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1. 发明申请

US20050053930A1 Therapeutic polypeptides, nucleic acids encoding same, and methods of use 审中-公开
标题翻译：治疗性多肽，编码其的核酸和使用方法
公开(公告)号：US20050053930A1
公开(公告)日：2005-03-10
申请号：US10454246
申请日：2003-06-03
申请人： David Anderson , Ferenc Boldog , Catherine Burgess , Stacie Casman , Shlomit Edinger , Andrew Eisen , Karen Ellerman , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Vladimir Gusev , Weizhen Ji , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Tatiana Ort , Muralidhara Padigaru , Sudhirdas Prayaga , Meera Patturajan , Carol Pena , John Peyman , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Glennda Smithson , Kimberly Spytek , David Stone , Raymond Taupier , Velizar Tchernev , Corine Vernet , Edward Voss , Bryan Zerhusen , Mei Zhong
发明人： David Anderson , Ferenc Boldog , Catherine Burgess , Stacie Casman , Shlomit Edinger , Andrew Eisen , Karen Ellerman , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Vladimir Gusev , Weizhen Ji , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Tatiana Ort , Muralidhara Padigaru , Sudhirdas Prayaga , Meera Patturajan , Carol Pena , John Peyman , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Glennda Smithson , Kimberly Spytek , David Stone , Raymond Taupier , Velizar Tchernev , Corine Vernet , Edward Voss , Bryan Zerhusen , Mei Zhong
IPC分类号： A61K38/17 , C07H21/04 , C07K14/47 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

2. 发明申请

US20060003323A1 Therapeutic polypeptides, nucleic acids encoding same, and methods of use 审中-公开
公开(公告)号：US20060003323A1
公开(公告)日：2006-01-05
申请号：US10453372
申请日：2003-06-03
申请人： John Alsobrook , Enrique Alvarez , David Anderson , Ferenc Boldog , Stacie Casman , Elina Catterton , Andrei Chapoval , Julie Crabtree-Bokor , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , Erik Gunther , Xiaojia (Sasha) Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Li Li , Xiaohong Liu , John MacDougall , Timothy Machlachlan , Uriel Malyankar , Amanda Mezick , Isabelle Millet , Vishnu Mishra , Muralidhara Padigaru , Meera Patturajan , Carol Pena , John Peyman , Debasish Raha , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Corine Vernet , Edward Voss , Mei Zhong , Hiahong Zhong
发明人： John Alsobrook , Enrique Alvarez , David Anderson , Ferenc Boldog , Stacie Casman , Elina Catterton , Andrei Chapoval , Julie Crabtree-Bokor , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , Erik Gunther , Xiaojia (Sasha) Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Li Li , Xiaohong Liu , John MacDougall , Timothy Machlachlan , Uriel Malyankar , Amanda Mezick , Isabelle Millet , Vishnu Mishra , Muralidhara Padigaru , Meera Patturajan , Carol Pena , John Peyman , Debasish Raha , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Corine Vernet , Edward Voss , Mei Zhong , Hiahong Zhong
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

3. 发明申请

US20060084054A1 Novel proteins and nucleic acids encoding same 审中-公开
标题翻译：新型蛋白质和编码相同的核酸
公开(公告)号：US20060084054A1
公开(公告)日：2006-04-20
申请号：US10455772
申请日：2003-06-04
申请人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
发明人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
IPC分类号： C12Q1/68 , C07H21/04 , C12N9/00
CPC分类号： C07K16/40 , C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态。更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

4. 发明申请

US20060009634A1 Proteins and nucleic acids encoding same 审中-公开
公开(公告)号：US20060009634A1
公开(公告)日：2006-01-12
申请号：US11019711
申请日：2004-12-21
申请人： Ramesh Kekuda , John Alsobrook , Velizar Tchernev , Xiaohong Liu , Kimberly Spytek , Meera Patturajan , William Grosse , Denise Lepley , Catherine Burgess , Corine Vernet , Li Li , Linda Gorman , Shlomit Edinger , Paul Sciore , Karen Ellerman , Uriel Malyankar , Mark Rothenberg , David Stone , Ferenc Boldog , Xiaojia Guo , Suresh Shenoy , David Anderson , Muralidhara Padigaru , Raymond Taupier , Charles Miller , Andrew Eisen
发明人： Ramesh Kekuda , John Alsobrook , Velizar Tchernev , Xiaohong Liu , Kimberly Spytek , Meera Patturajan , William Grosse , Denise Lepley , Catherine Burgess , Corine Vernet , Li Li , Linda Gorman , Shlomit Edinger , Paul Sciore , Karen Ellerman , Uriel Malyankar , Mark Rothenberg , David Stone , Ferenc Boldog , Xiaojia Guo , Suresh Shenoy , David Anderson , Muralidhara Padigaru , Raymond Taupier , Charles Miller , Andrew Eisen
IPC分类号： C07H21/04
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

5. 发明申请

US20060063200A1 Therapeutic polypeptides, nucleic acids encoding same, and methods of use 审中-公开
公开(公告)号：US20060063200A1
公开(公告)日：2006-03-23
申请号：US11051724
申请日：2005-02-02
申请人： David Anderson , Jason Baumgartner , Ferenc Boldog , Stacie Casman , Shlomit Edinger , Esha Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol Pena , Luca Rastelli , Richard Shimkets , David Stone , Kimberly Spytek , Corine Vernet , Edward Voss , Bryan Zerhusen
发明人： David Anderson , Jason Baumgartner , Ferenc Boldog , Stacie Casman , Shlomit Edinger , Esha Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol Pena , Luca Rastelli , Richard Shimkets , David Stone , Kimberly Spytek , Corine Vernet , Edward Voss , Bryan Zerhusen
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/18
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , A61K48/00
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

6. 发明申请

US20050260713A1 Polypeptides and nucleic acids encoding same 审中-公开
标题翻译：编码相同的多肽和核酸
公开(公告)号：US20050260713A1
公开(公告)日：2005-11-24
申请号：US11113424
申请日：2005-04-21
申请人： Esha Gangolli , Meera Patturajan , Corine Vernet , Uriel Malyankar , Ramesh Kekuda , David Stone , David Anderson , Richard Shimkets , Catherine Burgess , Bryan Zerhusen , Xiaohong Liu , Kimberly Spytek , Stacie Casman , Ference Boldog , Glennda Smithson , Li Li , Weizhen Ji , John MacDougall
发明人： Esha Gangolli , Meera Patturajan , Corine Vernet , Uriel Malyankar , Ramesh Kekuda , David Stone , David Anderson , Richard Shimkets , Catherine Burgess , Bryan Zerhusen , Xiaohong Liu , Kimberly Spytek , Stacie Casman , Ference Boldog , Glennda Smithson , Li Li , Weizhen Ji , John MacDougall
IPC分类号： A61K38/00 , C07K14/47 , C12N5/02 , C07H21/04 , C07K14/485 , C07K16/22 , C12P21/06
CPC分类号： C07K14/47 , A61K38/00 , G01N2500/04
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

7. 发明申请

US20060234257A1 Therapeutic polypeptides, nucleic acids encoding same, and methods of use 审中-公开
公开(公告)号：US20060234257A1
公开(公告)日：2006-10-19
申请号：US11351523
申请日：2006-02-08
申请人： Uriel Malyankar , Xiaojia Guo , Ferenc Boldog , Nikolai Khramstsov
发明人： Uriel Malyankar , Xiaojia Guo , Ferenc Boldog , Nikolai Khramstsov
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/47
CPC分类号： C07K14/47 , G01N33/6893 , G01N2500/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

8. 发明申请

US20060172941A1 Anti-angiogenic peptides and methods of use thereof 审中-公开
标题翻译：抗血管生成肽及其使用方法
公开(公告)号：US20060172941A1
公开(公告)日：2006-08-03
申请号：US11327849
申请日：2006-01-09
申请人： Luca Rastelli , Judith Landin , Uriel Malyankar , Richard Kitson , Melissa Corso , Kenneth Brunson
发明人： Luca Rastelli , Judith Landin , Uriel Malyankar , Richard Kitson , Melissa Corso , Kenneth Brunson
IPC分类号： A61K39/00 , C07K14/475
CPC分类号： C07K14/475 , A61K38/00 , A61K47/62 , C07K7/06 , C07K7/08 , C07K14/001
摘要： Anti-angiogenic peptides that inhibit activation or proliferation of endothelial cells are disclosed. Such peptides may be used to inhibit VEGF binding to the VEGFR2 receptor (also known as the kinase domain receptor or KDR) and bFGF binding to its receptor. Such peptides may also be used to inhibit, VEGF, bFGF, or integrin activation of endothelial cells in angiogenesis-associated diseases such as cancer, leukemia, multiple myeloma, inflammatory diseases, eye diseases and skin disorders.
摘要翻译：公开了抑制内皮细胞活化或增殖的抗血管生成肽。这样的肽可以用于抑制VEGF结合VEGFR2受体（也称为激酶结构域受体或KDR）和bFGF与其受体的结合。这些肽也可用于抑制血管生成相关疾病如癌症，白血病，多发性骨髓瘤，炎性疾病，眼睛疾病和皮肤疾病中的VEGF，bFGF或整合素激活内皮细胞。

9. 发明申请

US20080207502A1 Anti-Angiogenic Peptides and Methods of Use Thereof 审中-公开
标题翻译：抗血管生成肽及其使用方法
公开(公告)号：US20080207502A1
公开(公告)日：2008-08-28
申请号：US11665176
申请日：2005-10-14
申请人： Luca Rastelli , Judith Landin , Uriel Malyankar , Richard Kitson , Melissa Corso , Kenneth Brunson
发明人： Luca Rastelli , Judith Landin , Uriel Malyankar , Richard Kitson , Melissa Corso , Kenneth Brunson
IPC分类号： A61K38/17 , C07K14/435 , C07K7/08 , A61K38/03 , A61P35/04 , A61P27/02 , C12N5/02 , A61K38/10 , C07K4/12
CPC分类号： C07K14/475 , A61K38/00 , A61K47/62 , C07K7/06 , C07K7/08 , C07K14/001
摘要： Anti-angiogenic peptides that inhibit activation or proliferation of endothelial cells are disclosed. Such peptides maybe used to inhibit VEGF binding to the VEGFR2 receptor (also known as the kinase domain receptor or KDR) and bFGF binding to its receptor. Such peptides may also be used to inhibit, VEGF, bFGF, or integrin activation of endothelial cells in angiogenesis-associated diseases such as cancer, leukemia, multiple myeloma, inflammatory diseases, eye diseases and skin disorders.
摘要翻译：公开了抑制内皮细胞活化或增殖的抗血管生成肽。这样的肽可以用于抑制VEGF结合VEGFR2受体（也称为激酶结构域受体或KDR）和bFGF与其受体的结合。这些肽也可用于抑制血管生成相关疾病如癌症，白血病，多发性骨髓瘤，炎性疾病，眼睛疾病和皮肤疾病中的VEGF，bFGF或整合素激活内皮细胞。

10. 发明申请

US20070154517A1 METHODS AND DEVICES FOR PROMOTING ENDOTHELIAL MORPHOGENESIS 失效
标题翻译：促进内皮细胞生成的方法和装置
公开(公告)号：US20070154517A1
公开(公告)日：2007-07-05
申请号：US11675810
申请日：2007-02-16
申请人： Uriel Malyankar , Marta Scatena , Cecilia Giachelli
发明人： Uriel Malyankar , Marta Scatena , Cecilia Giachelli
IPC分类号： A61K48/00 , A61K38/18 , A61F2/02
CPC分类号： C12N5/069 , A61K38/00 , A61L27/227 , C07K14/70578 , C12N2500/90 , C12N2501/185
摘要： In one aspect the present invention provides methods for promoting endothelial morphogenesis. The methods of this aspect of the invention include the step of providing to one or more endothelial cells an amount of an osteoprotegerin sufficient to promote endothelial morphogenesis. The methods of this aspect of the invention can be practiced in vivo or in vitro. In another aspect, the present invention provides implantable medical devices that each include: (a) a device body; and (b) a layer attached to a surface of the device body, the layer comprising a molecule selected from the group consisting of osteoprotegerin and a nucleic acid molecule encoding osteoprotegerin, wherein the device is adapted to be completely or partially implanted into an animal body. The implanted medical device thus promotes the growth of blood vessels in the surrounding tissue, thereby reducing or preventing the formation of a collagenous capsule around the implanted medical device.
摘要翻译：一方面，本发明提供促进内皮形态发生的方法。本发明的这个方面的方法包括向一个或多个内皮细胞提供足以促进内皮形态发生的量的骨保护素的步骤。本发明的该方面的方法可以在体内或体外实施。在另一方面，本发明提供了可植入医疗装置，其各自包括：（a）装置主体; 和（b）附着到装置主体的表面的层，该层包含选自由骨保护素和编码骨保护素的核酸分子组成的组的分子，其中该装置适于完全或部分地植入动物体内。因此，植入的医疗装置促进周围组织中的血管的生长，从而减少或阻止在植入的医疗装置周围形成胶原胶囊。

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