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1. 发明申请

US20050053930A1 Therapeutic polypeptides, nucleic acids encoding same, and methods of use 审中-公开
标题翻译：治疗性多肽，编码其的核酸和使用方法
公开(公告)号：US20050053930A1
公开(公告)日：2005-03-10
申请号：US10454246
申请日：2003-06-03
申请人： David Anderson , Ferenc Boldog , Catherine Burgess , Stacie Casman , Shlomit Edinger , Andrew Eisen , Karen Ellerman , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Vladimir Gusev , Weizhen Ji , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Tatiana Ort , Muralidhara Padigaru , Sudhirdas Prayaga , Meera Patturajan , Carol Pena , John Peyman , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Glennda Smithson , Kimberly Spytek , David Stone , Raymond Taupier , Velizar Tchernev , Corine Vernet , Edward Voss , Bryan Zerhusen , Mei Zhong
发明人： David Anderson , Ferenc Boldog , Catherine Burgess , Stacie Casman , Shlomit Edinger , Andrew Eisen , Karen Ellerman , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Vladimir Gusev , Weizhen Ji , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Tatiana Ort , Muralidhara Padigaru , Sudhirdas Prayaga , Meera Patturajan , Carol Pena , John Peyman , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Glennda Smithson , Kimberly Spytek , David Stone , Raymond Taupier , Velizar Tchernev , Corine Vernet , Edward Voss , Bryan Zerhusen , Mei Zhong
IPC分类号： A61K38/17 , C07H21/04 , C07K14/47 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

2. 发明申请

US20050233328A1 Methods of identifying compounds that modulate protein activity 审中-公开
标题翻译：识别调节蛋白质活性的化合物的方法
公开(公告)号：US20050233328A1
公开(公告)日：2005-10-20
申请号：US10635407
申请日：2003-08-06
申请人： Constance Berghs , Karen Ellerman , Xiaojia Guo , Li Li , Tatiana Ort , Daniel Rieger , Corine Vernet , Mei Zhong
发明人： Constance Berghs , Karen Ellerman , Xiaojia Guo , Li Li , Tatiana Ort , Daniel Rieger , Corine Vernet , Mei Zhong
IPC分类号： A61K38/00 , A61K48/00 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P17/06 , A61P21/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07K14/47 , C12N1/21 , C12N5/02 , C12N5/08 , C12N9/00 , C12N15/12 , C12N15/16 , C12N15/18 , C12N15/19 , C12N15/53 , C12N15/54 , C12N15/57 , C12Q1/68 , C07H21/04 , C12N9/64 , C12N15/09 , C12P21/06 , G01N33/53
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N9/00
摘要： Methods of identifying compounds that modulate target polypeptide activity, where a test compound is combined with a target polypeptide and a substrate of the target polypeptide and where a determination is made as to whether the test compound modulates activity of the target polypeptide. The test compounds could be small molecule drugs used for treatment of obesity, diabetes, insulin resistance, and for enhancement of insulin secretion. Target polypeptides and their corresponding nucleic acids as well as their variants are also disclosed.
摘要翻译：鉴定调节靶多肽活性的化合物的方法，其中测试化合物与靶多肽和靶多肽的底物组合，并且确定测试化合物是否调节靶多肽的活性。测试化合物可以是用于治疗肥胖症，糖尿病，胰岛素抵抗和增强胰岛素分泌的小分子药物。还公开了靶多肽及其相应的核酸及其变体。

3. 发明申请

US20050048507A1 Therapeutic polypeptides, nucleic acids encoding same, and methods of use 审中-公开
标题翻译：治疗性多肽，编码其的核酸和使用方法
公开(公告)号：US20050048507A1
公开(公告)日：2005-03-03
申请号：US10659004
申请日：2003-09-09
申请人： Mei Zhong , Xiaojia Guo , David Anderson , Tatiana Ort , Muralidhara Padigaru , Daniel Rieger
发明人： Mei Zhong , Xiaojia Guo , David Anderson , Tatiana Ort , Muralidhara Padigaru , Daniel Rieger
IPC分类号： A61K38/00 , A61K39/00 , A61K47/48 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N9/36 , C12Q1/68 , A61K38/17 , G01N33/53
CPC分类号： C12N9/2462 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。载体，宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法也包括在内。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

4. 发明申请

US20090117122A1 Resistin Antagonists and Their Use 审中-公开
标题翻译：抵抗拮抗剂及其用途
公开(公告)号：US20090117122A1
公开(公告)日：2009-05-07
申请号：US12233683
申请日：2008-09-19
申请人： Jill Carton , Francis Farrell , Lynne Murray , Tatiana Ort , Alexey Teplyakov
发明人： Jill Carton , Francis Farrell , Lynne Murray , Tatiana Ort , Alexey Teplyakov
IPC分类号： A61K39/395 , C07K16/18 , C07K7/08 , C07H21/00
CPC分类号： C07H21/04 , A61K2039/505 , C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Antigens useful for raising antibodies against human resistin are also disclosed.
摘要翻译：公开了抗性拮抗剂，包括与限定的表位反应的抗体。还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性（包括间质性肺病，肥大性瘢痕形成，瘢痕疙瘩瘢痕形成和硬皮病）的疾病症状的方法。还公开了可用于提高抗人抵抗素抗体的抗原。

5. 发明申请

US20100056948A1 Stimulation of Satiety Hormone Release 审中-公开
标题翻译：刺激饱和激素释放
公开(公告)号：US20100056948A1
公开(公告)日：2010-03-04
申请号：US12546721
申请日：2009-08-25
申请人： Pamela J. Hornby , Tatiana Ort , Radhika Kajekar , Paul R. Wade
发明人： Pamela J. Hornby , Tatiana Ort , Radhika Kajekar , Paul R. Wade
IPC分类号： A61N1/36 , G01N33/53 , A61B5/05
CPC分类号： A61N1/36007
摘要： The present invention provides, among other things, a site specific way to enhance a natural hormonal response to nutrients entering the small intestine after gastric emptying, thereby providing therapeutic value for obesity or diabetic patients. In one aspect, the present invention provides methods of stimulating the release of satiety hormone in a subject comprising applying a first electrical stimulus to a tissue in the lumen of the gastrointestinal system of the subject contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus. In another aspect, the present invention provides methods for predicting patient response to a weight loss surgery comprising applying a first electrical stimulus to a tissue of the gastrointestinal system of said patient contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus, assessing the effect of the electrical stimulus in said patient, and, correlating said effect to said patient's response to a weight loss surgery.
摘要翻译：本发明尤其提供了一种在胃排空后增强对进入小肠的营养物的天然激素反应的位点特异性方法，从而为肥胖症或糖尿病患者提供治疗价值。在一个方面，本发明提供刺激受试者中饱腹感激素释放的方法，包括将第一次电刺激施用于患者的胃肠系统的内腔中的组织，同时使组织的L细胞与营养刺激。另一方面，本发明提供了用于预测患者对减肥手术的反应的方法，该方法包括：将第一电刺激与所述患者的胃肠系统的组织同时与组织的L细胞与营养刺激物接触，评估所述患者的电刺激的影响，以及将所述效果与所述患者对减肥手术的反应相关联。

6. 发明申请

US20090162375A1 RESISTIN ANTAGONISTS AND THEIR USE 审中-公开
标题翻译：电阻拮抗剂及其使用
公开(公告)号：US20090162375A1
公开(公告)日：2009-06-25
申请号：US11924108
申请日：2007-10-25
申请人： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
发明人： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
IPC分类号： A61K39/395 , C07K16/26 , C07K7/08 , C07H21/00 , C12Q1/02
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.
摘要翻译：公开了抗性拮抗剂，包括与限定的表位反应的抗体。还公开了可用于提高抗人抵抗素抗体的抗原。还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性（包括间质性肺病，肥大性瘢痕形成，瘢痕疙瘩瘢痕形成和硬皮病）的疾病症状的方法。还公开了利用抗性蛋白作为生物标志物来诊断骨关节炎的风险和/或进展的方法。进一步公开的是利用拮抗剂治疗或减轻骨关节炎症状的方法。

7. 发明授权

US08394378B2 Antibodies binding human collagen II 有权
标题翻译：抗体结合人类胶原II
公开(公告)号：US08394378B2
公开(公告)日：2013-03-12
申请号：US13245299
申请日：2011-09-26
申请人： John Kehoe , Jennifer Lee Gardiner , Tatiana Ort , Kristen Picha , Mary Ryan , John Wheeler
发明人： John Kehoe , Jennifer Lee Gardiner , Tatiana Ort , Kristen Picha , Mary Ryan , John Wheeler
IPC分类号： A61K39/00 , C07K16/00 , C07K16/46
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies against human collagen II, polypeptides and polynucleotides encoding human collagen II antibodies or fragments thereof, and methods of making and using the foregoing.
摘要翻译：本发明涉及针对人胶原II的抗体，编码人胶原II抗体或其片段的多肽和多核苷酸，以及制备和使用上述物质的方法。

8. 发明申请

US20120108795A1 Antibodies Binding Human Collagen II 有权
标题翻译：抗体结合人胶原蛋白II
公开(公告)号：US20120108795A1
公开(公告)日：2012-05-03
申请号：US13245299
申请日：2011-09-26
申请人： John Kehoe , Jennifer Lee Gardiner , Tatiana Ort , Kristen Picha , Mary Ryan , John Wheeler
发明人： John Kehoe , Jennifer Lee Gardiner , Tatiana Ort , Kristen Picha , Mary Ryan , John Wheeler
IPC分类号： C07K16/18 , C12N15/63 , C12N1/00 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/02
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies against human collagen II, polypeptides and polynucleotides encoding human collagen II antibodies or fragments thereof, and methods of making and using the foregoing.
摘要翻译：本发明涉及针对人胶原II的抗体，编码人胶原II抗体或其片段的多肽和多核苷酸，以及制备和使用上述物质的方法。

9. 发明申请

US20130035559A1 STIMULATION OF SATIETY HORMONE RELEASE 审中-公开
标题翻译：刺激激素释放激素
公开(公告)号：US20130035559A1
公开(公告)日：2013-02-07
申请号：US13464470
申请日：2012-05-04
申请人： Pamela J. Hornby , Tatiana Ort , Radhika Kajekar , Paul R. Wade
发明人： Pamela J. Hornby , Tatiana Ort , Radhika Kajekar , Paul R. Wade
IPC分类号： A61M37/00 , A61B5/145 , A61B5/05
CPC分类号： A61N1/36007
摘要： The present invention provides a site specific way to enhance a natural hormonal response to nutrients entering the small intestine after gastric emptying, thereby providing therapeutic value for obesity or diabetic patients. In one aspect, the present invention provides methods of stimulating the release of satiety hormone in a subject comprising applying a first electrical stimulus to a tissue in the lumen of the gastrointestinal system of the subject contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus. The present invention also provides methods for predicting patient response to a weight loss surgery comprising applying a first electrical stimulus to a tissue of the gastrointestinal system of said patient contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus, assessing the effect of the electrical stimulus in said patient, and, correlating said effect to said patient's response to a weight loss surgery.
摘要翻译：本发明提供了一种在胃排空后增强对进入小肠的营养物的天然激素反应的位点特异性方法，从而为肥胖症或糖尿病患者提供治疗价值。一方面，本发明提供刺激受试者中饱腹感激素释放的方法，其包括将第一次电刺激施用于受试者的胃肠系统的内腔中的组织，同时使组织的L细胞与营养刺激。本发明还提供了用于预测患者对减肥手术的反应的方法，其包括将所述患者的胃肠系统的组织同时与组织的L细胞接触营养刺激施加第一电刺激，评估效果的所述患者的电刺激，并且将所述效果与所述患者对减肥手术的反应相关联。

10. 发明申请

US20110071277A1 RESISTIN ANTAGONISTS AND THEIR USE 审中-公开
标题翻译：电阻拮抗剂及其使用
公开(公告)号：US20110071277A1
公开(公告)日：2011-03-24
申请号：US12722950
申请日：2010-03-12
申请人： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
发明人： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
IPC分类号： C07K16/00
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.
摘要翻译：公开了抵抗素拮抗剂，包括与限定的表位反应的抗体。还公开了可用于提高抗人抵抗素抗体的抗原。还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性（包括间质性肺病，肥大性瘢痕形成，瘢痕疙瘩瘢痕形成和硬皮病）的疾病症状的方法。还公开了利用抗性蛋白作为生物标志物来诊断骨关节炎的风险和/或进展的方法。进一步公开的是利用拮抗剂治疗或减轻骨关节炎症状的方法。

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