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1. 发明申请

US20110002962A1 Immunogenic PcpA Polypeptides and Uses Thereof 审中-公开
标题翻译：免疫原性PcpA多肽及其用途
公开(公告)号：US20110002962A1
公开(公告)日：2011-01-06
申请号：US12377446
申请日：2007-08-17
申请人： David E. Briles , Susan K. Hollingshead , Jeremy Yethon , Joe Wang
发明人： David E. Briles , Susan K. Hollingshead , Jeremy Yethon , Joe Wang
IPC分类号： A61K39/09 , C07K14/195 , A61K39/116 , A61P31/04
CPC分类号： C07K14/3156 , G01N33/56944 , G01N2400/10
摘要： Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PcpA and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
摘要翻译：本文提供了用于引发针对肺炎链球菌的免疫应答的组合物和方法。更具体地，组合物和方法涉及免疫原性多肽，包括PcpA及其变体的片段，以及编码或表达多肽的核酸，载体和转染的细胞。还描述了制备和使用免疫原性多肽的方法。

2. 发明申请

US20110104168A1 DETOXIFIED PNEUMOCOCCAL NEURAMINIDASE AND USES THEREOF 有权
标题翻译：脱氧肺炎球菌神经酰胺酶及其用途
公开(公告)号：US20110104168A1
公开(公告)日：2011-05-05
申请号：US12601233
申请日：2007-05-23
申请人： David E. Briles , Susan K. Hollingshead
发明人： David E. Briles , Susan K. Hollingshead
IPC分类号： A61K39/40 , C12N9/24 , C07K14/315 , A61K39/09 , A61P31/04 , A61P37/04
CPC分类号： C12N9/2402 , A61K39/092 , C12Y302/01018
摘要： Provided herein are compositions designed to reduce or prevent pneuomococcal infections, nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a polypeptide comprising the amino acid sequence of SEQ ID NO: 19 or a variant thereof that can elicit an anti-neuraminidase immune response. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein. Also provided are methods of reducing or preventing nasal carriage or pneumococcal infection in a subject comprising administering to the subject a composition taught herein.
摘要翻译：本文提供了旨在减少或预防球细胞感染，鼻运动，鼻腔定植和中枢神经系统侵袭的组合物。本文提供了包含包含SEQ ID NO：19的氨基酸序列的多肽或其可诱发抗神经氨酸酶免疫应答的变体的组合物。进一步提供制备和使用本文公开的组合物的方法。具体提供的是在受试者中产生抗体的方法，包括向受试者施用本文教导的试剂或组合物。还提供减少或预防受试者鼻腔运载或肺炎球菌感染的方法，包括向受试者施用本文教导的组合物。

3. 发明授权

US08252546B2 Diagnosing pneumococcal pneumonia 有权
标题翻译：诊断肺炎球菌肺炎
公开(公告)号：US08252546B2
公开(公告)日：2012-08-28
申请号：US12377440
申请日：2007-08-17
申请人： David E. Briles , Susan K. Hollingshead
发明人： David E. Briles , Susan K. Hollingshead
IPC分类号： G01N33/569
CPC分类号： C07K14/3156 , G01N33/56944 , G01N2400/10 , Y02A50/472
摘要： Compositions and methods for eliciting an immune response against Streptococcus pneumoniae are described. More particularly, the present disclosure relates to immunogenic PcpA polypeptides, including fragments of PcpA and variants thereof, and nucleic acids that encode the polypeptides. The present disclosure further relates to methods of making and using the immunogenic polypeptides. Further provided is a method of diagnosing pneumococcal infection (e.g., pneumonia) in a subject by obtaining a biological sample from the subject and detecting one or more pneumococcal antigens that are selectively expressed during invasion (e.g., PcpA or fragments thereof).
摘要翻译：描述了引起针对肺炎链球菌的免疫应答的组合物和方法。更具体地说，本公开内容涉及免疫原性PcpA多肽，包括PcpA及其变体的片段，以及编码多肽的核酸。本公开还涉及制备和使用免疫原性多肽的方法。还提供了通过从受试者获得生物样品并检测在入侵期间选择性表达的一种或多种肺炎球菌抗原（例如PcpA或其片段）来诊断受试者中的肺炎球菌感染（例如肺炎）的方法。

4. 发明授权

US07049419B2 Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor 有权
公开(公告)号：US07049419B2
公开(公告)日：2006-05-23
申请号：US10341201
申请日：2003-01-13
申请人： David E. Briles , Susan K. Hollingshead , Alexis Brooks-Walter
发明人： David E. Briles , Susan K. Hollingshead , Alexis Brooks-Walter
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , C12P21/06 , C12N15/09
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/51
摘要： Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least one epitope of PspC, uses for such nucleic acid molecules, e.g., to detect the presence of PspC or of S. pneumoniae by detecting a nucleic acid molecule therefor in a sample such as by amplification and/or a polymerase chain reaction, vectors or plasmids which contain and/or express such nucleic acid molecles, e.g., in vitro or in vivo, immunological, immunogenic or vaccine compositions including at least one PspC and/or a portion thereof (such as at least one epitopic region of at least one PspC and/or at least one polypeptide encoding at least one epitope of at least one PspC), either alone or in further combination with at least one second pneumococcal antigen, such as at least one different PspC and/or a fragment thereof and/or at least one PspA and/or at least one epitopic region of at least one PspA and/or at least one polypeptide including at least one epitope of PspA. PspC or a fragment thereof, and thus a composition including PspC or a fragment thereof, can be administered by the same routes, and in approximately the same amounts, as PspA. Thus, the invention further provides methods for administering PspC or a fragment thereof, as well as uses of PspC or a fragment thereof to formulate such compositions.

5. 发明授权

US07078042B2 Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor 失效
标题翻译：肺炎球菌表面蛋白C（PspC），其表位区和菌株的选择及其用途
公开(公告)号：US07078042B2
公开(公告)日：2006-07-18
申请号：US09298523
申请日：1999-04-23
申请人： David E. Briles , Susan K. Hollingshead , Alexis Brooks-Walter
发明人： David E. Briles , Susan K. Hollingshead , Alexis Brooks-Walter
IPC分类号： A61K39/395 , A61K39/40 , A61K39/00 , A61K39/38 , A61K38/00 , C07K14/00 , C07K16/00 , C07K7/00 , C07K17/00 , C07K5/00
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/51
摘要： Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least one epitope of PspC, uses for such nucleic acid molecules, e.g., to detect the presence of PspC or of S. pneumoniae by detecting a nucleic acid molecule therefor in a sample such as by amplification and/or a polymerase chain reaction, vectors or plasmids which contain and/or express such nucleic acid molecles, e.g., in vitro or in vivo, immunological, immunogenic or vaccine compositions including at least one PspC and/or a portion thereof (such as at least one epitopic region of at least one PspC and/or at least one polypeptide encoding at least one epitope of at least one PspC), either alone or in further combination with at least one second pneumococcal antigen, such as at least one different PspC and/or a fragment thereof and/or at least one PspA and/or at least one epitopic region of at least one PspA and/or at least one polypeptide including at least one epitope of PspA. PspC or a fragment thereof, and thus a composition including PspC or a fragment thereof, can be administered by the same routes, and in approximately the same amounts, as PspA. Thus, the invention further provides methods for administering PspC or a fragment thereof, as well as uses of PspC or a fragment thereof to formulate such compositions.
摘要翻译：公开并要求保护的是：肺炎球菌表面蛋白C或“PspC”的表位区域，PspC的不同分支，分离和/或纯化的核酸分子，例如编码PspC的片段或部分的DNA，如PspC的表位区域或至少 PspC的一个表位用于此类核酸分子，例如通过在样品中检测其核酸分子来检测PspC或肺炎链球菌的存在，例如通过扩增和/或聚合酶链反应，载体或质粒其包含和/或表达此类核酸分子，例如体外或体内免疫学，免疫原性或包含至少一个PspC和/或其部分的疫苗组合物（例如至少一个PspC的至少一个表位区域和或至少一种编码至少一个PspC的至少一个表位的多肽），单独或与至少一种第二肺炎球菌抗原进一步组合，例如至少一种不同的PspC和/或其片段和/ 或至少一个PspA的至少一个PspA和/或至少一个表位区域和/或包含至少一个PspA表位的至少一个多肽。 PspC或其片段，因此包含PspC或其片段的组合物可以以与PspA相同的途径和大致相同的量施用。因此，本发明还提供了施用PspC或其片段的方法，以及PspC或其片段的用途来配制这些组合物。

6. 发明授权

US08808704B2 Non-coiled protective regions of pneumococcal surface proteins PspA and PspC 有权
标题翻译：肺炎球菌表面蛋白PspA和PspC的非卷曲保护区
公开(公告)号：US08808704B2
公开(公告)日：2014-08-19
申请号：US12162566
申请日：2007-02-01
申请人： Susan K. Hollingshead , David E. Briles
发明人： Susan K. Hollingshead , David E. Briles
IPC分类号： A61K39/09 , C12N15/09
CPC分类号： A61K39/092 , A61K2039/55505 , C07K14/3156 , C07K16/1275
摘要： The embodiments described herein provide for immunogenic portions of Streptococcus pneumoniae surface protein A and surface protein C lacking alpha helical structure.
摘要翻译：本文描述的实施方案提供了肺炎链球菌表面蛋白A和缺乏α螺旋结构的表面蛋白C的免疫原性部分。

7. 发明授权

US08329195B2 Detoxified pneumococcal neuraminidase and uses thereof 有权
标题翻译：解毒型肺炎球菌神经氨酸酶及其用途
公开(公告)号：US08329195B2
公开(公告)日：2012-12-11
申请号：US12601233
申请日：2007-05-23
申请人： David E. Briles , Susan K. Hollingshead
发明人： David E. Briles , Susan K. Hollingshead
IPC分类号： A61K39/09 , C07K14/315
CPC分类号： C12N9/2402 , A61K39/092 , C12Y302/01018
摘要： Provided herein are compositions designed to reduce or prevent pneuomococcal infections, nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a polypeptide comprising the amino acid sequence of SEQ ID NO: 19 or a variant thereof that can elicit an anti-neuraminidase immune response. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein. Also provided are methods of reducing or preventing nasal carriage or pneumococcal infection in a subject comprising administering to the subject a composition taught herein.
摘要翻译：本文提供了旨在减少或预防球细胞感染，鼻运动，鼻腔定植和中枢神经系统侵袭的组合物。本文提供了包含包含SEQ ID NO：19的氨基酸序列的多肽或其可诱发抗神经氨酸酶免疫应答的变体的组合物。进一步提供制备和使用本文公开的组合物的方法。具体提供的是在受试者中产生抗体的方法，包括向受试者施用本文教导的试剂或组合物。还提供减少或预防受试者鼻腔运载或肺炎球菌感染的方法，包括向受试者施用本文教导的组合物。

8. 发明申请

US20100227341A1 Diagnosing Pneumococcal Pneumonia 有权
标题翻译：诊断肺炎球菌肺炎
公开(公告)号：US20100227341A1
公开(公告)日：2010-09-09
申请号：US12377440
申请日：2007-08-17
申请人： David E. Briles , Susan K. Hollingshead
发明人： David E. Briles , Susan K. Hollingshead
IPC分类号： G01N33/53
CPC分类号： C07K14/3156 , G01N33/56944 , G01N2400/10 , Y02A50/472
摘要： Compositions and methods for eliciting an immune response against Streptococcus pneumoniae are described. More particularly, the present disclosure relates to immunogenic PcpA polypeptides, including fragments of PcpA and variants thereof, and nucleic acids that encode the polypeptides. The present disclosure further relates to methods of making and using the immunogenic polypeptides. Further provided is a method of diagnosing pneumococcal infection (e.g., pneumonia) in a subject by obtaining a biological sample from the subject and detecting one or more pneumococcal antigens that are selectively expressed during invasion (e.g., PcpA or fragments thereof).
摘要翻译：描述了引起针对肺炎链球菌的免疫应答的组合物和方法。更具体地说，本公开内容涉及免疫原性PcpA多肽，包括PcpA及其变体的片段，以及编码多肽的核酸。本公开还涉及制备和使用免疫原性多肽的方法。还提供了通过从受试者获得生物样品并检测在入侵期间选择性表达的一种或多种肺炎球菌抗原（例如PcpA或其片段）来诊断受试者中的肺炎球菌感染（例如肺炎）的方法。

9. 发明申请

US20090170162A1 NON-COILED PROTECTIVE REGIONS OF PNEUMOCOCCAL SURFACE PROTEINS PSPA AND PSPC 有权
标题翻译：肺结核蛋白PSPA和PSPC的非卷曲保护区
公开(公告)号：US20090170162A1
公开(公告)日：2009-07-02
申请号：US12162566
申请日：2007-02-01
申请人： Susan K. Hollingshead , David E. Briles
发明人： Susan K. Hollingshead , David E. Briles
IPC分类号： C12P21/02 , C07K14/315 , C07H21/02 , C12N15/63 , C12N5/10 , A61K39/09 , A61P37/02
CPC分类号： A61K39/092 , A61K2039/55505 , C07K14/3156 , C07K16/1275
摘要： The embodiments described herein provide for immunogenic portions of Streptococcus pneumoniae surface protein A and surface protein C lacking alpha helical structure.
摘要翻译：本文描述的实施方案提供了肺炎链球菌表面蛋白A和缺乏α螺旋结构的表面蛋白C的免疫原性部分。

10. 发明授权

US6030624A Mucosal immunogens for novel vaccines 失效
标题翻译：新型疫苗的粘膜免疫原
公开(公告)号：US6030624A
公开(公告)日：2000-02-29
申请号：US912180
申请日：1997-08-15
申请人： Michael William Russell , Georgios Hajishengallis , Susan K. Hollingshead , Hong-Yin Wu , Suzanne Mary Michalek
发明人： Michael William Russell , Georgios Hajishengallis , Susan K. Hollingshead , Hong-Yin Wu , Suzanne Mary Michalek
IPC分类号： A61P37/04 , C07K14/28 , C07K14/315 , C12N1/21 , C12N15/62 , A61K39/02 , A61K39/09
CPC分类号： C12N15/62 , A61K39/092 , C07K14/28 , C07K14/315 , A61K2039/542 , A61K2039/6037 , C07K2319/00 , C07K2319/40 , C07K2319/55
摘要： The present invention provides chimeric proteins such as Salivary Binding Protein (SBR) coupled to the B subunit of cholera toxin. Such a chimeric protein, when expressed in attenuated Salmonella typhymurium produces significant increases in serum IgG and salivary IgA antibody levels after oral immunization. In another embodiment of the present invention, the recombinant plasmid contains a salivary binding protein-cholera toxin A2/B chimeric protein expressed in E. coli. Intragastric immunization of SBR coupled to CTB in this chimeric protein form leads to increased antigen responsive T cells. In another embodiment of the present invention, the recombinant plasmid contains a salivary binding protein-cholera toxin.sup..DELTA.A1 chimeric protein expressed in Salmonella typhimurium. Oral immunization using this recombinant plasmid results in increased serum IgG responses to antigen. Oral immunization using this recombinant plasmid also resulted in increased salivary IgA antibody responses to antigen.
摘要翻译：本发明提供了与霍乱毒素B亚基偶联的嵌合蛋白如唾液结合蛋白（SBR）。当在减毒的沙门氏菌中表达时，这种嵌合蛋白在口服免疫后产生血清IgG和唾液IgA抗体水平的显着增加。在本发明的另一个实施方案中，重组质粒含有在大肠杆菌中表达的唾液结合蛋白 - 霍乱毒素A2 / B嵌合蛋白。在该嵌合蛋白质形式中与CTB偶联的SBR的内部免疫导致增加的抗原应答性T细胞。在本发明的另一个实施方案中，重组质粒含有在鼠伤寒沙门氏菌中表达的唾液结合蛋白 - 霍乱毒素DELTA A1嵌合蛋白。使用这种重组质粒进行口服免疫可导致血清IgG对抗原的反应。使用这种重组质粒的口服免疫也导致唾液IgA抗体对抗原的反应增加。

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