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1. 发明授权

US08968681B2 Filtered assay device and method 有权
标题翻译：过滤测定装置和方法
公开(公告)号：US08968681B2
公开(公告)日：2015-03-03
申请号：US12582425
申请日：2009-10-20
申请人： David L. Putnam , Jason A. Putnam , Todd W. Hubbard
发明人： David L. Putnam , Jason A. Putnam , Todd W. Hubbard
IPC分类号： G01N1/40 , C12Q1/24
CPC分类号： C12Q1/24 , G01N1/405 , G01N2001/4088
摘要： A method and device is provided for collecting filterable material to perform assays on a filtration apparatus by applying negative-pressure to the inlet chamber of the filtration apparatus which is independent of negative or positive pressure applied to its fluid path. The negative-pressure applied to the inlet chamber serves to actively aspirate fluid and promote flow into the inlet chamber via the fluid pathway. The negative-pressure applied to the inlet chamber facilitates the use of either negative or positive-pressure based fluid-filtration approaches. Use of the invention improves the functionality and scope of applications that can be performed with enclosed filtration apparatuses.
摘要翻译：提供了一种方法和装置，用于收集可过滤材料，以通过向过滤装置的入口室施加负压而对过滤装置进行测定，该过滤装置独立于施加到其流体路径的负压或正压。施加到入口室的负压用于主动地吸入流体并促进经由流体通路流入入口室。施加到入口室的负压有利于使用负压或基于正压的流体过滤方法。本发明的使用改进了可以用封闭的过滤装置执行的应用的功能和范围。

2. 发明授权

US09068976B2 Integrated filtration bioanalyzer 有权
标题翻译：一体化过滤生物分析仪
公开(公告)号：US09068976B2
公开(公告)日：2015-06-30
申请号：US12582392
申请日：2009-10-20
申请人： David L. Putnam , Jason A. Putnam , Todd W. Hubbard , James A. van Zee
发明人： David L. Putnam , Jason A. Putnam , Todd W. Hubbard , James A. van Zee
IPC分类号： C12Q1/02 , G01N33/52 , C12Q1/24 , G01N1/40
CPC分类号： G01N33/52 , C12Q1/24 , G01N2001/4088
摘要： The present invention relates to an in vitro assay method and device that provides for detection and measurement of entities in a fluid sample that can be captured and concentrated in a unitized self-contained enclosed filter apparatus that is analyzed in an optical detection instrument for indications of the entity. It provides for analysis of biological material including cells, their enzymes, or other constituents thereof, that can be identified based on an indicator-generating means. The analysis provided for include detection of the presence of the entity, and changes in the entity over time, such as associated with growth and increasing metabolic activity with an expanding population of cells, or decreasing metabolic activity, for example, due to presence of inhibitory or toxic agents.
摘要翻译：本发明涉及一种体外测定方法和装置，其提供可以被捕获并集中在一个单独的独立封闭式过滤装置中的流体样品中的实体的检测和测量，该装置在光学检测仪器中被分析，用于指示实体。它提供了可以基于指示剂产生装置来鉴定的生物材料包括细胞，其酶或其它成分的分析。所提供的分析包括检测实体的存在以及随时间变化的实体的变化，例如与增长的细胞的增长和增加的代谢活动相关联，或者降低代谢活性，例如由于存在抑制性或有毒物质。

3. 发明申请

US20100133175A1 Filtered Assay Device and Method 有权
标题翻译：过滤分析装置和方法
公开(公告)号：US20100133175A1
公开(公告)日：2010-06-03
申请号：US12582425
申请日：2009-10-20
申请人： David L. PUTNAM , Jason A. Putnam , Todd W. Hubbard
发明人： David L. PUTNAM , Jason A. Putnam , Todd W. Hubbard
IPC分类号： B01D29/60 , B01D29/96 , B01D35/06 , B01D29/76
CPC分类号： C12Q1/24 , G01N1/405 , G01N2001/4088
摘要： A method and device is provided for collecting filterable material to perform assays on a filtration apparatus by applying negative-pressure to the inlet chamber of the filtration apparatus which is independent of negative or positive pressure applied to its fluid path. The negative-pressure applied to the inlet chamber serves to actively aspirate fluid and promote flow into the inlet chamber via the fluid pathway. The negative-pressure applied to the inlet chamber facilitates the use of either negative or positive-pressure based fluid-filtration approaches. Use of the invention improves the functionality and scope of applications that can be performed with enclosed filtration apparatuses.
摘要翻译：提供了一种方法和装置，用于收集可过滤材料，以通过向过滤装置的入口室施加负压而对过滤装置进行测定，该过滤装置独立于施加到其流体路径的负压或正压。施加到入口室的负压用于主动地吸入流体并促进经由流体通路流入入口室。施加到入口室的负压有利于使用负压或基于正压的流体过滤方法。本发明的使用改进了可以用封闭的过滤装置执行的应用的功能和范围。

4. 发明申请

US20100129852A1 Integrated Bioanalyzer 有权
标题翻译：综合生物分析仪
公开(公告)号：US20100129852A1
公开(公告)日：2010-05-27
申请号：US12582392
申请日：2009-10-20
申请人： David L. Putnam , Jason A. Putnam , Todd W. Hubbard , James A. van Zee
发明人： David L. Putnam , Jason A. Putnam , Todd W. Hubbard , James A. van Zee
IPC分类号： C12Q1/02
CPC分类号： G01N33/52 , C12Q1/24 , G01N2001/4088
摘要： The present invention relates to an in vitro assay method and device that provides for detection and measurement of entities in a fluid sample that can be captured and concentrated in a unitized self-contained enclosed filter apparatus that is analyzed in an optical detection instrument for indications of the entity. It provides for analysis of biological material including cells, their enzymes, or other constituents thereof, that can be identified based on an indicator-generating means. The analyses provided for include detection of the presence of the entity, and changes in the entity over time, such as associated with growth and increasing metabolic activity with an expanding population of cells, or decreasing metabolic activity, for example, due to presence of inhibitory or toxic agents.
摘要翻译：本发明涉及一种体外测定方法和装置，其提供可以被捕获并集中在一个单独的独立封闭式过滤装置中的流体样品中的实体的检测和测量，该装置在光学检测仪器中被分析，用于指示实体。它提供了可以基于指示剂产生装置来鉴定的生物材料包括细胞，其酶或其它成分的分析。所提供的分析包括检测实体的存在，以及实体随时间的变化，例如与生长相关的增长和随着细胞数量增加而增加的代谢活性，或降低代谢活性，例如由于存在抑制性或有毒物质。

5. 发明授权

US08202503B2 Visual, continuous and simultaneous measurement of solution ammonia and hydrogen ion concentration 有权
标题翻译：视觉，连续和同时测量溶液中的氨和氢离子浓度
公开(公告)号：US08202503B2
公开(公告)日：2012-06-19
申请号：US12870004
申请日：2010-08-27
申请人： David L. Putnam , Janice A. Sharick , Jason A. Putnam
发明人： David L. Putnam , Janice A. Sharick , Jason A. Putnam
IPC分类号： C01C1/00
CPC分类号： G01N33/18 , G01N31/221 , Y10T436/17
摘要： Particular aspects provide novel devices and methods for accurately measuring total ammonia (NH3 plus NH4+) in a solution (e.g., freshwater and saltwater) by spatially proximate, simultaneous and continuous quantitative measurement of solution pH and ammonia. The devices overcome prior art inaccuracies relating to non-homogeneous sampling, and to spatial, temporal and thermal sampling discontinuities. Particular embodiments provide a combination pH and ammonia measuring device, comprising: a submersible member; a submersible non-bleeding ammonia-sensing portion attached to the submersible member and suitable to provide for a continuous visual indicator of solution ammonia concentration; a submersible non-bleeding pH-sensing portion attached to the submersible member and suitable to provide for a continuous visual indicator of solution pH; visual ammonia and pH indicator comparison means suitable for comparative quantitative determination of solution ammonia concentration and pH. Additional aspects provide novel ultra-sensitive devices and methods using same for measuring ammonia in air or solution.
摘要翻译：具体方面提供用于通过空间接近，同时和连续的溶液pH和氨定量测量来精确测量溶液（例如淡水和盐水）中的总氨（NH 3 + NH 4 +）的新型装置和方法。这些装置克服了与非均匀采样有关的现有技术不准确以及空间，时间和热采样不连续性。具体实施方案提供了一种组合pH和氨测量装置，包括：潜水构件; 连接在潜水构件上的适合于提供溶液氨浓度的连续视觉指示剂的潜水非止血氨感测部分; 连接在潜水构件上的适合于提供溶液pH值的连续视觉指示剂的潜水非渗透性pH检测部分; 视觉氨和pH指标比较手段适用于比较定量测定溶液中氨浓度和pH值。另外的方面提供了新颖的超灵敏装置和方法，使用它们来测量空气或溶液中的氨。

6. 发明申请

US20110081728A1 VISUAL, CONTINUOUS AND SIMULTANEOUS MEASUREMENT OF SOLUTION AMMONIA AND HYDROGEN ION CONCENTRATION 有权
标题翻译：解决方案的可视化，连续和同时测量和氢离子浓度
公开(公告)号：US20110081728A1
公开(公告)日：2011-04-07
申请号：US12870004
申请日：2010-08-27
申请人： David L. Putnam , Janice A. Sharick , Jason A. Putnam
发明人： David L. Putnam , Janice A. Sharick , Jason A. Putnam
IPC分类号： G01N21/84
CPC分类号： G01N33/18 , G01N31/221 , Y10T436/17
摘要： Particular aspects provide novel devices and methods for accurately measuring total ammonia (NH3 plus NH4+) in a solution (e.g., freshwater and saltwater) by spatially proximate, simultaneous and continuous quantitative measurement of solution pH and ammonia. The devices overcome prior art inaccuracies relating to non-homogeneous sampling, and to spatial, temporal and thermal sampling discontinuities. Particular embodiments provide a combination pH and ammonia measuring device, comprising: a submersible member; a submersible non-bleeding ammonia-sensing portion attached to the submersible member and suitable to provide for a continuous visual indicator of solution ammonia concentration; a submersible non-bleeding pH-sensing portion attached to the submersible member and suitable to provide for a continuous visual indicator of solution pH; visual ammonia and pH indicator comparison means suitable for comparative quantitative determination of solution ammonia concentration and pH. Additional aspects provide novel ultra-sensitive devices and methods using same for measuring ammonia in air or solution.
摘要翻译：具体方面提供用于通过空间接近，同时和连续的溶液pH和氨定量测量来精确测量溶液（例如淡水和盐水）中的总氨（NH 3 + NH 4 +）的新型装置和方法。这些装置克服了与非均匀采样有关的现有技术不准确以及空间，时间和热采样不连续性。具体实施方案提供了一种组合pH和氨测量装置，包括：潜水构件; 连接在潜水构件上的适合于提供溶液氨浓度的连续视觉指示剂的潜水非止血氨感测部分; 连接在潜水构件上的适合于提供溶液pH值的连续视觉指示剂的潜水非渗透性pH检测部分; 视觉氨和pH指标比较手段适用于比较定量测定溶液中氨浓度和pH值。另外的方面提供了新颖的超灵敏装置和方法，使用它们来测量空气或溶液中的氨。

7. 发明授权

US07790113B2 Visual, continuous and simultaneous measurement of solution ammonia and hydrogen ion concentration 有权
标题翻译：视觉，连续和同时测量溶液中的氨和氢离子浓度
公开(公告)号：US07790113B2
公开(公告)日：2010-09-07
申请号：US11696695
申请日：2007-04-04
申请人： David L. Putnam , Janice A. Sharick , Jason A. Putnam
发明人： David L. Putnam , Janice A. Sharick , Jason A. Putnam
IPC分类号： G01N27/00
CPC分类号： G01N33/18 , G01N31/221 , Y10T436/17
摘要： Particular aspects provide novel devices and methods for accurately measuring total ammonia (NH3 plus NH4+) in a solution (e.g., freshwater and saltwater) by spatially proximate, simultaneous and continuous quantitative measurement of solution pH and ammonia. The devices overcome prior art inaccuracies relating to non-homogeneous sampling, and to spatial, temporal and thermal sampling discontinuities. Particular embodiments provide a combination pH and ammonia measuring device, comprising: a submersible member; a submersible non-bleeding ammonia-sensing portion attached to the submersible member and suitable to provide for a continuous visual indicator of solution ammonia concentration; a submersible non-bleeding pH-sensing portion attached to the submersible member and suitable to provide for a continuous visual indicator of solution pH; visual ammonia and pH indicator comparison means suitable for comparative quantitative determination of solution ammonia concentration and pH. Additional aspects provide novel ultra-sensitive devices and methods using same for measuring ammonia in air or solution.
摘要翻译：具体方面提供用于通过空间接近，同时和连续的溶液pH和氨定量测量来精确测量溶液（例如淡水和盐水）中的总氨（NH 3 + NH 4 +）的新型装置和方法。这些装置克服了与非均匀采样有关的现有技术不准确以及空间，时间和热采样不连续性。具体实施方案提供了一种组合pH和氨测量装置，包括：潜水构件; 连接在潜水构件上的适合于提供溶液氨浓度的连续视觉指示剂的潜水非止血氨感测部分; 连接在潜水构件上的适合于提供溶液pH值的连续视觉指示剂的潜水非渗透性pH检测部分; 视觉氨和pH指标比较手段适用于比较定量测定溶液中氨浓度和pH值。另外的方面提供了新颖的超灵敏装置和方法，使用它们来测量空气或溶液中的氨。

8. 发明申请

US20100136608A1 Multiple Filter Array Assay 审中-公开
标题翻译：多重滤波器阵列测定
公开(公告)号：US20100136608A1
公开(公告)日：2010-06-03
申请号：US12582447
申请日：2009-10-20
申请人： David L. PUTNAM , Jason A. Putnam
发明人： David L. PUTNAM , Jason A. Putnam
IPC分类号： C12Q1/04 , G01N1/34 , G01N33/00
CPC分类号： C12Q1/04 , B01L3/50255 , B01L2200/0605 , B01L2400/0487 , C12Q1/24 , G01N2001/4088 , Y10T436/255
摘要： The present invention relates to a method and device for the assay and determination of the concentration of organisms or other filterable constituents of a fluid test sample. The method includes the steps of exposing, processing, and analyzing a liquefied sample in a filter tray apparatus. Each filter element (FE) filters a volume of liquid from a common fluid test sample. Excess unfiltered liquid and filtrate is removed from the filter tray apparatus. Each filter element contained in the filter tray apparatus is exposed to culture medium and/or appropriate testing reagents introduced to the apparatus to generate an indicator of the filterable constituent. Final examination is conducted on the filter tray apparatus for the indication of the presence and/or absence of filtered constituents in the multiple filter elements. The presence/absence information defines the concentration of the filterable constituent in the fluid test sample.
摘要翻译：本发明涉及用于测定和测定流体测试样品的生物体或其它可滤过成分的浓度的方法和装置。该方法包括在过滤盘装置中暴露，处理和分析液化样品的步骤。每个过滤元件（FE）从普通流体测试样品中过滤一定体积的液体。过滤未过滤的液体和滤液从过滤盘装置中取出。包含在过滤盘装置中的每个过滤元件暴露于引入到装置中的培养基和/或适当的测试试剂以产生可过滤组分的指示剂。在过滤盘装置上进行最终检查，以指示多个过滤元件中是否存在过滤的成分。存在/不存在信息定义流体测试样品中可过滤组分的浓度。

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