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1. 发明申请

US20070082377A1 Cytotoxicity assays 审中-公开
标题翻译：细胞毒性测定
公开(公告)号：US20070082377A1
公开(公告)日：2007-04-12
申请号：US11246007
申请日：2005-10-07
申请人： Michael Olin , Gary Johnson , Brian Lee
发明人： Michael Olin , Gary Johnson , Brian Lee
IPC分类号： G01N1/30 , G01N33/48
CPC分类号： G01N1/30 , G01N33/5005 , G01N2333/96466
摘要： Certain embodiments of the invention provide methods and kits for determining cell viability and measuring cytotoxicity.
摘要翻译：本发明的某些实施方案提供了用于确定细胞存活力和测量细胞毒性的方法和试剂盒。

2. 发明申请

US20060148023A1 Affinity labeling of serine proteases for simultaneous detection of multiple serine protease activity levels 审中-公开
标题翻译：亲和标记丝氨酸蛋白酶同时检测多个丝氨酸蛋白酶活性水平
公开(公告)号：US20060148023A1
公开(公告)日：2006-07-06
申请号：US10872824
申请日：2004-06-21
申请人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
发明人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N33/5091 , G01N33/573 , G01N2500/04 , G01N2510/00 , G01N2800/52
摘要： The invention provides assay methods and reagents useful for evaluating the level of enzyme activities within living cells. Enzyme activity levels within living cells, such as Serine proteases, can be key determinates in assessing; 1) the presence of tumor (cancer) cells, 2) the predictive efficacy of a chemotherapeutic treatment regimen using a particular therapeutic agent or process, 4) the probability of graft rejection or acceptance, and 5) the disease state status of a cell. The identification of the up or down regulation relationships of serine proteases within living cell systems, provides a rapid, yet finely tuned mechanism for predicting the current and future physiological state of these cell populations.
摘要翻译：本发明提供了可用于评估活细胞内酶活性水平的测定方法和试剂。活细胞内的酶活性水平，如丝氨酸蛋白酶，可能是评估中的关键决定因素; 1）肿瘤（癌症）细胞的存在，2）使用特定治疗剂或过程的化学治疗方案的预测效果，4）移植排斥或接受的概率，以及5）细胞的疾病状态。识别活细胞系统中丝氨酸蛋白酶的上调或下调调节关系，为预测这些细胞群体的当前和未来生理状态提供了一种快速但精细调节的机制。

3. 发明申请

US20070269832A1 Novel affinity labels 审中-公开
标题翻译：新颖的亲和标签
公开(公告)号：US20070269832A1
公开(公告)日：2007-11-22
申请号：US10872754
申请日：2004-06-21
申请人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
发明人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
IPC分类号： C12Q1/02 , C07D311/82 , C12Q1/37 , G01N33/573
CPC分类号： C07K5/06191 , C12Q1/37 , G01N33/58 , G01N2500/04
摘要： The invention provides novel affinity labels for Ser proteases of formula: L-A-X—NH—CH(R′)C(═O)CH2Cl (I) wherein L, A, X, and R′ have any of the values defined in the specification, or salts thereof, as well as compositions comprising such compounds or salts. The composition of the amino acid side-chain (R′) along with the amino acid or amino acid sequence (peptide) of the X component of formula I, affect the target selectivity of the labeled affinity ligand. Utilization of cell permeable, enzyme selective, labeled affinity ligands, provides a precise mechanism for evaluating the current and future status of cell populations.
摘要翻译：本发明提供了用于下式的Ser蛋白酶的新型亲和标记：<？in-line-formula description =“In-line Formulas”end =“lead”？> LAX-NH-CH（R'）C（-O）CH 其中L，A，X和R'具有如下定义的任何值：（1）说明书或其盐，以及包含这些化合物或盐的组合物。氨基酸侧链（R'）的组成与式I的X组分的氨基酸或氨基酸序列（肽）一起影响标记的亲和配体的靶选择性。细胞可渗透，酶选择性，标记的亲和配体的利用提供了一种精确的机制来评估细胞群体的当前和未来状态。

4. 发明申请

US20050136492A1 Affinity labeling of enzymes for detection of enzyme activity level in living cells 审中-公开
标题翻译：用于检测活细胞中酶活性水平的酶的亲和标记
公开(公告)号：US20050136492A1
公开(公告)日：2005-06-23
申请号：US10872818
申请日：2004-06-21
申请人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
发明人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
IPC分类号： C12Q1/37 , G01N33/573 , G01N33/574
CPC分类号： G01N33/573 , C12Q1/37 , G01N33/574
摘要： The invention provides assay methods and reagents useful for evaluating the level of enzyme activities within living cells. Enzyme activity levels within living cells, such as caspases and Serine proteases, can be key determinates in assessing; 1) the apoptotic state of a cell, 2) the presence of tumor (cancer) cells, 3) the predictive efficacy of a chemotherapeutic treatment regimen using a particular therapeutic agent or process, 4) the probability of graft rejection or acceptance, identification of the up or down regulation relationships of serine proteases and caspases within living cell systems, provides a rapid, yet finely tuned mechanism for predicting the current and future state of these cell populations, and 5) the disease state status of a cell.
摘要翻译：本发明提供了可用于评估活细胞内酶活性水平的测定方法和试剂。活细胞内的酶活性，如胱天蛋白酶和丝氨酸蛋白酶，可以作为评估中的关键决定因素。 1）细胞的凋亡状态，2）肿瘤（癌症）细胞的存在，3）使用特定治疗剂或过程的化学治疗方案的预测效果，4）移植排斥或接受的概率，鉴定丝氨酸蛋白酶和半胱氨酸蛋白酶在活细胞系统中的向上或向下调节关系为预测这些细胞群体的当前和未来状态提供了一种快速但精细调节的机制，以及5）细胞的疾病状态。

5. 发明申请

US20210315756A1 Patient Raiser 有权
公开(公告)号：US20210315756A1
公开(公告)日：2021-10-14
申请号：US17309060
申请日：2019-10-17
申请人： Anita Nikora , Gary Johnson
发明人： Anita Nikora , Gary Johnson
IPC分类号： A61G7/053 , A61G7/10
摘要： The application relates to a device for, and method of transferring a patient on a bed between a lying position along a bed to a seated position facing the side of a bed. The device comprises an arm hold to allow the patient to clinch the arm hold to his or her chest, thereby enabling the device to transfer the patient between a lying position and a seated position. Preferably, the device further comprises a leg support to assist in transferring the lower portion of the patients body between a lying position and a seated position.

6. 发明授权

US08375312B2 Classifying digital media based on content 有权
标题翻译：基于内容分类数字媒体
公开(公告)号：US08375312B2
公开(公告)日：2013-02-12
申请号：US11760720
申请日：2007-06-08
申请人： Mike Marinkovich , Greg Lindley , Alan Cannistraro , Evan Doll , Gary Johnson
发明人： Mike Marinkovich , Greg Lindley , Alan Cannistraro , Evan Doll , Gary Johnson
IPC分类号： G06F3/00 , G06F3/048
CPC分类号： G06F17/30274
摘要： A computer-implemented method for classifying digital content can include displaying one or more poster frames in a user interface, wherein a poster frame corresponds to an item of digital content, displaying one or more first level classification panes adjacent to a poster frame corresponding to an item to be classified, wherein a first level classification pane is associated with a keyword, and enabling a user to associate a poster frame with a first level classification pane to cause the keyword associated with the first level classification pane to be associated with the item to which the poster frame corresponds.
摘要翻译：用于分类数字内容的计算机实现的方法可以包括在用户界面中显示一个或多个海报帧，其中海报帧对应于数字内容的项目，显示与对应于一个或多个内容的一个海报帧相邻的一个或多个第一级分类窗格要分类的项目，其中第一级分类窗格与关键字相关联，并且使用户能够将海报框与第一级分类窗格相关联，以使与第一级别分类窗格相关联的关键字与该项相关联海报框对应。

7. 发明申请

US20120274376A1 DUTY CYCLE CORRECTOR CIRCUITS 审中-公开
标题翻译：占空比校正电路
公开(公告)号：US20120274376A1
公开(公告)日：2012-11-01
申请号：US13544152
申请日：2012-07-09
申请人： Tyler Gomm , Gary Johnson
发明人： Tyler Gomm , Gary Johnson
IPC分类号： H03K5/06
CPC分类号： H03L7/08 , G11C7/222 , H03L7/0812
摘要： Duty cycle corrector circuits that utilize differing unit delay elements in their delay lines in either a graduated or a stepped unit time delay arrangement are for synchronizing with a clock signal. These graduated or a stepped unit time delays allow reduction in the number of the fine unit delay elements of the delay lines by placing a fine delay element granularity at the most critical timings to sense and adjust for the portion of the clock signal time period that are high speed or critical.
摘要翻译：利用其延迟线中的不同单位延迟元件在分级或阶梯单位时间延迟布置中的占空比校正器电路用于与时钟信号同步。这些渐变或阶梯式单位时间延迟允许通过在最关键的定时处放置精细的延迟元件粒度来减小延迟线的精细单元延迟元件的数量，以便感测和调整时钟信号时间段的部分高速还是关键

8. 发明授权

US08217694B2 Method and apparatus for synchronizing with a clock signal 有权
标题翻译：用于与时钟信号同步的方法和装置
公开(公告)号：US08217694B2
公开(公告)日：2012-07-10
申请号：US12901811
申请日：2010-10-11
申请人： Tyler Gomm , Gary Johnson
发明人： Tyler Gomm , Gary Johnson
IPC分类号： H03L7/06
CPC分类号： H03L7/08 , G11C7/222 , H03L7/0812
摘要： Clock synchronization and skew adjustment circuits that utilize differing unit delay elements in their delay lines in either a graduated or a stepped unit time delay arrangement are for synchronizing with a clock signal. These graduated or a stepped unit time delays allow reduction in the number of the fine unit delay elements of the delay lines by placing a fine delay element granularity at the most critical timings to sense and adjust for the portion of the clock signal time period that are high speed or critical.
摘要翻译：利用其延迟线中的不同单位延迟元件的时间同步和偏移调整电路是以刻度或阶梯单位时间延迟布置来进行的，用于与时钟信号同步。这些渐变或阶梯式单位时间延迟允许通过在最关键的定时处放置精细的延迟元件粒度来减小延迟线的精细单元延迟元件的数量，以便感测和调整时钟信号时间段的部分高速还是关键

9. 发明授权

US08209612B2 Application of speed effects to a video presentation 有权
标题翻译：速度效果应用于视频演示
公开(公告)号：US08209612B2
公开(公告)日：2012-06-26
申请号：US12762747
申请日：2010-04-19
申请人： Gary Johnson
发明人： Gary Johnson
IPC分类号： G06F3/00 , G06F3/048
CPC分类号： G11B27/34 , G11B27/005 , G11B27/034 , G11B27/036
摘要： Some embodiments provide a method of specifying speed effects for playing a video clip. The method defines a set of speed effects for the video clip. It then displays in real-time a presentation of the video clip that accounts for the set of speed effects defined for the video clip. In some embodiments, this method represents the playback speed of a video clip in terms of a graph that is part of a graphical user interface (“GUI”). This graph is defined along two axes, with one axis representing the playback time, and the other axis representing the content-time (i.e., the time within the video clip). In these embodiments, a user can change the playback speed of the video clip by using a set of GUI operations to select and modify the graph. For instance, a user can select and adjust the graph at different instances in time in order to change the playback speed of the video clip at these instances. Different embodiments use different types of graphs to represent playback speed. For instance, some embodiments use a deformable line bar that is superimposed on a rectangle that represents the video clip.
摘要翻译：一些实施例提供了一种指定用于播放视频剪辑的速度效果的方法。该方法定义了视频剪辑的一组速度效果。然后，它实时显示视频剪辑的呈现，该视频剪辑占用为视频剪辑定义的速度效果集。在一些实施例中，该方法表示作为图形用户界面（“GUI”）的一部分的图形的视频剪辑的回放速度。该图形沿两个轴定义，一个轴表示播放时间，另一个轴表示内容时间（即，视频剪辑内的时间）。在这些实施例中，用户可以通过使用一组GUI操作来改变视频剪辑的播放速度来选择和修改图形。例如，用户可以在不同的时间点选择和调整图形，以便在这些情况下改变视频剪辑的播放速度。不同的实施例使用不同类型的图表来表示播放速度。例如，一些实施例使用叠加在表示视频剪辑的矩形上的可变形线条。

10. 发明授权

US07812657B2 Methods and apparatus for synchronizing with a clock signal 有权
标题翻译：与时钟信号同步的方法和装置
公开(公告)号：US07812657B2
公开(公告)日：2010-10-12
申请号：US12345039
申请日：2008-12-29
申请人： Tyler Gomm , Gary Johnson
发明人： Tyler Gomm , Gary Johnson
IPC分类号： H03L7/06
CPC分类号： H03L7/08 , G11C7/222 , H03L7/0812
摘要： Clock synchronization and skew adjustment circuits that utilize differing unit delay elements in their delay lines in either a graduated or a stepped unit time delay arrangement are for synchronizing with a clock signal. These graduated or a stepped unit time delays allow reduction in the number of the fine unit delay elements of the delay lines by placing a fine delay element granularity at the most critical timings to sense and adjust for the portion of the clock signal time period that are high speed or critical.
摘要翻译：利用其延迟线中的不同单位延迟元件的时间同步和偏移调整电路是以刻度或阶梯单位时间延迟布置来进行的，用于与时钟信号同步。这些渐变或阶梯式单位时间延迟允许通过在最关键的定时处放置精细的延迟元件粒度来减小延迟线的精细单元延迟元件的数量，以便感测和调整时钟信号时间段的部分高速还是关键

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