专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070154517A1 METHODS AND DEVICES FOR PROMOTING ENDOTHELIAL MORPHOGENESIS 失效
标题翻译：促进内皮细胞生成的方法和装置
公开(公告)号：US20070154517A1
公开(公告)日：2007-07-05
申请号：US11675810
申请日：2007-02-16
申请人： Uriel Malyankar , Marta Scatena , Cecilia Giachelli
发明人： Uriel Malyankar , Marta Scatena , Cecilia Giachelli
IPC分类号： A61K48/00 , A61K38/18 , A61F2/02
CPC分类号： C12N5/069 , A61K38/00 , A61L27/227 , C07K14/70578 , C12N2500/90 , C12N2501/185
摘要： In one aspect the present invention provides methods for promoting endothelial morphogenesis. The methods of this aspect of the invention include the step of providing to one or more endothelial cells an amount of an osteoprotegerin sufficient to promote endothelial morphogenesis. The methods of this aspect of the invention can be practiced in vivo or in vitro. In another aspect, the present invention provides implantable medical devices that each include: (a) a device body; and (b) a layer attached to a surface of the device body, the layer comprising a molecule selected from the group consisting of osteoprotegerin and a nucleic acid molecule encoding osteoprotegerin, wherein the device is adapted to be completely or partially implanted into an animal body. The implanted medical device thus promotes the growth of blood vessels in the surrounding tissue, thereby reducing or preventing the formation of a collagenous capsule around the implanted medical device.
摘要翻译：一方面，本发明提供促进内皮形态发生的方法。本发明的这个方面的方法包括向一个或多个内皮细胞提供足以促进内皮形态发生的量的骨保护素的步骤。本发明的该方面的方法可以在体内或体外实施。在另一方面，本发明提供了可植入医疗装置，其各自包括：（a）装置主体; 和（b）附着到装置主体的表面的层，该层包含选自由骨保护素和编码骨保护素的核酸分子组成的组的分子，其中该装置适于完全或部分地植入动物体内。因此，植入的医疗装置促进周围组织中的血管的生长，从而减少或阻止在植入的医疗装置周围形成胶原胶囊。

2. 发明授权

US07521233B2 Methods and devices for promoting endothelial morphogenesis 失效
标题翻译：促进内皮形态发生的方法和装置
公开(公告)号：US07521233B2
公开(公告)日：2009-04-21
申请号：US11675810
申请日：2007-02-16
申请人： Uriel M. Malyankar , Marta Scatena , Cecilia M. Giachelli
发明人： Uriel M. Malyankar , Marta Scatena , Cecilia M. Giachelli
IPC分类号： C12N5/00 , C07K14/51
CPC分类号： C12N5/069 , A61K38/00 , A61L27/227 , C07K14/70578 , C12N2500/90 , C12N2501/185
摘要： In one aspect the present invention provides methods for promoting endothelial morphogenesis. The methods of this aspect of the invention include the step of providing to one or more endothelial cells an amount of an osteoprotegerin sufficient to promote endothelial morphogenesis. The methods of this aspect of the invention can be practiced in vivo or in vitro. In another aspect, the present invention provides implantable medical devices that each include: (a) a device body; and (b) a layer attached to a surface of the device body, the layer comprising a molecule selected from the group consisting of osteoprotegerin and a nucleic acid molecule encoding osteoprotegerin, wherein the device is adapted to be completely or partially implanted into an animal body. The implanted medical device thus promotes the growth of blood vessels in the surrounding tissue, thereby reducing or preventing the formation of a collagenous capsule around the implanted medical device.
摘要翻译：一方面，本发明提供促进内皮形态发生的方法。本发明的这个方面的方法包括向一个或多个内皮细胞提供足以促进内皮形态发生的量的骨保护素的步骤。本发明的该方面的方法可以在体内或体外实施。在另一方面，本发明提供了可植入医疗装置，其各自包括：（a）装置主体; 和（b）附着到装置主体的表面的层，该层包含选自由骨保护素和编码骨保护素的核酸分子组成的组的分子，其中该装置适于完全或部分地植入动物体内。因此，植入的医疗装置促进周围组织中的血管的生长，从而减少或阻止在植入的医疗装置周围形成胶原胶囊。

3. 发明申请

US20090181065A1 METHODS AND DEVICES FOR PROMOTING ENDOTHELIAL MORPHOGENESIS 审中-公开
标题翻译：促进内皮细胞生成的方法和装置
公开(公告)号：US20090181065A1
公开(公告)日：2009-07-16
申请号：US12404220
申请日：2009-03-13
申请人： Uriel M. Malyankar , Marta Scatena , Cecilia M. Giachelli
发明人： Uriel M. Malyankar , Marta Scatena , Cecilia M. Giachelli
IPC分类号： A61F2/04 , A61K31/7088 , A61K38/17 , A61K9/10 , A61K35/12
CPC分类号： C12N5/069 , A61K38/00 , A61L27/227 , C07K14/70578 , C12N2500/90 , C12N2501/185
摘要： In one aspect, the present invention provides methods for promoting endothelial morphogenesis. The methods of this aspect of the invention include the step of providing to one or more endothelial cells an amount of an osteoprotegerin sufficient to promote endothelial morphogenesis. The methods of this aspect of the invention can be practiced in vivo or in vitro. In another aspect, the present invention provides implantable medical devices that each include: (a) a device body; and (b) a layer attached to a surface of the device body, the layer comprising a molecule selected from the group consisting of osteoprotegerin and a nucleic acid molecule encoding osteoprotegerin, wherein the device is adapted to be completely or partially implanted into an animal body. The implanted medical device thus promotes the growth of blood vessels in the surrounding tissue, thereby reducing or preventing the formation of a collagenous capsule around the implanted medical device.
摘要翻译：一方面，本发明提供促进内皮形态发生的方法。本发明的这个方面的方法包括向一个或多个内皮细胞提供足以促进内皮形态发生的量的骨保护素的步骤。本发明的该方面的方法可以在体内或体外实施。在另一方面，本发明提供了可植入医疗装置，其各自包括：（a）装置主体; 和（b）附着到装置主体的表面的层，该层包含选自由骨保护素和编码骨保护素的核酸分子组成的组的分子，其中该装置适于完全或部分地植入动物体内。因此，植入的医疗装置促进周围组织中的血管的生长，从而减少或阻止在植入的医疗装置周围形成胶原胶囊。

4. 发明授权

US07198798B2 Methods and devices for promoting endothelial morphogenesis 失效
标题翻译：促进内皮形态发生的方法和装置
公开(公告)号：US07198798B2
公开(公告)日：2007-04-03
申请号：US10142658
申请日：2002-05-09
申请人： Uriel M. Malyankar , Marta Scatena , Cecilia M. Giachelli
发明人： Uriel M. Malyankar , Marta Scatena , Cecilia M. Giachelli
IPC分类号： A61F2/00 , A61K38/00 , C07K14/51
CPC分类号： C12N5/069 , A61K38/00 , A61L27/227 , C07K14/70578 , C12N2500/90 , C12N2501/185
摘要： In one aspect the present invention provides methods for promoting endothelial morphogenesis. The methods of this aspect of the invention include the step of providing to one or more endothelial cells an amount of an osteoprotegerin sufficient to promote endothelial morphogenesis. The methods of this aspect of the invention can be practiced in vivo or in vitro. In another aspect, the present invention provides implantable medical devices that each include: (a) a device body; and (b) a layer attached to a surface of the device body, the layer comprising a molecule selected from the group consisting of osteoprotegerin and a nucleic acid molecule encoding osteoprotegerin, wherein the device is adapted to be completely or partially implanted into an animal body. The implanted medical device thus promotes the growth of blood vessels in the surrounding tissue, thereby reducing or preventing the formation of a collagenous capsule around the implanted medical device.
摘要翻译：一方面，本发明提供促进内皮形态发生的方法。本发明的这个方面的方法包括向一个或多个内皮细胞提供足以促进内皮形态发生的量的骨保护素的步骤。本发明的该方面的方法可以在体内或体外实施。在另一方面，本发明提供了可植入医疗装置，其各自包括：（a）装置主体; 和（b）附着到装置主体的表面的层，该层包含选自由骨保护素和编码骨保护素的核酸分子组成的组的分子，其中该装置适于完全或部分地植入动物体内。因此，植入的医疗装置促进周围组织中的血管的生长，从而减少或阻止在植入的医疗装置周围形成胶原胶囊。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式