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1. 发明授权

US06580016B2 Animal model for detection of vulnerable plaques 失效
标题翻译：用于检测脆弱斑块的动物模型
公开(公告)号：US06580016B2
公开(公告)日：2003-06-17
申请号：US09760182
申请日：2001-01-12
申请人： Paul S. Teirstein , Kenneth W. Carpenter , Istvan Szinai , David A. Schwartz
发明人： Paul S. Teirstein , Kenneth W. Carpenter , Istvan Szinai , David A. Schwartz
IPC分类号： A01K6700
CPC分类号： A61K49/126 , A61B6/4057 , A61B6/481 , A61B6/508 , A61K49/0442 , A61K49/085 , A61K51/065 , G01N33/92 , G01N2400/40 , G01N2800/323
摘要： The present invention provides in vivo methods for detection of vulnerable plaque in a subject in need thereof. In the invention method the subject is administered a diagnostic amount of a biologically compatible detectable lipid-avid agent, the detectable lipid-avid agent is allowed to penetrate arterial walls and attach to any lipid accumulations of oxidized LDL-cholesterol in arterial walls in the wall of an artery; unbound detectable lipid-avid agent is allowed to clear from the body by natural processes, and the presence of the detectable lipid-avid agent attached to the lipid accumulation in the wall of the artery is detected. Detection of bound lipid-avid agent indicates the presence of a vulnerable plaque and predicts a heightened risk of lethal heart attack or thrombus. The detectable lipid-avid agent is selected for its ability to penetrate arterial walls and bind with oxidized LDL-cholesterol in the lipid accumulation in a vulnerable plaque. Alternatively, macrophage-avid agents, for example a lipid-avid agent attached to a macrophage-specific antibody, can be used in the invention methods. The invention further includes methods for in vitro assays for detecting vulnerable plaque and a porcine animal model of vulnerable plaque useful for testing treatment modalities.
摘要翻译：本发明提供了在有需要的受试者中检测易损斑块的体内方法。在本发明方法中，给予受试者诊断量的生物相容性可检测的脂质 - 抗体试剂，允许可检测的脂质激动剂渗透动脉壁并附着于壁中动脉壁中氧化的LDL-胆固醇的任何脂质积聚的动脉通过天然过程使未结合的可检测的脂质 - 抗体试剂从身体中清除，并且检测附着在动脉壁中的脂质积聚的可检测的脂质激动剂的存在。检测结合的脂质抗体剂表明存在易受伤害的斑块，并预测致死性心脏病发作或血栓的风险增加。选择可检测的脂质抗体试剂，以其穿透动脉壁并与氧化的LDL-胆固醇结合在易损斑块中的脂质积聚中。或者，巨噬细胞激动剂，例如与巨噬细胞特异性抗体连接的脂质 - 抗体试剂可用于本发明的方法中。本发明还包括用于检测易损斑块的体外测定方法和用于测试治疗方式的易损斑块的猪动物模型。

2. 发明授权

US08523824B2 Guidewire and catheter management device 有权
标题翻译：导丝管导管管理装置
公开(公告)号：US08523824B2
公开(公告)日：2013-09-03
申请号：US12498985
申请日：2009-07-07
申请人： Paul S. Teirstein , William Atkinson , William Gould , Yem Chin , Paul Scopton , Robert F. Carmichael, Jr.
发明人： Paul S. Teirstein , William Atkinson , William Gould , Yem Chin , Paul Scopton , Robert F. Carmichael, Jr.
IPC分类号： A61M5/32
CPC分类号： A61M25/02 , A61M2025/024 , A61M2025/0266 , A61M2025/028
摘要： Provided are devices and methods for catheter and guidewire management in a surgical setting. In one implementation, the device includes a housing having a curved bottom surface for accommodating the shape of a patient's leg. A retaining member is included, which can retain one or more guidewires, catheters, or the like. In another embodiment, the housing may include a number of vertical supports between which are mounted at least one retaining member housing. The retaining member housing may in turn house a retaining member, suitable for receiving and retaining one or more elongated devices such as catheters or guidewires. The retaining member may have a suitable size, shape, and level of flexibility to allow a catheter or guidewire to be placed therein and held with a desired level of force until such a time as a user desires to remove the catheter or guidewire.
摘要翻译：在外科手术中提供用于导管和导丝管理的装置和方法。在一个实施方案中，该装置包括具有用于容纳患者腿部的形状的弯曲底部表面的壳体。包括保持构件，其可以保持一个或多个导线，导管等。在另一个实施例中，壳体可以包括多个垂直支撑件，在其之间安装有至少一个保持构件壳体。保持构件壳体可以依次容纳适于接收和保持一个或多个细长装置（例如导管或导丝）的保持构件。保持构件可以具有合适的尺寸，形状和柔性水平，以允许将导管或导丝放置在其中并以期望的力量保持，直到用户期望去除导管或导丝的时间为止。

3. 发明授权

US5533978A Method and apparatus for uninterrupted delivery of radiographic dye 失效
标题翻译：射线染料不间断传送的方法和装置
公开(公告)号：US5533978A
公开(公告)日：1996-07-09
申请号：US336252
申请日：1994-11-07
申请人： Paul S. Teirstein
发明人： Paul S. Teirstein
IPC分类号： A61B6/00 , A61M5/00 , A61M5/14 , A61M5/36 , A61M5/40 , A61M5/178
CPC分类号： A61M5/007 , A61M5/1412 , A61M5/40 , A61M5/365
摘要： A method and apparatus for injecting radiographic dye during angiography are provided. A deformable holding chamber is interposed between a contrast dye bottle and a syringe manifold. A one-way valve and an integral disconnect/flow-stop are connected between the bottle and the holding chamber. A vent is provided in the holding chamber, with a second one-way valve. Squeezing and releasing the deformable chamber fills the chamber from the bottle. The holding chamber contains a floating baffle which acts as a shut off valve by plugging the chamber outlet if the chamber becomes empty. The syringe is used to withdraw dye from the holding chamber. If dye remains in the bottle after performance of the procedure, the disconnect/flow-stop fitting can be disconnected, and the dye can be saved.
摘要翻译：提供了用于在血管造影术期间注射放射线染料的方法和装置。可变形的保持室插入造影剂瓶和注射器歧管之间。瓶和保持室之间连接有单向阀和一体式断路器/止回阀。通气口设置在保持室中，具有第二单向阀。压缩和释放可变形室将瓶子从瓶中填充。保持室包含浮动挡板，如果腔室变空，则该浮动挡板用作切断阀。注射器用于从保持室中抽出染料。如果在执行程序后染料残留在瓶子中，则断开/止流配件可以断开，并且可以保存染料。

4. 发明授权

US08231550B2 Guide wire loading method and apparatus with towel attachment mechanism 有权
标题翻译：导丝加载方法和装置与毛巾附件机构
公开(公告)号：US08231550B2
公开(公告)日：2012-07-31
申请号：US12498965
申请日：2009-07-07
申请人： Paul S. Teirstein , Osama Amine , William Atkinson , William Gould , Yem Chin , Paul Scopton , Robert F. Carmichael, Jr.
发明人： Paul S. Teirstein , Osama Amine , William Atkinson , William Gould , Yem Chin , Paul Scopton , Robert F. Carmichael, Jr.
IPC分类号： A61B5/00 , A61B19/00 , A61B19/08 , A61F5/37 , A61F11/00 , A61M25/00
CPC分类号： A61M25/09
摘要： A device for loading a guide wire into the open end of a tubular instrument, such as a catheter. The device can be a block of material having a groove in its surface. The ends of the guide wire and the tubular instrument are placed into the groove and moved toward each other. When the ends meet, the groove guides the guide wire into the open end of the tubular instrument. The groove, or at least a portion of the groove, can have a cross-sectional contour that closely matches the outside radius of the tubular instrument. The groove can have a substantially vertical wall and a substantially non-vertical wall. A variety of attachment mechanisms may be provided for attaching the device to a towel draping a patient.
摘要翻译：用于将导丝装载到管状器械（例如导管）的开口端的装置。该装置可以是在其表面具有凹槽的材料块。引导线和管状器械的端部被放置在槽中并相互移动。当端部相接时，槽将引导线引导到管状器械的开口端。凹槽或凹槽的至少一部分可以具有与管状器械的外半径紧密匹配的横截面轮廓。凹槽可以具有基本垂直的壁和基本上非垂直的壁。可以提供各种附接机构用于将装置附接到悬垂患者的毛巾。

5. 发明授权

US06196996B1 Irradiation catheter and method of use 失效
标题翻译：照射导管及使用方法
公开(公告)号：US06196996B1
公开(公告)日：2001-03-06
申请号：US09034138
申请日：1998-02-20
申请人： Paul S. Teirstein
发明人： Paul S. Teirstein
IPC分类号： A61M2900
CPC分类号： A61N5/1002 , A61M25/1002 , A61M2025/0183 , A61M2025/1047 , A61N2005/1003
摘要： A catheter for use with a radioactive source within the catheter to irradiate a selected area of a blood vessel in combination with angioplasty procedures, to prevent restenosis of that area of the blood vessel. The catheter has a guidewire channel formed near its distal end to facilitate use of the catheter as a rapid exchange catheter, allowing insertion of the catheter over a guidewire also used in performance of an angioplasty procedure. The catheter also has a radiation lumen with a sealed end to retain the radioactive source within the catheter. The radiation lumen is sufficiently longer than the guidewire channel to extend into a non-sterile field, keeping the radiation source segregated from the blood, allowing the use of a non-sterile radiation source. The catheter can also be provided with a centering balloon or a set of centering wire loops to center the radioactive source radially within the blood vessel.
摘要翻译：导管，用于与导管内的放射源一起照射血管选定区域与血管成形术程序相结合，以防止血管区域的再狭窄。导管具有在其远端附近形成的导丝通道，以便于将导管用作快速交换导管，允许将导管插入也用于执行血管成形术程序的导丝。导管还具有带有密封端的放射腔，以将放射源保持在导管内。辐射管腔比导丝通道足够长以延伸到非无菌区域，保持辐射源与血液分离，允许使用非无菌辐射源。导管还可以设置有定心球或一组定心线环，以将放射源径向放置在血管内。

6. 发明授权

US5336184A Rapid exchange catheter 失效
标题翻译：快速交换导管
公开(公告)号：US5336184A
公开(公告)日：1994-08-09
申请号：US092332
申请日：1993-07-15
申请人： Paul S. Teirstein
发明人： Paul S. Teirstein
IPC分类号： A61M25/00 , A61M29/02 , A61N5/10 , A61M29/00 , A61M31/00
CPC分类号： A61M25/104 , A61M2025/0177 , A61M2025/0183 , A61M2025/1047 , A61M25/0023 , A61M25/0032 , A61N2005/1003
摘要： A novel over the wire-rapid exchange catheter is provided comprising a novel proximal end, which works in conjunction with the distal end of a traditional rapid exchange catheter, having a particular arrangement as shown in FIG. 1 which serves to enhance the users ability to properly operate and maneuver the guidewire/catheter, and thus to more effectively carry out the catherization procedure.Additionally, an OTW-RE catheter is provided with a means for rapidly removing the guidewire from the proximal end of the catheter, at the appropriate time during the procedure, while preserving the integrity of the device.
摘要翻译：提供了线 - 快速交换导管上的一种新颖的包括新颖的近端，其与传统的快速交换导管的远端相结合，具有如图1所示的特定布置。 1，其用于增强用户正确操作和操纵导丝/导管的能力，从而更有效地执行引导程序。此外，OTW-RE导管设置有用于在手术期间的适当时间从导管的近端快速移除导丝的装置，同时保持装置的完整性。

7. 发明授权

US08206321B2 Guide wire loading method and apparatus 有权
标题翻译：导丝加载方法及装置
公开(公告)号：US08206321B2
公开(公告)日：2012-06-26
申请号：US12218031
申请日：2008-07-09
申请人： Paul S. Teirstein , Osama Amine
发明人： Paul S. Teirstein , Osama Amine
IPC分类号： A61B5/00 , A61M25/00 , A61F11/00
CPC分类号： A61M25/09041
摘要： A device for loading a guide wire into the open end of a tubular instrument such as a catheter. The device can be a block of material having a groove in its surface. The ends of the guide wire and the tubular instrument are placed into the groove and moved toward each other. When the ends meet, the groove guides the guide wire into the open end of the tubular instrument. The groove, or at least a portion of the groove, can have a cross-sectional contour that closely matches the outside radius of the tubular instrument. The groove can have one portion with a shallower depth than the other portion, with the guide wire run in the shallower portion and the tubular instrument in the deeper portion. The guide wire and the tubular instrument can be angled above the device, with just their ends moving along the groove.
摘要翻译：用于将导丝装载到诸如导管的管状器械的开口端中的装置。该装置可以是在其表面具有凹槽的材料块。引导线和管状器械的端部被放置在槽中并相互移动。当端部相接时，槽将引导线引导到管状器械的开口端。凹槽或凹槽的至少一部分可以具有与管状器械的外半径紧密匹配的横截面轮廓。凹槽可以具有比另一部分浅的深度的一部分，导丝在更浅的部分中延伸并且管状器件在较深的部分中延伸。引导线和管状仪器可以在设备上方成角度，只是其端部沿着凹槽移动。

8. 发明申请

US20100010475A1 GUIDEWIRE AND CATHETER MANAGEMENT DEVICE 有权
标题翻译：导管和导管管理装置
公开(公告)号：US20100010475A1
公开(公告)日：2010-01-14
申请号：US12498985
申请日：2009-07-07
申请人： Paul S. Teirstein , William Atkinson , William Gould , Yem Chin , Paul Scopton , Robert F. Carmichael, JR.
发明人： Paul S. Teirstein , William Atkinson , William Gould , Yem Chin , Paul Scopton , Robert F. Carmichael, JR.
IPC分类号： A61M25/09 , F16L3/22 , B29C65/00
CPC分类号： A61M25/02 , A61M2025/024 , A61M2025/0266 , A61M2025/028
摘要： Provided are devices, systems, and methods for catheter and guidewire management in a surgical setting. In one implementation, the device may include a housing having a curved bottom surface for accommodating the shape of a patient's leg. Into the housing is mounted a retaining member, which can retain one or more guidewires, catheters, or the like. In another embodiment, the housing may include a number of vertical supports between which is mounted at least one retaining member housing. The retaining member housing may in turn house a retaining member, suitable for receiving and retaining one or more elongated devices such as catheters or guidewires. The retaining member may have a suitable size, shape, and level of flexibility to allow a catheter or guidewire to be placed therein and held with a desired level of force until such a time as a user desires to remove the catheter or guidewire. Using the device, catheter/guidewire combinations or other such paired devices, or indeed any devices, may be effectively managed in a surgical field.
摘要翻译：提供了用于外科手术中的导管和导丝管理的装置，系统和方法。在一个实施方式中，该装置可以包括具有用于容纳患者腿部的形状的弯曲底部表面的壳体。安装在壳体中的保持构件可保持一根或多根导线，导管等。在另一个实施例中，壳体可以包括多个垂直支撑件，在其之间安装有至少一个保持构件壳体。保持构件壳体可以依次容纳适于接收和保持一个或多个细长装置（例如导管或导丝）的保持构件。保持构件可以具有合适的尺寸，形状和柔性水平，以允许将导管或导丝放置在其中并且以期望的力量保持，直到用户期望去除导管或导丝的时间为止。使用该装置，导管/导丝组合或其他这样的配对装置，或实际上任何装置可以在手术领域中被有效地管理。

9. 发明授权

US5472425A Rapid exchange catheter 失效
标题翻译：快速交换导管
公开(公告)号：US5472425A
公开(公告)日：1995-12-05
申请号：US231423
申请日：1994-04-22
申请人： Paul S. Teirstein
发明人： Paul S. Teirstein
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02 , A61M36/04 , A61N5/10 , A61M29/00
CPC分类号： A61M25/0029 , A61M25/1002 , A61M25/104 , A61M29/02 , A61N5/1002 , A61M2025/0177 , A61M2025/0183 , A61M2025/1047 , A61M2025/1056 , A61M25/0023 , A61M25/0032 , A61N2005/1003
摘要： An over-the-wire rapid-exchange catheter having a guidewire channel and a rupturable membrane along one side of the guidewire channel. The catheter is exchanged by withdrawing the catheter from a guiding catheter, while stripping the operative catheter from the guidewire by tearing the guidewire through the rupturable membrane. The guidewire channel provides a sealing surface for a releasable seal on the guiding catheter, avoiding the gripping of the guidewire. A replacement catheter can be threaded onto the guidewire, and the end of the guidewire can puncture the rupturable membrane at a selected location to establish a guidewire channel at the distal end of the catheter.
摘要翻译：一种线上快速交换导管，其具有沿着导丝通道的一侧的导丝通道和可破裂膜。通过从引导导管中抽出导管来交换导管，同时通过将引导线撕裂穿过可破裂的膜而从导丝线上剥离手术导管。导丝通道为引导导管上的可释放密封提供密封表面，避免了导丝的夹持。替代导管可以被螺纹连接到导丝上，并且导丝的端部可以在选定位置刺穿可破裂的膜，以在导管的远端处建立导丝通道。

10. 发明授权

US5468225A Rapid exchange catheter 失效
标题翻译：快速交换导管
公开(公告)号：US5468225A
公开(公告)日：1995-11-21
申请号：US197970
申请日：1994-02-17
申请人： Paul S. Teirstein
发明人： Paul S. Teirstein
IPC分类号： A61M25/00 , A61M29/02 , A61N5/10 , A61M29/00 , A61M31/00
CPC分类号： A61M25/104 , A61M2025/0177 , A61M2025/0183 , A61M2025/1047 , A61M25/0023 , A61M25/0032 , A61N2005/1003
摘要： An over-the-wire rapid-exchange catheter having a distal guidewire channel and a proximal guidewire channel. The catheter is exchanged by withdrawing the catheter from a guiding catheter until the guidewire can be removed from the proximal guidewire channel and then further withdrawn in the conventional fashion. The proximal guidewire channel provides a sealing surface for a releasable seal on the guiding catheter, avoiding the gripping of the guidewire.
摘要翻译：一种线上快速交换导管，其具有远端导丝通道和近端导丝通道。通过从引导导管撤回导管来更换导管，直到导丝可以从近端导丝通道移除，然后以常规方式进一步退出。近端导丝通道为引导导管上的可释放密封提供密封表面，避免了导丝的夹持。

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