Robert Hunter , Gregory Pacofsky , Michael Peel , Jeffrey Stafford
发明人： Matthew Brown , Mui Cheung , Scott Dickerson , Cassandra Gauthier , Philip Harris , Robert Hunter , Gregory Pacofsky , Michael Peel , Jeffrey Stafford
IPC分类号： A61K31/4439 , A61K31/427 , A61K31/423 , C07D413/02 , C07D417/02
CPC分类号： C07D263/48 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译：本文描述了可用作VEGFR2，CDK2和CDK4抑制剂的恶唑衍生物。所述的发明还包括制备这种恶唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。

5. 发明申请

US20070015756A1 Chemical compounds 有权
标题翻译：化合物
公开(公告)号：US20070015756A1
公开(公告)日：2007-01-18
申请号：US11383229
申请日：2006-05-15
申请人： Amogh Boloor , Mui Cheung , Ronda Davis , Philip Harris , Kevin Hinkle , Robert Mook , Jeffery Stafford , James Veal
发明人： Amogh Boloor , Mui Cheung , Ronda Davis , Philip Harris , Kevin Hinkle , Robert Mook , Jeffery Stafford , James Veal
IPC分类号： A61K31/53 , A61K31/506 , C07D403/02
CPC分类号： C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要： Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译：本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。

6. 发明申请

US20050024284A1 Microwave demulsification of hydrocarbon emulsion 有权
标题翻译：微波乳化乳化液
公开(公告)号：US20050024284A1
公开(公告)日：2005-02-03
申请号：US10619011
申请日：2003-07-14
申请人： James Halek , Philip Harris , Richard Thompson , Robert Ferri , Jonathan Squires
发明人： James Halek , Philip Harris , Richard Thompson , Robert Ferri , Jonathan Squires
IPC分类号： H01Q1/04 , H01Q13/12 , H01Q13/10
CPC分类号： H01Q1/04 , H01Q13/12
摘要： Recovery of hydrocarbons, such as petroleum products, from a liquid or solid substrate is facilitated by the use of microwave energy to energize and separate molecular bonds between the hydrocarbons and the substrate. A radio frequency (RF) applicator delivers microwave energy to a treatment volume containing an emulsion of a hydrocarbon and a substrate. Delivering the microwave energy to the emulsion facilitates separation of the hydrocarbon and substrate molecules into layers. Hydrocarbons and other products can then be recovered from their respective layers. The treatment volume may be located either above or below ground. The RF applicator may include an antenna body with slots formed substantially parallel to one another in a substantially horizontal orientation. The RF applicator efficiently delivers microwave energy into the treatment volume. Substantially all of the power supplied to the RF applicator is radiated, with very little power reflected internally within the RF applicator.
摘要翻译：通过使用微波能量来激发和分离烃和基底之间的分子键，促进从液体或固体基质中回收烃类如石油产品。射频（RF）施加器将微波能量传递到含有烃和基底的乳液的处理体积。将微波能量提供给乳液有助于将烃和底物分子分离成层。然后可以从各自的层回收碳氢化合物和其他产物。治疗体积可以位于地面上方或下方。 RF施加器可以包括天线体，其具有基本上水平的方向基本上彼此平行的槽形成。 RF施加器有效地将微波能量传递到处理体积中。基本上所有供给到RF施加器的功率被辐射，其中在RF施加器内部反射的功率非常小。

7. 发明申请

US20140222563A1 Solutions For Hedging Against Foreign-Exchange Currency Risk 审中-公开
标题翻译：对付外汇货币风险的对策
公开(公告)号：US20140222563A1
公开(公告)日：2014-08-07
申请号：US14171201
申请日：2014-02-03
申请人： Raja Ramachandran , Pavan Trikutam , Philip Harris
发明人： Raja Ramachandran , Pavan Trikutam , Philip Harris
IPC分类号： G06Q40/04 , G06Q30/02
CPC分类号： G06Q40/04 , G06Q20/381 , G06Q30/0207
摘要： A service providing affinity and rewards to consumers based on their spending abroad to leverage foreign exchange currency gains or losses is described. The service automates the process of exchange rate gain or loss on a product or product category basis. The service may provide marketer incentives to compensate for all or some portion of the currency exchange-based gain or loss, including automated incentive rewards.
摘要翻译：描述了一种基于他们在海外支出来利用外汇货币收益或损失而向消费者提供亲和度和奖励的服务。该服务使产品或产品类别的汇率收益或损失流程自动化。该服务可能会提供营销人员奖励，以补偿基于货币兑换的收益或损失的全部或部分内容，包括自动激励奖励。

8. 发明申请

US20060046938A1 Methods and compositions for delinking crosslinked fluids 审中-公开
标题翻译：脱水交联流体的方法和组合物
公开(公告)号：US20060046938A1
公开(公告)日：2006-03-02
申请号：US10932749
申请日：2004-09-02
申请人： Philip Harris , Rajesh Saini , Bradley Todd
发明人： Philip Harris , Rajesh Saini , Bradley Todd
IPC分类号： C09K8/60 , E21B43/00
CPC分类号： C09K8/685 , C09K8/706
摘要： One embodiment of the present invention provides a method of treating a subterranean formation comprising introducing to a portion of a subterranean formation a slurry comprising a solid, particulate chelating agent substantially coated with a degradable material and a viscosified treatment fluid comprising a crosslinked gelling agent, allowing the degradable material to degrade and release the chelating agent into the viscosified treatment fluid; and, allowing the released chelating agent to delink at least a portion of the crosslinked gelling agent. Another embodiment provides a delinker for use in a viscosified treatment fluid comprising a crosslinked gelling agent, comprising a particulate chelating agent substantially coated with a degradable material wherein the degradable material is capable of degrading to release the chelating agent and wherein the released chelating agent is then capable of delinking at least a portion of the crosslinked gelling agent.
摘要翻译：本发明的一个实施方案提供了一种处理地下地层的方法，包括向地下地层的一部分引入包含基本上涂覆有可降解材料的固体颗粒螯合剂和包含交联胶凝剂的稠化处理流体的浆料，允许所述可降解材料将所述螯合剂降解并释放到所述粘稠处理液中; 并且释放的螯合剂使交联的胶凝剂的至少一部分脱水。另一个实施方案提供了用于包含交联胶凝剂的增粘处理流体的脱水器，其包含基本上涂覆有可降解材料的颗粒螯合剂，其中可降解材料能够降解以释放螯合剂，并且其中释放的螯合剂能够使至少一部分交联的胶凝剂脱胶。

9. 发明申请

US20050282810A1 Oxindole derivatives 审中-公开
标题翻译：羟吲哚衍生物
公开(公告)号：US20050282810A1
公开(公告)日：2005-12-22
申请号：US11196597
申请日：2005-08-03
申请人： Philip Harris , Robert Hunter , Lee Kuyper , Karen Lackey , Robert McNutt , Michael Peel , Edgar Wood
发明人： Philip Harris , Robert Hunter , Lee Kuyper , Karen Lackey , Robert McNutt , Michael Peel , Edgar Wood
IPC分类号： A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/4196 , A61K31/4245 , A61K31/454 , A61K31/53 , A61P7/02 , A61P9/10 , A61P29/00 , A61P29/02 , A61P35/00 , A61P43/00 , C07D209/14 , C07D209/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D487/04
CPC分类号： C07D401/12 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/4196 , A61K31/4245 , A61K31/454 , A61K31/53 , C07D209/14 , C07D209/34 , C07D403/12 , C07D405/12 , C07D487/04
摘要： The present invention is related to oxindole derivatives, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
摘要翻译：本发明涉及羟吲哚衍生物，含有它们的组合物及其使用和制造方法。这些化合物通常在药理学上作为通常通过改变促分裂原活化的信号通路而减轻的疾病状态中的药物有用，特别是在病理学上涉及异常细胞增殖的蛋白激酶的抑制或拮抗作用中。这种疾病状态包括肿瘤生长，再狭窄，动脉粥样硬化，疼痛和血栓形成。特别地，本发明涉及一系列取代的羟吲哚化合物，其表现出Trk家族蛋白酪氨酸激酶抑制，并且其可用于癌症治疗和慢性疼痛适应症。

10. 发明授权

US08720080B2 Method and apparatus for drying rooms within a building 有权
标题翻译：建筑物内干燥房间的方法和装置
公开(公告)号：US08720080B2
公开(公告)日：2014-05-13
申请号：US12491511
申请日：2009-06-25
申请人： Jonathan Robert Jayne , Mark Lee Robinson , Philip Harris , Daniel Court , Andrew Charles Habbershaw
发明人： Jonathan Robert Jayne , Mark Lee Robinson , Philip Harris , Daniel Court , Andrew Charles Habbershaw
IPC分类号： F26B19/00 , F26B21/08 , F26B5/04 , F26B3/00 , F26B7/00 , F26B21/00 , F26B3/02
CPC分类号： F26B3/02 , E04B1/7069 , F24F3/14 , F24F11/0001 , F24F11/30 , F24F2011/0002 , F24F2110/20 , F26B21/001 , F26B21/08
摘要： A method and apparatus for drying a room within a building by sealing the room from outside ambient air ingress, heating the room internally, sensing humidity levels within the room, exhausting the air from within the room and drawing in outside ambient air, sensing water content within the room, and repeating the sequence until a dry status indication is received that the water content within the room has been reduced a predetermined level.
摘要翻译：一种用于通过将房间与外部环境空气入口密封来干燥建筑物内的房间的方法和设备，在室内加热房间，感测房间内的湿度水平，从室内排出空气并吸入室外环境空气，感测水分含量并且重复该顺序，直到接收到干燥状态指示，使得房间内的含水量已经降低了预定水平。

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