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1. 发明申请

US20130325666A1 Collections of Matched Biological Reagents and Methods for Identifying Matched Reagents 审中-公开
公开(公告)号：US20130325666A1
公开(公告)日：2013-12-05
申请号：US13422202
申请日：2012-03-16
申请人： John CARRINO , Feng Liang , Siamak Baharloo , Barry I. Schweitzer
发明人： John CARRINO , Feng Liang , Siamak Baharloo , Barry I. Schweitzer
IPC分类号： G06Q30/06
CPC分类号： G06Q30/0627 , G06Q30/06 , G06Q50/22 , Y02A90/22 , Y02A90/24
摘要： Provided herein are collections of matched biological reagents selected from a larger collection of biological reagents, wherein the collection of matched biological reagents relate to a biological element. Also provided are methods for selling an isolated biomolecule or biological research reagent in a collection of matched biological reagents, and methods for selecting an isolated biomolecule or biological research reagent from a collection of biological reagents.

2. 发明申请

US20120203661A1 E-COMMERCE SYSTEMS AND METHODS 审中-公开
标题翻译：电子商务系统和方法
公开(公告)号：US20120203661A1
公开(公告)日：2012-08-09
申请号：US13021539
申请日：2011-02-04
申请人： Siamak BAHARLOO , James Gilmore , Michael Stapleton , Anthony Stevens , Martin Naley , Nicole Cheri Brockway
发明人： Siamak BAHARLOO , James Gilmore , Michael Stapleton , Anthony Stevens , Martin Naley , Nicole Cheri Brockway
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0607 , G06Q30/06 , G06Q30/0603 , G06Q30/0625 , G06Q30/0633 , H04L67/02 , H04L69/03
摘要： The invention is in general directed to methods and processes for generating revenue via an electronic commerce website. The invention is also directed to methods of processing product orders and selling product related to protocols, workflows, or other applications. The invention also contemplates methods for selling products, which include previously ordered products, related products, substitute products, and equivalent products, including but not limited to equivalent protocol products, matched reagent sets, kits, and biomodules for practicing said protocols and equivalent protocols.
摘要翻译：本发明一般涉及通过电子商务网站产生收入的方法和过程。本发明还涉及处理产品订单并销售与协议，工作流程或其他应用相关的产品的方法。本发明还考虑了销售产品的方法，包括先前订购的产品，相关产品，替代产品和等同产品，包括但不限于等效的协议产品，匹配的试剂盒，试剂盒和用于实施所述协议和等效协议的生物模块。

3. 发明申请

US20070203747A1 E-COMMERCE SYSTEMS AND METHODS 审中-公开
标题翻译：电子商务系统和方法
公开(公告)号：US20070203747A1
公开(公告)日：2007-08-30
申请号：US11567726
申请日：2006-12-06
申请人： Siamak Baharloo , James Gilmore , Michael Stapleton , Anthony Stevens , Martin Naley , Nicole Brockway
发明人： Siamak Baharloo , James Gilmore , Michael Stapleton , Anthony Stevens , Martin Naley , Nicole Brockway
IPC分类号： G06Q50/00 , G06Q10/00 , C12Q1/00
CPC分类号： G06Q30/00 , G06Q50/22 , Y02A90/22
摘要： The invention is in general directed to methods and processes for generating revenue via an electronic commerce website. The invention is also directed to methods of processing product orders and selling product related to protocols, workflows, or other applications. The invention also contemplates methods for selling products, which include previously ordered products, related products, substitute products, and equivalent products, including but not limited to equivalent protocol products, matched reagent sets, kits, and biomodules for practicing said protocols and equivalent protocols.
摘要翻译：本发明一般涉及通过电子商务网站产生收入的方法和过程。本发明还涉及处理产品订单并销售与协议，工作流程或其他应用相关的产品的方法。本发明还考虑了销售产品的方法，包括先前订购的产品，相关产品，替代产品和等同产品，包括但不限于等效的协议产品，匹配的试剂盒，试剂盒和用于实施所述协议和等效协议的生物模块。

4. 发明申请

US20050239080A1 Mismatch repair detection 审中-公开
标题翻译：不匹配修复检测
公开(公告)号：US20050239080A1
公开(公告)日：2005-10-27
申请号：US10728122
申请日：2003-12-03
申请人： David Cox , Malek Faham , Siamak Baharloo
发明人： David Cox , Malek Faham , Siamak Baharloo
IPC分类号： C12N1/21 , C12N15/74 , C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6897 , C12Q2600/156
摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.
摘要翻译：用于DNA变异检测的新方法的不匹配修复检测（MRD）利用细菌通过标记基因的表达变化来检测错配。将待筛选的DNA片段克隆到两个MRD质粒中，并用这些构建体的异源双链体转化细菌。得到的菌落在不存在错配的情况下表达标记基因，并且在存在失配的情况下缺乏表达。 MRD能够检测DNA的10 kb内的单一错配。此外，MRD可以同时分析许多片段，为高通量基因分型和突变检测提供了强大的方法。

5. 发明授权

US06406847B1 Mismatch repair detection 失效
公开(公告)号：US06406847B1
公开(公告)日：2002-06-18
申请号：US09271055
申请日：1999-03-17
申请人： David R. Cox , Malek Faham , Siamak Baharloo
发明人： David R. Cox , Malek Faham , Siamak Baharloo
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , C12Q1/6897 , C12Q2600/156
摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.

6. 发明授权

US07153652B2 Mismatch repair detection 失效
公开(公告)号：US07153652B2
公开(公告)日：2006-12-26
申请号：US10081771
申请日：2002-02-20
申请人： David R. Cox , Malek Faham , Siamak Baharloo
发明人： David R. Cox , Malek Faham , Siamak Baharloo
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C40B40/02 , C12N15/1037 , C12N15/64 , C12N15/70 , C12Q1/6827 , C12Q1/6897 , C12Q2600/156 , C12Q2521/507 , C12Q2521/514
摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and-lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.

7. 发明授权

US06709827B2 Mismatch repair detection 失效
标题翻译：不匹配修复检测
公开(公告)号：US06709827B2
公开(公告)日：2004-03-23
申请号：US10072047
申请日：2002-02-08
申请人： David R. Cox , Malek Faham , Siamak Baharloo
发明人： David R. Cox , Malek Faham , Siamak Baharloo
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , C12Q1/6897 , C12Q2600/156
摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.
摘要翻译：用于DNA变异检测的新方法的不匹配修复检测（MRD）利用细菌通过标记基因的表达变化来检测错配。将待筛选的DNA片段克隆到两个MRD质粒中，并用这些构建体的异源双链体转化细菌。得到的菌落在不存在错配的情况下表达标记基因，并且在存在失配的情况下缺乏表达。 MRD能够检测DNA的10 kb内的单一错配。此外，MRD可以同时分析许多片段，为高通量基因分型和突变检测提供了强大的方法。

8. 发明申请

US20120221432A1 METHODS AND SYSTEMS FOR IN SILICO EXPERIMENTAL DESIGN AND FOR PROVIDING A BIOTECHNOLOGY PRODUCT TO A CUSTOMER 审中-公开
标题翻译：用于硅胶实验设计和向客户提供生物技术产品的方法和系统
公开(公告)号：US20120221432A1
公开(公告)日：2012-08-30
申请号：US12791820
申请日：2010-06-01
申请人： Shao-Min Yuan , Michael Beltsov , Thomas G. Chappell , Kevin Clancy , Peter McGarvey , Sam Zaremba , James Caffrey , Konstantin Belov , Anatoliy Mnev , Siamak BAHARLOO , Aruna Myneni , James Gilmore
发明人： Shao-Min Yuan , Michael Beltsov , Thomas G. Chappell , Kevin Clancy , Peter McGarvey , Sam Zaremba , James Caffrey , Konstantin Belov , Anatoliy Mnev , Siamak BAHARLOO , Aruna Myneni , James Gilmore
IPC分类号： G06Q30/06
CPC分类号： G06Q30/0623 , G06Q50/22 , G06Q99/00 , G16B50/00 , Y02A90/22 , Y02A90/24
摘要： Provided herein is a method and computer program product for designing and/or simulating a biotechnology experiment in silico; and for providing and generating revenue from a customized list of one or more biotechnology products and/or services related to the in silico designed or simulated biotechnology experiment or the product of that experiment. In illustrative examples, the products and or services are indirectly related to a biomolecule designed by the in silico designed biotechnology experiment. In addition, provided herein is a method and computer system for generating revenue, that includes providing a customer with a first computer program product for designing or performing a biotechnology experiment in silico; and providing the customer with access to a purchase function for purchasing a second computer program product for designing or performing a biotechnology experiment in silico. Typically, functionality of the first computer product is less then and/or different than the functionality of the second computer product.
摘要翻译：本文提供了一种用于在计算机上设计和/或模拟生物技术实验的方法和计算机程序产品; 以及通过与计算机设计或模拟生物技术实验或该实验的产品相关的一个或多个生物技术产品和/或服务的定制列表来提供和产生收入。在说明性实例中，产品和/或服务与通过计算机设计的生物技术实验设计的生物分子间接相关。此外，本文提供了一种用于产生收入的方法和计算机系统，其包括为客户提供用于以计算机设计或执行生物技术实验的第一计算机程序产品; 并为客户提供访问购买功能以购买用于以计算机设计或执行生物技术实验的第二计算机程序产品。通常，第一计算机产品的功能小于和/或不同于第二计算机产品的功能。

9. 发明申请

US20060100788A1 Collections of matched biological reagents and methods for identifying matched reagents 审中-公开
标题翻译：匹配的生物试剂的集合和用于鉴定匹配试剂的方法
公开(公告)号：US20060100788A1
公开(公告)日：2006-05-11
申请号：US11112933
申请日：2005-04-22
申请人： John Carrino , Feng Liang , Siamak Baharloo , Barry Schweitzer
发明人： John Carrino , Feng Liang , Siamak Baharloo , Barry Schweitzer
IPC分类号： G06Q10/00 , G06F19/00
CPC分类号： G06Q30/0627 , G06Q30/06 , G06Q50/22 , Y02A90/22 , Y02A90/24
摘要： Provided herein are collections of matched biological reagents selected from a larger collection of biological reagents, wherein the collection of matched biological reagents relate to a biological element. Also provided are methods for selling an isolated biomolecule or biological research reagent in a collection of matched biological reagents, and methods for selecting an isolated biomolecule or biological research reagent from a collection of biological reagents.
摘要翻译：本文提供了选自更大量的生物试剂的匹配生物试剂的集合，其中匹配的生物试剂的收集涉及生物学元件。还提供了在匹配的生物试剂的集合中销售分离的生物分子或生物研究试剂的方法，以及从生物试剂的集合中选择分离的生物分子或生物研究试剂的方法。

10. 发明申请

US20060064247A1 Methods and systems for in silico experimental design and for providing a biotechnology product to a customer 审中-公开
标题翻译：计算机实验设计的方法和系统，以及为客户提供生物技术产品
公开(公告)号：US20060064247A1
公开(公告)日：2006-03-23
申请号：US11182574
申请日：2005-07-14
申请人： Shao-Min Yuan , Michael Beltsov , Thomas Chappell , Kevin Clancy , Peter McGarvey , Sam Zaremba , James Caffrey , Konstantin Belov , Anatoliy Mnev , Siamak Baharloo , Aruna Myneni , James Gilmore
发明人： Shao-Min Yuan , Michael Beltsov , Thomas Chappell , Kevin Clancy , Peter McGarvey , Sam Zaremba , James Caffrey , Konstantin Belov , Anatoliy Mnev , Siamak Baharloo , Aruna Myneni , James Gilmore
IPC分类号： G06Q10/00 , G06F19/00
CPC分类号： G06Q30/0623 , G06Q50/22 , G06Q99/00 , G16B50/00 , Y02A90/22 , Y02A90/24
摘要： Provided herein is a method and computer program product for designing and/or simulating a biotechnology experiment in silico; and for providing and generating revenue from a customized list of one or more biotechnology products and/or services related to the in silico designed or simulated biotechnology experiment or the product of that experiment. In illustrative examples, the products and or services are indirectly related to a biomolecule designed by the in silico designed biotechnology experiment. In addition, provided herein is a method and computer system for generating revenue, that includes providing a customer with a first computer program product for designing or performing a biotechnology experiment in silico; and providing the customer with access to a purchase function for purchasing a second computer program product for designing or performing a biotechnology experiment in silico. Typically, functionality of the first computer product is less then and/or different than the functionality of the second computer product.
摘要翻译：本文提供了一种用于在计算机上设计和/或模拟生物技术实验的方法和计算机程序产品; 以及通过与计算机设计或模拟生物技术实验或该实验的产品相关的一个或多个生物技术产品和/或服务的定制列表来提供和产生收入。在说明性实例中，产品和/或服务与通过计算机设计的生物技术实验设计的生物分子间接相关。此外，本文提供了一种用于产生收入的方法和计算机系统，其包括为客户提供用于以计算机设计或执行生物技术实验的第一计算机程序产品; 并为客户提供访问购买功能以购买用于以计算机设计或执行生物技术实验的第二计算机程序产品。通常，第一计算机产品的功能小于和/或不同于第二计算机产品的功能。

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