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1. 发明授权

US07153652B2 Mismatch repair detection 失效
公开(公告)号：US07153652B2
公开(公告)日：2006-12-26
申请号：US10081771
申请日：2002-02-20
申请人： David R. Cox , Malek Faham , Siamak Baharloo
发明人： David R. Cox , Malek Faham , Siamak Baharloo
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C40B40/02 , C12N15/1037 , C12N15/64 , C12N15/70 , C12Q1/6827 , C12Q1/6897 , C12Q2600/156 , C12Q2521/507 , C12Q2521/514
摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and-lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.

2. 发明授权

US06709827B2 Mismatch repair detection 失效
标题翻译：不匹配修复检测
公开(公告)号：US06709827B2
公开(公告)日：2004-03-23
申请号：US10072047
申请日：2002-02-08
申请人： David R. Cox , Malek Faham , Siamak Baharloo
发明人： David R. Cox , Malek Faham , Siamak Baharloo
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , C12Q1/6897 , C12Q2600/156
摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.
摘要翻译：用于DNA变异检测的新方法的不匹配修复检测（MRD）利用细菌通过标记基因的表达变化来检测错配。将待筛选的DNA片段克隆到两个MRD质粒中，并用这些构建体的异源双链体转化细菌。得到的菌落在不存在错配的情况下表达标记基因，并且在存在失配的情况下缺乏表达。 MRD能够检测DNA的10 kb内的单一错配。此外，MRD可以同时分析许多片段，为高通量基因分型和突变检测提供了强大的方法。

3. 发明授权

US06406847B1 Mismatch repair detection 失效
公开(公告)号：US06406847B1
公开(公告)日：2002-06-18
申请号：US09271055
申请日：1999-03-17
申请人： David R. Cox , Malek Faham , Siamak Baharloo
发明人： David R. Cox , Malek Faham , Siamak Baharloo
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , C12Q1/6897 , C12Q2600/156
摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.

4. 发明申请

US20110020815A1 METHODS FOR GENOMIC ANALYSIS 审中-公开
标题翻译：基因分析方法
公开(公告)号：US20110020815A1
公开(公告)日：2011-01-27
申请号：US12795361
申请日：2010-06-07
申请人： Nila Patil , David R. Cox , Anthony J. Berno , David A. Hinds
发明人： Nila Patil , David R. Cox , Anthony J. Berno , David A. Hinds
IPC分类号： C12Q1/68
CPC分类号： G16B30/00 , C12Q1/6827 , G16B40/00 , Y10T436/143333
摘要： The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.
摘要翻译：本发明涉及用于鉴定在人类基因组中发生的变异并将这些变异与疾病和药物反应的遗传基础相关联的方法。特别地，本发明涉及鉴定单个SNP，确定SNP单倍型区块和模式，并且还涉及使用SNP单倍型区块和模式来解剖疾病和药物反应的遗传基础。本发明的方法可用于全基因组分析。

5. 发明授权

US06969589B2 Methods for genomic analysis 有权
公开(公告)号：US06969589B2
公开(公告)日：2005-11-29
申请号：US10106097
申请日：2002-03-26
申请人： Nila Patil , David R. Cox , Anthony J. Berno , David A. Hinds
发明人： Nila Patil , David R. Cox , Anthony J. Berno , David A. Hinds
IPC分类号： G01N33/53 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/09 , C12P19/34 , C12Q1/68 , G01N33/00 , G01N33/566 , G06F19/22 , G06F19/24
CPC分类号： G06F19/22 , C12Q1/6827 , G06F19/24 , Y10T436/143333
摘要： The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.

6. 发明授权

US08462959B2 Managing acoustic noise produced by a device 有权
标题翻译：管理由设备产生的声音噪声
公开(公告)号：US08462959B2
公开(公告)日：2013-06-11
申请号：US11867622
申请日：2007-10-04
申请人： Paul J. Costa , David R. Cox , Benjamin A. Bard
发明人： Paul J. Costa , David R. Cox , Benjamin A. Bard
IPC分类号： H03B29/00
CPC分类号： G10K11/16 , G06F1/20 , H05K7/20209
摘要： One embodiment of the present invention provides a system that manages the acoustic noise produced by a device. During operation, the system receives a set of acoustic characteristics for the device. The system then uses these acoustic characteristics to estimate the acoustic noise being generated by the device. Next, the system uses the estimated acoustic noise to adjust a setting in the device to manage the acoustic noise produced by the device.
摘要翻译：本发明的一个实施例提供一种管理由设备产生的声学噪声的系统。在操作期间，系统接收一组该设备的声学特性。然后，系统使用这些声学特性来估计由设备产生的声学噪声。接下来，系统使用估计的声学噪声来调整设备中的设置以管理由设备产生的声学噪声。

7. 发明授权

US06955883B2 Life sciences business systems and methods 有权
标题翻译：生命科学业务系统和方法
公开(公告)号：US06955883B2
公开(公告)日：2005-10-18
申请号：US10402839
申请日：2003-03-26
申请人： Bradley A. Margus , David R. Cox , Stephen P. A. Fodor
发明人： Bradley A. Margus , David R. Cox , Stephen P. A. Fodor
IPC分类号： C12N15/09 , A61K31/00 , A61K31/711 , A61K38/00 , A61K39/395 , A61K48/00 , A61P3/10 , A61P31/04 , A61P35/00 , A61P37/02 , C12Q1/68 , G01N20060101 , G01N33/48 , G01N33/50 , G06F19/00 , G06Q50/22 , G06Q50/24
CPC分类号： G06F19/18 , G06Q50/22 , G06Q50/24 , G06Q99/00 , Y02A90/22
摘要： Improved life sciences business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic developments.
摘要翻译：披露了改进的生命科学业务系统和方法。一个或多个基因组扫描单核苷酸多态性。将多态性分配给单倍型区段，并且来自单倍型区段的代表性SNP用于药物和诊断发展的关联研究。

8. 发明授权

US06897025B2 Genetic analysis systems and methods 有权
标题翻译：遗传分析系统和方法
公开(公告)号：US06897025B2
公开(公告)日：2005-05-24
申请号：US10042819
申请日：2002-01-07
申请人： David R. Cox , Bradley A. Margus , Nila Patil
发明人： David R. Cox , Bradley A. Margus , Nila Patil
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6827 , C12Q2565/125 , C12Q2565/501
摘要： Improved systems and methods for performing genetic analyses. Full genomic DNA scans are performed on the genetic DNA from a plurality of individuals to identify genetic variants. For those variants, but not based on a full genetic DNA scan, the variants alone are scanned in additional individuals to identify blocks of the variants that tend to be inherited together.
摘要翻译：改进的用于进行遗传分析的系统和方法。对来自多个个体的遗传DNA进行全基因组DNA扫描，以鉴定遗传变异。对于这些变体，但不是基于完整的基因DNA扫描，单独的变体被扫描在另外的个体中以鉴定易于一起遗传的变体块。

9. 发明申请

US20080299125A1 Genetic basis of treatment response in depression patients 审中-公开
标题翻译：抑郁症患者治疗反应的遗传依据
公开(公告)号：US20080299125A1
公开(公告)日：2008-12-04
申请号：US11810694
申请日：2007-06-05
申请人： David A. Hinds , David R. Cox , Craig L. Hyde , Hakan Sakul
发明人： David A. Hinds , David R. Cox , Craig L. Hyde , Hakan Sakul
IPC分类号： C12Q1/68 , A61K39/395 , A61K38/16 , A01K67/027 , A61P25/24 , A61K31/7088 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The invention provides a collection of polymorphic sites associated with response to treatment by an SSRI or placebo in depression patients. The polymorphic sites and others in linkage disequilibrium with them are useful in determining whether to treat a patient with an SSRI or include a patient in a clinical trial to test an SSRI.
摘要翻译：本发明提供了与抑郁症患者中SSRI或安慰剂治疗反应相关的多态性位点的集合。与它们连锁不平衡的多态性位点和其他位点可用于确定是否用SSRI治疗患者或在临床试验中包括患者以测试SSRI。

10. 发明授权

US06432635B1 Cystatin B mutants 失效
标题翻译：半胱氨酸蛋白酶抑制剂B突变体
公开(公告)号：US06432635B1
公开(公告)日：2002-08-13
申请号：US08819872
申请日：1997-03-18
申请人： Richard M. Myers , David R. Cox , Len A. Pennacchio , Anna-Elina Lehesjoki , Albert De La Chapelle
发明人： Richard M. Myers , David R. Cox , Len A. Pennacchio , Anna-Elina Lehesjoki , Albert De La Chapelle
IPC分类号： C12Q168
CPC分类号： C07K14/8139 , Y10S435/81
摘要： An isolated nucleic acid molecule, wherein the molecule contains: (1) a first sequence consisting of human cystatin B genomic DNA as set forth in FIG. 3 (SEQ ID NO:1); (2) a second sequence, wherein said second sequence is a subsequence of said first sequence, is at least nucleotides in length, and is not present in human cystatin B cDNA; (3) a third sequence in which at least one nucleotide of said first or second sequences is replaced by a different nucleotide; or (4) a fourth sequence complementary to any of said first, second or third sequences; with the proviso that (I) if said molecule is an RNA molecule, U replaces T in said sequence of said molecule, and (ii) said third sequence is at least 95% identical to said first or second sequence.
摘要翻译：一种分离的核酸分子，其中所述分子含有：（1）由人半胱氨酸蛋白酶抑制剂B基因组DNA组成的第一序列，如图1所示。 3（SEQ ID NO：1）;（2）第二序列，其中所述第二序列是所述第一序列的亚序列，长度至少为核苷酸，并且不存在于人半胱氨酸蛋白酶抑制剂B cDNA中;（3）第三序列其中所述第一或第二序列的至少一个核苷酸被不同核苷酸替代的序列; 或（4）与所述第一，第二或第三序列中的任一个互补的第四序列;条件是（I）如果所述分子是RNA分子，则U代替所述分子的所述序列中的T，和（ii）所述第三序列与所述第一或第二序列至少95％相同。

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