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1. 发明授权

US07049419B2 Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor 有权
公开(公告)号：US07049419B2
公开(公告)日：2006-05-23
申请号：US10341201
申请日：2003-01-13
申请人： David E. Briles , Susan K. Hollingshead , Alexis Brooks-Walter
发明人： David E. Briles , Susan K. Hollingshead , Alexis Brooks-Walter
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , C12P21/06 , C12N15/09
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/51
摘要： Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least one epitope of PspC, uses for such nucleic acid molecules, e.g., to detect the presence of PspC or of S. pneumoniae by detecting a nucleic acid molecule therefor in a sample such as by amplification and/or a polymerase chain reaction, vectors or plasmids which contain and/or express such nucleic acid molecles, e.g., in vitro or in vivo, immunological, immunogenic or vaccine compositions including at least one PspC and/or a portion thereof (such as at least one epitopic region of at least one PspC and/or at least one polypeptide encoding at least one epitope of at least one PspC), either alone or in further combination with at least one second pneumococcal antigen, such as at least one different PspC and/or a fragment thereof and/or at least one PspA and/or at least one epitopic region of at least one PspA and/or at least one polypeptide including at least one epitope of PspA. PspC or a fragment thereof, and thus a composition including PspC or a fragment thereof, can be administered by the same routes, and in approximately the same amounts, as PspA. Thus, the invention further provides methods for administering PspC or a fragment thereof, as well as uses of PspC or a fragment thereof to formulate such compositions.

2. 发明授权

US07078042B2 Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor 失效
标题翻译：肺炎球菌表面蛋白C（PspC），其表位区和菌株的选择及其用途
公开(公告)号：US07078042B2
公开(公告)日：2006-07-18
申请号：US09298523
申请日：1999-04-23
申请人： David E. Briles , Susan K. Hollingshead , Alexis Brooks-Walter
发明人： David E. Briles , Susan K. Hollingshead , Alexis Brooks-Walter
IPC分类号： A61K39/395 , A61K39/40 , A61K39/00 , A61K39/38 , A61K38/00 , C07K14/00 , C07K16/00 , C07K7/00 , C07K17/00 , C07K5/00
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/51
摘要： Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least one epitope of PspC, uses for such nucleic acid molecules, e.g., to detect the presence of PspC or of S. pneumoniae by detecting a nucleic acid molecule therefor in a sample such as by amplification and/or a polymerase chain reaction, vectors or plasmids which contain and/or express such nucleic acid molecles, e.g., in vitro or in vivo, immunological, immunogenic or vaccine compositions including at least one PspC and/or a portion thereof (such as at least one epitopic region of at least one PspC and/or at least one polypeptide encoding at least one epitope of at least one PspC), either alone or in further combination with at least one second pneumococcal antigen, such as at least one different PspC and/or a fragment thereof and/or at least one PspA and/or at least one epitopic region of at least one PspA and/or at least one polypeptide including at least one epitope of PspA. PspC or a fragment thereof, and thus a composition including PspC or a fragment thereof, can be administered by the same routes, and in approximately the same amounts, as PspA. Thus, the invention further provides methods for administering PspC or a fragment thereof, as well as uses of PspC or a fragment thereof to formulate such compositions.
摘要翻译：公开并要求保护的是：肺炎球菌表面蛋白C或“PspC”的表位区域，PspC的不同分支，分离和/或纯化的核酸分子，例如编码PspC的片段或部分的DNA，如PspC的表位区域或至少 PspC的一个表位用于此类核酸分子，例如通过在样品中检测其核酸分子来检测PspC或肺炎链球菌的存在，例如通过扩增和/或聚合酶链反应，载体或质粒其包含和/或表达此类核酸分子，例如体外或体内免疫学，免疫原性或包含至少一个PspC和/或其部分的疫苗组合物（例如至少一个PspC的至少一个表位区域和或至少一种编码至少一个PspC的至少一个表位的多肽），单独或与至少一种第二肺炎球菌抗原进一步组合，例如至少一种不同的PspC和/或其片段和/ 或至少一个PspA的至少一个PspA和/或至少一个表位区域和/或包含至少一个PspA表位的至少一个多肽。 PspC或其片段，因此包含PspC或其片段的组合物可以以与PspA相同的途径和大致相同的量施用。因此，本发明还提供了施用PspC或其片段的方法，以及PspC或其片段的用途来配制这些组合物。

3. 发明授权

US06592876B1 Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products 失效
标题翻译：肺炎球菌基因，其部分，其表达产物，以及这些基因，部分和产物的用途
公开(公告)号：US06592876B1
公开(公告)日：2003-07-15
申请号：US08529055
申请日：1995-09-15
申请人： David E. Briles , Larry S. McDaniel , Edwin Swiatlo , Janet Yother , Alexis Brooks-Walter
发明人： David E. Briles , Larry S. McDaniel , Edwin Swiatlo , Janet Yother , Alexis Brooks-Walter
IPC分类号： A61K3909
CPC分类号： C07K14/7151 , A61K38/00 , A61K39/00 , A61K39/092 , C07K14/28 , C07K14/3156 , C07K2319/00 , C07K2319/02 , C12N15/74 , C12N15/746 , C12Q1/689 , G01N33/56911 , G06K15/02 , G06T9/005 , G11B5/012 , G11B20/10 , G11B25/043
摘要： PspAs, portions thereof, DNA therefor, and immunological compositions, primers and probes based thereon are disclosed claimed.
摘要翻译： PspAs，其部分，其DNA，免疫组合物，基于其的引物和探针被公开。

4. 发明授权

US06500613B1 Pneumococcal surface proteins and uses thereof 失效
标题翻译：肺炎球菌表面蛋白及其用途
公开(公告)号：US06500613B1
公开(公告)日：2002-12-31
申请号：US08714741
申请日：1996-09-16
申请人： David E. Briles , Larry S. McDaniel , Edwin Swiatlo , Janet Yother , Marilyn J. Crain , Susan Hollingshead , Rebecca Tart , Alexis Brooks-Walter
发明人： David E. Briles , Larry S. McDaniel , Edwin Swiatlo , Janet Yother , Marilyn J. Crain , Susan Hollingshead , Rebecca Tart , Alexis Brooks-Walter
IPC分类号： C12Q168
CPC分类号： C07K14/7151 , A61K38/00 , A61K39/00 , A61K39/092 , C07K14/28 , C07K14/3156 , C07K2319/00 , C07K2319/02 , C12N15/74 , C12N15/746 , C12Q1/689 , G01N33/56911 , G06K15/02 , G06T9/005 , G11B5/012 , G11B20/10 , G11B25/043
摘要： The present invention relates to pneumococcal genes, portions thereof, expression products therefrom and uses of such genes, portions and products; especially to genes of Streptococcus pneumoniae, e.g., the gene encoding pneumococcal surface protein A (PspA), i.e., the pspA gene, the gene encoding pneumococcal surface protein A-like proteins, such as pspA-like genes, e.g., the gene encoding pneumococcal surface protein C (PspC), i.e., the pspC gene, portions of such genes, expression products therefrom, and the uses of such genes, portions thereof and expression products therefrom.
摘要翻译：本发明涉及肺炎球菌基因，其部分，其表达产物及其用途及其用途; 特别是肺炎链球菌的基因，例如编码肺炎球菌表面蛋白A（PspA）的基因，即pspA基因，编码肺炎球菌表面蛋白A样蛋白的基因，如pspA样基因，例如编码肺炎球菌的基因表面蛋白C（PspC），即pspC基因，这些基因的部分，其表达产物，以及这些基因，其部分及其表达产物的用途。

5. 发明申请

US20050196405A1 PNEUMOCOCCAL SURFACE PROTEIN C (PSPC), EPITOPIC REGIONS AND STRAIN SELECTION THEREOF, AND USES THEREFOR 有权
标题翻译：阳性表面蛋白C（PSPC），外源性区域和菌株选择及其用途
公开(公告)号：US20050196405A1
公开(公告)日：2005-09-08
申请号：US10341201
申请日：2003-01-13
申请人： David Briles , Susan Hollingshead , Alexis Brooks-Walter
发明人： David Briles , Susan Hollingshead , Alexis Brooks-Walter
IPC分类号： A61K39/00 , A61K39/02 , C07H21/04 , C07K14/31 , C07K14/315 , C12N1/21 , C12N15/74 , C12Q1/68
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/51
摘要： Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least one epitope of PspC, uses for such nucleic acid molecules, e.g., to detect the presence of PspC or of S. pneumoniae by detecting a nucleic acid molecule therefor in a sample such as by amplification and/or a polymerase chain reaction, vectors or plasmids which contain and/or express such nucleic acid molecles, e.g., in vitro or in vivo, immunological, immunogenic or vaccine compositions including at least one PspC and/or a portion thereof (such as at least one epitopic region of at least one PspC and/or at least one polypeptide encoding at least one epitope of at least one PspC), either alone or in further combination with at least one second pneumococcal antigen, such as at least one different PspC and/or a fragment thereof and/or at least one PspA and/or at least one epitopic region of at least one PspA and/or at least one polypeptide including at least one epitope of PspA. PspC or a fragment thereof, and thus a composition including PspC or a fragment thereof, can be administered by the same routes, and in approximately the same amounts, as PspA. Thus, the invention further provides methods for administering PspC or a fragment thereof, as well as uses of PspC or a fragment thereof to formulate such compositions.
摘要翻译：公开并要求保护的是：肺炎球菌表面蛋白C或“PspC”的表位区域，PspC的不同分支，分离和/或纯化的核酸分子，例如编码PspC的片段或部分的DNA，如PspC的表位区域或至少 PspC的一个表位用于此类核酸分子，例如通过在样品中检测其核酸分子来检测PspC或肺炎链球菌的存在，例如通过扩增和/或聚合酶链反应，载体或质粒其包含和/或表达这样的核酸分子，例如体外或体内免疫学，免疫原性或包含至少一个PspC和/或其部分的疫苗组合物（例如至少一个PspC的至少一个表位区域和或至少一种编码至少一个PspC的至少一个表位的多肽），单独或与至少一种第二肺炎球菌抗原进一步组合，例如至少一种不同的PspC和/或其片段和/ 或至少一个PspA的至少一个PspA和/或至少一个表位区域和/或包含至少一个PspA表位的至少一个多肽。 PspC或其片段，因此包含PspC或其片段的组合物可以以与PspA相同的途径和大致相同的量施用。因此，本发明还提供了施用PspC或其片段的方法，以及PspC或其片段的用途来配制这些组合物。

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