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1. 发明授权

US07141367B2 Variant TLR4 nucleic acid and uses thereof 失效
公开(公告)号：US07141367B2
公开(公告)日：2006-11-28
申请号：US10010066
申请日：2001-12-07
申请人： David A. Schwartz , Brian C. Schutte , Eva Lorenz
发明人： David A. Schwartz , Brian C. Schutte , Eva Lorenz
IPC分类号： C12Q1/68 , C12P19/358 , C07H21/04
CPC分类号： C07K14/705 , A01K2217/05
摘要： The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.

2. 发明申请

US20090258361A1 VARIANT TLR4 NUCLEIC ACID AND USES THEREOF 有权
标题翻译：变种TLR4核酸及其用途
公开(公告)号：US20090258361A1
公开(公告)日：2009-10-15
申请号：US12365739
申请日：2009-02-04
申请人： David A. Schwartz , Brian C. Schutte
发明人： David A. Schwartz , Brian C. Schutte
IPC分类号： C12Q1/68 , C12N5/08
CPC分类号： C07K14/705 , A01K2217/05
摘要： The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.
摘要翻译：本发明提供了鉴定人TLR4基因座上的多态性的方法，以及识别具有增加其发病率和死亡率的适应症风险的个体的方法。

3. 发明授权

US06740487B1 Variant TLR4 nucleic acid and uses thereof 失效
标题翻译：变体TLR4核酸及其用途
公开(公告)号：US06740487B1
公开(公告)日：2004-05-25
申请号：US09329515
申请日：1999-06-10
申请人： David A. Schwartz , Brian C. Schutte
发明人： David A. Schwartz , Brian C. Schutte
IPC分类号： C12Q168
CPC分类号： C07K14/705 , A01K2217/05
摘要： The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.
摘要翻译：本发明提供了鉴定人TLR4基因座上的多态性的方法，以及识别具有增加发病率和死亡率的适应症风险的个体的方法。

4. 发明授权

US07785794B2 Variant TLR4 nucleic acid and uses thereof 有权
标题翻译：变体TLR4核酸及其用途
公开(公告)号：US07785794B2
公开(公告)日：2010-08-31
申请号：US12365739
申请日：2009-02-04
申请人： David A. Schwartz , Brian C. Schutte
发明人： David A. Schwartz , Brian C. Schutte
IPC分类号： C12Q1/68 , C12P19/34 , C07K14/435 , C07K14/705
CPC分类号： C07K14/705 , A01K2217/05
摘要： The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.
摘要翻译：本发明提供了鉴定人TLR4基因座上的多态性的方法，以及识别具有增加其发病率和死亡率的适应症风险的个体的方法。

5. 发明授权

US07498151B2 Variant TLR4 nucleic acid and uses thereof 失效
公开(公告)号：US07498151B2
公开(公告)日：2009-03-03
申请号：US11517172
申请日：2006-09-07
申请人： David A. Schwartz , Brian C. Schutte
发明人： David A. Schwartz , Brian C. Schutte
IPC分类号： C12N15/12 , C12N15/64 , C12N5/10 , C12P21/02 , C07K14/47
CPC分类号： C07K14/705 , A01K2217/05
摘要： The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.

6. 发明授权

US08673565B2 Methods and compositions for risk prediction, diagnosis, prognosis, and treatment of pulmonary disorders 有权
标题翻译：风险预测，诊断，预后和治疗肺功能障碍的方法和组成
公开(公告)号：US08673565B2
公开(公告)日：2014-03-18
申请号：US13014589
申请日：2011-01-26
申请人： David A. Schwartz , Max Seibold
发明人： David A. Schwartz , Max Seibold
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N2333/4725 , G01N2800/12
摘要： The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.
摘要翻译：本发明提供用于肺部疾病，特别是纤维化性肺病的诊断和治疗靶标。发明人已经发现遗传变异MUC5B基因与基因表达增加相关，发展肺部疾病的风险增加，以及发展肺部疾病的患者的预后和存活率改善。

7. 发明授权

US08592419B2 Ceramides and apoptosis-signaling ligand 有权
标题翻译：神经酰胺和凋亡信号传导配体
公开(公告)号：US08592419B2
公开(公告)日：2013-11-26
申请号：US11666519
申请日：2005-10-31
申请人： Alicja Bielawska , Yusuf A. Hannun , James Norris , Zdzislaw M. Szulc , Jian-yun Dong , Jacek Bielawski , David A. Schwartz , David H. Holman , Ahmed M. El-Zawahry , John McKillop
发明人： Alicja Bielawska , Yusuf A. Hannun , James Norris , Zdzislaw M. Szulc , Jian-yun Dong , Jacek Bielawski , David A. Schwartz , David H. Holman , Ahmed M. El-Zawahry , John McKillop
IPC分类号： A61K31/40 , A61K31/44 , A61K31/415 , A61K31/445 , A61K31/497 , A61K31/535 , C07D211/00 , C07D213/06 , C07D207/00 , C07D233/00 , C07D295/00
CPC分类号： C07D213/56 , C07C215/18 , C07C215/28 , C07C275/24
摘要： The invention provides the compounds of formula (): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，A，X，Y，a，b和n如本文所定义。还公开了制备式（I）化合物及其用于治疗或预防与细胞过度增生和功能失调的鞘脂信号转导相关的疾病的方法。本发明还包括与凋亡信号传导配体如Fas配体组合的化合物的用途。优选地，Fas配体以基因治疗剂的形式施用。

8. 发明申请

US20120258881A1 Methods and/or Use of Oligonucleotide Conjugates for Assays and Microscopy/Imaging Detections 审中-公开
标题翻译：用于测定和显微镜/成像检测的寡核苷酸缀合物的方法和/或用途
公开(公告)号：US20120258881A1
公开(公告)日：2012-10-11
申请号：US13302890
申请日：2011-11-22
申请人： David A. Schwartz , Jimmy Williams , Xinfang Zhao , Chunfang Zhao , William B. Busa , Stephen J. Kron , Amy Catherine Flor
发明人： David A. Schwartz , Jimmy Williams , Xinfang Zhao , Chunfang Zhao , William B. Busa , Stephen J. Kron , Amy Catherine Flor
IPC分类号： C12Q1/68 , G01N21/76 , G01N21/00 , G01N21/59 , G01N21/47 , G01N21/64 , G01N21/25 , G01N21/66 , G01N21/65 , G01N24/00 , G01N27/72 , C40B30/04 , C12Q1/70 , B82Y15/00
CPC分类号： C12Q1/6804 , C07H21/00 , C12Q1/6834 , C12Q2565/113
摘要： The present disclosure is directed to methods and/or uses of oligonucleotide conjugates for assays and microscopy/imaging detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.
摘要翻译：本公开涉及用于测定和显微镜/成像检测和相关系统和/或试剂盒的寡核苷酸缀合物的方法和/或用途。某些方法涉及用于在检测测定中检测样品的一种或多种生物学靶标的方法，其包括：向包含一种或多种生物靶标的样品提供包含结合部分和寡核苷酸序列的分子探针; 将一种或多种生物靶与结合部分结合; 向所述样品提供可检测组分，其中所述可检测组分包含与与所述分子探针的寡核苷酸序列互补的寡核苷酸序列缀合的信号产生部分; 将靶结合分子探针的寡核苷酸序列杂交到可检测组分; 以及检测由所述可混合的可检测组分产生的信号。本文公开了各种其它实施例，应用等。

9. 发明授权

US07040205B2 Blind and shade cutting center with movable cutting station 有权
标题翻译：带可移动切割台的盲帘切割中心
公开(公告)号：US07040205B2
公开(公告)日：2006-05-09
申请号：US10463710
申请日：2003-06-16
申请人： David Roberts , Thomas A. Caputo , Richard D. Coulcher, Jr. , David A. Schwartz
发明人： David Roberts , Thomas A. Caputo , Richard D. Coulcher, Jr. , David A. Schwartz
IPC分类号： B26D7/20
CPC分类号： B23D45/003 , B23D23/00 , B23D35/008 , E06B9/266 , Y10T29/39 , Y10T83/04 , Y10T83/0453 , Y10T83/05 , Y10T83/0586 , Y10T83/141 , Y10T83/162 , Y10T83/207 , Y10T83/222 , Y10T83/404 , Y10T83/408 , Y10T83/412 , Y10T83/654 , Y10T83/6608 , Y10T83/6656 , Y10T83/7487 , Y10T83/7493 , Y10T83/7593 , Y10T83/76 , Y10T83/7607 , Y10T83/7647 , Y10T83/7693 , Y10T83/819 , Y10T83/853 , Y10T83/857 , Y10T83/858 , Y10T83/929 , Y10T83/95
摘要： An apparatus for sizing a window covering in a retail outlet includes a housing having a first end and a second end, and a top operating surface adapted to support a window covering to be sized. Movably disposed at the first end of the housing is a first cutting station that includes a stationary die and a movable die. The stationary die and the movable die are adapted to receive and size a window covering. The first cutting station further has a top portion and is movable from a first operating position to size a window covering to a retracted position in which the top portion is substantially flush with or lower than the top operating surface.
摘要翻译：用于调整零售口中的窗口覆盖物的尺寸的装置包括具有第一端和第二端的壳体，以及适于支撑要覆盖的窗户覆盖物的顶部操作表面。可移动地设置在壳体的第一端处的是包括固定模具和可动模具的第一切割站。固定模具和可移动模具适于接收和尺寸窗户覆盖物。第一切割台还具有顶部，并且可从第一操作位置移动到窗口覆盖件的尺寸，缩回位置，其中顶部基本上与顶部操作表面齐平或相比较。

10. 发明授权

US06580016B2 Animal model for detection of vulnerable plaques 失效
标题翻译：用于检测脆弱斑块的动物模型
公开(公告)号：US06580016B2
公开(公告)日：2003-06-17
申请号：US09760182
申请日：2001-01-12
申请人： Paul S. Teirstein , Kenneth W. Carpenter , Istvan Szinai , David A. Schwartz
发明人： Paul S. Teirstein , Kenneth W. Carpenter , Istvan Szinai , David A. Schwartz
IPC分类号： A01K6700
CPC分类号： A61K49/126 , A61B6/4057 , A61B6/481 , A61B6/508 , A61K49/0442 , A61K49/085 , A61K51/065 , G01N33/92 , G01N2400/40 , G01N2800/323
摘要： The present invention provides in vivo methods for detection of vulnerable plaque in a subject in need thereof. In the invention method the subject is administered a diagnostic amount of a biologically compatible detectable lipid-avid agent, the detectable lipid-avid agent is allowed to penetrate arterial walls and attach to any lipid accumulations of oxidized LDL-cholesterol in arterial walls in the wall of an artery; unbound detectable lipid-avid agent is allowed to clear from the body by natural processes, and the presence of the detectable lipid-avid agent attached to the lipid accumulation in the wall of the artery is detected. Detection of bound lipid-avid agent indicates the presence of a vulnerable plaque and predicts a heightened risk of lethal heart attack or thrombus. The detectable lipid-avid agent is selected for its ability to penetrate arterial walls and bind with oxidized LDL-cholesterol in the lipid accumulation in a vulnerable plaque. Alternatively, macrophage-avid agents, for example a lipid-avid agent attached to a macrophage-specific antibody, can be used in the invention methods. The invention further includes methods for in vitro assays for detecting vulnerable plaque and a porcine animal model of vulnerable plaque useful for testing treatment modalities.
摘要翻译：本发明提供了在有需要的受试者中检测易损斑块的体内方法。在本发明方法中，给予受试者诊断量的生物相容性可检测的脂质 - 抗体试剂，允许可检测的脂质激动剂渗透动脉壁并附着于壁中动脉壁中氧化的LDL-胆固醇的任何脂质积聚的动脉通过天然过程使未结合的可检测的脂质 - 抗体试剂从身体中清除，并且检测附着在动脉壁中的脂质积聚的可检测的脂质激动剂的存在。检测结合的脂质抗体剂表明存在易受伤害的斑块，并预测致死性心脏病发作或血栓的风险增加。选择可检测的脂质抗体试剂，以其穿透动脉壁并与氧化的LDL-胆固醇结合在易损斑块中的脂质积聚中。或者，巨噬细胞激动剂，例如与巨噬细胞特异性抗体连接的脂质 - 抗体试剂可用于本发明的方法中。本发明还包括用于检测易损斑块的体外测定方法和用于测试治疗方式的易损斑块的猪动物模型。

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