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1. 发明申请

US20070142437A1 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：US20070142437A1
公开(公告)日：2007-06-21
申请号：US11670498
申请日：2007-02-02
申请人： Matthew Brown , Mui Cheung , Scott Dickerson , Cassandra Gauthier , Philip Harris , Robert Hunter , Gregory Pacofsky , Michael Peel , Jeffrey Stafford
发明人： Matthew Brown , Mui Cheung , Scott Dickerson , Cassandra Gauthier , Philip Harris , Robert Hunter , Gregory Pacofsky , Michael Peel , Jeffrey Stafford
IPC分类号： A61K31/4439 , A61K31/427 , A61K31/423 , C07D413/02 , C07D417/02
CPC分类号： C07D263/48 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译：本文描述了可用作VEGFR2，CDK2和CDK4抑制剂的恶唑衍生物。所述的发明还包括制备这种恶唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。

2. 发明申请

US20050288515A1 Chemical compounds 失效
标题翻译：化合物
公开(公告)号：US20050288515A1
公开(公告)日：2005-12-29
申请号：US10530810
申请日：2003-10-10
申请人： Matthew Brown , Mui Cheung , Scott, Howard Dickerson , Cassandra Gauthier , Philip, Anthony Harris , Robert, Neil Hunter , Gregory Pacofsky , Michael, Robert Peel , Jeffrey, Alan Stafford
发明人： Matthew Brown , Mui Cheung , Scott, Howard Dickerson , Cassandra Gauthier , Philip, Anthony Harris , Robert, Neil Hunter , Gregory Pacofsky , Michael, Robert Peel , Jeffrey, Alan Stafford
IPC分类号： A61K20060101 , A61K31/421 , A61K31/422 , C07D263/30 , C07D263/48 , C07D413/02 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12
CPC分类号： C07D263/48 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12
摘要： Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译：本文描述了可用作VEGFR2，CDK2和CDK4抑制剂的恶唑衍生物。所述的发明还包括制备这种恶唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。

3. 发明申请

US20050267133A1 Pyrazolopyrimidines as kinase inhibitors 审中-公开
标题翻译：吡唑并嘧啶作为激酶抑制剂
公开(公告)号：US20050267133A1
公开(公告)日：2005-12-01
申请号：US10521910
申请日：2003-07-21
申请人： Matthew Brown , Mui Cheung , Scott Dickerson , David Drewry , Karen Lackey , Andrew Peat , Stephen Thomson , James Veal , Jayme Wilson
发明人： Matthew Brown , Mui Cheung , Scott Dickerson , David Drewry , Karen Lackey , Andrew Peat , Stephen Thomson , James Veal , Jayme Wilson
IPC分类号： A61K31/519 , A61P3/06 , A61P5/48 , A61P9/10 , A61P9/12 , A61P15/08 , A61P17/14 , A61P25/28 , A61P35/00 , A61P37/04 , A61P43/00 , C07D487/02 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： The present invention relates generally to inhibitors of the kinases and more particularly to novel pyrazolopyrimidine compounds
摘要翻译：本发明一般涉及激酶的抑制剂，更具体地涉及新的吡唑并嘧啶化合物

4. 发明授权

US08653968B2 Systems and methods for predictive building energy monitoring 有权
标题翻译：预测建筑能量监测的系统和方法
公开(公告)号：US08653968B2
公开(公告)日：2014-02-18
申请号：US12646764
申请日：2009-12-23
申请人： Matthew Brown , Christopher Barrington-Leigh , Christopher Porter , Neil Gentleman
发明人： Matthew Brown , Christopher Barrington-Leigh , Christopher Porter , Neil Gentleman
IPC分类号： G08B1/08
CPC分类号： H02J13/0062 , F24F11/46 , F24F2140/60 , G06Q10/04 , G06Q50/06 , H02J3/00 , H02J2003/003 , Y02B90/2638 , Y04S40/124
摘要： A system and method for predictive modeling of building energy consumption provides predicted building energy load values which are determined using kernel smoothing of historical building energy load values for a building using defined scaling factors for scaling predictor variables associated with building energy consumption. Predictor variables may include temperature, humidity, windspeed or direction, occupancy, time, day, date, and solar radiation. Scaling factor values may be defined by optimization training using historical building energy load values and measured predictor variable values for a building. Predicted and measured building energy load values are compared to determine if a preset difference threshold has been exceeded, in which case an alert signal or message is generated and transmitted to electronically and/or physically signal a user. The building energy monitoring system may be integrated with a building automation system, or may be operated as a separate system receiving building energy and predictor variable values.
摘要翻译：建筑能耗预测建模的系统和方法提供了预测的建筑物能量负荷值，其使用内部平滑建筑物的历史建筑物能量负荷值确定的建筑物能量负荷值，使用定义的缩放因子来缩放与建筑能耗相关联的预测变量。预测变量可能包括温度，湿度，风速或方向，占用率，时间，日期，日期和太阳辐射。缩放因子值可以通过使用历史建筑物能量负荷值和建筑物的测量预测变量值的优化训练来定义。比较预测和测量的建筑物能量负载值以确定是否已经超过预设的差异阈值，在这种情况下，生成警报信号或者将信息发送到电子和/或物理地向用户发出信号。建筑能量监测系统可以与楼宇自动化系统集成，或者可以作为接收建筑能量和预测变量值的单独系统来操作。

5. 发明授权

US08249080B1 Ethernet to multilane optical transport network traffic interface 有权
标题翻译：以太网到多路光传输网络流量接口
公开(公告)号：US08249080B1
公开(公告)日：2012-08-21
申请号：US12959211
申请日：2010-12-02
申请人： Dimitrios Giannakopoulos , Matthew Ornes , Matthew Brown , Tracy Ma
发明人： Dimitrios Giannakopoulos , Matthew Ornes , Matthew Brown , Tracy Ma
IPC分类号： H04L12/28 , H04L12/56 , H04J3/16 , H04J3/22
CPC分类号： H04J3/1658 , H04J2203/0085 , H04L5/00 , H04L12/4633
摘要： A system and method are provided for transporting a serial stream via a lower speed network using multiple parallel paths. At a transmitter, an optical or electromagnetic waveform is accepted representing a serial stream of digital information, and unbundled into n virtual information streams. Each virtual information stream is divided into a sequence of segments. Each segment is encapsulated, creating a sequence of packets by adding a start indicator to the beginning of each segment, and a terminate indicator to the end of each segment. Each packet is disinterleaved across m lanes and reinterleaved into n branches of framed data. Optical or electromagnetic waveforms representing the framed data are transmitted via n network branches. A receiver is also provided, which essentially reverses the above-described transmission method.
摘要翻译：提供了一种用于通过使用多个并行路径的低速网络传送串行流的系统和方法。在发射机处，接收表示数字信息的串行流的光学或电磁波形，并将其分解成n个虚拟信息流。每个虚拟信息流被分成一段段。每个段被封装，通过将开始指示符添加到每个段的开始，并且将终止指示符添加到每个段的末尾来创建数据包序列。每个数据包在m个通道上解交错，并重新交织成成帧数据的n个分支。通过n个网络分支传送表示成帧数据的光学或电磁波形。还提供接收机，其基本上反转了上述传输方法。

6. 发明申请

US20120094972A1 HETEROCYCLIC COMPOUNDS AND THEIR USES 失效
公开(公告)号：US20120094972A1
公开(公告)日：2012-04-19
申请号：US13377210
申请日：2010-06-25
申请人： Matthew Brown , Yi Chen , Timothy David Cushing , Felix Gonzalez Lopez De Turiso , Xiao He , Todd J. Kohn , Julia Winslow Lohman , Vatee Pattaropong , Jennifer Seganish , Youngsook Shin , Jillian L. Simard
发明人： Matthew Brown , Yi Chen , Timothy David Cushing , Felix Gonzalez Lopez De Turiso , Xiao He , Todd J. Kohn , Julia Winslow Lohman , Vatee Pattaropong , Jennifer Seganish , Youngsook Shin , Jillian L. Simard
IPC分类号： A61K31/5415 , C07D491/107 , C07D471/04 , C07D401/14 , C07D491/20 , C07D473/00 , C07D417/14 , C07D513/04 , A61K31/5377 , A61K31/506 , A61K31/4709 , A61K31/52 , A61K31/538 , A61P19/08 , A61P19/02 , A61P27/02 , A61P29/00 , A61P17/06 , A61P1/00 , A61P13/10 , A61P17/00 , A61P35/00 , C07D413/14
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/107 , C07D491/113 , C07D491/20 , C07D495/10 , C07D513/04
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

7. 发明申请

US20110060011A1 OXAZOLE COMPOUNDS COMPOSITIONS AND METHODS OF USE 有权
标题翻译：奥沙唑化合物组合物和使用方法
公开(公告)号：US20110060011A1
公开(公告)日：2011-03-10
申请号：US12920258
申请日：2009-03-13
申请人： Matthew Brown , Michael Johnson
发明人： Matthew Brown , Michael Johnson
IPC分类号： A61K31/4439 , C07D263/34 , A61K31/42 , A61P35/00 , C07D413/04
CPC分类号： C07D263/50 , C07D263/32 , C07D413/12
摘要： The present invention relates generally to compounds represented in Formula (I), pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
摘要翻译：本发明一般涉及式（I）表示的化合物，包含它们的药物组合物和治疗诸如癌症的疾病或病症的方法。

8. 发明申请

US20100075613A1 System and Method for Link Rate Negotiation 有权
标题翻译：链路速率协商的系统和方法
公开(公告)号：US20100075613A1
公开(公告)日：2010-03-25
申请号：US12236918
申请日：2008-09-24
申请人： Matthew Brown , Marika Herod , Yanming Gao
发明人： Matthew Brown , Marika Herod , Yanming Gao
IPC分类号： H04B7/00
CPC分类号： H04W28/22 , H04L5/1446
摘要： A system and method are provided for negotiating a link data rate in a communication system using a plurality of data rates. In a system including a first device network-connected to a second device, auto-negotiation (AN) messages are mutually transmitted. The AN messages indicate rate information such as preferred data rate capabilities, if the device has a dual-rate capability, or a single data rate capabilities. If the AN messages are mutually transmitted, a negotiated link data rate is established. However, if one of the devices cannot send AN messages, the other device times-out, and a link data rate is established at the data rate transmitted by the device that is not AN-capable.
摘要翻译：提供了一种用于在使用多个数据速率的通信系统中协商链路数据速率的系统和方法。在包括与第二设备网络连接的第一设备的系统中，自动协商（AN）消息被相互传输。 AN消息指示诸如优选数据速率能力的速率信息，如果设备具有双速率能力或单个数据速率能力。如果AN消息相互发送，则建立协商的链路数据速率。然而，如果其中一个设备不能发送AN消息，则其他设备超时和链路数据速率以不是AN的能力的设备传输的数据速率建立。

9. 发明申请

US20100008087A1 OPTICAL INTEGRATING CHAMBER LIGHTING USING ONE OR MORE ADDITIONAL COLOR SOURCES TO ADJUST WHITE LIGHT 审中-公开
标题翻译：使用一个或多个附加颜色来源调整白光的光学集成室内照明
公开(公告)号：US20100008087A1
公开(公告)日：2010-01-14
申请号：US12563632
申请日：2009-09-21
申请人： Jack C. RAINS, JR. , Matthew Brown
发明人： Jack C. RAINS, JR. , Matthew Brown
IPC分类号： F21V9/00
CPC分类号： F21S10/02 , F21S2/00 , F21S8/00 , F21V5/002 , F21V5/008 , F21V7/22 , F21V11/10 , F21V14/06 , F21V2200/13 , F21W2131/406 , F21Y2113/00 , F21Y2113/13 , F21Y2113/20 , F21Y2115/10 , G01J1/08 , G01J3/0254 , G01J3/0264 , G01J3/10 , G01J3/501 , G02B5/0252 , G02B5/0278 , G02B5/0284 , G02B6/0008 , G03B15/06 , G09F13/0404 , G09F13/06 , G09F13/14 , G09F13/22 , H05B33/0812 , H05B33/0842 , H05B33/0863 , H05B33/0869 , H05B33/0872 , H05B35/00 , Y02B20/343 , Y10S362/80 , Y10S362/812
摘要： A system provides white light having a selectable spectral characteristic (e.g. a selectable color temperature) using an optical integrating cavity to combine energy of different wavelengths from different sources with white light. The cavity has a diffusely reflective interior surface and an aperture for allowing emission of combined light. Control of the intensity of emission of the sources sets the amount of primary color light of each wavelength added to the substantially white input light output and thus determines a spectral characteristic of the white light output through the aperture. A variety of different elements may optically process the combined light output, such a deflector, a variable iris, a lens, a variable focusing lens system, a collimator, a holographic diffuser and combinations thereof.
摘要翻译：系统使用光学积分腔提供具有可选择的光谱特性（例如，可选色温）的白光，以将来自不同光源的不同波长的能量与白光组合。空腔具有漫反射内表面和用于允许发射组合光的孔。源的发射强度的控制设定了添加到基本为白色输入光输出的每个波长的原色光的量，从而确定通过孔输出的白光的光谱特性。各种不同的元件可以光学处理组合光输出，例如偏转器，可变虹膜，透镜，可变聚焦透镜系统，准直仪，全息漫射器及其组合。

10. 发明授权

US07625098B2 Optical integrating chamber lighting using multiple color sources to adjust white light 有权
标题翻译：光学积分室照明采用多种颜色源调节白光
公开(公告)号：US07625098B2
公开(公告)日：2009-12-01
申请号：US10558481
申请日：2005-04-25
申请人： Jack C. Rains, Jr. , Matthew Brown
发明人： Jack C. Rains, Jr. , Matthew Brown
IPC分类号： F21V9/16 , F21V7/22
CPC分类号： F21S10/02 , F21S2/00 , F21S8/00 , F21V5/002 , F21V5/008 , F21V7/22 , F21V11/10 , F21V14/06 , F21V2200/13 , F21W2131/406 , F21Y2113/00 , F21Y2113/13 , F21Y2113/20 , F21Y2115/10 , G01J1/08 , G01J3/0254 , G01J3/0264 , G01J3/10 , G01J3/501 , G02B5/0252 , G02B5/0278 , G02B5/0284 , G02B6/0008 , G03B15/06 , G09F13/0404 , G09F13/06 , G09F13/14 , G09F13/22 , H05B33/0812 , H05B33/0842 , H05B33/0863 , H05B33/0869 , H05B33/0872 , H05B35/00 , Y02B20/343 , Y10S362/80 , Y10S362/812
摘要： A system provides white light having a selectable spectral characteristic (e.g. a selectable color temperature) using an optical integrating cavity to combine energy of different wavelengths from different sources with white light. The cavity has a diffusely reflective interior surface and an aperture for allowing emission of combined light. Control of the intensity of emission of the sources sets the amount of primary color light of each wavelength added to the substantially white input light output and thus determines a spectral characteristic of the white light output through the aperture. A variety of different elements may optically process the combined light output, such a deflector, a variable iris, a lens, a variable focusing lens system, a collimator, a holographic diffuser and combinations thereof.
摘要翻译：系统使用光学积分腔提供具有可选择的光谱特性（例如，可选色温）的白光，以将来自不同光源的不同波长的能量与白光组合。空腔具有漫反射内表面和用于允许发射组合光的孔。源的发射强度的控制设定了添加到基本为白色输入光输出的每个波长的原色光的量，从而确定通过孔输出的白光的光谱特性。各种不同的元件可以光学处理组合光输出，例如偏转器，可变虹膜，透镜，可变聚焦透镜系统，准直仪，全息漫射器及其组合。

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