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1. 发明授权

US09068976B2 Integrated filtration bioanalyzer 有权
标题翻译：一体化过滤生物分析仪
公开(公告)号：US09068976B2
公开(公告)日：2015-06-30
申请号：US12582392
申请日：2009-10-20
申请人： David L. Putnam , Jason A. Putnam , Todd W. Hubbard , James A. van Zee
发明人： David L. Putnam , Jason A. Putnam , Todd W. Hubbard , James A. van Zee
IPC分类号： C12Q1/02 , G01N33/52 , C12Q1/24 , G01N1/40
CPC分类号： G01N33/52 , C12Q1/24 , G01N2001/4088
摘要： The present invention relates to an in vitro assay method and device that provides for detection and measurement of entities in a fluid sample that can be captured and concentrated in a unitized self-contained enclosed filter apparatus that is analyzed in an optical detection instrument for indications of the entity. It provides for analysis of biological material including cells, their enzymes, or other constituents thereof, that can be identified based on an indicator-generating means. The analysis provided for include detection of the presence of the entity, and changes in the entity over time, such as associated with growth and increasing metabolic activity with an expanding population of cells, or decreasing metabolic activity, for example, due to presence of inhibitory or toxic agents.
摘要翻译：本发明涉及一种体外测定方法和装置，其提供可以被捕获并集中在一个单独的独立封闭式过滤装置中的流体样品中的实体的检测和测量，该装置在光学检测仪器中被分析，用于指示实体。它提供了可以基于指示剂产生装置来鉴定的生物材料包括细胞，其酶或其它成分的分析。所提供的分析包括检测实体的存在以及随时间变化的实体的变化，例如与增长的细胞的增长和增加的代谢活动相关联，或者降低代谢活性，例如由于存在抑制性或有毒物质。

2. 发明申请

US20100133175A1 Filtered Assay Device and Method 有权
标题翻译：过滤分析装置和方法
公开(公告)号：US20100133175A1
公开(公告)日：2010-06-03
申请号：US12582425
申请日：2009-10-20
申请人： David L. PUTNAM , Jason A. Putnam , Todd W. Hubbard
发明人： David L. PUTNAM , Jason A. Putnam , Todd W. Hubbard
IPC分类号： B01D29/60 , B01D29/96 , B01D35/06 , B01D29/76
CPC分类号： C12Q1/24 , G01N1/405 , G01N2001/4088
摘要： A method and device is provided for collecting filterable material to perform assays on a filtration apparatus by applying negative-pressure to the inlet chamber of the filtration apparatus which is independent of negative or positive pressure applied to its fluid path. The negative-pressure applied to the inlet chamber serves to actively aspirate fluid and promote flow into the inlet chamber via the fluid pathway. The negative-pressure applied to the inlet chamber facilitates the use of either negative or positive-pressure based fluid-filtration approaches. Use of the invention improves the functionality and scope of applications that can be performed with enclosed filtration apparatuses.
摘要翻译：提供了一种方法和装置，用于收集可过滤材料，以通过向过滤装置的入口室施加负压而对过滤装置进行测定，该过滤装置独立于施加到其流体路径的负压或正压。施加到入口室的负压用于主动地吸入流体并促进经由流体通路流入入口室。施加到入口室的负压有利于使用负压或基于正压的流体过滤方法。本发明的使用改进了可以用封闭的过滤装置执行的应用的功能和范围。

3. 发明授权

US08968681B2 Filtered assay device and method 有权
标题翻译：过滤测定装置和方法
公开(公告)号：US08968681B2
公开(公告)日：2015-03-03
申请号：US12582425
申请日：2009-10-20
申请人： David L. Putnam , Jason A. Putnam , Todd W. Hubbard
发明人： David L. Putnam , Jason A. Putnam , Todd W. Hubbard
IPC分类号： G01N1/40 , C12Q1/24
CPC分类号： C12Q1/24 , G01N1/405 , G01N2001/4088
摘要： A method and device is provided for collecting filterable material to perform assays on a filtration apparatus by applying negative-pressure to the inlet chamber of the filtration apparatus which is independent of negative or positive pressure applied to its fluid path. The negative-pressure applied to the inlet chamber serves to actively aspirate fluid and promote flow into the inlet chamber via the fluid pathway. The negative-pressure applied to the inlet chamber facilitates the use of either negative or positive-pressure based fluid-filtration approaches. Use of the invention improves the functionality and scope of applications that can be performed with enclosed filtration apparatuses.
摘要翻译：提供了一种方法和装置，用于收集可过滤材料，以通过向过滤装置的入口室施加负压而对过滤装置进行测定，该过滤装置独立于施加到其流体路径的负压或正压。施加到入口室的负压用于主动地吸入流体并促进经由流体通路流入入口室。施加到入口室的负压有利于使用负压或基于正压的流体过滤方法。本发明的使用改进了可以用封闭的过滤装置执行的应用的功能和范围。

4. 发明申请

US20100129852A1 Integrated Bioanalyzer 有权
标题翻译：综合生物分析仪
公开(公告)号：US20100129852A1
公开(公告)日：2010-05-27
申请号：US12582392
申请日：2009-10-20
申请人： David L. Putnam , Jason A. Putnam , Todd W. Hubbard , James A. van Zee
发明人： David L. Putnam , Jason A. Putnam , Todd W. Hubbard , James A. van Zee
IPC分类号： C12Q1/02
CPC分类号： G01N33/52 , C12Q1/24 , G01N2001/4088
摘要： The present invention relates to an in vitro assay method and device that provides for detection and measurement of entities in a fluid sample that can be captured and concentrated in a unitized self-contained enclosed filter apparatus that is analyzed in an optical detection instrument for indications of the entity. It provides for analysis of biological material including cells, their enzymes, or other constituents thereof, that can be identified based on an indicator-generating means. The analyses provided for include detection of the presence of the entity, and changes in the entity over time, such as associated with growth and increasing metabolic activity with an expanding population of cells, or decreasing metabolic activity, for example, due to presence of inhibitory or toxic agents.
摘要翻译：本发明涉及一种体外测定方法和装置，其提供可以被捕获并集中在一个单独的独立封闭式过滤装置中的流体样品中的实体的检测和测量，该装置在光学检测仪器中被分析，用于指示实体。它提供了可以基于指示剂产生装置来鉴定的生物材料包括细胞，其酶或其它成分的分析。所提供的分析包括检测实体的存在，以及实体随时间的变化，例如与生长相关的增长和随着细胞数量增加而增加的代谢活性，或降低代谢活性，例如由于存在抑制性或有毒物质。

5. 发明授权

US07014612B2 Method for diagnosis of helicobacter pylori infection 失效
标题翻译：诊断幽门螺杆菌感染的方法
公开(公告)号：US07014612B2
公开(公告)日：2006-03-21
申请号：US10294352
申请日：2002-11-13
申请人： Todd W. Hubbard , David L. Putnam
发明人： Todd W. Hubbard , David L. Putnam
IPC分类号： A61B5/08 , G01N1/22
CPC分类号： A61B5/083
摘要： A rapid, non-invasive breath-test method and device for diagnosing the presence or absence of H. pylori in a subject without administration of isotopic tracers is described. The device consists of a highly sensitive colorimetric ammonia sensor placed in contact with sampled subject breath. The sensor is measured using appropriate reflection spectroscopy instrumentation. The breath-test method consists of measuring a basal ammonia level with the device, administering non-isotopic urea and continuing measurement of the ammonia content in a plurality of consecutive breaths. Diagnostic differences in breath ammonia are identified between H. pylori infected and uninfected individuals.
摘要翻译：描述了一种用于在不施用同位素示踪剂的情况下诊断幽门螺杆菌存在或不存在的快速，非侵入性呼气测试方法和装置。该设备由高度敏感的比色氨传感器组成，与传统的被摄体呼吸接触。使用适当的反射光谱仪测量传感器。呼吸试验方法包括用装置测量基础氨水平，施用非同位素尿素并连续测量多个连续呼吸中的氨含量。在幽门螺杆菌感染和未感染个体之间鉴定呼吸氨的诊断差异。

6. 发明授权

US08173438B1 Microbiological assessment method and device utilizing oxygen gradient sensing 失效
标题翻译：微生物评估方法和利用氧梯度检测的装置
公开(公告)号：US08173438B1
公开(公告)日：2012-05-08
申请号：US08946823
申请日：1997-10-08
申请人： David L. Putnam , Todd W. Hubbard , Gamal E. Khalil
发明人： David L. Putnam , Todd W. Hubbard , Gamal E. Khalil
IPC分类号： G01N33/00 , G01N21/76 , C12Q1/02 , C12Q1/18
CPC分类号： C12M41/46 , C12Q1/22 , G01N33/528 , Y10T436/209163
摘要： There is disclosed a biological indicator (BI) test utilizing oxygen sensing within a microenvironment as a means for determining the presence of viable microorganisms capable of growth, a method for biological indicator (BI) testing for determining the completeness of a sterilization cycle utilizing oxygen sensing as the means for determining the presence of viable microorganism survival, a device for determining oxygen content in a biological indicator (BI) assay vessel containing an optical oxygen sensor, and a method and device for determining antimicrobial drug resistance or sensitivity to a contaminated sample.
摘要翻译：公开了一种利用微环境中的氧气感测的生物指示剂（BI）检测方法，作为确定能够生长的活微生物的存在的手段，一种生物指示剂（BI）检测方法，用于确定使用氧气感测的灭菌循环的完整性作为用于确定存活微生物存活的手段，用于测定含有光学氧传感器的生物学指示剂（BI）测定容器中的氧含量的装置，以及用于确定对受污染样品的抗微生物药物抗性或敏感性的方法和装置。

7. 发明申请

US20100330692A1 AMMONIA DETECTION AND MEASUREMENT DEVICE 审中-公开
标题翻译： AMMONIA检测和测量装置
公开(公告)号：US20100330692A1
公开(公告)日：2010-12-30
申请号：US12561163
申请日：2009-09-16
申请人： Gamal E. Khalil , David L. Putnam , Todd W. Hubbard
发明人： Gamal E. Khalil , David L. Putnam , Todd W. Hubbard
IPC分类号： G01N21/62
CPC分类号： G01N21/783 , G01N31/223 , G01N33/0054 , G01N33/12 , Y10T436/15 , Y10T436/153333 , Y10T436/17 , Y10T436/173845 , Y10T436/174614 , Y10T436/175383 , Y10T436/177692
摘要： There is disclosed an apparatus and method for detecting and measuring volatile acidic or basic components including ammonia, ammonium, or volatile amines (compound) in a gas or liquid state fluid. Specifically, the present invention provides a PTFE-carrier solid phase indicator film having an ammonia-sensitive indicator dye embedded therein, such that the dye moiety changes color or spectral properties upon exposure to the compound to be detected.
摘要翻译：公开了一种在气体或液态流体中检测和测量包括氨，铵或挥发性胺（化合物）的挥发性酸性或碱性组分的装置和方法。具体地说，本发明提供了一种其中嵌有氨敏感指示剂染料的PTFE载体固相指示膜，使得染料部分在暴露于待检测化合物时会改变颜色或光谱性质。

8. 发明授权

US07592184B2 Ammonia detection and measurement device 有权
标题翻译：氨检测仪器
公开(公告)号：US07592184B2
公开(公告)日：2009-09-22
申请号：US10157209
申请日：2002-05-28
申请人： Gamal E. Khalil , David L. Putnam , Todd W. Hubbard
发明人： Gamal E. Khalil , David L. Putnam , Todd W. Hubbard
IPC分类号： G01N33/00 , G01N21/27 , G01N21/64
CPC分类号： G01N21/783 , Y10T436/15 , Y10T436/153333 , Y10T436/17 , Y10T436/173845 , Y10T436/174614 , Y10T436/175383 , Y10T436/177692
摘要： There is disclosed an apparatus and method for detecting and measuring volatile acidic or basic components including ammonia, ammonium, or volatile amines (compound) in a gas or liquid state fluid. Specifically, the present invention provides a PTFE-carrier solid phase indicator film having an ammonia-sensitive indicator dye embedded therein, such that the dye moiety changes color or spectral properties upon exposure to the compound to be detected.
摘要翻译：公开了一种在气体或液态流体中检测和测量包括氨，铵或挥发性胺（化合物）的挥发性酸性或碱性组分的装置和方法。具体地说，本发明提供了一种其中嵌有氨敏感指示剂染料的PTFE载体固相指示膜，使得染料部分在暴露于待检测化合物时会改变颜色或光谱性质。

9. 发明授权

US5047627A Configuration fiber-optic blood gas sensor bundle and method of making 失效
标题翻译：配置光纤血气传感器束及其制作方法
公开(公告)号：US5047627A
公开(公告)日：1991-09-10
申请号：US526185
申请日：1990-05-18
申请人： Jeffrey B. Yim , Todd W. Hubbard , Lori D. Melkerson , Michael A. Sexton , Bruce M. Fieggen
发明人： Jeffrey B. Yim , Todd W. Hubbard , Lori D. Melkerson , Michael A. Sexton , Bruce M. Fieggen
IPC分类号： A61B5/145 , A61B5/1459 , G01N21/31 , G01N21/55 , G01N21/64 , G01N21/77 , G01N21/78 , G01N21/80 , G01N33/49 , G01N33/84
CPC分类号： G01N21/7703 , G01N33/84 , G01N2021/3181 , G01N2021/6434 , G01N2021/772 , G01N21/783 , G01N21/80
摘要： A bundle of fiber-optic sensors that resist breakage, for use in measuring pH, CO.sub.2, and O.sub.2 concentration, and a method of making the same. Three otpical fibers are enclosed in a common polyimide sheath and extend parallel to one another toward a distal end of the sensor, where they are bonded together in a mutually supportive array. At the distal end of one of these optical fibers is disposed a pellet comprising a CO.sub.2 analyte indicator molecule codissolved within a polymer matrix. A thin reflective surface of gold foil is provided on the pellet such that incident light transmitted through the optical fiber and polymer matrix is reflected back into the optical fiber. The CO.sub.2 polymer matrix absorbs light of a given wavelength to an extent dependent upon the level of CO.sub.2 present. Similarly, on the distal end of a second optical fiber is disposed a pH pellet comprising a pH analyte indicator matrix with a thin reflective gold foil attached for reflecting light that has passed through the pH analyte indicator matrix back into the optical fiber. The pH analyte indicator matrix absorbs light of a given wavelenth to an extent dependent upon the hydrogen ion concentration (pH level) of a surrounding fluid. The third optical fiber is used for measuring oxygen concentration. An O.sub.2 indicator matrix covers the distal ends of at least two of the three optical fibers; however, at least a portion of the pH optical fiber and the pH pellet are free of the O.sub.2 indicator matrix, which is hydrophobic. The oxygen indicator matrix phosphoresces for an interval of time that decreases in proportion to the surrounding oxygen gas concentration. The phosphorescent and reflected light signals are transmitted to light detectors through the optical fibers for comparison to reference signals, so that the analyte concentrations can be determined.

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