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1. 发明申请

US20060148023A1 Affinity labeling of serine proteases for simultaneous detection of multiple serine protease activity levels 审中-公开
标题翻译：亲和标记丝氨酸蛋白酶同时检测多个丝氨酸蛋白酶活性水平
公开(公告)号：US20060148023A1
公开(公告)日：2006-07-06
申请号：US10872824
申请日：2004-06-21
申请人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
发明人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N33/5091 , G01N33/573 , G01N2500/04 , G01N2510/00 , G01N2800/52
摘要： The invention provides assay methods and reagents useful for evaluating the level of enzyme activities within living cells. Enzyme activity levels within living cells, such as Serine proteases, can be key determinates in assessing; 1) the presence of tumor (cancer) cells, 2) the predictive efficacy of a chemotherapeutic treatment regimen using a particular therapeutic agent or process, 4) the probability of graft rejection or acceptance, and 5) the disease state status of a cell. The identification of the up or down regulation relationships of serine proteases within living cell systems, provides a rapid, yet finely tuned mechanism for predicting the current and future physiological state of these cell populations.
摘要翻译：本发明提供了可用于评估活细胞内酶活性水平的测定方法和试剂。活细胞内的酶活性水平，如丝氨酸蛋白酶，可能是评估中的关键决定因素; 1）肿瘤（癌症）细胞的存在，2）使用特定治疗剂或过程的化学治疗方案的预测效果，4）移植排斥或接受的概率，以及5）细胞的疾病状态。识别活细胞系统中丝氨酸蛋白酶的上调或下调调节关系，为预测这些细胞群体的当前和未来生理状态提供了一种快速但精细调节的机制。

2. 发明申请

US20050136492A1 Affinity labeling of enzymes for detection of enzyme activity level in living cells 审中-公开
标题翻译：用于检测活细胞中酶活性水平的酶的亲和标记
公开(公告)号：US20050136492A1
公开(公告)日：2005-06-23
申请号：US10872818
申请日：2004-06-21
申请人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
发明人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
IPC分类号： C12Q1/37 , G01N33/573 , G01N33/574
CPC分类号： G01N33/573 , C12Q1/37 , G01N33/574
摘要： The invention provides assay methods and reagents useful for evaluating the level of enzyme activities within living cells. Enzyme activity levels within living cells, such as caspases and Serine proteases, can be key determinates in assessing; 1) the apoptotic state of a cell, 2) the presence of tumor (cancer) cells, 3) the predictive efficacy of a chemotherapeutic treatment regimen using a particular therapeutic agent or process, 4) the probability of graft rejection or acceptance, identification of the up or down regulation relationships of serine proteases and caspases within living cell systems, provides a rapid, yet finely tuned mechanism for predicting the current and future state of these cell populations, and 5) the disease state status of a cell.
摘要翻译：本发明提供了可用于评估活细胞内酶活性水平的测定方法和试剂。活细胞内的酶活性，如胱天蛋白酶和丝氨酸蛋白酶，可以作为评估中的关键决定因素。 1）细胞的凋亡状态，2）肿瘤（癌症）细胞的存在，3）使用特定治疗剂或过程的化学治疗方案的预测效果，4）移植排斥或接受的概率，鉴定丝氨酸蛋白酶和半胱氨酸蛋白酶在活细胞系统中的向上或向下调节关系为预测这些细胞群体的当前和未来状态提供了一种快速但精细调节的机制，以及5）细胞的疾病状态。

3. 发明申请

US20070269832A1 Novel affinity labels 审中-公开
标题翻译：新颖的亲和标签
公开(公告)号：US20070269832A1
公开(公告)日：2007-11-22
申请号：US10872754
申请日：2004-06-21
申请人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
发明人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
IPC分类号： C12Q1/02 , C07D311/82 , C12Q1/37 , G01N33/573
CPC分类号： C07K5/06191 , C12Q1/37 , G01N33/58 , G01N2500/04
摘要： The invention provides novel affinity labels for Ser proteases of formula: L-A-X—NH—CH(R′)C(═O)CH2Cl (I) wherein L, A, X, and R′ have any of the values defined in the specification, or salts thereof, as well as compositions comprising such compounds or salts. The composition of the amino acid side-chain (R′) along with the amino acid or amino acid sequence (peptide) of the X component of formula I, affect the target selectivity of the labeled affinity ligand. Utilization of cell permeable, enzyme selective, labeled affinity ligands, provides a precise mechanism for evaluating the current and future status of cell populations.
摘要翻译：本发明提供了用于下式的Ser蛋白酶的新型亲和标记：<？in-line-formula description =“In-line Formulas”end =“lead”？> LAX-NH-CH（R'）C（-O）CH 其中L，A，X和R'具有如下定义的任何值：（1）说明书或其盐，以及包含这些化合物或盐的组合物。氨基酸侧链（R'）的组成与式I的X组分的氨基酸或氨基酸序列（肽）一起影响标记的亲和配体的靶选择性。细胞可渗透，酶选择性，标记的亲和配体的利用提供了一种精确的机制来评估细胞群体的当前和未来状态。

4. 发明申请

US20070082377A1 Cytotoxicity assays 审中-公开
标题翻译：细胞毒性测定
公开(公告)号：US20070082377A1
公开(公告)日：2007-04-12
申请号：US11246007
申请日：2005-10-07
申请人： Michael Olin , Gary Johnson , Brian Lee
发明人： Michael Olin , Gary Johnson , Brian Lee
IPC分类号： G01N1/30 , G01N33/48
CPC分类号： G01N1/30 , G01N33/5005 , G01N2333/96466
摘要： Certain embodiments of the invention provide methods and kits for determining cell viability and measuring cytotoxicity.
摘要翻译：本发明的某些实施方案提供了用于确定细胞存活力和测量细胞毒性的方法和试剂盒。

5. 发明授权

US08726103B2 Visual outage management tool 失效
标题翻译：视觉中断管理工具
公开(公告)号：US08726103B2
公开(公告)日：2014-05-13
申请号：US12962215
申请日：2010-12-07
申请人： Brian Lee
发明人： Brian Lee
IPC分类号： G06F11/00
CPC分类号： G06F11/328 , G06F11/3006 , G06F11/3017 , G06F11/302 , G06F11/3055 , G06Q10/06
摘要： Described herein are systems related to a visual tool for providing a dynamic and accessible collaborative environment during a production outage or network downtime. An outage management tool comprising a server application tool receiving and storing monitoring data related to an operation of a network and application-level components of the network, wherein the monitoring data includes outage information corresponding to one of the network and the application-level components, and a visualization tool generating an interactive representation of the network including the outage information, the visualization tool and generating, in response to a request, an adjusted interactive representation of the network including application-level components affected by an outage and event traffic related to the outage.
摘要翻译：这里描述的是与可视化工具相关的系统，用于在生产中断或网络停机期间提供动态和可访问的协作环境。一种中断管理工具，包括服务器应用工具，其接收和存储与网络的操作和网络的应用级组件相关的监控数据，其中所述监控数据包括与所述网络和所述应用级组件之一相对应的中断信息，以及可视化工具，其生成包括所述中断信息，所述可视化工具的所述网络的交互式表示，并响应于所述请求生成所述网络的经调整的交互式表示，所述交互式表示包括由与所述中断相关的中断和事件流量影响的应用级组件停电

6. 发明授权

US08541247B2 Non-volatile memory cell with lateral pinning 失效
标题翻译：具有侧向锁定的非易失性存储单元
公开(公告)号：US08541247B2
公开(公告)日：2013-09-24
申请号：US12973536
申请日：2010-12-20
申请人： Haiwen Xi , Antoine Khoueir , Brian Lee , Patrick J. Ryan
发明人： Haiwen Xi , Antoine Khoueir , Brian Lee , Patrick J. Ryan
IPC分类号： H01L27/115
CPC分类号： H01L43/08 , B82Y40/00 , G11C11/161 , G11C11/1675 , H01F10/3254 , H01F10/3272 , H01F10/329 , H01F41/303 , H01L43/12
摘要： An apparatus and associated method for a non-volatile memory cell, such as an STRAM cell. In accordance with various embodiments, a magnetic free layer is laterally separated from an antiferromagnetic layer (AFM) by a non-magnetic spacer layer and medially separated from a synthetic antiferromagnetic layer (SAF) by a magnetic tunneling junction. The AFM pins the magnetization of the SAF through contact with a pinning region of the SAF that laterally extends beyond the magnetic tunneling junction.
摘要翻译：用于非易失性存储器单元（例如STRAM单元）的装置和相关方法。根据各种实施例，无磁性层通过非磁性间隔层与反铁磁层（AFM）横向分离，并通过磁性隧道结从中间分离的合成反铁磁层（SAF）。 AFM通过与SAF的钉扎区域的接触来引导SAF的磁化，该区域横向延伸超过磁性隧道结。

7. 发明授权

US08508981B2 Apparatus for variable resistive memory punchthrough access method 有权
标题翻译：用于可变电阻存储器穿透访问方法的装置
公开(公告)号：US08508981B2
公开(公告)日：2013-08-13
申请号：US13478174
申请日：2012-05-23
申请人： Maroun Georges Khoury , Hongyue Liu , Brian Lee , Andrew John Gjevre Carter
发明人： Maroun Georges Khoury , Hongyue Liu , Brian Lee , Andrew John Gjevre Carter
IPC分类号： G11C11/00
CPC分类号： G11C11/1675 , G11C11/1659
摘要： Variable resistive punchthrough access methods are described. The methods include switching a variable resistive data cell from a high resistance state to a low resistance state by passing a write current through the magnetic tunnel junction data cell in a first direction. The write current is provided by a transistor being electrically coupled to the variable resistive data cell and a source line. The write current passes through the transistor in punchthrough mode.
摘要翻译：描述了可变电阻穿透访问方法。所述方法包括通过使写入电流沿着第一方向通过磁性隧道结数据单元，将可变电阻数据单元从高电阻状态切换到低电阻状态。写入电流由电耦合到可变电阻数据单元和源极线的晶体管提供。写入电流在穿通模式下通过晶体管。

8. 发明授权

US08448766B2 Bi-directional clutch with staggered roller elements 有权
标题翻译：具有交错滚子元件的双向离合器
公开(公告)号：US08448766B2
公开(公告)日：2013-05-28
申请号：US12818751
申请日：2010-06-18
申请人： Tomas Smetana , Brian Lee
发明人： Tomas Smetana , Brian Lee
IPC分类号： F16D15/00 , F16D41/06
CPC分类号： F16D41/088 , F16D15/00
摘要： A coupling having at least two concentric rings, each having a circumferential surface and a recess, and at least two roller elements. The roller elements are each disposed in a channel formed by the circumferential surface of one of the rings and the recess of another of the rings. In some example embodiments of the invention, the coupling includes a coupling member with a bearing surface, at least one of the rings includes a split and the split ring is urged against the bearing surface when there is relative rotation between the rings. The coupling member is, for example, a shaft or a gear.
摘要翻译：具有至少两个同心环的联接器，每个具有圆周表面和凹槽，以及至少两个滚子元件。辊元件各自设置在由一个环的圆周表面和另一个环的凹部形成的通道中。在本发明的一些示例性实施例中，联接器包括具有支承表面的联接构件，至少一个环包括开口，并且当环之间存在相对旋转时，开口环被推靠在支承表面上。联接构件例如是轴或齿轮。

9. 发明申请

US20120120628A1 MODULAR FLAT-PANEL MONITOR STAND 有权
标题翻译：模块化平板监视器
公开(公告)号：US20120120628A1
公开(公告)日：2012-05-17
申请号：US13386428
申请日：2009-07-22
申请人： Robert P Bliven , Jacques Gagne , Kenneth G. Robertson , Brian Lee , Brian David Perry
发明人： Robert P Bliven , Jacques Gagne , Kenneth G. Robertson , Brian Lee , Brian David Perry
IPC分类号： H05K7/02 , F16L3/23 , H05K7/00
CPC分类号： G06F1/1601 , F16M11/041 , F16M11/10 , F16M13/00
摘要： A flat-panel display stand in accordance with the present invention includes a modular assembly for supporting a display on a horizontal surface so that the display tilt can be adjusted by the user. The stand has a modular design with only two modules: a retainer clip and supporting leg that are uniquely hinged together and connected to the rear of the display.
摘要翻译：根据本发明的平板显示支架包括用于在水平表面上支撑显示器的模块化组件，使得显示器倾斜度可以由用户调节。支架具有仅具有两个模块的模块化设计：保持夹和支撑腿，其独特地铰接在一起并连接到显示器的后部。

10. 发明授权

US08065204B2 System and method for software integration and factory deployment 失效
标题翻译：用于软件集成和工厂部署的系统和方法
公开(公告)号：US08065204B2
公开(公告)日：2011-11-22
申请号：US11541433
申请日：2006-09-29
申请人： Eric Gerzymisch , Vijayanand Muralidhar Kallianpur , Sean Patrick Kennedy , Masafumi Kuboyama , Brian Lee , Yoshiro Muraoka , Victor Glenn Reha
发明人： Eric Gerzymisch , Vijayanand Muralidhar Kallianpur , Sean Patrick Kennedy , Masafumi Kuboyama , Brian Lee , Yoshiro Muraoka , Victor Glenn Reha
IPC分类号： A01K5/02 , G06F17/50 , G06G1/14 , G06Q20/00 , G06Q30/00 , G06Q10/00
CPC分类号： G06F8/61 , G06Q10/087 , G06Q10/0875 , G06Q20/203 , G06Q30/0621 , G06Q30/0623 , G06Q30/0631
摘要： A software management database contains data structures supporting computer software provisioning for a range of CTO/BTO variations, language variations, region variations, and operating system variations.
摘要翻译：软件管理数据库包含支持针对一系列CTO / BTO变体，语言变化，区域变化和操作系统变化的计算机软件配置的数据结构。

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