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1. 发明授权

US10155795B2 Compositions comprising hypoxia inducible factor-1 alpha and methods of using the same 有权
公开(公告)号：US10155795B2
公开(公告)日：2018-12-18
申请号：US14776516
申请日：2014-03-14
申请人： David B. Weiner , Karuppiah Muthumani , Emile Mohler , Geoffrey Ouma
发明人： David B. Weiner , Karuppiah Muthumani , Emile Mohler , Geoffrey Ouma
IPC分类号： C07H21/04 , C12N15/09 , C12N15/11 , C12N15/63 , A61P9/10 , C07K14/47 , A61K38/17 , A61K39/00 , A61K41/00 , A61N1/32 , A61K48/00
摘要： Disclosed herein is a therapeutic comprising hypoxia inducible factor-1 alpha (HIF-1α). Also disclosed herein is a method for treating hypoxia or ischemia in a subject in need thereof. The method may comprise administering the vaccine to the subject in need thereof.

2. 发明授权

US10226528B2 Vaccines with biomolecular adjuvants 有权
公开(公告)号：US10226528B2
公开(公告)日：2019-03-12
申请号：US14774428
申请日：2014-03-14
申请人： David B. Weiner , Karuppiah Muthumani
发明人： David B. Weiner , Karuppiah Muthumani
IPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , C07K14/52 , C12N7/00 , A61K41/00 , C07K14/47 , A61K39/00
摘要： Disclosed herein is a vaccine comprising an antigen and one or more bimolecular adjuvant. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.

3. 发明申请

US20090170800A1 GENETIC CONSTRUCTS AND COMPOSITIONS COMPRISING RRE AND CTE AND USES THEREOF 有权
标题翻译：包含RRE和CTE的遗传构建体和组合物及其用途
公开(公告)号：US20090170800A1
公开(公告)日：2009-07-02
申请号：US12275192
申请日：2008-11-20
申请人： David B. Weiner , Karuppiah Muthumani
发明人： David B. Weiner , Karuppiah Muthumani
IPC分类号： A61K31/7088 , C12N15/63 , C12P21/06
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322 , C12N2740/16334
摘要： Genetic constructs that comprise a coding sequence for HIV-1 Rev, and a coding sequence for a desired protein are disclosed. Compositions that comprise at least two nucleic acid molecules in which at least one nucleic acid molecule comprises a coding sequence for HIV-1 Rev, and at least one nucleic acid molecule comprises a coding sequence for a desired protein are disclosed. In such genetic constructs and compositions comprising nucleic acid molecules, the coding sequence for the desired protein comprises at least a portion of coding sequence for an HIV structural protein that includes an RRE and at least one CTE. Methods of inducing an immune response against an immunogen in an individual, methods of delivering proteins to an individual and methods of producing proteins are also disclosed.
摘要翻译：公开了包含HIV-1 Rev编码序列的遗传构建体和所需蛋白质的编码序列。包含至少两个核酸分子的组合物，其中至少一个核酸分子包含HIV-1 Rev的编码序列，并且至少一个核酸分子包含所需蛋白质的编码序列。在包含核酸分子的这种遗传构建体和组合物中，所需蛋白质的编码序列包含HIV结构蛋白的编码序列的至少一部分，其包括RRE和至少一种CTE。还公开了诱导针对个体免疫原的免疫应答的方法，将蛋白递送给个体的方法和生产蛋白质的方法。

4. 发明申请

US20120282217A1 FOOT AND MOUTH DISEASE VIRUS (FMDV) CONSENSUS PROTEINS, CODING SEQUENCES THEREFOR AND VACCINES MADE THEREFROM 有权
标题翻译： FOOD和MOUD疾病病毒（FMDV）共识蛋白，其编码序列及其制备的疫苗
公开(公告)号：US20120282217A1
公开(公告)日：2012-11-08
申请号：US13503828
申请日：2010-11-02
申请人： David B. Weiner , Bernadette Ferraro , Jian Yan , Patricia A. Brown , Rodney A. Bowling , Douglas R. Kern , Mathura P. Ramanathan , Niranjan Y. Sardesai , Karuppiah Muthumani
发明人： David B. Weiner , Bernadette Ferraro , Jian Yan , Patricia A. Brown , Rodney A. Bowling , Douglas R. Kern , Mathura P. Ramanathan , Niranjan Y. Sardesai , Karuppiah Muthumani
IPC分类号： A61K39/135 , C12N15/62 , C12N15/57 , C12N15/63 , A61M37/00 , C07K14/09 , C07K19/00 , C12N9/50 , C12Q1/70 , G01N33/569 , C12N15/42 , A61K38/20
CPC分类号： C07K14/005 , A61K39/12 , A61K39/135 , A61K39/39 , A61K2039/523 , A61K2039/53 , A61K2039/552 , A61M37/00 , A61N1/327 , C12N7/00 , C12N2770/32122 , C12N2770/32134 , G01N33/56983 , G01N2333/09 , G01N2469/20
摘要： Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
摘要翻译：本文提供的是包含FMDV亚型A，亚洲1，C，O，SAT1，SAT2和SAT3的口蹄疫FMDV VP1-4外壳蛋白的共有氨基酸序列的核酸，以及表达序列。本文还提供了使用上述疫苗产生针对一种或多种FMDV亚型的免疫应答的方法以及用疫苗接种的哺乳动物和用FMDV感染的哺乳动物之间进行解密的方法。

5. 发明授权

US07455841B2 Genetic constructs and compositions comprising RRE and CTE and uses thereof 有权
标题翻译：包含RRE和CTE的遗传构建体和组合物及其用途
公开(公告)号：US07455841B2
公开(公告)日：2008-11-25
申请号：US10535326
申请日：2003-11-19
申请人： David B. Weiner , Karuppiah Muthumani
发明人： David B. Weiner , Karuppiah Muthumani
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322 , C12N2740/16334
摘要： Genetic constructs that comprise a coding sequence for HIV-1 Rev, and a coding sequence for a desired protein are disclosed. Compositions that comprise at least two nucleic acid molecules in which at least one nucleic acid molecule comprises a coding sequence for HIV-1 Rev, and at least one nucleic acid molecule comprises a coding sequence for a desired protein are disclosed. In such genetic constructs and compositions comprising nucleic acid molecules, the coding sequence for the desired protein comprises at least a portion of coding sequence for an HIV structural protein that includes an RRE and at least one CTE. Methods of inducing an immune response against an immunogen in an individual, methods of delivering proteins to an individual and methods of producing proteins are also disclosed.
摘要翻译：公开了包含HIV-1 Rev编码序列的遗传构建体和所需蛋白质的编码序列。包含至少两个核酸分子的组合物，其中至少一个核酸分子包含HIV-1 Rev的编码序列，并且至少一个核酸分子包含所需蛋白质的编码序列。在包含核酸分子的这种遗传构建体和组合物中，所需蛋白质的编码序列包含HIV结构蛋白的编码序列的至少一部分，其包括RRE和至少一种CTE。还公开了诱导针对个体免疫原的免疫应答的方法，将蛋白递送给个体的方法和生产蛋白质的方法。

6. 发明授权

US09993545B2 Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom 有权
公开(公告)号：US09993545B2
公开(公告)日：2018-06-12
申请号：US14774356
申请日：2014-03-17
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , David B. Weiner , Jian Yan , Karuppiah Muthumani , Niranjan Y. Sardesai
发明人： David B. Weiner , Jian Yan , Karuppiah Muthumani , Niranjan Y. Sardesai
IPC分类号： C12N7/00 , A61K39/135 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/135 , A61K39/12 , A61K2039/53 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2770/32134
摘要： The present invention relates to synthetic, consensus foot-and-mouth disease virus (FMDV) immunogenic proteins and nucleic acid molecule encoding such proteins, to vaccines against FMDV, to methods for inducing immune responses against FMVD, to methods for distinguishing between individuals infected with FMDV versus those vaccinated against FMDV, and methods of prophylactically and/or therapeutically immunizing individuals against FMDV.

7. 发明申请

US20120230945A1 TARGETED PARTICLES AND METHODS OF USING THE SAME 有权
标题翻译：目标颗粒及其使用方法
公开(公告)号：US20120230945A1
公开(公告)日：2012-09-13
申请号：US13422864
申请日：2012-03-16
申请人： David B. Weiner , Karuppiah Muthumani , Donghui Zhang , Mathura P. Ramanathan
发明人： David B. Weiner , Karuppiah Muthumani , Donghui Zhang , Mathura P. Ramanathan
IPC分类号： A61K39/395 , A61P37/02 , C07K16/18 , C12N5/02 , A61K38/20
CPC分类号： C12N15/86 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55522 , A61K2039/55555 , A61K2039/6031 , C07K14/005 , C07K14/475 , C07K14/70596 , C07K2319/00 , C07K2319/33 , C12N2740/16043 , C12N2740/16045 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2810/855
摘要： Drug delivery compositions and methods of delivering compounds are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译：公开了递送组合物和递送化合物的方法。公开了免疫个体的疫苗和方法。公开了用于药物递送的组合物，包括基因治疗和使用这些组合物治疗个体的方法。

8. 发明授权

US08008265B2 Vaccines, immunotherapeutics and methods for using the same 有权
标题翻译：疫苗，免疫治疗剂及其使用方法
公开(公告)号：US08008265B2
公开(公告)日：2011-08-30
申请号：US10560653
申请日：2004-06-14
申请人： David B. Weiner , Karuppiah Muthumani , Michele Kutzler , Andrew Y. Choo , Michael A. Chattergoon
发明人： David B. Weiner , Karuppiah Muthumani , Michele Kutzler , Andrew Y. Choo , Michael A. Chattergoon
IPC分类号： A61K48/00 , A61K38/00
CPC分类号： A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/53 , A61K2039/55516 , A61K2039/575 , A61K2039/6031 , C07K14/005 , C12N2740/16022 , C12N2740/16122 , C12N2740/16134 , Y02A50/394
摘要： Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes an immunomodulator protein selected from the group consisting of: Fos, c-jun, Sp-1, Ap-1, Ap-2, p38, p65Rel, MyD88, IRAK, TRAF6, IkB, Inactive NIK, SAP K, SAP-1, JNK, interferon response genes, NFkB, Bax, TRAIL, TRAILrec, TRAILrecDRC5, TRAIL-R3, TRAIL-R4, RANK, RANK LIGAND, Ox40, Ox40 LIGAND, NKG2D, MICA, MICB, NKG2A, NKG2B, NKG2C, NKG2E, NKG2F, TAP1, TAP2 and functional fragments thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
摘要翻译：组合物，重组疫苗和活减毒病原体，其包含编码免疫原的分离的一个或多个分离的核酸分子，其与编码免疫调节蛋白的分离的核酸分子组合，所述免疫调节蛋白选自：Fos，c-jun，Sp-1， Ap-1，Ap-2，p38，p65Rel，MyD88，IRAK，TRAF6，IkB，非活性NIK，SAPK，SAP-1，JNK，干扰素应答基因，NFkB，Bax，TRAIL，TRAILrec，TRAILrecDRC5，TRAIL-R3，公开了TRAIL-R4，RANK，RANK LIGAND，Ox40，Ox40LIGAND，NKG2D，MICA，MICB，NKG2A，NKG2B，NKG2C，NKG2E，NKG2F，TAP1，TAP2及其功能片段。公开了使用这种组合物诱导个体对免疫原的免疫应答的方法。

9. 发明申请

US20190091322A1 DNA ANTIBODY CONSTRUCTS AND METHOD OF USING SAME 审中-公开
公开(公告)号：US20190091322A1
公开(公告)日：2019-03-28
申请号：US16087146
申请日：2017-03-21
申请人： David B. Weiner , Karuppiah Muthumani , Seleeke Flingai , Niranjan Sardesai , Sarah Elliott , Jian Yan , Ami Patel
发明人： David B. Weiner , Karuppiah Muthumani , Seleeke Flingai , Niranjan Sardesai , Sarah Elliott , Jian Yan , Ami Patel
IPC分类号： A61K39/12 , A61K39/42 , C07K16/10
摘要： Disclosed herein is a composition comprising the combination of a nucleic acid sequence encoding a desired polypeptide that elicits an immune response in a mammal and a nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof.

10. 发明授权

US07348138B2 Method of inducing cell death using West Nile virus capsid protein 失效
标题翻译：使用西尼罗病毒衣壳蛋白诱导细胞死亡的方法
公开(公告)号：US07348138B2
公开(公告)日：2008-03-25
申请号：US10966576
申请日：2004-10-14
申请人： David B. Weiner , Joo-Sung Yang , Karuppiah Muthumani
发明人： David B. Weiner , Joo-Sung Yang , Karuppiah Muthumani
IPC分类号： C12Q1/70 , A61K39/12
CPC分类号： A61K38/162 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K2319/02 , C12N2740/16222 , C12N2770/24122 , C12N2770/24322 , G01N33/56983 , G01N2469/20 , Y02A50/394
摘要： This invention provides methods of inducing cell death with Flavivirus or Pestivirus capsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from diseases characterized by hyperproliferating cells by administering pharmaceutical compositions comprising WNV or other virus including Flavivirus or Pestivirus capsid or other protein or a nucleic acid molecule encoding the same. Methods of identifying compounds which have anti-viral and/or anti-WNV and/or anti-Flavivirus and/or anti-Pestivirus capsid or other protein activity are disclosed. The invention also provides vaccine compositions comprising capsid or other proteins, or fragments thereof, or nucleic acids encoding same, from WNV or other virus including Flavivirus or Pestivirus and a pharmaceutically acceptable carrier. The invention also provides diagnostic methods and kits for identifying individuals exposed to WNV or other viruses including Flavivirus or Pestivirus.
摘要翻译：本发明提供了用黄病毒或瘟病毒衣壳蛋白（例如西尼罗河病毒（WNV）衣壳蛋白）及其功能片段诱导细胞死亡的方法。本发明还提供了通过施用包含WNV或其它病毒（包括黄病毒或瘟病毒衣壳或其他蛋白质）的药物组合物或其编码的核酸分子来治疗患有特征在于过度增殖细胞的疾病的患者的方法。公开了鉴定具有抗病毒和/或抗WNV和/或抗黄病毒和/或抗瘟病毒衣壳或其它蛋白质活性的化合物的方法。本发明还提供包含衣壳或其它蛋白质或其片段，或编码其的核酸的疫苗组合物，来自WNV或其它病毒，包括黄病毒或瘟病毒和药学上可接受的载体。本发明还提供用于鉴定暴露于WNV或其它病毒（包括黄病毒或瘟病毒）的个体的诊断方法和试剂盒。

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