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    • 1. 发明申请
    • Mitral Valve System
    • 二尖瓣系统
    • US20080221672A1
    • 2008-09-11
    • US12028572
    • 2008-02-08
    • David G. LamphereTuan Anh NguyenHoward C. HerrmannTodd C. TombaRobert C. GormanJoseph H. Gorman
    • David G. LamphereTuan Anh NguyenHoward C. HerrmannTodd C. TombaRobert C. GormanJoseph H. Gorman
    • A61F2/24
    • A61F2/2418A61F2/2436A61F2/2439A61F2220/0016A61F2220/0075A61F2230/008
    • Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements. The proximal, distal, and intermediate tissue-engaging regions are cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure so as to stabilize a position of the valve prosthesis with respect to the anatomical structure, including wherein for purposes of so simultaneously engaging the separate corresponding areas of tissue, at least one of the first, second, and third elongate tissue-piercing elements is pointed at least partially opposite the direction of blood flow, and at least another thereof is pointed at least partially along the direction of blood flow. The valve prosthesis may also include a skirt mounted with respect to the resilient ring for sealing a periphery of the valve prosthesis against a reverse flow of blood around the valve prosthesis.
    • 公开了适于相对于心脏环的安全和对准放置的阀门假体。 瓣膜假体可以以非侵入性方式放置,例如通过反式导管技术。 瓣膜假体可以包括弹性环,相对于弹性环安装的多个传膜,以及相对于柔性环可移动地安装的多个定位元件。 每个定位元件限定相应的近端,中间和远侧组织接合区域,其协作地构造和尺寸设计成同时接合解剖结构的组织的分开的对应区域,包括相应的第一,第二和第三细长组织刺穿元件。 近端,远端和中间组织接合区域协同地构造和尺寸设计以同时接合解剖结构的组织的分开的对应区域,以便相对于解剖结构稳定瓣膜假体的位置,包括其中为了目的 同时接合组织的单独的对应区域,第一,第二和第三细长组织刺穿元件中的至少一个至少部分地相对于血流方向指向,并且至少另一个至少部分地沿着 血流方向。 瓣膜假体还可以包括相对于弹性环安装的裙部,用于抵抗瓣膜假体周围的逆流血液密封阀门假体的周边。
    • 2. 发明授权
    • Mitral valve system
    • 二尖瓣系统
    • US08070802B2
    • 2011-12-06
    • US12028572
    • 2008-02-08
    • David G. LamphereTuan Anh NguyenHoward C. HerrmannTodd C. TombaRobert C. GormanJoseph H. Gorman, III
    • David G. LamphereTuan Anh NguyenHoward C. HerrmannTodd C. TombaRobert C. GormanJoseph H. Gorman, III
    • A61F2/24A61F2/06
    • A61F2/2418A61F2/2436A61F2/2439A61F2220/0016A61F2220/0075A61F2230/008
    • Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via transcatheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements. The proximal, distal, and intermediate tissue-engaging regions are cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure so as to stabilize a position of the valve prosthesis with respect to the anatomical structure, including wherein for purposes of so simultaneously engaging the separate corresponding areas of tissue, at least one of the first, second, and third elongate tissue-piercing elements is pointed at least partially opposite the direction of blood flow, and at least another thereof is pointed at least partially along the direction of blood flow. The valve prosthesis may also include a skirt mounted with respect to the resilient ring for sealing a periphery of the valve prosthesis against a reverse flow of blood around the valve prosthesis.
    • 公开了适于相对于心脏环的安全和对准放置的阀门假体。 瓣膜假体可以以非侵入性方式放置,例如通过经导管技术。 瓣膜假体可以包括弹性环,相对于弹性环安装的多个传膜,以及相对于柔性环可移动地安装的多个定位元件。 每个定位元件限定相应的近端,中间和远侧组织接合区域,其协作地构造和尺寸设计成同时接合解剖结构的组织的分开的对应区域,包括相应的第一,第二和第三细长组织刺穿元件。 近端,远端和中间组织接合区域协同地构造和尺寸设计以同时接合解剖结构的组织的分开的对应区域,以便相对于解剖结构稳定瓣膜假体的位置,包括其中为了目的 同时接合组织的单独的对应区域,第一,第二和第三细长组织刺穿元件中的至少一个至少部分地相对于血流方向指向,并且至少另一个至少部分地沿着 血流方向。 瓣膜假体还可以包括相对于弹性环安装的裙部,用于抵抗瓣膜假体周围的逆流血液密封阀门假体的周边。
    • 6. 发明申请
    • IN VIVO MEASUREMENT OF MITOCHONDRIAL FUNCTION
    • 人体功能测量
    • US20110288418A1
    • 2011-11-24
    • US12935755
    • 2009-04-01
    • Joseph H. Gorman, IIIRobert C. GormanMahsa Ranji
    • Joseph H. Gorman, IIIRobert C. GormanMahsa Ranji
    • A61B6/00
    • A61B5/413A61B5/0071A61B5/0075A61B5/0084
    • Disclosed herein are devices for assessing mitochondrial function in a living subject comprising a catheter comprising a sheath defining a lumen, a distal end, and a proximal end comprising a light guide for radiating light onto a target within the subject and for receiving a fluorescence signal from the target; a light source, wherein the catheter is adapted for transmitting light from the light source to the light guide; and, a detector for receiving the fluorescence signal from the light guide and for correlating the fluorescence signal to the mitochondrial function of the target. Also disclosed are methods for assessing mitochondrial function in a living subject comprising placing a catheter proximate to a site of interest within the subject; using the catheter to acquire fluorescence signals from cells at the site of interest; and, correlating the fluorescence signals to the mitochondrial function of the cells.
    • 本文公开了用于评估活体受试者的线粒体功能的装置,其包括导管,其包括限定内腔,远端和近端的护套,所述护套包括用于将光照射到受试者内的靶上的光导,并用于接收来自 目标; 光源,其中所述导管适于将光从所述光源传输到所述光导; 以及用于从光导接收荧光信号并将荧光信号与靶的线粒体功能相关联的检测器。 还公开了评估活体受试者线粒体功能的方法,包括将导管放置在受试者内的感兴趣位点附近; 使用导管从感兴趣的位点的细胞获得荧光信号; 并将荧光信号与细胞的线粒体功能相关联。