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1. 发明授权

US08070802B2 Mitral valve system 有权
标题翻译：二尖瓣系统
公开(公告)号：US08070802B2
公开(公告)日：2011-12-06
申请号：US12028572
申请日：2008-02-08
申请人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann , Todd C. Tomba , Robert C. Gorman , Joseph H. Gorman, III
发明人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann , Todd C. Tomba , Robert C. Gorman , Joseph H. Gorman, III
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/0075 , A61F2230/008
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via transcatheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements. The proximal, distal, and intermediate tissue-engaging regions are cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure so as to stabilize a position of the valve prosthesis with respect to the anatomical structure, including wherein for purposes of so simultaneously engaging the separate corresponding areas of tissue, at least one of the first, second, and third elongate tissue-piercing elements is pointed at least partially opposite the direction of blood flow, and at least another thereof is pointed at least partially along the direction of blood flow. The valve prosthesis may also include a skirt mounted with respect to the resilient ring for sealing a periphery of the valve prosthesis against a reverse flow of blood around the valve prosthesis.
摘要翻译：公开了适于相对于心脏环的安全和对准放置的阀门假体。瓣膜假体可以以非侵入性方式放置，例如通过经导管技术。瓣膜假体可以包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。每个定位元件限定相应的近端，中间和远侧组织接合区域，其协作地构造和尺寸设计成同时接合解剖结构的组织的分开的对应区域，包括相应的第一，第二和第三细长组织刺穿元件。近端，远端和中间组织接合区域协同地构造和尺寸设计以同时接合解剖结构的组织的分开的对应区域，以便相对于解剖结构稳定瓣膜假体的位置，包括其中为了目的同时接合组织的单独的对应区域，第一，第二和第三细长组织刺穿元件中的至少一个至少部分地相对于血流方向指向，并且至少另一个至少部分地沿着血流方向。瓣膜假体还可以包括相对于弹性环安装的裙部，用于抵抗瓣膜假体周围的逆流血液密封阀门假体的周边。

2. 发明申请

US20080221672A1 Mitral Valve System 有权
标题翻译：二尖瓣系统
公开(公告)号：US20080221672A1
公开(公告)日：2008-09-11
申请号：US12028572
申请日：2008-02-08
申请人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann , Todd C. Tomba , Robert C. Gorman , Joseph H. Gorman
发明人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann , Todd C. Tomba , Robert C. Gorman , Joseph H. Gorman
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/0075 , A61F2230/008
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements. The proximal, distal, and intermediate tissue-engaging regions are cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure so as to stabilize a position of the valve prosthesis with respect to the anatomical structure, including wherein for purposes of so simultaneously engaging the separate corresponding areas of tissue, at least one of the first, second, and third elongate tissue-piercing elements is pointed at least partially opposite the direction of blood flow, and at least another thereof is pointed at least partially along the direction of blood flow. The valve prosthesis may also include a skirt mounted with respect to the resilient ring for sealing a periphery of the valve prosthesis against a reverse flow of blood around the valve prosthesis.
摘要翻译：公开了适于相对于心脏环的安全和对准放置的阀门假体。瓣膜假体可以以非侵入性方式放置，例如通过反式导管技术。瓣膜假体可以包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。每个定位元件限定相应的近端，中间和远侧组织接合区域，其协作地构造和尺寸设计成同时接合解剖结构的组织的分开的对应区域，包括相应的第一，第二和第三细长组织刺穿元件。近端，远端和中间组织接合区域协同地构造和尺寸设计以同时接合解剖结构的组织的分开的对应区域，以便相对于解剖结构稳定瓣膜假体的位置，包括其中为了目的同时接合组织的单独的对应区域，第一，第二和第三细长组织刺穿元件中的至少一个至少部分地相对于血流方向指向，并且至少另一个至少部分地沿着血流方向。瓣膜假体还可以包括相对于弹性环安装的裙部，用于抵抗瓣膜假体周围的逆流血液密封阀门假体的周边。

3. 发明授权

US07753949B2 Valve prosthesis systems and methods 有权
标题翻译：阀门假体系统及方法
公开(公告)号：US07753949B2
公开(公告)日：2010-07-13
申请号：US11869972
申请日：2007-10-10
申请人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann
发明人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , A61F2/2436 , A61F2/2439
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region. The positioning elements are adapted to substantially completely invert by rotating relative to the resilient ring between a first position in which each of the first and second tissue engaging regions is inwardly directed for facilitating positioning of the valve prosthesis within a delivery catheter, and a second position in which each of the first and second tissue engaging regions is outwardly directed for engaging tissue. The valve prosthesis may also include a valve skirt mounted with respect to the resilient ring.
摘要翻译：公开了适于相对于心脏环的安全和对准放置的阀门假体。瓣膜假体可以以非侵入性方式放置，例如经由导管技术，并且可以定位/重新定位，直到实现适当的对准和定位。瓣膜假体可以包括弹性环，相对于弹性环安装的多个小叶膜和相对于柔性环可移动地安装的多个定位元件，每个定位元件限定第一组织接合区域和第二组织接合区域与第一组织接合区域间隔开。定位元件适于在第一位置和第二位置之间通过相对于弹性环的旋转基本上完全反转，在第一位置中，第一和第二组织接合区域中的每一个向内指向，以便于将瓣膜假体定位在输送导管内，其中第一和第二组织接合区域中的每一个向外指向用于接合组织。瓣膜假体还可以包括相对于弹性环安装的阀裙。

4. 发明申请

US20080208332A1 Valve Prosthesis Systems and Methods 有权
标题翻译：瓣膜假体系统和方法
公开(公告)号：US20080208332A1
公开(公告)日：2008-08-28
申请号：US11869972
申请日：2007-10-10
申请人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann
发明人： David G. Lamphere , Tuan Anh Nguyen , Howard C. Herrmann
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , A61F2/2436 , A61F2/2439
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region. The positioning elements are adapted to substantially completely invert by rotating relative to the resilient ring between a first position in which each of the first and second tissue engaging regions is inwardly directed for facilitating positioning of the valve prosthesis within a delivery catheter, and a second position in which each of the first and second tissue engaging regions is outwardly directed for engaging tissue. The valve prosthesis may also include a valve skirt mounted with respect to the resilient ring.
摘要翻译：公开了适于相对于心脏环的安全和对准放置的阀门假体。瓣膜假体可以以非侵入性方式放置，例如经由导管技术，并且可以定位/重新定位，直到实现适当的对准和定位。瓣膜假体可以包括弹性环，相对于弹性环安装的多个小叶膜和相对于柔性环可移动地安装的多个定位元件，每个定位元件限定第一组织接合区域和第二组织接合区域与第一组织接合区域间隔开。定位元件适于在第一位置和第二位置之间通过相对于弹性环的旋转基本上完全反转，在第一位置中，第一和第二组织接合区域中的每一个向内指向，以便于将瓣膜假体定位在输送导管内，其中第一和第二组织接合区域中的每一个向外指向用于接合组织。瓣膜假体还可以包括相对于弹性环安装的阀裙。

5. 发明授权

US08663301B2 Method and apparatus for restricting flow through an opening in the side wall of a body lumen, and/or for reinforcing a weakness in the side wall of a body lumen, while still maintaining substantially normal flow through the body lumen 有权
标题翻译：用于限制通过体腔侧壁中的开口的流动和/或用于加强身体腔的侧壁中的虚弱的方法和装置，同时仍然保持基本上正常的流过体腔的流动
公开(公告)号：US08663301B2
公开(公告)日：2014-03-04
申请号：US12657598
申请日：2010-01-22
申请人： Howard Riina , Robert Andrews , Clair Strohl , Jeffrey Milsom , J. Frederick Cornhill , Kevin Thomas Smith , David G. Lamphere , Tuan Anh Nguyen
发明人： Howard Riina , Robert Andrews , Clair Strohl , Jeffrey Milsom , J. Frederick Cornhill , Kevin Thomas Smith , David G. Lamphere , Tuan Anh Nguyen
IPC分类号： A61F2/06 , A61F2/02 , A61M29/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12118 , A61B17/12131 , A61B17/1214 , A61B17/12172 , A61B17/12177 , A61B17/1219 , A61B2017/00867 , A61B2017/00871 , A61B2017/12054 , A61F2/82 , A61F2/86 , A61F2/91 , A61F2/95 , A61F2002/30242 , A61F2002/823 , A61F2002/9505 , A61F2230/005 , A61F2230/0071 , A61F2230/0091 , A61F2230/0095
摘要： An expandable substantially spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame formed out of a closed loop of filament and configured to assume (i) a collapsed configuration in the form of a substantially two-dimensional elongated loop structure so as to facilitate insertion into the blood vessel or other body lumen, and (ii) an expanded configuration in the form of a three-dimensional substantially spherical structure so as to facilitate retention at a site in the blood vessel or other body lumen; and a flow-restricting face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the flow-restricting face is configured so as to restrict flow therethrough.
摘要翻译：一种用于展开在血管或其他体腔中的可扩张的基本上为球形的结构，包括：由细丝的闭合环形成的开放框架，并且构造成采取以下步骤：（i）呈基本上二维细长环的形式的折叠构型结构，以便于插入到血管或其他体腔中，以及（ii）三维大致球形结构形式的扩张构型，以便于保持在血管或其他体腔中的部位; 以及由开放框架承载的流动限制面; 其中，所述开放框架构造成当所述开放框架处于其膨胀构造时允许基本上正常的流过其中，并且进一步其中所述流动限制面被构造成限制流过其中。

6. 发明申请

US20100268260A1 Method and apparatus for restricting flow through an opening in the side wall of a body lumen, and/or for reinforcing a weakness in the side wall of a body lumen, while still maintaining substantially normal flow through the body lumen 有权
标题翻译：用于限制通过体腔侧壁中的开口的流动和/或用于加强身体腔的侧壁中的虚弱的方法和装置，同时仍然保持基本上正常的流过体腔的流动
公开(公告)号：US20100268260A1
公开(公告)日：2010-10-21
申请号：US12657598
申请日：2010-01-22
申请人： Howard Riina , Robert Andrews , Clair Strohl , Jeffrey Milsom , J. Frederick Cornhill , Kevin Thomas Smith , David G. Lamphere , Tuan Anh Nguyen
发明人： Howard Riina , Robert Andrews , Clair Strohl , Jeffrey Milsom , J. Frederick Cornhill , Kevin Thomas Smith , David G. Lamphere , Tuan Anh Nguyen
IPC分类号： A61B17/03 , A61F2/06
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12118 , A61B17/12131 , A61B17/1214 , A61B17/12172 , A61B17/12177 , A61B17/1219 , A61B2017/00867 , A61B2017/00871 , A61B2017/12054 , A61F2/82 , A61F2/86 , A61F2/91 , A61F2/95 , A61F2002/30242 , A61F2002/823 , A61F2002/9505 , A61F2230/005 , A61F2230/0071 , A61F2230/0091 , A61F2230/0095
摘要： An expandable substantially spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame formed out of a closed loop of filament and configured to assume (i) a collapsed configuration in the form of a substantially two-dimensional elongated loop structure so as to facilitate insertion into the blood vessel or other body lumen, and (ii) an expanded configuration in the form of a three-dimensional substantially spherical structure so as to facilitate retention at a site in the blood vessel or other body lumen; and a flow-restricting face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the flow-restricting face is configured so as to restrict flow therethrough.
摘要翻译：一种用于展开在血管或其他体腔中的可扩张的基本上为球形的结构，包括：由细丝的闭合环形成的开放框架，并且构造成采取以下步骤：（i）呈基本上二维细长环的形式的折叠构型结构，以便于插入到血管或其他体腔中，以及（ii）三维大致球形结构形式的扩张构型，以便于保持在血管或其他体腔中的部位; 以及由开放框架承载的流动限制面; 其中，所述开放框架构造成当所述开放框架处于其膨胀构造时允许基本上正常的流过其中，并且进一步其中所述流动限制面被构造成限制流过其中。

7. 发明授权

US08728141B2 Method and apparatus for sealing an opening in the side wall of a body lumen, and/or for reinforcing a weakness in the side wall of a body lumen, while maintaining substantially normal flow through the body lumen 有权
标题翻译：用于密封身体腔的侧壁中的开口的方法和装置，和/或用于加强身体腔的侧壁中的弱点，同时保持基本上正常的流过体腔的流动
公开(公告)号：US08728141B2
公开(公告)日：2014-05-20
申请号：US12332727
申请日：2008-12-11
申请人： Howard Riina , Robert Andrews , Clair Strohl , Jeffrey Milsom , J. Fredrick Cornhill , Kevin Thomas Smith , David G. Lamphere , Tuan Anh Nguyen
发明人： Howard Riina , Robert Andrews , Clair Strohl , Jeffrey Milsom , J. Fredrick Cornhill , Kevin Thomas Smith , David G. Lamphere , Tuan Anh Nguyen
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61B17/12022 , A61B17/12113 , A61B17/12118 , A61B17/12131 , A61B17/12172 , A61B17/1219 , A61B2017/00867 , A61B2017/12054 , A61F2/82 , A61F2/91 , A61F2/95 , A61F2002/30242 , A61F2002/823 , A61F2230/005 , A61F2230/0071 , A61F2230/0091 , A61F2230/0095
摘要： An expandable spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame configured to assume a collapsed configuration and an expanded configuration; and a closed face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the closed face is configured so as to obstruct flow therethrough.
摘要翻译：一种用于部署在血管或其他体腔中的可扩张球形结构，包括：开放框架，其构造为呈现收缩构型和扩张构型; 和由开放框架承载的封闭面; 其中所述开放框架构造成当所述开放框架处于其膨胀构型时允许基本上正常的流过其中，并且其中所述闭合面构造成妨碍流过其中。

8. 发明申请

US20090264914A1 METHOD AND APPARATUS FOR SEALING AN OPENING IN THE SIDE WALL OF A BODY LUMEN, AND/OR FOR REINFORCING A WEAKNESS IN THE SIDE WALL OF A BODY LUMEN, WHILE MAINTAINING SUBSTANTIALLY NORMAL FLOW THROUGH THE BODY LUMEN 有权
标题翻译：用于在身体壁的侧壁中密封开口的方法和装置，和/或用于在体内保持通过身体的大量正常流动的身体壁的侧壁中增强弱化的方法和装置
公开(公告)号：US20090264914A1
公开(公告)日：2009-10-22
申请号：US12332727
申请日：2008-12-11
申请人： Howard Riina , Robert Andrews , Clair Strohl , Jeffrey Milsom , J. Fredrick Cornhill , Kevin Thomas Smith , David G. Lamphere , Tuan Anh Nguyen
发明人： Howard Riina , Robert Andrews , Clair Strohl , Jeffrey Milsom , J. Fredrick Cornhill , Kevin Thomas Smith , David G. Lamphere , Tuan Anh Nguyen
IPC分类号： A61M29/00 , A61F2/06 , A61B17/03
CPC分类号： A61F2/86 , A61B17/12022 , A61B17/12113 , A61B17/12118 , A61B17/12131 , A61B17/12172 , A61B17/1219 , A61B2017/00867 , A61B2017/12054 , A61F2/82 , A61F2/91 , A61F2/95 , A61F2002/30242 , A61F2002/823 , A61F2230/005 , A61F2230/0071 , A61F2230/0091 , A61F2230/0095
摘要： An expandable spherical structure for deployment in a blood vessel or other body lumen, comprising: an open frame configured to assume a collapsed configuration and an expanded configuration; and a closed face carried by the open frame; wherein the open frame is configured so as to permit substantially normal flow therethrough when the open frame is in its expanded configuration, and further wherein the closed face is configured so as to obstruct flow therethrough.
摘要翻译：一种用于部署在血管或其他体腔中的可扩张球形结构，包括：开放框架，其构造为呈现收缩构型和扩张构型; 和由开放框架承载的封闭面; 其中所述开放框架构造成当所述开放框架处于其膨胀构型时允许基本上正常的流过其中，并且其中所述闭合面构造成妨碍流过其中。

9. 发明授权

US08956475B2 Method and apparatus for restricting flow through an opening in the side wall of a body lumen, and/or for reinforcing a weakness in the side wall of a body lumen, while still maintaining substantially normal flow through the body lumen 有权
标题翻译：用于限制通过体腔侧壁中的开口的流动和/或用于加强身体腔的侧壁中的虚弱的方法和装置，同时仍然保持基本上正常的流过体腔的流动
公开(公告)号：US08956475B2
公开(公告)日：2015-02-17
申请号：US13437777
申请日：2012-04-02
申请人： Howard Riina , Jeffrey Milsom , J. Frederick Cornhill , Tuan Anh Nguyen , Kevin Smith , Kevin Keough , Robert Andrews
发明人： Howard Riina , Jeffrey Milsom , J. Frederick Cornhill , Tuan Anh Nguyen , Kevin Smith , Kevin Keough , Robert Andrews
IPC分类号： C22F1/18 , A61F2/86 , A61N5/06 , C22F1/00 , A61B17/12 , A61H23/00 , A61B17/00 , A61F2/82 , A61F2/91 , A61F2/95 , A61F2/30
CPC分类号： A61B17/12172 , A61B17/12022 , A61B17/12118 , A61B17/12131 , A61B2017/00867 , A61B2017/12054 , A61F2/82 , A61F2/86 , A61F2/91 , A61F2/95 , A61F2002/30242 , A61F2002/823 , A61F2230/005 , A61F2230/0071 , A61F2230/0091 , A61F2230/0095 , A61H23/00 , A61N5/0616 , C22F1/006
摘要： A method for making a device for causing thrombosis of an aneurysm, wherein said device comprises a single elastic filament configurable between (i) an elongated, substantially linear configuration, and (ii) a longitudinally-contracted, substantially three-dimensional configuration, said method comprising: providing a sheet of shape memory material; producing a single filament, two-dimensional interim structure from said sheet of shape memory material; mounting said single filament, two-dimensional interim structure to a fixture so that said single filament, two-dimensional interim structure is transformed into said longitudinally-contracted, substantially three-dimensional configuration; and heat treating said single filament, two-dimensional interim structure while it is mounted to said fixture so as to produce said device in its longitudinally-contracted, substantially three-dimensional configuration.
摘要翻译：一种用于制造用于引起动脉瘤血栓形成的装置的方法，其中所述装置包括在（i）细长的，基本上线性的构型和（ii）纵向收缩的基本上三维构型之间可配置的单个弹性丝，所述方法包括：提供一片形状记忆材料; 从所述形状记忆材料片产生单丝，二维中间结构; 将所述单丝，二维临时结构安装到固定装置，使得所述单丝，二维中间结构转变成所述纵向收缩的基本上三维构造; 以及在安装到所述固定装置上时对所述单丝进行热处理，所述二维中间结构在其纵向收缩的基本三维构型中产生所述装置。

10. 发明申请

US20120310342A1 INTRAOCULAR LENS 审中-公开
标题翻译：内窥镜
公开(公告)号：US20120310342A1
公开(公告)日：2012-12-06
申请号：US13588629
申请日：2012-08-17
申请人： Tuan Anh Nguyen , Gholam-Reza Zadno-Azizi , Scott Evans
发明人： Tuan Anh Nguyen , Gholam-Reza Zadno-Azizi , Scott Evans
IPC分类号： A61F2/16
CPC分类号： A61F2/1616 , A61F2/1629 , A61F2/1648
摘要： An accommodating intraocular lens has an anterior portion including an anterior viewing element and an anterior biasing element connected to the anterior viewing element. A posterior portion has a posterior viewing element and a posterior biasing element connected to the posterior viewing element. The anterior and posterior biasing elements are connected at first and second apices. First and second distending members are connected to the posterior portion. The first and second distending members extend to locations significantly anterior of an anterior side of the posterior viewing element.
摘要翻译：容纳人工晶状体具有前部，其包括前部观察元件和连接到前部观察元件的前部偏置元件。后部具有后观察元件和连接到后视元件的后偏置元件。前和后偏置元件在第一和第二顶点连接。第一和第二扩张构件连接到后部。第一和第二扩张构件延伸到显着前后观察元件前侧的位置。

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