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1. 发明授权

US06432635B1 Cystatin B mutants 失效
标题翻译：半胱氨酸蛋白酶抑制剂B突变体
公开(公告)号：US06432635B1
公开(公告)日：2002-08-13
申请号：US08819872
申请日：1997-03-18
申请人： Richard M. Myers , David R. Cox , Len A. Pennacchio , Anna-Elina Lehesjoki , Albert De La Chapelle
发明人： Richard M. Myers , David R. Cox , Len A. Pennacchio , Anna-Elina Lehesjoki , Albert De La Chapelle
IPC分类号： C12Q168
CPC分类号： C07K14/8139 , Y10S435/81
摘要： An isolated nucleic acid molecule, wherein the molecule contains: (1) a first sequence consisting of human cystatin B genomic DNA as set forth in FIG. 3 (SEQ ID NO:1); (2) a second sequence, wherein said second sequence is a subsequence of said first sequence, is at least nucleotides in length, and is not present in human cystatin B cDNA; (3) a third sequence in which at least one nucleotide of said first or second sequences is replaced by a different nucleotide; or (4) a fourth sequence complementary to any of said first, second or third sequences; with the proviso that (I) if said molecule is an RNA molecule, U replaces T in said sequence of said molecule, and (ii) said third sequence is at least 95% identical to said first or second sequence.
摘要翻译：一种分离的核酸分子，其中所述分子含有：（1）由人半胱氨酸蛋白酶抑制剂B基因组DNA组成的第一序列，如图1所示。 3（SEQ ID NO：1）;（2）第二序列，其中所述第二序列是所述第一序列的亚序列，长度至少为核苷酸，并且不存在于人半胱氨酸蛋白酶抑制剂B cDNA中;（3）第三序列其中所述第一或第二序列的至少一个核苷酸被不同核苷酸替代的序列; 或（4）与所述第一，第二或第三序列中的任一个互补的第四序列;条件是（I）如果所述分子是RNA分子，则U代替所述分子的所述序列中的T，和（ii）所述第三序列与所述第一或第二序列至少95％相同。

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