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1. 发明授权

US08473036B2 In vivo measurement of mitochondrial function 有权
标题翻译：体内线粒体功能测定
公开(公告)号：US08473036B2
公开(公告)日：2013-06-25
申请号：US12935755
申请日：2009-04-01
申请人： Joseph H. Gorman, III , Robert C. Gorman , Mahsa Ranji
发明人： Joseph H. Gorman, III , Robert C. Gorman , Mahsa Ranji
IPC分类号： A61B6/00
CPC分类号： A61B5/413 , A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： Disclosed herein are devices for assessing mitochondrial function in a living subject comprising a catheter comprising a sheath defining a lumen, a distal end, and a proximal end comprising a light guide for radiating light onto a target within the subject and for receiving a fluorescence signal from the target; a light source, wherein the catheter is adapted for transmitting light from the light source to the light guide; and, a detector for receiving the fluorescence signal from the light guide and for correlating the fluorescence signal to the mitochondrial function of the target. Also disclosed are methods for assessing mitochondrial function in a living subject comprising placing a catheter proximate to a site of interest within the subject; using the catheter to acquire fluorescence signals from cells at the site of interest; and, correlating the fluorescence signals to the mitochondrial function of the cells.
摘要翻译：本文公开了用于评估活体受试者的线粒体功能的装置，其包括导管，其包括限定内腔，远端和近端的护套，所述护套包括用于将光照射到受试者内的靶上的光导，并用于接收来自目标; 光源，其中所述导管适于将光从所述光源传输到所述光导; 以及用于从光导接收荧光信号并将荧光信号与靶的线粒体功能相关联的检测器。还公开了评估活体受试者线粒体功能的方法，包括将导管放置在受试者内的感兴趣位点附近; 使用导管从感兴趣的位点的细胞获得荧光信号; 并将荧光信号与细胞的线粒体功能相关联。

2. 发明申请

US20110288418A1 IN VIVO MEASUREMENT OF MITOCHONDRIAL FUNCTION 有权
标题翻译：人体功能测量
公开(公告)号：US20110288418A1
公开(公告)日：2011-11-24
申请号：US12935755
申请日：2009-04-01
申请人： Joseph H. Gorman, III , Robert C. Gorman , Mahsa Ranji
发明人： Joseph H. Gorman, III , Robert C. Gorman , Mahsa Ranji
IPC分类号： A61B6/00
CPC分类号： A61B5/413 , A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： Disclosed herein are devices for assessing mitochondrial function in a living subject comprising a catheter comprising a sheath defining a lumen, a distal end, and a proximal end comprising a light guide for radiating light onto a target within the subject and for receiving a fluorescence signal from the target; a light source, wherein the catheter is adapted for transmitting light from the light source to the light guide; and, a detector for receiving the fluorescence signal from the light guide and for correlating the fluorescence signal to the mitochondrial function of the target. Also disclosed are methods for assessing mitochondrial function in a living subject comprising placing a catheter proximate to a site of interest within the subject; using the catheter to acquire fluorescence signals from cells at the site of interest; and, correlating the fluorescence signals to the mitochondrial function of the cells.
摘要翻译：本文公开了用于评估活体受试者的线粒体功能的装置，其包括导管，其包括限定内腔，远端和近端的护套，所述护套包括用于将光照射到受试者内的靶上的光导，并用于接收来自目标; 光源，其中所述导管适于将光从所述光源传输到所述光导; 以及用于从光导接收荧光信号并将荧光信号与靶的线粒体功能相关联的检测器。还公开了评估活体受试者线粒体功能的方法，包括将导管放置在受试者内的感兴趣位点附近; 使用导管从感兴趣的位点的细胞获得荧光信号; 并将荧光信号与细胞的线粒体功能相关联。

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